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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T0396	Pipemidic acid 吡哌酸,Acido pipemidico	Antibacterial; Antibiotic	Microbiology/Virology
	Pipemidic acid (Acido pipemidico) 是一种新型抗菌剂，对革兰氏阴性菌和某些革兰氏阳性细菌具有活性，可研究肠道、泌尿和胆道感染。
TQ0107	Pemafibrate (R)-K-13675	PPAR	DNA Damage/DNA Repair; Metabolism
	Pemafibrate ((R)-K-13675) 是一种高度特异性的 PPARα 激动剂 (EC50: 1 nM)。
T68126	Pemedolac Dexpemedolac	COX	Immunology/Inflammation; Neuroscience
	Pemedolac (Dexpemedolac)是一种小分子 COX 抑制剂，可作为一种新型长效非麻醉性镇痛化合物，可用于治疗神经系统疾病、皮肤和肌肉骨骼疾病。
T0296	Pempidine 潘必定,1,2,2,6,6-Pentamethylpiperidine,Perolysen,Pyrilene	Others; AChR	Neuroscience; Others
	Pempidine (1,2,2,6,6-Pentamethylpiperidine) 是一种口服具有活力的神经节阻断试剂，用于研究高血压。
T9908	Pembrolizumab	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Pembrolizumab 是一种抑制 PD-1 受体的人源化单克隆抗体，是一个 HER2 二聚化抑制剂类，它会削弱 HER2 与 HER 家族其他成员结合的能力。
T6226	Pemetrexed disodium hemipenta hydrate 培美曲塞二钠一水合物,Pemetrexed Disodium Hydrate,LY-231514 Disodium Hydrate,Pemetrexed sodium hydrate,培美曲塞二钠水合物	Apoptosis; DHFR; DNA/RNA Synthesis; Antifolate; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Pemetrexed disodium hemipenta hydrate (LY-231514 Disodium Hydrate) 是一种叶酸拮抗剂。抑制胸苷酸合成酶 (TS)，二氢叶酸还原酶 (DHFR) 和甘氨酰胺核苷酸甲酰转移酶 (GARFT)，Ki 分别为 1.3 nM，7.2 nM 和 65 nM。
T15461	Halopemide	Others; Phospholipase; Dopamine Receptor	GPCR/G Protein; Metabolism; Neuroscience; Others
	Halopemide 是一种有效的 PLD 抑制剂（对人 PLD1 和 PLD2 的 IC50 = 220 和 310 nM）。 Halopemid 是多巴胺受体的拮抗剂。Halopemid 可用于精神药物研究。
T1425	Pemirolast potassium BMY 26517,TWT-8152,吡嘧司特钾	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Pemirolast potassium (TWT-8152) 是 H1组胺受体拮抗剂和肥大细胞稳定剂，是一种具有抗过敏特性的嘧啶酮衍生物。
T0189	Pemetrexed Pemetrexed acid,培美曲塞,LY231514,培美曲唑,LY-231514 Disodium Hydrate	DHFR; DNA/RNA Synthesis; Antifolate; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Pemetrexed (LY-231514 Disodium Hydrate) acid 是一种鸟嘌呤衍生的抗肿瘤药物，可结合并抑制胸苷酸合酶、二氢叶酸还原酶和甘氨酰胺核苷酸甲酰转移酶的 Ki 分别为 1.3 nM、7.2 nM 和 65 nM。
T27322	Fispemifene HM-101,HM 101,HM101	Others	Others
	Fispemifene (HM-101) 是一种雌激素受体调节剂（SERM），可用于治疗泌尿生殖系统综合征和阴道萎缩。
T0189L	Pemetrexed disodium 培美曲塞二钠盐,LY-231514,LY231514 disodium,培美曲塞二钠,Pemetrexed	Apoptosis; DHFR; DNA/RNA Synthesis; Antifolate; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Pemetrexed disodium (LY-231514) 是一种叶酸拮抗剂，用于治疗非小细胞肺癌和恶性间皮瘤。它抑制胸苷酸合成酶，二氢叶酸还原酶和甘氨酰胺核苷酸甲酰转移酶的Ki 分别为 1.3 nM，7.2 nM 和 65 nM。
T12401	Pemigatinib INCB054828	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Pemigatinib (INCB054828) 是一种口服具有活力的，选择性的 FGFR 抑制剂，能够作用于 FGFR1 (IC50:0.4 nM)，FGFR2 (IC50:0.5 nM)，FGFR3 (IC50:1.2 nM)，FGFR4 (IC50:30 nM)，有用于胆管癌的潜力。
T13814	Pemafibrate (racemate) K13675 (racemate)	Others	Others
	Pemafibrate racemate is the racemate of pemafibrate
T70583	Pemetrexed Diethyl Ester
	Pemetrexed Diethyl Ester is a protected intermediate in the synthesis of Pemetrexed, a multi-targeted anti-folate that inhibits thymidylate synthase as well as other folate dependent enzymes.
T25929	Pemetrexed tromethamine Pemetrexed ditromethamine dihydrate
	Pemetrexed tromethamine is a chemotherapy drug used for pleural mesothelioma and non-small cell lung cancer.
T38610	Pirepemat IRL752
	Pirepemat (IRL752) is a cortical-preferring catecholamine agent that enhances cognition. It is utilized in the investigation of Parkinson's disease.
T60289	Pemirolast
	Pemirolast 是一种具有口服活性的抗过敏剂。Pemirolast 通过抑制感觉神经肽的释放来减轻紫杉醇超敏反应，可用于对支气管哮喘和结膜炎的研究。
T12329	Ospemifene D4 FC-1271a D4	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor.
T74421	Pemvidutide
	Pemvidutide 是一种GLP-1R/GCGR 双重激动剂，可导致体重、肝脏脂肪和血清脂质的显著降低。Pemvidutide 可用于非酒精性脂肪性肝炎 (NASH) 和肥胖症的研究。
T66032	Pemetrexed disodium heptahydrate
	Pemetrexed disodium is a guanine-derived antineoplastic agent that functions as a nucleic acid synthesis inhibitor through its binding to, and inhibition of, thymidylate synthase.
T40860	Ivospemin
	Ivospemin is an antineoplastic spermine analog.
T70125	Pemrametostat succinate
	Pemrametostat succinate is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) that potently inhibits tumor growth in vitro and in vivo in animal models.
T10817	Cipemastat Ro 32-3555	Others	Others
	Cipemastat is a competitive inhibitor of human collagenases 1, 2, and 3 (Kis: 3.0, 4.4, and 3.4 nM).
T77156	Depemokimab
	Depemokimab (GSK-3511294) 是一种长效的抗IL-15单克隆抗体。Depemokimab 可用于哮喘研究。
T78658	Pemvidutide TFA
	Pemvidutide (TFA) 是一款针对GLP-1R/GCGR的双重激动剂，有助于显著降低体重、肝脏脂肪以及血清脂质水平。该化合物主要适用于非酒精性脂肪性肝炎（NASH）和肥胖症的研究领域。
T60950	Pirepemat fumarate
	Pirepemat (IRL752) fumarate 可用于研究帕金森病。Pireemat fumarate 是一种偏向皮质的儿茶酚胺传递剂和认知促进剂。
T69120	Pempidine tartrate
	Pempidine tartrate is a nicotinic antagonist most commonly used as an experimental tool. It has been used as a ganglionic blocker in the treatment of hypertension but has largely been supplanted for that purpose by more specific drugs.
T68992	Pempidine HCl
	Pempidine HCl is a nicotinic antagonist most commonly used as an experimental tool. It has been used as a ganglionic blocker in the treatment of hypertension but has largely been supplanted for that purpose by more specific drugs.
T74111	N-Methyl pemetrexed
	N-Methyl pemetrexed，Pemetrexed 的一种杂质，为抗叶酸细胞毒剂，应用于癌症研究。
T69191	Pemaglitazar
	Pemaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonist, with hypoglycemic activity.

化合物

Pipemidic acid

Cat.No: T0396

Synonym: 吡哌酸,Acido pipemidico

Target: Antibacterial, Antibiotic

Pemafibrate

Cat.No: TQ0107

Synonym: (R)-K-13675

Target: PPAR

Pemedolac

Cat.No: T68126

Synonym: Dexpemedolac

Target: COX

Pempidine

Cat.No: T0296

Synonym: 潘必定,1,2,2,6,6-Pentamethylpiperidine,Perolysen,Pyrilene

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Cat. No.	Product Name	Species	Expression System
TMPY-02005	Mucin-1/MUC1 Protein, Human, Recombinant (hFc) PEM,ADMCKD1,CA15-3,CD227,MCD,mucin 1, cell surface ...	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42 kDa and the accession number is P15941-11.
TMPY-04340	Mucin-1/MUC1 Protein, Human, Recombinant mucin 1, cell surface associated,MUC-1/SEC,PEM,MUC1...	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.4 kDa and the accession number is P15941-11.
TMPK-00828	Mucin-1/MUC1 Isoform Y Protein, Human, Recombinant (hFc) PEMT,Episialin,Mucin1,PUM,KL-6,MUC-1,Mucin-1,H23AG,...	Human	HEK293 Cells
	MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire variable number of tandem repeat region, are involved in oncogenic processes by enhancing tumour initiation. MUC1/Y is therefore considered a promising target for the identification and treatment of epithelial cancers.
TMPY-06832	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-380, His) PEM,MUC-1,EMA,H23AG,Mucin 1,PEMT,mucin 1, ...	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-380, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.19 kDa and the accession number is P15941-1.
TMPY-06833	Mucin-1/MUC1 Protein, Human, Recombinant (aa 890-1158, His) MUC1/ZD,MUC-1,MUC-1/SEC,CA15-3,mucin 1, cell surface associa...	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (aa 890-1158, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29.28 kDa and the accession number is P15941-1.
TMPJ-00155	Mucin-1/MUC1 Protein, Human, Recombinant (hFc&Avi), Biotinylated Polymorphic epithelial mucin,KL-6,Cancer antigen 15-3,PE...	Human	HEK293 Cells
	Mucin-1, is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. MUC-1 exclusively located in the apical domain of the plasma membrane ...
TMPY-06707	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His) ADMCKD,PEMT,KL-6,ADMCKD1,H23AG,mucin 1, cell surfac...	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (aa 1-173, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.49 kDa and the accession number is P15941-8.
TMPY-02871	Mucin-1/MUC1 Protein, Human, Recombinant (mFc) mucin 1, cell surface associated,ADMCKD1,EMA,MCKD1,Mucin 1,M...	Human	HEK293 Cells
	Mucin-1/MUC1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 41 kDa and the accession number is P15941-11.

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