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Cat. No. | Product Name | Target | Signaling Pathways |
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T79860 |
TIE-2/VEGFR-2 kinase-IN-5
|
VEGFR; Tie-2 | Angiogenesis; Tyrosine Kinase/Adaptors |
TIE-2/VEGFR-2 kinase-IN-5 是一种高效的 TIE-2 和 VEGFR-2 酪氨酸激酶受体抑制剂,具有的抗血管生成活性,常用于血管生成相关的生物医学研究领域。 | |||
T40581 |
TIE-2/VEGFR-2 kinase-IN-2
|
||
TIE-2/VEGFR-2 kinase-IN-2 is a powerful inhibitor of both VEGFR2 and Tie-2 kinases, displaying noteworthy pIC 50 values of 8.61 and 8.56, respectively. This compound acts as an anti-angiogenic agent, making it highly relevant for cancer research. | |||
T6335 |
Tie2 kinase inhibitor 1
Tie2 kinase inhibitor |
Tie-2 | Tyrosine Kinase/Adaptors |
Tie2 kinase inhibitor 1 (Tie2 kinase inhibitor) 是Tie2激酶选择性抑制剂9IC50:250 nM),具有抗癌作用。 | |||
T8817 |
TIE-2/VEGFR-2 kinase-IN-1
|
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TIE-2/VEGFR-2 kinase-IN-1 用于合成TIE-2或者VEGFR-2抑制剂,可用于研究不适当的血管生成的相关疾病。 | |||
T36718 |
Tie2 Inhibitor 7
|
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Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 μM. This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization. | |||
T16724 |
Razuprotafib
AKB-9778 |
Phosphatase; Others | Metabolism; Others |
Razuprotafib (AKB-9778) 是一种 VE-PTP (HPTPß)催化活性的有效选择性抑制剂,抑制结构相关磷酸酶 PTP1B。除 HPTPη 和 HPTPγ 外,它对 VE-PTP 具有良好的选择性。它能够促进 TIE2 活化,增强 ANG1 诱导的 TIE2 活化,并刺激 TIE2 通路中信号分子的磷酸化。 | |||
T79859 |
TIE-2/VEGFR-2 kinase-IN-4
|
||
TIE-2/VEGFR-2 kinase-IN-4,一种苯并咪唑衍生物,作为有效的TIE-2和VEGFR-2酪氨酸激酶受体抑制剂,其IC50值分别为5.2 nM和5.1 nM,适用于血管生成相关研究。 | |||
T79858 |
TIE-2/VEGFR-2 kinase-IN-3
|
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TIE-2/VEGFR-2 kinase-IN-3,为苯并咪唑衍生物,具备高效的抑制作用于TIE-2与VEGFR-2受体酪氨酸激酶,其IC50值分别达到6.9 nM和3.5 nM。本化合物主要用于血管生成相关研究。 | |||
T22259 |
AMG-Tie2-1
AMG-Tie2,4-甲基-3-[[3-[2-(甲基氨基)-4-嘧啶基]-2-吡啶基]氧基]-N-[3-(三氟甲基)苯基]苯甲酰胺 |
Others | Others |
AMG-Tie2-1 is a dual inhibitor of VEGF receptor 2 (VEGFR2) and tunica interna endothelial cell kinase 2 (Tie2). | |||
T36125 |
Tienilic Acid
|
P450 | Metabolism |
Tienilic Acid 是一种具有一定肝毒性的排尿酸利尿剂 | |||
T67847 |
Imatinib impurities3
|
Bcr-Abl; PDGFR; c-Kit | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Imatinib impurities3是一种蛋白激酶抑制剂,对 ABL1 wt、KIT wt 和 PDGFRR wt 的 IC50值分别为6.95μM 、0.245μM 和0.139μM 。 | |||
T68161L |
Tienoxolol FA
Tienoxolol FA (90055-97-3 Free base) |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Tienoxolol FA 是一种小分子 β-肾上腺素能受体拮抗剂,可用于治疗心血管疾病和研究高血压、心机缺血。 | |||
T19228 |
Calcitriol Impurities D
24-Homo Calcitriol,24-Homo-1,25-dihydroxyvitamin D3 |
Antiviral | Immunology/Inflammation |
Calcitriol Impurities D (24-Homo Calcitriol) 是维生素的一种激素形式,可促进HL-60人早幼粒细胞白血病细胞分化为单核细胞。Calcitriol Impurities D 具有骨吸收活性,抑制人类免疫缺陷病毒在人体细胞中的复制。Calcitriol Impurities D 具有抗病毒活性们可以用于治疗艾滋病和病毒感染。 | |||
T131465 |
Pelletierine
|
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T19227 |
Calcitriol Impurities A
|
Others | Others |
Calcitriol Impurities A refers to the contaminants found in Calcitriol, the hormonally active metabolite of vitamin D3, which serves to activate the vitamin D receptor. | |||
T24882 |
Tiemonium iodide
Cerfa-114,Visceralgine,Cerfa 114,Tiemozyl,Visceralgin |
||
Tiemonium iodide is a muscarinic receptor antagonist. It is also an anticholinergic and a parasympatholytic. | |||
T124545 |
Pseudopelletierine hydrochloride
|
||
Pseudopelletierine hydrochloride 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124545。 | |||
T68161 |
tienoxolol
|
||
Tienoxolol 具有利尿、利钠和阻断 p 肾上腺素受体的分子特性。此外,Tienoxolol 与Al 和A2腺苷受体结合。 | |||
T21094 |
Pseudopelletierine free base
NSC 116056,Granatonine,Pseudopelletierine,Granatan-3-one |
||
Pseudopelletierine is the main alkaloid derived from the root-bark of Punica granatum, along with at least three other alkaloids: isopelletierine, methylpelleteirine (C9H17ON) and pelletierine, which yield 1.8, 0.01, 0.20 and 0.52 grams per kilogram of ra | |||
T76200 |
STIEEQAKTFLDKFNHEAEDLFYQSSLASWN
|
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STIEEQAKTFLDKFNHEAEDLFYQSSLASWN 是与血管紧张素转换酶 2 (ACE2) 相关的肽,适用于研究 ACE2 功能。 | |||
T38930 |
BAY-826
|
Tie-2 | Tyrosine Kinase/Adaptors |
BAY-826 是一种新型、高效且具有选择性的 TIE-2 抑制剂,抑制 TIE-2 磷酸化,可用于研究肿瘤。 | |||
T6934 |
Pexmetinib
ARRY-614 |
Tie-2; p38 MAPK; Autophagy | Autophagy; MAPK; Tyrosine Kinase/Adaptors |
Pexmetinib (ARRY-614) 是一种口服生物可利用的双重 p38 MAPK/Tie-2 抑制剂,可研究急性骨髓性白血病。在 HEK-293 细胞系中的 IC50 为 4 nM/18 nM。 | |||
T4318 |
EOC317
ACTB-1003,ACTB1003,ACTB 1003 |
VEGFR; FGFR; Tie-2 | Angiogenesis; Tyrosine Kinase/Adaptors |
EOC317 (ACTB-1003) 是一种口服可用的激酶抑制剂,能够抑制 FGFR1 (IC50:6 nM),VEGFR2 (IC50:2 nM) 和 Tie-2 (IC50:4 nM)。 | |||
T2640 |
Rebastinib
DCC2036,DCC 2036,DCC-2036 |
Apoptosis; FLT; Bcr-Abl; Src | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Rebastinib (DCC-2036) 是一种口服有效的,非 ATP 竞争性的 Bcr-Abl 抑制剂,作用于 Abl1WT 和 Abl1T315I,IC50分别为 0.8 nM 和 4 nM,还抑制 LYN、SRC、HCK、FGR、FLT3、KDR 和 Tie-2,对 c-Kit 的活性低。Rebastinib 对 Angiopoietin2-Tie2通路具有抑制作用。 | |||
T2054 |
Altiratinib
DCC-2701 |
VEGFR; Tie-2; FLT; Trk receptor; c-Met/HGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Altiratinib (DCC-2701) 是一种多靶点激酶抑制剂,能够抑制 MET (IC50:2.7 nM),TIE2 (IC50:8 nM),VEGFR2 (IC50:9.2 nM),FLT3 (IC50:9.3 nM),Trk1 (IC50:0.85 nM),Trk2 (IC50:4.6 nM) 和 Trk3 (IC50:0.83 nM)。 | |||
T71979 |
TP-S1-68
|
||
TP-S1-68 is a Type-I inhibitor of TIE-2. | |||
T11519 |
GW768505A free base
|
Others | Others |
GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2 (pIC50: 7.81 for VEGFR2) with anti-angiogenic activity. | |||
T68484 | 2-MT-63 | ||
2-MT 63 is a novel TIE-2 kinase inhibitor that demonstrates unique and improved kinase selectivity compared to other inhibitors known to interact with TIE-2. 2-MT 63 has a good kinase selectivity profile in enzyme assays with >30-fold selectivity (typically much greater) against the tested kinases. Importantly, the profile includes selectivity against other targets of relevance for angiogenesis (KDR, PDGFR, EPHB4). | |||
T71819 |
RK-20448
|
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RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R, and Tie-2. It also inhibits BLK, Csk, Fyn, and Lyn. RK-20448 is the cis isomer of A-419259 | |||
T68389 | LY2457546 | ||
LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. LY2457546 demonstrates potent activity against targets that include VEGFR2 (KDR), PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. In vivo, LY2457546 inhibited VEGF-driven autophosphorylation of lung KDR in the mouse and rat in a dose and concentration dependent manner. LY2457546 was well tolerated and exhibited efficacy in a 13762 synge... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN4560 |
Methylisopelletierine
|
Others | Others |
N-Methylisopelletierine has hepatoprotective activity. | |||
T75568 | Z-Antiepilepsirine | ||
Z-Antiepilepsirine 是一种酰胺生物碱,存在于 Piper capense L.f 中。Z-Antiepilepsirine 显示抗疟原虫活性,对 PlasmodiumfalciparumW2 菌株的 IC50值为 27 µM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01064 |
TIE2 Protein, Human, Recombinant (His)
TIE2,VMCM,CD202B,TEK tyrosine kinase, endothelial,V... |
Human | HEK293 Cells |
TIE2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82 kDa and the accession number is AAA61139.1. | |||
TMPY-00930 |
TIE2 Protein, Human, Recombinant (His & hFc)
VMCM1,TIE2,CD202B,TEK tyrosine kinase, endothelial,... |
Human | HEK293 Cells |
TIE2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 108.5 kDa and the accession number is AAA61139.1. | |||
TMPY-04545 |
TIE2 Protein, Human, Recombinant (His & GST)
VMCM,CD202B,TIE-2,VMCM1,TEK tyrosine kinase, endoth... |
Human | Baculovirus Insect Cells |
TIE2 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 68.3 kDa and the accession number is Q02763-1. | |||
TMPY-05244 |
TIE2 Protein, Human, Recombinant (His), Biotinylated
TIE2,TEK tyrosine kinase, endothelial,CD202B,VMCM,V... |
Human | HEK293 Cells |
TIE2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82 kDa and the accession number is AAA61139.1. | |||
TMPY-01910 |
TIE1 Protein, Human, Recombinant (His)
tyrosine kinase with immunoglobulin-like and EGF-like domain... |
Human | HEK293 Cells |
Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as Tie1 is an angiopoietin receptor and is an orphan receptor tyrosine kinase that is expressed almost exclusively in endothelial cells and that is required for normal embryonic vascular development. The receptor tyrosine kinase Tie1 is expressed primarily in vascular endothelial cells. The receptor has also been detected in epithelial tumours in breast, thyroid and gastric cancers and in tumour cell lines where it appear... | |||
TMPY-01954 |
TIE2 Protein, Mouse, Recombinant (hFc)
Tie-2,STK1,Tie2,Hyk,Cd202b,AA517024,TEK ty... |
Mouse | HEK293 Cells |
TIE2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 107.7 kDa and the accession number is B1AWS8. | |||
TMPY-06974 |
TIE2 Protein, Mouse, Recombinant (His), Biotinylated
AA517024,Tie2,STK1,Hyk,Tie-2,TEK tyrosine ... |
Mouse | HEK293 Cells |
TIE2 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82.03 kDa and the accession number is Q02858. | |||
TMPY-04575 |
TIE2 Protein, Mouse, Recombinant (aa 770-1122, His & GST)
Cd202b,AA517024,STK1,Tie2,Tie-2,TEK tyrosi... |
Mouse | Baculovirus Insect Cells |
TIE2 Protein, Mouse, Recombinant (aa 770-1122, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 68.2kDa and the accession number is Q02858. | |||
TMPJ-00642 |
TIE2 Protein, Human, Recombinant (hFc)
TEK tyrosine kinase, endothelial,EC 2.7.10,Tie2,h |
Human | HEK293 Cells |
TIE2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 120-150 KDa and the accession number is Q02763-1. | |||
TMPJ-00643 |
TIE2 Protein, Human, Recombinant (aa 23-745, His)
VMCM1,TEK,Tie2,hTIE2,p140 TEK,soluble ... |
Human | HEK293 Cells |
TIE2 Protein, Human, Recombinant (aa 23-745, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-120 KDa and the accession number is Q02763-1. | |||
TMPY-03563 |
TIE2 Protein, Cynomolgus, Recombinant (hFc)
TEK tyrosine kinase, endothelial |
Cynomolgus | HEK293 Cells |
TIE2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 107.6 kDa and the accession number is G7PS68. | |||
TMPY-02508 |
TIE2 Protein, Rat, Recombinant (hFc)
TEK tyrosine kinase, endothelial |
Rat | HEK293 Cells |
TIE2 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 108 kDa and the accession number is A6JRG8. | |||
TMPY-05049 |
TIE2 Protein, Rhesus, Recombinant (His)
TEK tyrosine kinase, endothelial |
Rhesus | HEK293 Cells |
TIE2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.2 kDa and the accession number is G7NFP9. | |||
TMPY-02404 |
ADAM9 Protein, Mouse, Recombinant (His)
mKIAA0021,AU020942,ADAM metallopeptidase domain 9,Mltng,MDC9 |
Mouse | HEK293 Cells |
ADAM9 (A disintegrin and metallopeptidase domain 9, MDC9, meltrin gamma), is a type 1 transmembrane protein that has been associated with cancer development and metastases. ADAM9 is consistently overexpressed in various human cancers, and plays a role in tumorigenesis in mouse models. ADAM9 cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as EGF, FGFR2iiib, Tie-2, Flk-1, EphB4, CD40, VCAM-1, and VE-cadherin, and could represent a potential t... |