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37

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1271L	Calmodulin-Dependent Protein Kinase II 290-309 acetate Calmodulin-Dependent Protein Kinase II 290-309 acetate (115044-69-4 Free base)	CaMK	Neuroscience
	Calmodulin-Dependent Protein Kinase II 290-309 acetate 是 Ca2+/calmodulin-dependent protein kinase II 的有效拮抗剂（IC50 = 52 nM）。
T4380	Ac-CoA Synthase Inhibitor1 ACSS2 inhibitor	RSV; Fatty Acid Synthase	Metabolism; Microbiology/Virology
	Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) 是一种可逆的醋酸盐依赖性乙酰辅酶 A 合成酶 2 抑制剂，IC50为 0.6 µM，可抑制呼吸道合胞病毒。
T75959	Calmodulin-Dependent Protein Kinase II(290-309) acetate
	Calmodulin-Dependent Protein Kinase II (290-309) acetate 是有效的 CaMK 拮抗剂，抑制抑制 Ca2+/钙调蛋白依赖性蛋白激酶II 的IC50值为52 nM。
TP1485L	Calcineurin substrate acetate	Autophagy	Autophagy
	Calcineurin substrate acetate 来自 cAMP 依赖性蛋白激酶的调节 RII 亚基。
T21470L	Davunetide acetate Davunetide acetate(211439-12-2 Free base)	Beta Amyloid; Microtubule Associated	Cytoskeletal Signaling; Neuroscience
	Davunetide acetate 源自哺乳动物 CNS 中存在的活性依赖性神经保护蛋白。 Davunetide acetate 是一种微管稳定肽，可抑制 Aβ 聚集和 Aβ 诱导的神经毒性。 Davunetide acetate 具有神经保护、神经营养和认知保护特性。
T37422L	Ras Inhibitory Peptide acetate Ras Inhibitory Peptide acetate(159088-48-9 Free base)	Ras	GPCR/G Protein; MAPK
	Ras Inhibitory Peptide acetate 是一种参与 Ras 依赖性信号通路的肽，Ras 在致癌受体引发的人类癌症中起重要作用。
T40437L	Caloxin 2A1 acetate	Proton pump	Membrane transporter/Ion channel
	Caloxin 2A1 acetate 是细胞外质膜 Ca2+-ATPase (PMCA) 肽的抑制剂。 Caloxin 2A1 acetate 抑制 140-kDa 酸稳定酰基磷酸盐的 Ca2+ 依赖性形成。
T37588L	GIP (1-30) amide, porcine acetate	IGF-1R	Tyrosine Kinase/Adaptors
	GIP (1-30) amide, porcine acetate 是完全葡萄糖依赖性促胰岛素多肽 (GIP) 受体的激动剂。它可弱抑制胃酸分泌，强烈刺激胰岛素。
TP1220L	Carperitide acetate 醋酸卡培立肽,Carperitide acetate (89213-87-6 Free base),Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate	Endothelin Receptor	GPCR/G Protein
	Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate) 是一种由 28 个氨基酸组成的激素，由心脏产生并分泌，以响应心脏损伤和机械拉伸。Carperitide acetate 抑制内皮素-1 (endothelin-1) 分泌。
TP2018L	GIP (human) acetate GIP (human) acetate(100040-31-1 Free base)	IGF-1R	Tyrosine Kinase/Adaptors
	GIP (human) acetate 是葡萄糖依赖性胰岛素分泌的刺激剂和胃酸分泌的弱抑制剂。 GIP (human) acetate 在脂质代谢和肥胖的发展中起着至关重要的作用。
T21983L	PKI 14-22 amide, myristoylated Acetate PKI 14-22 amide, myristoylated Acetate(201422-03-9 Free base)	PKA	Tyrosine Kinase/Adaptors
	PKI 14-22 amide, myristoylated Acetate 抑制 cAMP 依赖性蛋白激酶 (PKA) 并阻断脊髓给药 8-溴-cAMP 产生的痛觉过敏。
TP1403L	Syntide 2 acetate(108334-68-5 free base)	CaMK	Neuroscience
	Syntide 2 acetate(108334-68-5 free base) 是一种合成肽，被 Ca2+/钙调蛋白依赖性蛋白激酶 II (CaMKII; Km = 12 µM) 识别为底物。
TP1914L1	BAM (8-22) acetate BAM (8-22) acetate(412961-36-5 free base)	Others	Others
	BAM (8-22) acetate 是脑啡肽原 A 的蛋白水解产物。BAM (8-22) acetate 可激活 Mas 相关的 G 蛋白偶联受体 (Mrgprs)、MrgprC11 和 hMrgprX1，并以 Mrgpr 依赖性方式诱导小鼠抓挠。
TP1909L1	CALP2 acetate(261969-04-4 free base)	CaMK; PDE	Metabolism; Neuroscience
	CALP2 acetate 是一种钙调蛋白拮抗剂，对与 CaM EF-hand/Ca2+-结合位点具有高亲和力，Kd 为 7.9 µM。它有效抑制粘附和脱粒。它也是肺泡巨噬细胞的强激活剂。它抑制 CaM 依赖性磷酸二酯酶活性并增加细胞内 Ca2+ 浓度。
T21309	Nafarelin acetate(76932-56-4 free base) RS-94991-298,醋酸萘法瑞林,Nafarelin acetate,Nafarelin acetate hydrate,Synarel	GNRH Receptor	GPCR/G Protein
	Nafarelin acetate(76932-56-4 free base) (RS-94991-298) 是一种 GnRH 激动剂，可作为 GnRH 的类似物。 Nafarelin acetate(76932-56-4 free base) 导致促性腺激素促黄体激素 (LH) 和促卵泡激素 (FSH) 的垂体分泌减少。它可用于治疗雌激素依赖性病症。
TP1789L	Malantide acetate(86555-35-3 free base)	PKA; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Malantide acetate(86555-35-3 free base) 是一种由环 AMP 依赖性蛋白激酶 (PKA) 磷酸化的十二肽，可增加 PKA 活性。 Malantide 是一种由 PKA 磷酸化的合成肽，用于在体外测量 PKA 活性。
TP1051L	Protein Kinase C Peptide Substrate acetate Protein Kinase C Peptide Substrate acetate(120253-69-2 free base)	Others	Others
	Protein Kinase C Peptide Substrate acetate(120253-69-2 free base) 以依赖于第二信使和特定衔接蛋白的方式靶向特定细胞间隔物，以响应激活 g 蛋白偶联受体、酪氨酸激酶受体或酪氨酸激酶偶联受体的细胞外信号。
TP1787L	PKG Substrate acetate（81187-14-6 free base)	PKA	Tyrosine Kinase/Adaptors
	PKG Substrate acetate（81187-14-6 free base) 是 cGMP 依赖性蛋白激酶 (PKG) 的选择性底物。PKG Substrate 是蛋白激酶 G (PKG) 的选择性底物，PKG Iα (Km = 59 µM) 优于 PKG II (Km = 305)微米）。
T21410	Triptorelin acetate(57773-63-4 free base) 醋酸曲普瑞林,Wy 42422,Triptorelin Acetate,CL 118532,AY 25650,CL 118,532,Wy 42462,BIM 21003	GNRH Receptor	GPCR/G Protein
	Triptorelin acetate(57773-63-4 free base) (CL 118,532) 用作 GnRH 激动剂。它通过引起垂体的持续刺激来减少垂体促性腺激素促黄体激素 (LH) 和促卵泡激素 (FSH) 的分泌。曲普瑞林可用于治疗激素反应性癌症，如乳腺癌或前列腺癌、性早熟、雌激素依赖性疾病和辅助生殖。
T37207L	Cdk5 Substrate acetate	CDK	Cell Cycle/Checkpoint
	Cdk5 Substrate acetate 是一种丝氨酸/苏氨酸激酶，主要在神经元组织中具有活性。与 p25 或 p35 一起，Cdk5 磷酸化一系列蛋白质，包括组蛋白 H1 和 tau。它是一种合成肽 (PKTPKKAKKL)，对应于组蛋白 H1 的序列。它被 Cdk5 磷酸化，Km 值为 5 µM。
TP1910L1	CALP1 acetate CALP1 acetate(145224-99-3 free base)	CaMK	Neuroscience
	CALP1 acetate 是一种钙调蛋白 (CaM) 激动剂（Kd 为 88 µM），可与 CaM EF-hand/Ca2+ 结合位点结合。 CALP1 通过抑制钙通道的开放来阻断钙流入和细胞凋亡（IC50 为 44.78 µM）。 CALP1 阻断谷氨酸受体通道并阻断储存操作的非选择性阳离子通道。 CALP1 激活依赖于 CaM 的磷酸二酯酶活性。
T37589L	GIP (3-42), human acetate GIP (3-42), human acetate(1802086-25-4 Free base)	IGF-1R	Tyrosine Kinase/Adaptors
	GIP (3-42), human acetate 是葡萄糖依赖性促胰岛素多肽 (GIP) 受体的拮抗剂，可调节体内胰岛素分泌和 GIP 代谢。
T38063L	N-Acetyl lysyltyrosylcysteine amide acetate N-Acetyl lysyltyrosylcysteine amide acetate(1287585-40-3 Free base)	Glutathione Peroxidase	Metabolism
	N-Acetyl lysyltyrosylcysteine amide acetate 是一种有效且特异性的髓过氧化物酶 (MPO) 三肽抑制剂。 N-Acetyl lysyltyrosylcysteine amide acetate 抑制 MPO 依赖性次氯酸的生成、蛋白质硝化和 LDL 氧化反应。 N-Acetyl lysyltyrosylcysteine amide acetate 可减少中风后大脑中的神经元损伤并保护脑组织和神经功能。
T76262L	Cagrilintide acetate
	Cagrilintide acetate 是一种非选择性的 AMYR/CTR 激动剂和长效酰化淀粉酶类似物。Cagrilintide acetate 以剂量依赖的方式导致食物摄入减少和体重明显下降。Cagrilintide acetate 可用于肥胖症的研究。
T76041	GIP (1-30) amide,human acetate
	GIP (1-30) amide, human acetate 为葡萄糖依赖性促胰岛素多肽（GIP）的片段，作为一种肠降血糖素激素，它能在10^-9至10^-6M的剂量范围内，依赖剂量地促进胰岛素的分泌，并有效减缓餐后血糖波动。
T61358	AKN-028 acetate
	AKN-028 acetate 是一种新型酪氨酸激酶 (TKI) 抑制剂，是一种有效的口服活性的 FMS 样受体酪氨酸激酶 3 (FLT3) 抑制剂，其 IC50值为 6 nM。AKN-028 acetate 抑制 FLT3 自磷酸化。AKN-028 acetate 诱导剂量依赖性的细胞毒性反应 (平均IC50=1 μM)。AKN-028 acetate 通过激活 caspase 3 诱导细胞凋亡 (apoptosis)。AKN-028 acetate 可用于急性髓系白血病 (AML) 的研究。
T3650	STO-609 acetate	CaMK	Neuroscience
	STO-609 acetate 是选择性的、细胞可渗透的 Ca2+-钙调蛋白依赖性蛋白激酶激酶抑制剂（Ki：80/15 ng/ml，对于 CaM-KKα/KKβ）；竞争 ATP 结合位点。它比 CaMK1/2/4、PKC、MLCK、PKA 和 p42 MAPK 显示 > 80 倍的选择性。
T36412	Multiflorenol
	Multiflorenol is a triterpene that has been found in T. kirilowii seeds.1 It inhibits in vitro activation of Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter phorbol 12-myristate 13-acetate in a concentration-dependent manner. \|1. Akihisa, T., Tokuda, H., Ichiishi, E., et al. Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines. Cancer Lett. 173(1), 9-14 (2001).
T74072	R-BC154 acetate
	R-BC154 acetate为选择性的荧光α9β1整合素拮抗剂，其作为高亲和力、活化依赖的整合素探针，主要应用于研究促细胞生长因子α9β1和α4β1的结合活性。
T76048	TAK-683 acetate
	TAK-683 acetate是一种高效的KISS1R激动剂(IC50=170 pM)，改善了代谢稳定性。作为九肽metastin的类似物，对人和大鼠的EC50值分别为0.96 nM和1.6 nM。该化合物通过消耗下丘脑GnRH，能够降低血浆FSH、LH、睾酮水平，展示了对研究激素依赖性前列腺癌的潜力。
T73658	Orexin A (human, rat, mouse) (acetate)
	Orexin A (Hypocretin-1) (human, rat, mouse) acetate 是一种具有镇痛特性的下丘脑神经肽 (可透过血脑屏障)。Orexin A (human, rat, mouse) acetate 也是一种OX1R 激动剂，能以时间和剂量依赖性的方式诱导 SH-SY5Y 细胞BDNF 和TH 蛋白的表达。Orexin A (human, rat, mouse) acetate 可用于食欲调节、神经退行性疾病，以及调节伤害性信息传递的研究。
TD0048	5-(and-6)-Carboxy SNARF-1, Acetoxymethyl Ester, Acetate
	The cell-permeant pH indicator, carboxy SNARF-1, acetoxymethyl ester, acetate (CAS #126208-13-7) has a pKa of ~7.5 after de-esterification, thus is useful for measuring pH changes between pH 7 and pH 8. Carboxy-SNARF-1 exhibits a significant pH-dependent
T80084	Retatrutide acetate LY3437943 acetate
	Retatrutide (LY3437943) acetate 是一种针对胰高血糖素受体（GCGR）、葡萄糖依赖性促胰岛素多肽受体（GIPR）和胰高血糖素样肽-1 受体（GLP-1R）的三重肽激动剂。该化合物能有效抑制这三种受体，其EC50值分别为GCGR 5.79 nM、GIPR 0.0643 nM和GLP-1R 0.775 nM，是肥胖研究领域的潜在工具。
T71149	Triptorelin pamoate
	Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, es...
T36998	7β,27-dihydroxy Cholesterol 7β,27-DHC,7β,27-dihydroxy Cholesterol
	7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 &#181M. It increases IL-17A production in Th17-polarized isolated hum...
T68525	Nafarelin acetate hydrate
	Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estrogen/progesterone. When administered, Nafarelin has the purpose of causing increase estrogen that will negatively feed back upon hypothalamus to decrease GnRH ( negative feedback loop ) Through negative feedback, Nafarelin causes a decrease in pituitary secretion of gonadotropins lu...
T36221	2-chloro Palmitic Acid
	2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endot...

化合物

Calmodulin-Dependent Protein Kinase II 290-309 acetate

Cat.No: TP1271L

Synonym: Calmodulin-Dependent Protein Kinase II 290-309 acetate (115044-69-4 Free base)

Target: CaMK

Ac-CoA Synthase Inhibitor1

Cat.No: T4380

Synonym: ACSS2 inhibitor

Target: RSV, Fatty Acid Synthase

Calmodulin-Dependent Protein Kinase II(290-309) acetate

Cat.No: T75959

Calcineurin substrate acetate

Cat.No: TP1485L

Target: Autophagy

Davunetide acetate

Cat.No: T21470L

Synonym: Davunetide acetate(211439-12-2 Free base)

Target: Beta Amyloid, Microtubule Associated

Ras Inhibitory Peptide acetate

Cat.No: T37422L

Synonym: Ras Inhibitory Peptide acetate(159088-48-9 Free base)

Target: Ras

Caloxin 2A1 acetate

Cat.No: T40437L

Target: Proton pump

GIP (1-30) amide, porcine acetate

Cat.No: T37588L

Target: IGF-1R

Carperitide acetate

Cat.No: TP1220L

Synonym: 醋酸卡培立肽,Carperitide acetate (89213-87-6 Free base),Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate

Target: Endothelin Receptor

GIP (human) acetate

Cat.No: TP2018L

Synonym: GIP (human) acetate(100040-31-1 Free base)

Target: IGF-1R

PKI 14-22 amide, myristoylated Acetate

Cat.No: T21983L

Synonym: PKI 14-22 amide, myristoylated Acetate(201422-03-9 Free base)

Target: PKA

Syntide 2 acetate(108334-68-5 free base)

Cat.No: TP1403L

Target: CaMK

BAM (8-22) acetate

Cat.No: TP1914L1

Synonym: BAM (8-22) acetate(412961-36-5 free base)

Target: Others

CALP2 acetate(261969-04-4 free base)

Cat.No: TP1909L1

Target: CaMK, PDE

Nafarelin acetate(76932-56-4 free base)

Cat.No: T21309

Synonym: RS-94991-298,醋酸萘法瑞林,Nafarelin acetate,Nafarelin acetate hydrate,Synarel

Target: GNRH Receptor

Malantide acetate(86555-35-3 free base)

Cat.No: TP1789L

Target: PKA, PKC

Protein Kinase C Peptide Substrate acetate

Cat.No: TP1051L

Synonym: Protein Kinase C Peptide Substrate acetate(120253-69-2 free base)

Target: Others

PKG Substrate acetate（81187-14-6 free base)

Cat.No: TP1787L

Target: PKA

Triptorelin acetate(57773-63-4 free base)

Cat.No: T21410

Synonym: 醋酸曲普瑞林,Wy 42422,Triptorelin Acetate,CL 118532,AY 25650,CL 118,532,Wy 42462,BIM 21003

Target: GNRH Receptor

Cdk5 Substrate acetate

Cat.No: T37207L

Target: CDK

CALP1 acetate

Cat.No: TP1910L1

Synonym: CALP1 acetate(145224-99-3 free base)

Target: CaMK

GIP (3-42), human acetate

Cat.No: T37589L

Synonym: GIP (3-42), human acetate(1802086-25-4 Free base)

Target: IGF-1R

N-Acetyl lysyltyrosylcysteine amide acetate

Cat.No: T38063L

Synonym: N-Acetyl lysyltyrosylcysteine amide acetate(1287585-40-3 Free base)

Target: Glutathione Peroxidase

Cagrilintide acetate

Cat.No: T76262L

GIP (1-30) amide,human acetate

Cat.No: T76041

AKN-028 acetate

Cat.No: T61358

STO-609 acetate

Cat.No: T3650

Target: CaMK

Cat.No: T36412

R-BC154 acetate

Cat.No: T74072

TAK-683 acetate

Cat.No: T76048

Orexin A (human, rat, mouse) (acetate)

Cat.No: T73658

5-(and-6)-Carboxy SNARF-1, Acetoxymethyl Ester, Acetate

Cat.No: TD0048

Retatrutide acetate

Cat.No: T80084

Synonym: LY3437943 acetate

Triptorelin pamoate

Cat.No: T71149

7β,27-dihydroxy Cholesterol

Cat.No: T36998

Synonym: 7β,27-DHC,7β,27-dihydroxy Cholesterol

Nafarelin acetate hydrate

Cat.No: T68525

2-chloro Palmitic Acid

Cat.No: T36221

Cat. No.	Product Name	Target	Signaling Pathways
T4946	(+)-Columbianetin acetate 二氢欧山芹醇醋酸酯,COLUMBIANETIN ACETATE	Others	Others
	(+)-Columbianetin acetate (COLUMBIANETIN ACETATE) 是一种 Columbianetin 异构体。其中Columbianetin 是植物抗毒素，与芹菜贮藏过程中对病原体的抗性有关，表现出良好的抗炎及抗真菌活性。
TN6394	Alisol B acetate
	Alisol B acetate can induce Bax nuclear translocation and apoptosis in human hormone-resistant prostate cancer PC-3 cells, the Bax activation and translocation from the cytosol to nucleus might be a crucial response to the apoptotic effect. Alisol B aceta

天然产物

(+)-Columbianetin acetate

Cat.No: T4946

Synonym: 二氢欧山芹醇醋酸酯,COLUMBIANETIN ACETATE

Target: Others

Alisol B acetate

Cat.No: TN6394

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