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N-Acetyl lysyltyrosylcysteine amide acetate

产品编号 T38063L

别名: N-Acetyl lysyltyrosylcysteine amide acetate(1287585-40-3 Free base)

N-Acetyl lysyltyrosylcysteine amide acetate 是一种有效且特异性的髓过氧化物酶 (MPO) 三肽抑制剂。 N-Acetyl lysyltyrosylcysteine amide acetate 抑制 MPO 依赖性次氯酸的生成、蛋白质硝化和 LDL 氧化反应。 N-Acetyl lysyltyrosylcysteine amide acetate 可减少中风后大脑中的神经元损伤并保护脑组织和神经功能。

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N-Acetyl lysyltyrosylcysteine amide acetate Chemical Structure

N-Acetyl lysyltyrosylcysteine amide acetate, CAS N/A

规格	价格/CNY	货期
1 mg	￥ 777	待询
5 mg	￥ 1,992	待询
10 mg	￥ 3,387	待询
25 mg	￥ 5,987	待询
50 mg	￥ 8,977	待询
100 mg	￥ 13,467	待询
200 mg	￥ 19,987	待询

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N-Acetyl lysyltyrosylcysteine amide acetate 的其他形式现货产品:

N-Acetyl lysyltyrosylcysteine amide

其他形式的 N-Acetyl lysyltyrosylcysteine amide acetate:

N-Acetyl lysyltyrosylcysteine amide
现货

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生物活性

化学信息

存储 & 溶解度

参考文献

相关产品

产品描述

N-Acetyl lysyltyrosylcysteine amide acetate is an effective and selective tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide acetate inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL ox

体内活性

N-Acetyl lysyltyrosylcysteine amide acetate (10 mg/kg; i.p.; daily 7 days) significantly protects BBB function and decreased neutrophil infiltration. N-Acetyl lysyltyrosylcysteine amide acetate (10 mg/kg; i.p.; daily 7 days) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice. N-Acetyl lysyltyrosylcysteine amide acetate (10 mg/kg; i.p.; daily for 3-7 days) decreases apoptosis and cell injury in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide acetate reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide acetate reduces NO2Tyr and 4-HNE in MCAO mice. N-Acetyl lysyltyrosylcysteine amide acetate significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice. N-Acetyl lysyltyrosylcysteine amide acetate (10 mg/kg; i.p.; daily for 3-7 days) significantly reduces neurological severity scores and infarct size in MCAO mice[2].

别名	N-Acetyl lysyltyrosylcysteine amide acetate(1287585-40-3 Free base)
分子量	513.61
分子式	C22H35N5O7S

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

计算器

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参考文献

1. Zhang H, et al. N-acetyl lysyltyrosylcysteine amide inhibits myeloperoxidase, a novel tripeptide inhibitor. J Lipid Res. 2013;54(11):3016-3029. 2. Yu G, et al. Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke [published correction appears in J Neuroinflammation. 2016;13(1):166]. J Neuroinflammation. 2016;13(1):11

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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