39
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9590 |
T-1095
|
SGLT; transporter | GPCR/G Protein; Metabolism |
T-1095 是一种口服有活性的Na+-葡萄糖协同转运蛋白选择性抑制剂,能够抑制 SGLT1 (IC50:22.8 µm) 及 SGLT2 (IC50:2.3 µm) 。它可用于研究糖尿病。 | |||
T2385 |
Ipragliflozin
伊格列净,ASP1941 |
SGLT | GPCR/G Protein |
Ipragliflozin (ASP1941) 是一种口服有效的,选择性的 SGLT2抑制剂,对人 SGLT2 和 SGLT1,大鼠 SGLT2 和 SGLT1,小鼠 SGLT2 和 SGLT1 的 IC50分别为 7.38 和 1876 nM,6.73 和 1166 nM,5.64 和 1380 nM。Ipragliflozin 具有抗糖尿病活性。 | |||
T4999 |
Ertugliflozin
埃格列净,MK-8835,PF-04971729 |
SGLT | GPCR/G Protein |
Ertugliflozin (PF-04971729) 是选择性的、口服有效的钠离子依赖的葡萄糖协同转运蛋白2 (SGLT2) 抑制剂,对h-SGLT2 的IC50值为 0.877 nM。Ertugliflozin 在2型糖尿病中有研究价值。 | |||
T1782 |
Canagliflozin
卡格列净,JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754 |
SGLT | GPCR/G Protein |
Canagliflozin (JNJ 28431754AAA) 是SGLT2的选择性抑制剂,在表达 mSGLT2,rSGLT2 和 hSGLT2 的 CHO 细胞上,IC50分别为 2 nM,3.7 nM 和 4.4 nM。 | |||
T34286 |
Remogliflozin etabonate
GSK189075,GSK 189075,GSK-189075A,GSK189075A,GSK-189075,GSK 189075A |
SGLT | GPCR/G Protein |
Remogliflozin etabonate (GSK189075A) 是 regaliflozin 的前药和 SGLT2 抑制剂,对 hSGLT2、rSGLT2、rSGLT1 和 hSGLT1 的 Ki 值分别为 1.95、2.14、8.57 和 43.1μM。 | |||
T2389 |
Dapagliflozin
达格列净,BMS-512148 |
SGLT; HIF | Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein |
Dapagliflozin (BMS-512148) 竞争性的葡萄糖协同转运蛋白2 (SGLT2) 抑制剂,可促进尿液中葡萄糖的排泄,在糖尿病 (DM) 研究中具有价值。Dapagliflozin 诱导 HIF1表达并减轻肾脏 IR 损伤。 | |||
T4460 |
Dapagliflozin ((2S)-1,2-propanediol, hydrate)
BMS-512148 (2S)-1,2-propanediol, hydrate,达格列净 (2S)-1,2-丙二醇水合物,Dapagliflozin propanediol monohydrate |
SGLT | GPCR/G Protein |
Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) 是 Dapagliflozin 1,2-propanediol, hydrate 的 S 型异构体,是竞争性葡萄糖协同转运蛋白2 抑制剂,可促进尿液中葡萄糖的排泄,可用于糖尿病的研究。它诱导 HIF1表达并减轻肾脏 IR 损伤。 | |||
T67849 |
O-Desethyl Dapagliflozin
Empagliflozin-4 |
SGLT | GPCR/G Protein |
O-Desethyl Dapagliflozin (Empagliflozin-4) 是一种 SGLT2 抑制剂, IC50=33nM. | |||
T7217 |
Bexagliflozin
THR-1442,EGT1442,EGT0001442 |
SGLT | GPCR/G Protein |
Bexagliflozin (EGT1442) 是一种选择性的,口服有效的钠葡萄糖协同转运蛋白-2 (SGLT2) 抑制剂,对人 SGLT2 和 SGLT1 作用的 IC50值分别为 2 nM 和 5.6 μM。EGT1442在 2 型糖尿病中有研究价值。 | |||
T5016 |
Tofogliflozin (hydrate)
托格列净,Tofogliflozin hydrate,CSG-452 hydrate |
SGLT; Reactive Oxygen Species; ROS | GPCR/G Protein; Immunology/Inflammation; Metabolism; NF-κB |
Tofogliflozin hydrate (CSG-452 hydrate) 是一种有效的,选择性的 SGLT2抑制剂,IC50为 2.9 nM,对人、大鼠和小鼠 SGLT2的Ki 分别为 2.9 nM,14.9 nM 和 6.4 nM。Tofogliflozin hydrate 对肾小管细胞中高葡萄糖诱导的ROS 生成具有部分抑制作用。 | |||
T68174 |
Sergliflozin A
|
SGLT | GPCR/G Protein |
Sergliflozin A 是一种选择型SGLT2抑制剂,以剂量依赖性方式诱导糖尿。可降低高血糖。 | |||
T16083 |
Mizagliflozin
GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base |
SGLT | GPCR/G Protein |
Mizagliflozin (GSK-1614235 free base) 是口服有效的、选择性的 SGLT1抑制剂,对人 SGLT1 的 Ki 值为 27 nM。Mizagliflozin 对 SGLT1 的选择性是 SGLT2的303 倍。它是抗糖尿病药物,可以改善餐后血糖波动。它在改善慢性便秘方面具有潜在的作用。 | |||
T3547 |
Sotagliflozin
LX-4211,LP-802034 |
SGLT | GPCR/G Protein |
Sotagliflozin (LP-802034) 是有效的SGLT1/2抑制剂,用作抗糖尿病剂。 | |||
T28757 |
Sergliflozin etabonate
GW-869682,GW-869682X,KGT-1251,GW869682X,GW869682,KGT1251 |
SGLT | GPCR/G Protein |
Sergliflozin etabonate (KGT-1251) 是一种 SGLT-2 抑制剂,可用于 2 型糖尿病和肥胖症的研究。 | |||
T15656 |
KGA-2727
|
SGLT | GPCR/G Protein |
KGA-2727是选择性,高亲和力和口服有效的 SGLT1抑制剂,对人和大鼠 SGLT1的 Ki 分别为 97.4 nM 和 43.5 nM,对 SGLT1的选择性比人SGLT2 高 140 倍 ,大鼠SGLT2高390 倍。KGA-2727具有抗糖尿病活性。 | |||
T1782L |
Canagliflozin hemihydrate
JNJ28431754,TA 7284,TA7284,TA-7284,JNJ 28431754,JNJ-28431754 |
SGLT | GPCR/G Protein |
Canagliflozin hemihydrate (TA 7284) (JNJ28431754 hemihydrate) 是一种选择性的 SGLT2 抑制剂,作用于表达 mSGLT2,rSGLT2 和 hSGLT2 的 CHO 细胞,IC50 分别为 2 nM,3.7 nM 和 4.4 nM。 | |||
T15244 |
Ertugliflozin L-pyroglutamic acid
埃格列净,PF-04971729 L-pyroglutamic acid |
Others; SGLT | GPCR/G Protein; Others |
Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) 是一种特异性和口服活性的 hSGLT2 抑制剂,IC50 为 0.877 nM。 Ertugliflozin L-pyroglutamic acid 可用于治疗 2 型糖尿病的研究。 | |||
T1766 |
Empagliflozin
BI 10773,恩格列净 |
SGLT | GPCR/G Protein |
Empagliflozin (BI 10773) 是一种 SGLT-2 抑制剂 (IC50=3.1 nM),具有有效的和选择性,对 SGLT-1/4/5/6 的选择性高 300 倍以上。Empagliflozin 可用于治疗二型糖尿病。 | |||
T15505 |
HSK0935
HSK 0935,HSK-0935 |
SGLT | GPCR/G Protein |
HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities. | |||
T38539 |
Luseogliflozin hydrate
鲁格列净水合物,TS 071 hydrate |
||
Luseogliflozin (TS 071) hydrate, a second-generation sodium-glucose co-transporter 2 (SGLT2) inhibitor, exhibits selective potency and oral activity, with an IC50 of 2.26 nM. This compound is utilized in research for the treatment of type 2 diabetes mellitus (T2DM). | |||
T21399 |
Luseogliflozin
TS71,TS-071,TS 71,TS071,TS-71,TS 071 |
||
Luseogliflozin, a potent and competitive inhibitor of sodium-dependent glucose cotransporter 2 (SGLT2), competitively inhibits human SGLT2-mediated glucose uptake with a Ki value of 1.10 nM. | |||
T32058 |
Henagliflozin
SHR3824,SHR 3824,SHR-3824 |
||
Henagliflozin (SHR3824) is an effective, oral, and selective SGLT2 inhibitor that effectively inhibits human SGLT2 in vitro, but has very weak inhibitory effects on human SGLT1. | |||
T13179 |
Tofogliflozin
CSG452 |
Others | Others |
Tofogliflozin is a highly specific inhibitor of sodium/glucose cotransporter 2 (SGLT2) (Kis: 2.9, 14.9, and 6.4 nM for human, rat, and mouse SGLT2. IC50s: 2.9/14.9/6.4 nM (human/rat/mouse SGLT2)). | |||
T15752 |
Licogliflozin
LIK066 |
SGLT | GPCR/G Protein |
Licogliflozin (LIK066) 是钠-葡萄糖协同转运蛋白 (SGLT1和SGLT2) 的有效抑制剂。 | |||
T3450 |
LX4211 N-4 Intermediate 9
索格列净中间体9,Sotagliflozin Intermediate 9 |
||
LX4211 N-4 Intermediate 9 是 Sotagliflozin 的中间体,Sotagliflozin 是一种口服生物可利用的 SGLT1 和 SGLT2 抑制剂。 | |||
T11667 |
Ipragliflozin (L-Proline)
Ipragliflozin L-Proline |
Others | Others |
Ipragliflozin is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM; little and NO potency for SGLT1/3/4/5/6. | |||
T10669 |
Canagliflozin-d4
Canagliflozin D4 |
Others | Others |
Canagliflozin D4 is a deuterium-labeled Canagliflozin. Canagliflozin is an SGLT2 inhibitor. | |||
T39966 |
SGLT1/2-IN-2
SGLT1/2-IN-2 |
||
SGLT1/2-IN-2 is a chemical compound with robust dual inhibitory properties, exhibiting potent activities against SGLT1 (IC50 = 96 nM) and SGLT2 (IC50 = 1.3 nM). | |||
T15797 |
LX2761
|
Others | Others |
LX2761 is a chemically stable and effective inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 (IC50s: 2.2 nM and 2.7nM for hSGLT1 and hSGLT2). However, it shows specific SGLT1 inhibition in the gastrointestinal (GI) tract. | |||
T72143 |
Velagliflozin proline hydrate
|
||
Velagliflozin proline hydrate 是 Velagliflozin 的临床形式。Velagliflozin 是一种可口服的钠-葡萄糖协同转运蛋白 2 (SGLT2) 抑制剂,具有抗糖尿病的活性。 特别是,Velagliflozin 减少肾葡萄糖重吸收,促进葡萄糖尿,从而降低血糖和胰岛素浓度。 | |||
T30534 |
BMS-639432
|
||
BMS-639432 is a potent sodium-glucose cotransporter type II (SGLT2) inhibitor. | |||
T35619 |
Dapagliflozin-3-O-β-D-Glucuronide
|
||
Dapagliflozin-3-O-β-D-glucuronide is a metabolite of dapagliflozin . Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport.[1] Dapagliflozin is metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A9 to dapagliflozin-3-O-β-D-glucuronide, which is 2,600-fold less potent than the parent compound with regard to SGLT2 inhibition.[2] | |||
T62830 |
SGLT1/2-IN-1
|
||
SGLT1/2-IN-1 是一种 SGLT1/SGLT2 双重抑制剂. | |||
T24708 |
Remogliflozin
GSK189074,Remogliflozin A,GSK-189074,GSK 189074 |
||
Remogliflozin is an effective sodium-glucose transporter 2 inhibitor (Kis = 12.4 and 26 nM for human and rat SGLT2, respectively). | |||
T70390 |
YM-543 choline
|
||
YM-543, also known as ASP-543, is a selective SGLT2 inhibitor. Sodium-glucose cotransporter 2 (SGLT2) is a specifically expressed transporter in the kidney that plays an important role in renal glucose reabsorption, and its inhibition may present a novel therapeutic strategy for treating diabetes. YM543 potently and selectively inhibited mouse and human SGLT2 activities at nanomolar ranges. In vivo single oral administration of YM543 dose-dependently and significantly reduced blood glucose level... | |||
T10958 |
Dapagliflozin-d5
BMS-512148 D5 |
Others | Others |
Dapagliflozin D5 (BMS-512148 D5) is deuterated Dapagliflozin. Dapagliflozin is a competitive SGLT2 inhibitor. | |||
T34767 |
TA-1887
TA 1887,TA1887 |
||
TA-1887 is a new type of selective inhibitor of sglt2 for the treatment of type 2 diabetes. It has a significant hypoglycemic effect in KK (HF-KK) mice fed a high-fat diet. TA-1887 has good pharmacokinetic characteristics and significantly increases UGE | |||
T12892 |
SGL5213
|
SGLT | GPCR/G Protein |
SGL5213 is an oral active and low-absorbable inhibitor of sodium-dependent glucose cotransporter 1 (SGLT1)(hSGLT1 and hSGLT2 with IC50 values of 29 nM and 20 nM , respectively),and has potential to treat type 2 diabetes. | |||
T12893 |
SGLT inhibitor-1
|
SGLT | GPCR/G Protein |
SGLT inhibitor-1 is a potentsodium glucose co-transporter proteins (SGLTs) dual inhibitor(hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively). |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1847 |
Kushenol X
苦参醇X |
Others | Others |
Kushenol X exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). | |||
TN1841 |
Kushenol A
苦参新醇 A,Leachianone E |
cAMP | GPCR/G Protein |
Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kushenol A and kushenol C exhibit inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). | |||
T2922 |
Phlorizin
Floridzin,根皮甙,根皮苷,NSC 2833,Phloridzin |
ATPase; SGLT | GPCR/G Protein; Membrane transporter/Ion channel |
Phlorizin (Phloridzin) 是非选择性的SGLT 抑制剂,也是Na+/K+-ATPase 抑制剂,对于hSGLT1和hSGLT2的Ki 值分别为 300 和 39 nM。 | |||
TN1842 |
Kushenol I
|
GABA Receptor; Antifection | Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience |
Kushenol I is a GABAA receptor modulator, it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).Kushenol I is shown to be active against the plant pathogenic fungus Cladosporium cucumerinum. | |||
TN4399 | Kushenol C | SGLT; NF-κB; ROS; BACE; Antifection | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB |
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). Kushenol C shows antimicrobial activity against Staphylococcus aureus and Streptococcus mutan |