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Search Results for " tie "

Targets Recommended: Tie-2 VEGFR Tie-2

30

抑制剂 & 化合物

2

天然产物

14

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T79860	TIE-2/VEGFR-2 kinase-IN-5	VEGFR; Tie-2	Angiogenesis; Tyrosine Kinase/Adaptors
	TIE-2/VEGFR-2 kinase-IN-5 是一种高效的 TIE-2 和 VEGFR-2 酪氨酸激酶受体抑制剂，具有的抗血管生成活性，常用于血管生成相关的生物医学研究领域。
T40581	TIE-2/VEGFR-2 kinase-IN-2
	TIE-2/VEGFR-2 kinase-IN-2 is a powerful inhibitor of both VEGFR2 and Tie-2 kinases, displaying noteworthy pIC 50 values of 8.61 and 8.56, respectively. This compound acts as an anti-angiogenic agent, making it highly relevant for cancer research.
T6335	Tie2 kinase inhibitor 1 Tie2 kinase inhibitor	Tie-2	Tyrosine Kinase/Adaptors
	Tie2 kinase inhibitor 1 (Tie2 kinase inhibitor) 是Tie2激酶选择性抑制剂9IC50:250 nM)，具有抗癌作用。
T8817	TIE-2/VEGFR-2 kinase-IN-1
	TIE-2/VEGFR-2 kinase-IN-1 用于合成TIE-2或者VEGFR-2抑制剂，可用于研究不适当的血管生成的相关疾病。
T36718	Tie2 Inhibitor 7
	Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 μM. This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.
T16724	Razuprotafib AKB-9778	Phosphatase; Others	Metabolism; Others
	Razuprotafib (AKB-9778) 是一种 VE-PTP (HPTPß)催化活性的有效选择性抑制剂，抑制结构相关磷酸酶 PTP1B。除 HPTPη 和 HPTPγ 外，它对 VE-PTP 具有良好的选择性。它能够促进 TIE2 活化，增强 ANG1 诱导的 TIE2 活化，并刺激 TIE2 通路中信号分子的磷酸化。
T79859	TIE-2/VEGFR-2 kinase-IN-4
	TIE-2/VEGFR-2 kinase-IN-4，一种苯并咪唑衍生物，作为有效的TIE-2和VEGFR-2酪氨酸激酶受体抑制剂，其IC50值分别为5.2 nM和5.1 nM，适用于血管生成相关研究。
T79858	TIE-2/VEGFR-2 kinase-IN-3
	TIE-2/VEGFR-2 kinase-IN-3，为苯并咪唑衍生物，具备高效的抑制作用于TIE-2与VEGFR-2受体酪氨酸激酶，其IC50值分别达到6.9 nM和3.5 nM。本化合物主要用于血管生成相关研究。
T22259	AMG-Tie2-1 AMG-Tie2,4-甲基-3-[[3-[2-(甲基氨基)-4-嘧啶基]-2-吡啶基]氧基]-N-[3-(三氟甲基)苯基]苯甲酰胺	Others	Others
	AMG-Tie2-1 is a dual inhibitor of VEGF receptor 2 (VEGFR2) and tunica interna endothelial cell kinase 2 (Tie2).
T36125	Tienilic Acid	P450	Metabolism
	Tienilic Acid 是一种具有一定肝毒性的排尿酸利尿剂
T67847	Imatinib impurities3	Bcr-Abl; PDGFR; c-Kit	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Imatinib impurities3是一种蛋白激酶抑制剂，对 ABL1 wt、KIT wt 和 PDGFRR wt 的 IC50值分别为6.95μM 、0.245μM 和0.139μM 。
T68161L	Tienoxolol FA Tienoxolol FA (90055-97-3 Free base)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tienoxolol FA 是一种小分子 β-肾上腺素能受体拮抗剂，可用于治疗心血管疾病和研究高血压、心机缺血。
T19228	Calcitriol Impurities D 24-Homo Calcitriol,24-Homo-1,25-dihydroxyvitamin D3	Antiviral	Immunology/Inflammation
	Calcitriol Impurities D (24-Homo Calcitriol) 是维生素的一种激素形式，可促进HL-60人早幼粒细胞白血病细胞分化为单核细胞。Calcitriol Impurities D 具有骨吸收活性，抑制人类免疫缺陷病毒在人体细胞中的复制。Calcitriol Impurities D 具有抗病毒活性们可以用于治疗艾滋病和病毒感染。
T131465	Pelletierine

T19227	Calcitriol Impurities A	Others	Others
	Calcitriol Impurities A refers to the contaminants found in Calcitriol, the hormonally active metabolite of vitamin D3, which serves to activate the vitamin D receptor.
T24882	Tiemonium iodide Cerfa-114,Visceralgine,Cerfa 114,Tiemozyl,Visceralgin
	Tiemonium iodide is a muscarinic receptor antagonist. It is also an anticholinergic and a parasympatholytic.
T21094	Pseudopelletierine free base NSC 116056,Granatonine,Pseudopelletierine,Granatan-3-one
	Pseudopelletierine is the main alkaloid derived from the root-bark of Punica granatum, along with at least three other alkaloids: isopelletierine, methylpelleteirine (C9H17ON) and pelletierine, which yield 1.8, 0.01, 0.20 and 0.52 grams per kilogram of ra
T68161	tienoxolol
	Tienoxolol 具有利尿、利钠和阻断 p 肾上腺素受体的分子特性。此外，Tienoxolol 与Al 和A2腺苷受体结合。
T124545	Pseudopelletierine hydrochloride
	Pseudopelletierine hydrochloride 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124545。
T76200	STIEEQAKTFLDKFNHEAEDLFYQSSLASWN
	STIEEQAKTFLDKFNHEAEDLFYQSSLASWN 是与血管紧张素转换酶 2 (ACE2) 相关的肽，适用于研究 ACE2 功能。
T38930	BAY-826	Tie-2	Tyrosine Kinase/Adaptors
	BAY-826 是一种新型、高效且具有选择性的 TIE-2 抑制剂，抑制 TIE-2 磷酸化，可用于研究肿瘤。
T6934	Pexmetinib ARRY-614	Tie-2; p38 MAPK; Autophagy	Autophagy; MAPK; Tyrosine Kinase/Adaptors
	Pexmetinib (ARRY-614) 是一种口服生物可利用的双重 p38 MAPK/Tie-2 抑制剂，可研究急性骨髓性白血病。在 HEK-293 细胞系中的 IC50 为 4 nM/18 nM。
T2640	Rebastinib DCC2036,DCC 2036,DCC-2036	Apoptosis; FLT; Bcr-Abl; Src	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Rebastinib (DCC-2036) 是一种口服有效的，非 ATP 竞争性的 Bcr-Abl 抑制剂，作用于 Abl1WT 和 Abl1T315I，IC50分别为 0.8 nM 和 4 nM，还抑制 LYN、SRC、HCK、FGR、FLT3、KDR 和 Tie-2，对 c-Kit 的活性低。Rebastinib 对 Angiopoietin2-Tie2通路具有抑制作用。
T4318	EOC317 ACTB-1003,ACTB1003,ACTB 1003	VEGFR; FGFR; Tie-2	Angiogenesis; Tyrosine Kinase/Adaptors
	EOC317 (ACTB-1003) 是一种口服可用的激酶抑制剂，能够抑制 FGFR1 (IC50:6 nM)，VEGFR2 (IC50:2 nM) 和 Tie-2 (IC50:4 nM)。
T2054	Altiratinib DCC-2701	VEGFR; Tie-2; FLT; Trk receptor; c-Met/HGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Altiratinib (DCC-2701) 是一种多靶点激酶抑制剂，能够抑制 MET (IC50:2.7 nM)，TIE2 (IC50:8 nM)，VEGFR2 (IC50:9.2 nM)，FLT3 (IC50:9.3 nM)，Trk1 (IC50:0.85 nM)，Trk2 (IC50:4.6 nM) 和 Trk3 (IC50:0.83 nM)。
T71979	TP-S1-68
	TP-S1-68 is a Type-I inhibitor of TIE-2.
T11519	GW768505A free base	Others	Others
	GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2 (pIC50: 7.81 for VEGFR2) with anti-angiogenic activity.
T68484	2-MT-63
	2-MT 63 is a novel TIE-2 kinase inhibitor that demonstrates unique and improved kinase selectivity compared to other inhibitors known to interact with TIE-2. 2-MT 63 has a good kinase selectivity profile in enzyme assays with >30-fold selectivity (typically much greater) against the tested kinases. Importantly, the profile includes selectivity against other targets of relevance for angiogenesis (KDR, PDGFR, EPHB4).
T71819	RK-20448
	RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R, and Tie-2. It also inhibits BLK, Csk, Fyn, and Lyn. RK-20448 is the cis isomer of A-419259
T68389	LY2457546
	LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. LY2457546 demonstrates potent activity against targets that include VEGFR2 (KDR), PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. In vivo, LY2457546 inhibited VEGF-driven autophosphorylation of lung KDR in the mouse and rat in a dose and concentration dependent manner. LY2457546 was well tolerated and exhibited efficacy in a 13762 synge...

化合物

TIE-2/VEGFR-2 kinase-IN-5

Cat.No: T79860

Target: VEGFR, Tie-2

TIE-2/VEGFR-2 kinase-IN-2

Cat.No: T40581

Tie2 kinase inhibitor 1

Cat.No: T6335

Synonym: Tie2 kinase inhibitor

Target: Tie-2

TIE-2/VEGFR-2 kinase-IN-1

Cat.No: T8817

Tie2 Inhibitor 7

Cat.No: T36718

Cat.No: T16724

Synonym: AKB-9778

Target: Phosphatase, Others

TIE-2/VEGFR-2 kinase-IN-4

Cat.No: T79859

TIE-2/VEGFR-2 kinase-IN-3

Cat.No: T79858

Cat.No: T22259

Synonym: AMG-Tie2,4-甲基-3-[[3-[2-(甲基氨基)-4-嘧啶基]-2-吡啶基]氧基]-N-[3-(三氟甲基)苯基]苯甲酰胺

Target: Others

Tienilic Acid

Cat.No: T36125

Target: P450

Imatinib impurities3

Cat.No: T67847

Target: Bcr-Abl, PDGFR, c-Kit

Tienoxolol FA

Cat.No: T68161L

Synonym: Tienoxolol FA (90055-97-3 Free base)

Target: Adrenergic Receptor

Calcitriol Impurities D

Cat.No: T19228

Synonym: 24-Homo Calcitriol,24-Homo-1,25-dihydroxyvitamin D3

Target: Antiviral

Cat.No: T131465

Calcitriol Impurities A

Cat.No: T19227

Target: Others

Tiemonium iodide

Cat.No: T24882

Synonym: Cerfa-114,Visceralgine,Cerfa 114,Tiemozyl,Visceralgin

Pseudopelletierine free base

Cat.No: T21094

Synonym: NSC 116056,Granatonine,Pseudopelletierine,Granatan-3-one

Cat.No: T68161

Pseudopelletierine hydrochloride

Cat.No: T124545

STIEEQAKTFLDKFNHEAEDLFYQSSLASWN

Cat.No: T76200

Cat.No: T38930

Target: Tie-2

Cat.No: T6934

Synonym: ARRY-614

Target: Tie-2, p38 MAPK, Autophagy

Cat.No: T2640

Synonym: DCC2036,DCC 2036,DCC-2036

Target: Apoptosis, FLT, Bcr-Abl, Src

Cat.No: T4318

Synonym: ACTB-1003,ACTB1003,ACTB 1003

Target: VEGFR, FGFR, Tie-2

Cat.No: T2054

Synonym: DCC-2701

Target: VEGFR, Tie-2, FLT, Trk receptor, c-Met/HGFR

Cat.No: T71979

GW768505A free base

Cat.No: T11519

Target: Others

Cat.No: T68484

Cat.No: T71819

Cat.No: T68389

Cat. No.	Product Name	Target	Signaling Pathways
TN4560	Methylisopelletierine	Others	Others
	N-Methylisopelletierine has hepatoprotective activity.
T75568	Z-Antiepilepsirine
	Z-Antiepilepsirine 是一种酰胺生物碱，存在于 Piper capense L.f 中。Z-Antiepilepsirine 显示抗疟原虫活性，对 PlasmodiumfalciparumW2 菌株的 IC50值为 27 µM。

天然产物

Methylisopelletierine

Cat.No: TN4560

Target: Others

Z-Antiepilepsirine

Cat.No: T75568

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00930	TIE2 Protein, Human, Recombinant (His & hFc) VMCM1,TIE2,CD202B,TEK tyrosine kinase, endothelial,...	Human	HEK293 Cells
	TIE2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 108.5 kDa and the accession number is AAA61139.1.
TMPY-01064	TIE2 Protein, Human, Recombinant (His) TIE2,VMCM,CD202B,TEK tyrosine kinase, endothelial,V...	Human	HEK293 Cells
	TIE2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82 kDa and the accession number is AAA61139.1.
TMPY-04545	TIE2 Protein, Human, Recombinant (His & GST) VMCM,CD202B,TIE-2,VMCM1,TEK tyrosine kinase, endoth...	Human	Baculovirus Insect Cells
	TIE2 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 68.3 kDa and the accession number is Q02763-1.
TMPY-05244	TIE2 Protein, Human, Recombinant (His), Biotinylated TIE2,TEK tyrosine kinase, endothelial,CD202B,VMCM,V...	Human	HEK293 Cells
	TIE2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82 kDa and the accession number is AAA61139.1.
TMPY-01910	TIE1 Protein, Human, Recombinant (His) tyrosine kinase with immunoglobulin-like and EGF-like domain...	Human	HEK293 Cells
	Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as Tie1 is an angiopoietin receptor and is an orphan receptor tyrosine kinase that is expressed almost exclusively in endothelial cells and that is required for normal embryonic vascular development. The receptor tyrosine kinase Tie1 is expressed primarily in vascular endothelial cells. The receptor has also been detected in epithelial tumours in breast, thyroid and gastric cancers and in tumour cell lines where it appear...
TMPY-01954	TIE2 Protein, Mouse, Recombinant (hFc) Tie-2,STK1,Tie2,Hyk,Cd202b,AA517024,TEK ty...	Mouse	HEK293 Cells
	TIE2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 107.7 kDa and the accession number is B1AWS8.
TMPY-06974	TIE2 Protein, Mouse, Recombinant (His), Biotinylated AA517024,Tie2,STK1,Hyk,Tie-2,TEK tyrosine ...	Mouse	HEK293 Cells
	TIE2 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82.03 kDa and the accession number is Q02858.
TMPY-04575	TIE2 Protein, Mouse, Recombinant (aa 770-1122, His & GST) Cd202b,AA517024,STK1,Tie2,Tie-2,TEK tyrosi...	Mouse	Baculovirus Insect Cells
	TIE2 Protein, Mouse, Recombinant (aa 770-1122, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 68.2kDa and the accession number is Q02858.
TMPJ-00642	TIE2 Protein, Human, Recombinant (hFc) TEK tyrosine kinase, endothelial,EC 2.7.10,Tie2,h	Human	HEK293 Cells
	TIE2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 120-150 KDa and the accession number is Q02763-1.
TMPJ-00643	TIE2 Protein, Human, Recombinant (aa 23-745, His) VMCM1,TEK,Tie2,hTIE2,p140 TEK,soluble ...	Human	HEK293 Cells
	TIE2 Protein, Human, Recombinant (aa 23-745, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-120 KDa and the accession number is Q02763-1.
TMPY-03563	TIE2 Protein, Cynomolgus, Recombinant (hFc) TEK tyrosine kinase, endothelial	Cynomolgus	HEK293 Cells
	TIE2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 107.6 kDa and the accession number is G7PS68.
TMPY-02508	TIE2 Protein, Rat, Recombinant (hFc) TEK tyrosine kinase, endothelial	Rat	HEK293 Cells
	TIE2 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 108 kDa and the accession number is A6JRG8.
TMPY-05049	TIE2 Protein, Rhesus, Recombinant (His) TEK tyrosine kinase, endothelial	Rhesus	HEK293 Cells
	TIE2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.2 kDa and the accession number is G7NFP9.
TMPY-02404	ADAM9 Protein, Mouse, Recombinant (His) mKIAA0021,AU020942,ADAM metallopeptidase domain 9,Mltng,MDC9	Mouse	HEK293 Cells
	ADAM9 (A disintegrin and metallopeptidase domain 9, MDC9, meltrin gamma), is a type 1 transmembrane protein that has been associated with cancer development and metastases. ADAM9 is consistently overexpressed in various human cancers, and plays a role in tumorigenesis in mouse models. ADAM9 cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as EGF, FGFR2iiib, Tie-2, Flk-1, EphB4, CD40, VCAM-1, and VE-cadherin, and could represent a potential t...

重组蛋白

TIE2 Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-00930

Species: Human

Expression System: HEK293 Cells

TIE2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01064

Species: Human

Expression System: HEK293 Cells

TIE2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04545

Species: Human

Expression System: Baculovirus Insect Cells

TIE2 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05244

Species: Human

Expression System: HEK293 Cells

TIE1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01910

Species: Human

Expression System: HEK293 Cells

TIE2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01954

Species: Mouse

Expression System: HEK293 Cells

TIE2 Protein, Mouse, Recombinant (His), Biotinylated

Cat.No: TMPY-06974

Species: Mouse

Expression System: HEK293 Cells

TIE2 Protein, Mouse, Recombinant (aa 770-1122, His & GST)

Cat.No: TMPY-04575

Species: Mouse

Expression System: Baculovirus Insect Cells

TIE2 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00642

Species: Human

Expression System: HEK293 Cells

TIE2 Protein, Human, Recombinant (aa 23-745, His)

Cat.No: TMPJ-00643

Species: Human

Expression System: HEK293 Cells

TIE2 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPY-03563

Species: Cynomolgus

Expression System: HEK293 Cells

TIE2 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-02508

Species: Rat

Expression System: HEK293 Cells

TIE2 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-05049

Species: Rhesus

Expression System: HEK293 Cells

ADAM9 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02404

Species: Mouse

Expression System: HEK293 Cells

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