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Search Results for " smmc-7721 "

5

抑制剂 & 化合物

21

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1406	Amantadine hydrochloride 盐酸金刚烷胺,1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride	Dopamine Receptor; Influenza Virus	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Amantadine hydrochloride (CI-719) 是一种抗病毒药物，用于预防或对症治疗甲型流感和帕金森病。它阻断质子流通过 M2 离子通道，从而阻止病毒 RNA 释放到感染细胞的细胞质中。
T12009	Telomerase-IN-1	Telomerase	DNA Damage/DNA Repair
	Telomease-IN-1是一种端粒酶抑制剂（IC50：0.19μM）。Telomease-IN-1通过ER 过度反应（EOR）的内质网应激（ERS）激活hTERT 的表达，然后诱导ERS，导致细胞凋亡。Telomease-IN-1通过表达下游信号分子包括CHOP（CAAT /增强子结合蛋白同源蛋白））和线粒体凋亡途径，导致细胞增殖受到抑制。Telomease-IN-1对端粒酶具有较高的抑制活性，对SMMC-7721细胞具有较高的抗增殖能力，对人正常肝细胞无明显毒性作用。Telomease-IN-1 在异种移植肿瘤模型表现出抗肿瘤活性。
T73421	CPT-Se3	Topoisomerase	DNA Damage/DNA Repair
	CPT-Se3为含硒的喜树碱前体活性分子，其杀癌和抗肿瘤效力显著。它通过降低GSH/GSSG比率及总硫醇水平，增加Hep G2细胞中ROS含量，触发癌细胞凋亡。CPT-Se3对HeLa、Hep G2、A549及SMMC-7721细胞线具备显着细胞毒性，IC50值介于2.19-4.7 μM。
T73422	CPT-Se4	Topoisomerase	DNA Damage/DNA Repair
	CPT-Se4为含硒前体活性分子的喜树碱(CPT)衍生物，对癌细胞具有较高杀伤力和抑制肿瘤生长效果。在降低GSH/GSSG比率和总硫醇的同时，CPT-Se4能够增加Hep G2细胞中的ROS水平，触发癌细胞凋亡。此化合物对HeLa、Hep G2、A549和SMMC-7721细胞系显示出显著的细胞毒性，IC50值范围为2.54-6.4 μM。
T36848	Combretastatin A-1 Combretastatin A1	Akt; Microtubule Associated	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Combretastatin A-1 是一种有效的微管抑制剂，具有抗肿瘤和抗血管活性，通过微管蛋白解聚介导的 AKT 失活抑制 Wnt/β-catenin 通路发挥作用，可用于研究肝癌。

化合物

Amantadine hydrochloride

Cat.No: T1406

Synonym: 盐酸金刚烷胺,1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride

Target: Dopamine Receptor, Influenza Virus

Telomerase-IN-1

Cat.No: T12009

Target: Telomerase

Cat.No: T73421

Target: Topoisomerase

Cat.No: T73422

Target: Topoisomerase

Combretastatin A-1

Cat.No: T36848

Synonym: Combretastatin A1

Target: Akt, Microtubule Associated

Cat. No.	Product Name	Target	Signaling Pathways
T3981	Acacetin 4'-Methoxyapigenin,金合欢素,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin	Apoptosis; IAP; COX; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Neuroscience
	Acacetin (5,7-Dihydroxy-4'-methoxyflavone) 是一种来自狗舌草的口服有效类黄酮。它停在 PI3Kγ 的 ATP 结合口袋中，可导致癌细胞周期停滞，并诱导细胞凋亡和自噬。它有抗癌和抗炎活性，有潜力研究疼痛相关疾病。
T7060	Amantadine 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine	Others	Others
	Amantadine (1-Aminoadamantane) 是抗病毒药物，也是是 NMDA 型谷氨酸受体的弱拮抗剂，能促进高多巴胺的释放，并阻断多巴胺的再摄取。
TN1600	Eclalbasaponin I	Others	Others
	Eclalbasaponin I 分离自鳢肠中，具有抗肿瘤作用，能够抑制肝癌细胞 smmc-7721 的增殖(IC50:111.1703 μg/ml)。
T5352	GLYCODEOXYCHOLIC ACID	Others; Endogenous Metabolite	Metabolism; Others
	Glycodeoxycholic Acid 是内源性代谢产物的一种。
T5826	Eupalinolide A	HSP	Cytoskeletal Signaling; Metabolism
	Eupalinolide A 是分离于林泽兰中的一种天然产物，通过抑制 HSF1 与 HSP90 的相互作用，激活 HSF1，诱导 HSP70 的表达。它对 A-549、BGC-823、SMMC-7721 和 HL-60 肿瘤细胞系具有强大的细胞毒性。
T5S0761	Nitidine chloride	Apoptosis; ERK; FAK; p38 MAPK; NF-κB; Topoisomerase; STAT; Parasite	Angiogenesis; Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Nitidine chloride 是从Zanthoxylum nitidum (Roxb) DC 中分离得到的，具有抗疟疾活性。它通过多个靶点通路，起抗癌作用，抑制STAT3、DNA 拓扑异构酶1和2A、ERK 和c-Src/FAK 相关信号通路。它通过MAPK 和NF-kB 途径抑制Lps 诱导的炎性细胞因子的产生。
TN3371	Albatrelin G	Others	Others
	Albatrelin G shows weak cytotoxic activity to cell lines HL-60, SMMC-7721, A-549, and MCF-7, in vitro.
TN1200	19-Oxocinobufotalin	Others	Others
	19-Oxocinobufotalin 3-adipoylarginine ester shows significant inhibition effect against human hepatocellular carcinoma cell line SMMC-7721 in vitro.
TN5574	Heudelotinone
	Heudelotinone shows cytotoxicity against three cancer cell lines A549, Hela, and SMMC-7721( IC50 values of 16.04, 10.67 and 21.68 uM , respectively).
TN5676	Musellarin B
	Musellarin B is cytotoxic toward several of the human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480).
TN3825	Demethylmurrayanine	Others	Others
	O-Demethylmurrayanine and clausine D exhibit strong cytotoxicity against MCF-7 and SMMC-7721 with IC50 values in the range 2.63-7.59 ug/ml.
TN3250	7-Prenyljacareubin	Others	Others
	7-Prenyljacareubin shows moderate cytotoxic activity against HL-60, SMMC-7721, A549, MCF-7, and SW480 cell lines.
TN3740	Cyclocommunol	PAFR	GPCR/G Protein
	Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong inhibition of arachidonic acid (AA)- and collagen-induced platelet aggregation.
TN1865	Licoricesaponin A3 甘草皂苷A3	Others	Others
	Licoricesaponin A3 shows the cytotoxic activity against the human cancer cell lines MGC-803, SW620, and SMMC-7721 with IC50 > 100 μMol/L.
TN5204	Uralsaponin C	Others	Others
	Uralsaponin C shows the cytotoxic activity against the human cancer cell lines MGC-803, SW620, and SMMC-7721 with IC50 > 100 μmol/L.
TN2052	Periplocoside M	Others	Others
	Periplocoside M possesses observably antitumor activity against SMMC-7721( IC 50=12.9 ng/L),Hela( IC 50=8.63 ng/L) and MCF-7( IC 50=18.5 ng/L) cancer cell lines.
T83461	11-Oxomogroside IV A
	11-Oxomogroside IV A（化合物12）是从罗汉果未成熟果实中分离出的葫芦二烷三萜糖苷，对SMMC-772肿瘤细胞具有细胞毒性（IC50：288 μg/mL），显示出抗肿瘤活性。
TN3925	Eichlerianic acid	HSV	Microbiology/Virology
	Eichlerianic acid is a trypanocidal compound with an IC50 value of 10 mg/mL. Eichlerianic acid may have antiviral activity against Herpes simplex virus types I and II in vitro. Eichlerianic acid shows weak cytotoxicity (IC50 6.87 to >40 μM) against human cancer cell (HL-60, SMMC-7721, A-549, MCF-7 and SW480).
TN1498	Cimigenol	Others	Others
	Cimigenol is a potential antitumor compound, combination of it with an autophagy inhibitor may be a valuable strategy for the chemoprevention or treatment of colon cancer. It exerted potent cytotoxic activity against SMMC-7721 (7.87μM) and A-549 (12.16 μM
TN4624	Nantenine	Others	Others
	Nantenine is an acetylcholinesterase inhibitor, it functions as an effective antagonist against a wide range of MDMA-induced effects in mice. Nantenine has anticonvulsant effect, which seems attributable to its stimulation and the resultant decrease of Ca
TN3616	Cedrelone	Apoptosis; MMP; Antifection	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Cedrelone 是一种柠檬苦素类化合物，是一种吩嗪生物合成样结构域蛋白 (PBLD) 激活剂。Cedrelone 可诱导癌细胞凋亡 (apoptosis)。Cedrelone 是一种非常有效的细胞凋亡诱导剂，它能导致细胞周期停止。Cedrelone 具有杀虫活性，可抑制 P. saucia 的箭毒生长，并可抑制乳草蝽（Oncopeltus fasciatus）的蜕皮。Cedrelone具有抗肿瘤作用，对SMMC-7721、A-549、MCF-7 和 SW480 等癌细胞株具有显著的细胞毒性。

天然产物

Cat.No: T3981

Synonym: 4'-Methoxyapigenin,金合欢素,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin

Target: Apoptosis, IAP, COX, Autophagy

Cat.No: T7060

Synonym: 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine

Target: Others

Eclalbasaponin I

Cat.No: TN1600

Target: Others

GLYCODEOXYCHOLIC ACID

Cat.No: T5352

Target: Others, Endogenous Metabolite

Cat.No: T5826

Target: HSP

Nitidine chloride

Cat.No: T5S0761

Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite

Cat.No: TN3371

Target: Others

19-Oxocinobufotalin

Cat.No: TN1200

Target: Others

Cat.No: TN5574

Cat.No: TN5676

Demethylmurrayanine

Cat.No: TN3825

Target: Others

7-Prenyljacareubin

Cat.No: TN3250

Target: Others

Cat.No: TN3740

Target: PAFR

Licoricesaponin A3

Cat.No: TN1865

Synonym: 甘草皂苷A3

Target: Others

Cat.No: TN5204

Target: Others

Periplocoside M

Cat.No: TN2052

Target: Others

11-Oxomogroside IV A

Cat.No: T83461

Eichlerianic acid

Cat.No: TN3925

Target: HSV

Cat.No: TN1498

Target: Others

Cat.No: TN4624

Target: Others

Cat.No: TN3616

Target: Apoptosis, MMP, Antifection

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