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Targets Recommended: Tie-2 VEGFR Tie-2

30

抑制剂 & 化合物

2

天然产物

14

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T79860 TIE-2/VEGFR-2 kinase-IN-5

VEGFR; Tie-2 Angiogenesis; Tyrosine Kinase/Adaptors
TIE-2/VEGFR-2 kinase-IN-5 是一种高效的 TIE-2 和 VEGFR-2 酪氨酸激酶受体抑制剂,具有的抗血管生成活性,常用于血管生成相关的生物医学研究领域。
T40581 TIE-2/VEGFR-2 kinase-IN-2

TIE-2/VEGFR-2 kinase-IN-2 is a powerful inhibitor of both VEGFR2 and Tie-2 kinases, displaying noteworthy pIC 50 values of 8.61 and 8.56, respectively. This compound acts as an anti-angiogenic agent, making it highly relevant for cancer research.
T6335 Tie2 kinase inhibitor 1

Tie2 kinase inhibitor

Tie-2 Tyrosine Kinase/Adaptors
Tie2 kinase inhibitor 1 (Tie2 kinase inhibitor) 是Tie2激酶选择性抑制剂9IC50:250 nM),具有抗癌作用。
T8817 TIE-2/VEGFR-2 kinase-IN-1

TIE-2/VEGFR-2 kinase-IN-1 用于合成TIE-2或者VEGFR-2抑制剂,可用于研究不适当的血管生成的相关疾病。
T36718 Tie2 Inhibitor 7

Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 μM. This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.
T16724 Razuprotafib

AKB-9778

Phosphatase; Others Metabolism; Others
Razuprotafib (AKB-9778) 是一种 VE-PTP (HPTPß)催化活性的有效选择性抑制剂,抑制结构相关磷酸酶 PTP1B。除 HPTPη 和 HPTPγ 外,它对 VE-PTP 具有良好的选择性。它能够促进 TIE2 活化,增强 ANG1 诱导的 TIE2 活化,并刺激 TIE2 通路中信号分子的磷酸化。
T79859 TIE-2/VEGFR-2 kinase-IN-4

TIE-2/VEGFR-2 kinase-IN-4,一种苯并咪唑衍生物,作为有效的TIE-2和VEGFR-2酪氨酸激酶受体抑制剂,其IC50值分别为5.2 nM和5.1 nM,适用于血管生成相关研究。
T79858 TIE-2/VEGFR-2 kinase-IN-3

TIE-2/VEGFR-2 kinase-IN-3,为苯并咪唑衍生物,具备高效的抑制作用于TIE-2与VEGFR-2受体酪氨酸激酶,其IC50值分别达到6.9 nM和3.5 nM。本化合物主要用于血管生成相关研究。
T22259 AMG-Tie2-1

AMG-Tie2,4-甲基-3-[[3-[2-(甲基氨基)-4-嘧啶基]-2-吡啶基]氧基]-N-[3-(三氟甲基)苯基]苯甲酰胺

Others Others
AMG-Tie2-1 is a dual inhibitor of VEGF receptor 2 (VEGFR2) and tunica interna endothelial cell kinase 2 (Tie2).
T36125 Tienilic Acid

P450 Metabolism
Tienilic Acid 是一种具有一定肝毒性的排尿酸利尿剂
T67847 Imatinib impurities3

Bcr-Abl; PDGFR; c-Kit Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
Imatinib impurities3是一种蛋白激酶抑制剂,对 ABL1 wt、KIT wt 和 PDGFRR wt 的 IC50值分别为6.95μM 、0.245μM 和0.139μM 。
T68161L Tienoxolol FA

Tienoxolol FA (90055-97-3 Free base)

Adrenergic Receptor GPCR/G Protein; Neuroscience
Tienoxolol FA 是一种小分子 β-肾上腺素能受体拮抗剂,可用于治疗心血管疾病和研究高血压、心机缺血。
T19228 Calcitriol Impurities D

24-Homo Calcitriol,24-Homo-1,25-dihydroxyvitamin D3

Antiviral Immunology/Inflammation
Calcitriol Impurities D (24-Homo Calcitriol) 是维生素的一种激素形式,可促进HL-60人早幼粒细胞白血病细胞分化为单核细胞。Calcitriol Impurities D 具有骨吸收活性,抑制人类免疫缺陷病毒在人体细胞中的复制。Calcitriol Impurities D 具有抗病毒活性们可以用于治疗艾滋病和病毒感染。
T131465 Pelletierine

T19227 Calcitriol Impurities A

Others Others
Calcitriol Impurities A refers to the contaminants found in Calcitriol, the hormonally active metabolite of vitamin D3, which serves to activate the vitamin D receptor.
T24882 Tiemonium iodide

Cerfa-114,Visceralgine,Cerfa 114,Tiemozyl,Visceralgin

Tiemonium iodide is a muscarinic receptor antagonist. It is also an anticholinergic and a parasympatholytic.
T124545 Pseudopelletierine hydrochloride

Pseudopelletierine hydrochloride 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124545。
T68161 tienoxolol

Tienoxolol 具有利尿、利钠和阻断 p 肾上腺素受体的分子特性。此外,Tienoxolol 与Al 和A2腺苷受体结合。
T21094 Pseudopelletierine free base

NSC 116056,Granatonine,Pseudopelletierine,Granatan-3-one

Pseudopelletierine is the main alkaloid derived from the root-bark of Punica granatum, along with at least three other alkaloids: isopelletierine, methylpelleteirine (C9H17ON) and pelletierine, which yield 1.8, 0.01, 0.20 and 0.52 grams per kilogram of ra
T76200 STIEEQAKTFLDKFNHEAEDLFYQSSLASWN

STIEEQAKTFLDKFNHEAEDLFYQSSLASWN 是与血管紧张素转换酶 2 (ACE2) 相关的肽,适用于研究 ACE2 功能。
T38930 BAY-826

Tie-2 Tyrosine Kinase/Adaptors
BAY-826 是一种新型、高效且具有选择性的 TIE-2 抑制剂,抑制 TIE-2 磷酸化,可用于研究肿瘤。
T6934 Pexmetinib

ARRY-614

Tie-2; p38 MAPK; Autophagy Autophagy; MAPK; Tyrosine Kinase/Adaptors
Pexmetinib (ARRY-614) 是一种口服生物可利用的双重 p38 MAPK/Tie-2 抑制剂,可研究急性骨髓性白血病。在 HEK-293 细胞系中的 IC50 为 4 nM/18 nM。
T4318 EOC317

ACTB-1003,ACTB1003,ACTB 1003

VEGFR; FGFR; Tie-2 Angiogenesis; Tyrosine Kinase/Adaptors
EOC317 (ACTB-1003) 是一种口服可用的激酶抑制剂,能够抑制 FGFR1 (IC50:6 nM),VEGFR2 (IC50:2 nM) 和 Tie-2 (IC50:4 nM)。
T2640 Rebastinib

DCC2036,DCC 2036,DCC-2036

Apoptosis; FLT; Bcr-Abl; Src Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
Rebastinib (DCC-2036) 是一种口服有效的,非 ATP 竞争性的 Bcr-Abl 抑制剂,作用于 Abl1WT 和 Abl1T315I,IC50分别为 0.8 nM 和 4 nM,还抑制 LYN、SRC、HCK、FGR、FLT3、KDR 和 Tie-2,对 c-Kit 的活性低。Rebastinib 对 Angiopoietin2-Tie2通路具有抑制作用。
T2054 Altiratinib

DCC-2701

VEGFR; Tie-2; FLT; Trk receptor; c-Met/HGFR Angiogenesis; Tyrosine Kinase/Adaptors
Altiratinib (DCC-2701) 是一种多靶点激酶抑制剂,能够抑制 MET (IC50:2.7 nM),TIE2 (IC50:8 nM),VEGFR2 (IC50:9.2 nM),FLT3 (IC50:9.3 nM),Trk1 (IC50:0.85 nM),Trk2 (IC50:4.6 nM) 和 Trk3 (IC50:0.83 nM)。
T71979 TP-S1-68

TP-S1-68 is a Type-I inhibitor of TIE-2.
T11519 GW768505A free base

Others Others
GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2 (pIC50: 7.81 for VEGFR2) with anti-angiogenic activity.
T68484 2-MT-63

2-MT 63 is a novel TIE-2 kinase inhibitor that demonstrates unique and improved kinase selectivity compared to other inhibitors known to interact with TIE-2. 2-MT 63 has a good kinase selectivity profile in enzyme assays with >30-fold selectivity (typically much greater) against the tested kinases. Importantly, the profile includes selectivity against other targets of relevance for angiogenesis (KDR, PDGFR, EPHB4).
T71819 RK-20448

RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R, and Tie-2. It also inhibits BLK, Csk, Fyn, and Lyn. RK-20448 is the cis isomer of A-419259
T68389 LY2457546

LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. LY2457546 demonstrates potent activity against targets that include VEGFR2 (KDR), PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. In vivo, LY2457546 inhibited VEGF-driven autophosphorylation of lung KDR in the mouse and rat in a dose and concentration dependent manner. LY2457546 was well tolerated and exhibited efficacy in a 13762 synge...

化合物

TIE-2/VEGFR-2 kinase-IN-5
Cat.No: T79860
Synonym:
Target: VEGFR, Tie-2
TIE-2/VEGFR-2 kinase-IN-2
Cat.No: T40581
Synonym:
Target:
Tie2 kinase inhibitor 1
Cat.No: T6335
Synonym: Tie2 kinase inhibitor
Target: Tie-2
TIE-2/VEGFR-2 kinase-IN-1
Cat.No: T8817
Synonym:
Target:
Tie2 Inhibitor 7
Cat.No: T36718
Synonym:
Target:
Razuprotafib
Cat.No: T16724
Synonym: AKB-9778
Target: Phosphatase, Others
TIE-2/VEGFR-2 kinase-IN-4
Cat.No: T79859
Synonym:
Target:
TIE-2/VEGFR-2 kinase-IN-3
Cat.No: T79858
Synonym:
Target:
AMG-Tie2-1
Cat.No: T22259
Synonym: AMG-Tie2,4-甲基-3-[[3-[2-(甲基氨基)-4-嘧啶基]-2-吡啶基]氧基]-N-[3-(三氟甲基)苯基]苯甲酰胺
Target: Others
Tienilic Acid
Cat.No: T36125
Synonym:
Target: P450
Imatinib impurities3
Cat.No: T67847
Synonym:
Target: Bcr-Abl, PDGFR, c-Kit
Tienoxolol FA
Cat.No: T68161L
Synonym: Tienoxolol FA (90055-97-3 Free base)
Target: Adrenergic Receptor
Calcitriol Impurities D
Cat.No: T19228
Synonym: 24-Homo Calcitriol,24-Homo-1,25-dihydroxyvitamin D3
Target: Antiviral
Pelletierine
Cat.No: T131465
Synonym:
Target:
Calcitriol Impurities A
Cat.No: T19227
Synonym:
Target: Others
Tiemonium iodide
Cat.No: T24882
Synonym: Cerfa-114,Visceralgine,Cerfa 114,Tiemozyl,Visceralgin
Target:
Pseudopelletierine hydrochloride
Cat.No: T124545
Synonym:
Target:
tienoxolol
Cat.No: T68161
Synonym:
Target:
Pseudopelletierine free base
Cat.No: T21094
Synonym: NSC 116056,Granatonine,Pseudopelletierine,Granatan-3-one
Target:
STIEEQAKTFLDKFNHEAEDLFYQSSLASWN
Cat.No: T76200
Synonym:
Target:
BAY-826
Cat.No: T38930
Synonym:
Target: Tie-2
Pexmetinib
Cat.No: T6934
Synonym: ARRY-614
Target: Tie-2, p38 MAPK, Autophagy
EOC317
Cat.No: T4318
Synonym: ACTB-1003,ACTB1003,ACTB 1003
Target: VEGFR, FGFR, Tie-2
Rebastinib
Cat.No: T2640
Synonym: DCC2036,DCC 2036,DCC-2036
Target: Apoptosis, FLT, Bcr-Abl, Src
Altiratinib
Cat.No: T2054
Synonym: DCC-2701
Target: VEGFR, Tie-2, FLT, Trk receptor, c-Met/HGFR
TP-S1-68
Cat.No: T71979
Synonym:
Target:
GW768505A free base
Cat.No: T11519
Synonym:
Target: Others
2-MT-63
Cat.No: T68484
Synonym:
Target:
RK-20448
Cat.No: T71819
Synonym:
Target:
LY2457546
Cat.No: T68389
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
TN4560 Methylisopelletierine

Others Others
N-Methylisopelletierine has hepatoprotective activity.
T75568 Z-Antiepilepsirine

Z-Antiepilepsirine 是一种酰胺生物碱,存在于 Piper capense L.f 中。Z-Antiepilepsirine 显示抗疟原虫活性,对 PlasmodiumfalciparumW2 菌株的 IC50值为 27 µM。

天然产物

Methylisopelletierine
Cat.No: TN4560
Synonym:
Target: Others
Z-Antiepilepsirine
Cat.No: T75568
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPY-01064 TIE2 Protein, Human, Recombinant (His)

TIE2,VMCM,CD202B,TEK tyrosine kinase, endothelial,V...

Human HEK293 Cells
TIE2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82 kDa and the accession number is AAA61139.1.
TMPY-00930 TIE2 Protein, Human, Recombinant (His & hFc)

VMCM1,TIE2,CD202B,TEK tyrosine kinase, endothelial,...

Human HEK293 Cells
TIE2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 108.5 kDa and the accession number is AAA61139.1.
TMPY-04545 TIE2 Protein, Human, Recombinant (His & GST)

VMCM,CD202B,TIE-2,VMCM1,TEK tyrosine kinase, endoth...

Human Baculovirus Insect Cells
TIE2 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 68.3 kDa and the accession number is Q02763-1.
TMPY-05244 TIE2 Protein, Human, Recombinant (His), Biotinylated

TIE2,TEK tyrosine kinase, endothelial,CD202B,VMCM,V...

Human HEK293 Cells
TIE2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82 kDa and the accession number is AAA61139.1.
TMPY-01910 TIE1 Protein, Human, Recombinant (His)

tyrosine kinase with immunoglobulin-like and EGF-like domain...

Human HEK293 Cells
Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as Tie1 is an angiopoietin receptor and is an orphan receptor tyrosine kinase that is expressed almost exclusively in endothelial cells and that is required for normal embryonic vascular development. The receptor tyrosine kinase Tie1 is expressed primarily in vascular endothelial cells. The receptor has also been detected in epithelial tumours in breast, thyroid and gastric cancers and in tumour cell lines where it appear...
TMPY-01954 TIE2 Protein, Mouse, Recombinant (hFc)

Tie-2,STK1,Tie2,Hyk,Cd202b,AA517024,TEK ty...

Mouse HEK293 Cells
TIE2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 107.7 kDa and the accession number is B1AWS8.
TMPY-06974 TIE2 Protein, Mouse, Recombinant (His), Biotinylated

AA517024,Tie2,STK1,Hyk,Tie-2,TEK tyrosine ...

Mouse HEK293 Cells
TIE2 Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82.03 kDa and the accession number is Q02858.
TMPY-04575 TIE2 Protein, Mouse, Recombinant (aa 770-1122, His & GST)

Cd202b,AA517024,STK1,Tie2,Tie-2,TEK tyrosi...

Mouse Baculovirus Insect Cells
TIE2 Protein, Mouse, Recombinant (aa 770-1122, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 68.2kDa and the accession number is Q02858.
TMPJ-00642 TIE2 Protein, Human, Recombinant (hFc)

TEK tyrosine kinase, endothelial,EC 2.7.10,Tie2,h

Human HEK293 Cells
TIE2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 120-150 KDa and the accession number is Q02763-1.
TMPJ-00643 TIE2 Protein, Human, Recombinant (aa 23-745, His)

VMCM1,TEK,Tie2,hTIE2,p140 TEK,soluble ...

Human HEK293 Cells
TIE2 Protein, Human, Recombinant (aa 23-745, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-120 KDa and the accession number is Q02763-1.
TMPY-03563 TIE2 Protein, Cynomolgus, Recombinant (hFc)

TEK tyrosine kinase, endothelial

Cynomolgus HEK293 Cells
TIE2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 107.6 kDa and the accession number is G7PS68.
TMPY-02508 TIE2 Protein, Rat, Recombinant (hFc)

TEK tyrosine kinase, endothelial

Rat HEK293 Cells
TIE2 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 108 kDa and the accession number is A6JRG8.
TMPY-05049 TIE2 Protein, Rhesus, Recombinant (His)

TEK tyrosine kinase, endothelial

Rhesus HEK293 Cells
TIE2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.2 kDa and the accession number is G7NFP9.
TMPY-02404 ADAM9 Protein, Mouse, Recombinant (His)

mKIAA0021,AU020942,ADAM metallopeptidase domain 9,Mltng,MDC9

Mouse HEK293 Cells
ADAM9 (A disintegrin and metallopeptidase domain 9, MDC9, meltrin gamma), is a type 1 transmembrane protein that has been associated with cancer development and metastases. ADAM9 is consistently overexpressed in various human cancers, and plays a role in tumorigenesis in mouse models. ADAM9 cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as EGF, FGFR2iiib, Tie-2, Flk-1, EphB4, CD40, VCAM-1, and VE-cadherin, and could represent a potential t...

重组蛋白

TIE2 Protein, Human, Recombinant (His)
Cat.No: TMPY-01064
Species: Human
Expression System: HEK293 Cells
TIE2 Protein, Human, Recombinant (His & hFc)
Cat.No: TMPY-00930
Species: Human
Expression System: HEK293 Cells
TIE2 Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04545
Species: Human
Expression System: Baculovirus Insect Cells
TIE2 Protein, Human, Recombinant (His), Biotinylated
Cat.No: TMPY-05244
Species: Human
Expression System: HEK293 Cells
TIE1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01910
Species: Human
Expression System: HEK293 Cells
TIE2 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-01954
Species: Mouse
Expression System: HEK293 Cells
TIE2 Protein, Mouse, Recombinant (His), Biotinylated
Cat.No: TMPY-06974
Species: Mouse
Expression System: HEK293 Cells
TIE2 Protein, Mouse, Recombinant (aa 770-1122, His & GST)
Cat.No: TMPY-04575
Species: Mouse
Expression System: Baculovirus Insect Cells
TIE2 Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-00642
Species: Human
Expression System: HEK293 Cells
TIE2 Protein, Human, Recombinant (aa 23-745, His)
Cat.No: TMPJ-00643
Species: Human
Expression System: HEK293 Cells
TIE2 Protein, Cynomolgus, Recombinant (hFc)
Cat.No: TMPY-03563
Species: Cynomolgus
Expression System: HEK293 Cells
TIE2 Protein, Rat, Recombinant (hFc)
Cat.No: TMPY-02508
Species: Rat
Expression System: HEK293 Cells
TIE2 Protein, Rhesus, Recombinant (His)
Cat.No: TMPY-05049
Species: Rhesus
Expression System: HEK293 Cells
ADAM9 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02404
Species: Mouse
Expression System: HEK293 Cells
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