|
TP1198
|
Sincalide ammonium
SQ19844 ammonium,CCK-8 ammonium,Cholecystokinin octapeptide ammonium
|
cholecystokinin |
GPCR/G Protein |
|
Sincalide ammonium (CCK-8 ammonium) 是一种有效的氨基酸多肽激素胆囊收缩素 (CCK) 的类似物，是保留了 CCK 的大部分生物活性的活性片段。Sincalide ammonium 促进胆汁的分泌，使胆囊收缩并使 Oddi 的括约肌松弛，从而促进胆汁排入十二指肠。Sincalide ammonium 可通过注射促进胆囊收缩，常用于辅助诊断胆囊、胰腺疾病和胆囊造影术。 |
|
T14932L1
|
Ceruletide Ammonium Salt
Caerulein Ammonium Salt,Ceruletide Ammonium Salt（17650-98-5 Free base),FI-6934 Ammonium Salt,Cerulein Ammonium Salt
|
cholecystokinin |
GPCR/G Protein |
|
Ceruletide Ammonium Salt 是一种十肽，起源于热带青蛙的皮肤，是一种有效的胆囊收缩素受体 (cholecystokinin receptor) 激动剂，也是一种安全有效的胆囊收缩剂，对胆囊肌肉和胆管有直接的痉挛性作用。Ceruletide Ammonium Salt 具有镇静活性，可用于研究慢性精神分裂症。 |
|
T9518
|
Inarigivir ammonium
ORI-9020 ammonium,SB-9200 ammonium,Inarigivir铵
|
HBV |
Microbiology/Virology |
|
Inarigivir ammonium (SB-9200 ammonium) 是一种二核苷酸抗病毒化合物，可显着降低表达乙型肝炎病毒的转基因小鼠的 HBV DNA。它是一种激活细胞内先天免疫的视黄酸诱导基因-I 激动剂。 |
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T10252L2
|
ADU-S100 ammonium salt
ML RR-S2 CDA ammonium salt,MIW815 ammonium salt
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STING |
Immunology/Inflammation |
|
ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt) 是干扰素基因刺激物的激活剂。 ADU-S100 ammonium salt 可导致有效的全身性肿瘤消退和免疫。 |
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T17210L
|
Vaborbactam ammonium salt
RPX7009 ammonium salt,Vaborbactam ammonium salt（1360457-46-0 Free base）
|
Antibacterial |
Microbiology/Virology |
|
Vaborbactam ammonium salt 是一种 β-内酰胺酶抑制剂，可以恢复碳青霉烯类药物对 KPC 生产菌株的活性，常与其它药物连用来研究真菌感染。 |
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T3147
|
Pyrrolidinedithiocarbamate ammonium
PDTC,Pyrrolidinedithiocarbamate,吡咯烷二硫代氨基甲酸铵,APDC,1-Pyrrolidinedithiocarboxylic acid ammonium salt,Ammonium pyrrolidinedithiocarbamate,吡咯烷二硫代甲酸铵
|
NF-κB |
NF-κB |
|
Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt) 是一种选择性的、能透过血脑屏障的NF-κB 抑制剂。 |
|
TP1565L1
|
Foxy-5 Ammonium Salt
Foxy-5 Ammonium Salt（881188-51-8 Free base)
|
Wnt/beta-catenin |
Cytoskeletal Signaling;
Stem Cells |
|
Foxy-5 Ammonium Salt是 WNT5A 激动剂，是 WNT5A 的一个模拟肽，是 Wnt 家族的非经典成员。Foxy-5 Ammonium Salt可在不影响 β-catenin 激活的情况下触发胞浆游离钙信号传导，并可抑制上皮癌细胞的迁移和侵袭。Foxy-5 Ammonium Salt在原位小鼠模型中能有效降低 WNT5A 低表达的前列腺癌细胞的转移扩散。 |
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T15391
|
Glufosinate ammonium
|
Others |
Others |
|
Glufosinate ammonium 是谷氨酸的一种膦酸类似物，是一种除草剂，在植物细胞中转化为 PT (L-phosphinothricin) 。Glufosinate ammonium 显示出神经毒性作用。 |
|
TP1881L1
|
Pep 2-8 ammonium salt(1541011-97-5 free base)
|
Others |
Others |
|
Pep 2-8 ammonium salt(1541011-97-5 free base) 是 Proprotein 转化酶枯草杆菌蛋白酶/kexin 9 型 (PCSK9) 抑制剂。 PCSK9 与 LDL 受体结合的强效抑制剂 (IC50 = 0.8 μM)。恢复用 PCSK9 处理的 HepG2 细胞中的 LDL 摄取。 |
|
T14932L
|
Ceruletide Ammonium acetate
FI-6934 Ammonium acetate,Caerulein Ammonium acetate,Ceruletide Ammonium acetate (17650-98-5 free base)
|
cholecystokinin |
GPCR/G Protein |
|
Ceruletide Ammonium acetate (FI-6934 Ammonium acetate) 是一种胆囊收缩素 (CCK) 受体激动剂。它是一种安全有效的胆囊动力剂和小肠和胰腺外分泌兴奋剂。 |
|
T12407
|
Pepstatin Ammonium
Pepstatin A Ammonium
|
Others |
Others |
|
Pepstatin Ammonium is a specific inhibitor of aspartic proteaseproduced by actinomycetes(hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM |
|
T78081
|
Farnesyl Pyrophosphate ammonium
Farnesyl diphosphate ammonium
|
|
|
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Farnesyl pyrophosphate ammonium salt为15碳类异戊二烯代谢中间体，源自MVA途径，兼具TRPM2激动剂功能，能够触发TRPM2通道开放并促进离子流入细胞。它亦是胆固醇合成、泛醌合成、蛋白质法尼基化修饰以及GGPP合成的关键底物。 |
|
T19668
|
Tiomolibdate diammonium
Ammonium molybdenum sulfide,Ammonium tetrathiomolybdate,NSC 286644,ATTM,四硫钼酸铵,Coprexa
|
Others |
Others |
|
Tiomolibdate diammonium (NSC-286644) 是超氧化物歧化酶 1 (SOD1) 的抑制剂，具有抗血管生成和抗肿瘤活性。 Tiomolibdate diammonium 抑制铜酶的活性，包括 SOD1 和 COX。 |
|
T36863
|
Geranylgeranyl Pyrophosphate (ammonium salt)
Geranylgeranyl Pyrophosphate (ammonium salt),GGPP
|
|
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Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids.[1] It is also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.[2] This post-translational modification is necessary for correct localization of proteins to intracellular membranes for proper functionality and has become a focus of anticancer drug disco... |
|
T64295
|
Talotrexin ammonium
|
DHFR |
Cell Cycle/Checkpoint;
DNA Damage/DNA Repair;
Metabolism |
|
Talotrexin ammonium 是一种不可多聚谷氨酸抗叶酸类药物。Talotrexin ammonium 通过针对二氢叶酸还原酶（DHFR）来抑制肿瘤生长，从而提高了在广泛癌症模型中的抗肿瘤活性，有助于抑制肿瘤的增长。 |
|
T64755
|
Ammonium Chloride
|
Autophagy;
Antifungal |
Autophagy;
Microbiology/Virology |
|
|
|
T37475
|
Cyclic ADP-Ribose (ammonium salt)
cADP-Ribose,cADPR,Cyclic ADP-Ribose (ammonium salt)
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|
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|
Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second messenger is generated via the cADP-ribose synthases CD38 and CD157.[6],[5],[7] cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.[8] In vitro, cADP-ribose modulates Ca2+ signaling in rat and mouse cardiomyocytes treated with i... |
|
T40238
|
Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium
Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium
|
|
|
|
Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) displays a prolonged half-life (t1/2) compared to tenofovir in human liver microsomes. Moreover, it demonstrates potent in vitro anti-HIV activity and improves in vivo pharmacokinetic properties. |
|
T40239
|
Tenofovir-C3-O-C15-CF3 ammonium
Tenofovir-C3-O-C15-CF3 ammonium
|
|
|
|
Tenofovir-C3-O-C15-CF3 (ammonium) demonstrates prolonged half-life values compared to tenofovir in human liver microsomes. It exhibits potent anti-HIV activity in vitro and enhances pharmacokinetic properties in vivo. |
|
T10252L
|
ADU-S100 enantiomer ammonium salt
MIW815 enantiomer ammonium salt,ML RR-S2 CDA enantiomer ammonium salt
|
Others |
Others |
|
ADU-S100 (MIW815) enantiomer ammonium salt is the less active enantiomer of ADU-S100. ADU-S100 is an activator of the stimulator of interferon genes (STING). |
|
T64988
|
Ammonium sulfate
|
Reactive Oxygen Species |
Immunology/Inflammation;
Metabolism;
NF-κB |
|
Ammonium sulfate 是一种无机实验常用化合物之一，常用作氧化剂和漂白剂。 |
|
T36413
|
N-glycolyl-Ganglioside GM3 Mixture (ammonium salt)
N-glycolyl-Ganglioside GM3 Mixture (ammonium salt)
|
|
|
|
N-glycolyl-Ganglioside GM3(NeuGc-GM3) is a form of ganglioside GM3 that contains an N-glycolylated sialic acid (NeuGc). |
|
T39510
|
DL-TBOA ammonium
|
|
|
|
DL-TBOA ammonium is a potent, non-transportable inhibitor of excitatory amino acid transporters. Its inhibitory effects are demonstrated by IC50 values of 70 μM, 6 μM, and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2, and EAAT3, respectively. Additionally, DL-TBOA ammonium significantly hampers the uptake of [14C]glutamate in COS-1 cell lines expressing human EAAT1 and EAAT2, evident by Ki values of 42 μM and 5.7 μM, respectively. Furthermore, this compound competitively blocks EA... |
|
T36939
|
PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)
PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)
|
|
|
|
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3, also known as PIP3, is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. PIP3 can serve as an anchor for the binding of signal transd... |
|
T22981
|
Tetradecyltrimethylammonium bromide
MitMAB,Cetrimide,tetradecyl trimethyl ammonium bromide,十四烷基三甲基溴化铵
|
Dynamin |
Cytoskeletal Signaling |
|
Tetradecyltrimethylammonium bromide (MitMAB) 是一种具有不对称结构的阳离子表面活性剂，是一种有机结构单元。 |
|
T37030
|
PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
|
|
|
|
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. PtdIns-(4)-P1 can be phosphorylated to di- ... |
|
T37315
|
Fluo-3 (ammonium salt)
|
|
|
|
Fluo-3 (ammonium salt) is a fluorescent calcium indicator commonly used in flow cytometry and cell-based experiments to detect changes in intracellular calcium levels. [1] Its absorption maximum at 506 nm makes it compatible with excitation at 488 nm by argon-ion laser sources. Fluo-3 provides intense fluorescence upon binding calcium, detected at a maximum emission at 526 nm which can be monitored by FL1 (green, 525 nm band pass) sensors in flow cytometry. |
|
T30005
|
Ammonium mandelate
|
|
|
|
Ammonium mandelate is a biochemical. |
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T30003
|
Ammonium acryloyldimethyltaurate
|
|
|
|
Ammonium acryloyldimethyltaurate is a bioactive chemical. |
|
T31556
|
DNOC-ammonium
Krezonite E,Krezonit E
|
|
|
|
DNOC-ammonium is an Agricultural Chemical. |
|
T37775
|
Farnesyl Pyrophosphate (ammonium salt)
|
|
|
|
Farnesyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway and used in the biosynthesis of terpenes, terpenoids, and sterols. It also serves as a donor in post-translational isoprenylation of proteins. FPP has been identified as an antagonist of P2Y12 receptors (IC50 = 45 μM), attenuating platelet aggregation. It has also been shown to regulate adipocyte function as an endogenous PPARγ agonist. Additionally, because of a flexible hydrocarbon chain that enables different conformat... |
|
T38039
|
(E)-C-HDMAPP (ammonium salt)
|
|
|
|
Synthetic and natural alkyl phosphates, also known as phosphoantigens, stimulate the proliferation of γδ-T lymphocytes. Isopentenyl pyrophosphate, and related derivatives including (E)-hydroxy-dimethyl-allyl pyrophosphate ((E)-HDMAPP), are particularly effective activators of γδ-T cells. (E)-C-HDMAPP is the pyrophosphonate form of (E)-HDMAPP. The pyrophosphonate moiety in (E)-C-HDMAPP is much less susceptible to chemical or enzymatic hydrolysis than its pyrophosphate counterpart. As a result, (E... |
|
T38090
|
3'-sulfo Galactosylsphingosine (ammonium salt)
|
|
|
|
3'-sulfo Galactosylsphingosine is a form of sulfatide that is lacking the fatty acyl group. It decreases migration and adhesion of B35 neuroblastoma cells and increases cell rounding when used at a concentration of 20 μM. It also inhibits PKC and cytochrome c oxidase activity when used at concentrations of 150 and 50-100 μM, respectively. 3'-sulfo Galactosylsphingosine accumulates in patients with metachromatic leukodystrophy, a lysosomal storage disorder characterized by arylsulfatase A (ASA) d... |
|
T35454
|
γ-Glu-Cys (ammonium salt)
|
|
|
|
γ-Glu-Cys is an intermediate in glutathione (GSH) synthesis.1It is formed by ATP-dependent condensation of cysteine and glutamate by γ-glutamylcysteine synthetase. γ-Glu-Cys is also an essential component of phytochelatins, the heavy metal detoxifying enzymes in plants.2 |
|
T37691
|
Phosphatidic Acids (egg) (ammonium salt)
|
|
|
|
Phosphatidic acid is a phospholipid and an intermediate in glycerolipid biosynthesis. It is a transient intermediate in the synthesis of various phospholipid species that is synthesized de novo in cells via multiple routes, including the glycerol-3 phosphate and dihydroxyacetone phosphate pathways, enzymatic conversion of phosphatidylcholine by phospholipase D, and acetylation of lysophosphatidic acid by lysoPA-acyltransferase, among others. It has roles in shaping cellular membranes, cellular ... |
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T36346
|
Ac-VEID-AMC (ammonium acetate salt)
|
|
|
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Ac-VEID-AMC is a fluorogenic substrate based on the caspase-6 cleavage site in lamin A at amino acids VEID during apoptosis.1It has also been reported to be cleaved by related proteases, including caspase-8.2Caspase activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm.
1.Talanian, R.V., Quinlan, C., Trautz, S., et al.Substrate specificities of caspase family proteasesJ. Biol. Chem.272(15)9... |
|
T8902
|
DOTMA
Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride,N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium
|
Others |
Others |
|
DOTMA (N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium) 作为 tetra-methylated DOTA 类似物，是一种阳离子脂类，被用作基因治疗的非病毒载体。它已被用作脂质体的成分，可用于封装 siRNA、microRNA 和寡核苷酸，并用于体外基因转染。在体外和体内均表现出良好的基因转染效果。DOTMA 诱导脂质体上的正电荷，从而促进脂质体与细胞膜的有效相互作用。 |
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T39183
|
Okadaic acid ammonium salt
|
|
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Okadaic acid ammonium salt, a marine toxin, serves as an inhibitor of protein phosphatases (PP), displaying a higher affinity for PP2A (IC 50 =0.1-0.3 nM) alongside inhibitory effects on PP1 (IC 50 =15-50 nM), PP3 (IC 50 =3.7-4 nM), PP4 (IC 50 =0.1 nM), and PP5 (IC 50 =3.5 nM), but does not affect PP2C. By inhibiting PPs, this compound promotes protein phosphorylation and acts as a tumor promoter. Additionally, it is involved in inducing tau phosphorylation. |
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T36452
|
1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)
|
|
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1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl glycerol . 1-Arachidonoyl lysophosphatidic acid binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM. It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS. It also decreases differe... |
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T30020
|
Ammonium, p-phenylenebis(trimethyl-, diiodide
|
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Ammonium, p-phenylenebis(trimethyl-, diiodide is a bioactive chemical. |
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T35938
|
D-myo-Inositol-4-phosphate (ammonium salt)
|
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D-myo-Inositol-4-phosphate (Ins(4)P1) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intr... |
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T23196
|
PSB 0777 ammonium salt
|
Others |
Others |
|
adenosine A2A receptor full agonist |
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T37582
|
Ganglioside GM1 Mixture (ovine) (ammonium salt)
|
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Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane.3It associates with growth factor receptors, including TrkA, TrkB, and the GDNF receptor complex containing Ret and GFRα, and is required for TrkA expression on the cell surface. Ganglioside GM1interacts with other proteins to increase calcium i... |
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T37059
|
D-myo-Inositol-1,3,4,6-tetraphosphate (ammonium salt)
|
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The inositol phosphates (IPs) are a family of molecules produced by altering the phosphorylation status of each of the six carbons on the cyclic inositol structure. They act as second messengers, regulating a wide array of cellular functions. D-myo-inositol-1,3,4,6-tetraphosphate(Ins(1,3,4,6)-P4) largely acts an intermediate, serving as substrate for inositol-1,3,4,6-tetraphosphate 5-kinase to produce inositol-1,3,4,5,6-pentaphosphate, or inositol-1,3,4,6-tetraphosphate 2-kinase to give inositol... |
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T37002
|
7-Fluoro-2,1,3-benzoxadiazole-4-sulfonate (ammonium salt)
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7-Fluoro-2,1,3-benzoxadiazole-4-sulfonate (SBD-F) is a thiol-reactive fluorogenic probe.1It has been used to quantify the levels of homocysteine, cysteine, and cysteamine in human plasma.2SBD-F displays excitation/emission maxima of 380/515 nm, respectively.1
1.Imai, K., Toyo’oka, T., and Watanabe, Y.A novel fluorogenic reagent for thiols: Ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonateAnal. Biochem.128(2)471-473(1983) 2.Ichinose, S., Nakamura, M., Maeda, M., et al.A validated HPLC-fluoresc... |
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T30018
|
Ammonium, (p-trimethylammonio)benzyltrimethyl-, diiodide
|
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Ammonium, (p-trimethylammonio)benzyltrimethyl-, diiodide is a bioactive chemical. |
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T12872
|
SDZ 220-581 Ammonium salt
|
Others |
Others |
|
SDZ 220-581 Ammonium salt is a potent, orally active and competitive antagonist of NMDA receptor(pKi : 7.7). |
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T30007
|
Ammonium, ((p-ethyldimethylammonio)phenethyl)ethyldimethyl-, diiodide
|
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Ammonium, ((p-ethyldimethylammonio)phenethyl)ethyldimethyl-, diiodide is a bioactive chemical. |
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T30006
|
Ammonium, ((p-diethylmethylammonio)phenethyl)diethylmethyl-, diiodide
|
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Ammonium, ((p-diethylmethylammonio)phenethyl)diethylmethyl-, diiodide is a bioactive chemical. |
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T30008
|
Ammonium, ((p-triethylammonio)phenethyl)triethyl-, diiodide
|
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Ammonium, ((p-triethylammonio)phenethyl)triethyl-, diiodide is a bioactive chemical. |
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