113
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Cat. No. | Product Name | Target | Signaling Pathways |
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T38260 |
SP 600125, negative control
JNK Inhibitor II, negative control |
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SP 600125, negative control 是 SP 600125 的甲基化类似物,可用作SP 600125的阴性对照,对 DTP3和GADD45β/MKK7(生长停滞和 DNA 损伤诱导型 β/介原活化蛋白激酶激酶 7)具有抑制作用,能够恢复活化。SP 600125, negative control 对 JNK2 和 JNK3 的 IC50s 分别为 18 和 24 μM。 | |||
T39317 |
ELA-14 negative control
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ELA-14 negative control is an inactive peptide that serves as a negative control for ELA-14. | |||
T41227 |
ARCC 4 negative control
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ARCC 4 negative control is a negative control for ARCC 4. Binds androgen receptors (AR) without inducing degradation. | |||
TP2203 |
Bax inhibitor peptide, negative control
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Others | Others |
The compound is a negative control peptide for the Bax inhibitor peptides V5 and P5. | |||
T23150 |
PHGDH-inactive
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Others | Others |
PHGDH-inactive 对 PHGDH 无活性,IC50大于57 μM,可用作 NCT-502 和 NCT-503 的阴性对照。 | |||
T71316 |
ERK Inhibitor II (Negative control)
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ERK InhibitorII (Negative control)为高效的细胞外信号调节激酶(ERK)抑制剂,能抑制胰岛素受体(Insulin Receptor)激活,适用于糖尿病研究。 | |||
T19578 |
TH-263
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Others | Others |
TH-263 是二芳基磺酰胺衍生物,可用作 TH-257 的阴性对照,对 LIMK1 和 LIMK2 均无抑制活性。 | |||
T24677 |
PS47
PS 47,PS-47 |
PDK | PI3K/Akt/mTOR signaling |
PS-47(PS 47) 是一种 PS48 的非活性 E-异构体。其中 PS48 是一种 PDK1 的激活剂。PS47 (PS 47) 可用作 PS48 的阴性对照。 | |||
T74869 | SiRNA Negative Control | ||
SiRNA Negative Control 是 21个核苷酸的 siRNA,可作为阴性对照使用。 | |||
T41214 |
(S)-BAY-293
BAY 294,BAY 293 Negative Control |
Ras | GPCR/G Protein; MAPK |
(S)-BAY-293 是一种有效的 pan-KRAS 抑制剂,可用于研究原发性非小肺癌和胰腺癌。 | |||
T71314 | GL-V9 | ||
GL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy. | |||
T10608 |
BRD5648
(R)-BRD0705 |
GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
BRD5648 ((R)-BRD0705) 是 BRD0705 的 阴性对照,BRD0705 是旁系选择性和口服有效的 GSK3α 抑制剂,Kd 为 4.8 μM,IC50为 66 nM。与 GSK3β (IC50为 515 nM) 相比,BRD0705 对 GSK3α 的选择性更高 (8 倍)。BRD0705 可用于急性髓细胞性白血病。 | |||
T23176 |
PP 3
|
Src | Angiogenesis; Tyrosine Kinase/Adaptors |
PP 3 是 Src 激酶抑制剂 PP 2 的阴性对照 | |||
T23237L |
RLLFT-NH2 acetate
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Others | Others |
RLLFT-NH2 acetate 是 TFLLR-NH2 的反向氨基酸序列阴性对照肽。 | |||
T23160 |
PIR 3.5
6,6′-Dithiodi(2-naphthol),双(6-羟基-2-萘)二硫 |
PAK | Cytoskeletal Signaling |
PIR 3.5 (6,6′-Dithiodi(2-naphthol)) 是 IPA 3 的阴性对照,IPA 3 是 Pak1 抑制剂。 | |||
T35478 |
cis VH 032, amine dihydrochloride
(S,S,S)-AHPC |
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cis VH 032, amine dihydrochloride ((S,S,S)-AHPC) 是 功能性 VHL ligand VH 032, amine 的阴性对照. | |||
T9554 |
SN-008
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STING | Immunology/Inflammation |
SN-008 是 SN-011 的低活性类似物,可作为阴性对照。 | |||
T22175L |
ZIP (SCRAMBLED) Acetate
ZIP (SCRAMBLED) Acetate(908012-18-0 Free Base) |
Others | Others |
ZIP (SCRAMBLED) Acetate (ZIP (SCRAMBLED) Acetate (908012-18-0 Free Base)) 是一种乱序肽,可用作 zeta 抑制肽 (ZIP) 的阴性对照。 | |||
T7157 |
XY1
N-2-萘基-N'-[2-氧代-2-(1-吡咯烷基)乙基]脲 |
Histone Methyltransferase | Chromatin/Epigenetic |
XY1是 SGC707的类似物,SGC707是选择性PRMT3抑制剂,IC50值为31 nM。 | |||
T30579 |
BRD4097
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HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
BRD4097是HDAC1/2/3/8检测中的阴性对照品,是一种选择性组蛋白去乙酰化酶(HDAC3)抑制剂,可用于保护b 细胞和改善胰岛素抵抗,有助于促进认知功能和增强学习和记忆的形成。 | |||
T2035 |
WHI-P258
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EGFR; JAK; JNK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Stem Cells; Tyrosine Kinase/Adaptors |
WHI-P258 是喹唑啉化合物,结合到JAK3的活性位点(Ki:72 µM)。甚至当WHI-P258到达 100 μM 时也不会抑制 JAK3 ,且对凝血酶诱导的血小板聚集无影响。 | |||
T22775 |
exo-IWR-1
exo-IWR 1 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
exo-IWR-1 (exo-IWR 1) 是一种 IWR-1 的阴性对照无活性异构体。其中IWR-1是一种端锚聚合酶抑制剂,能够抑制Wnt/β-catenin 信号传导途径。 | |||
T13877 |
(S,S,S)-AHPC hydrochloride
(S,S,S)-VH032-NH2 hydrochloride,(S,S,S)-AHPC盐酸盐 |
Ligand for E3 Ligase | PROTAC |
(S,S,S)-AHPC hydrochloride ((S,S,S)-VH032-NH2 hydrochloride) 是 von Hippel-Lindau (VHL) 氨基砌块。(S,S,S)-AHPC (Compound 27) 常作为 (S,R,S)-AHPC 的阴性对照。(S,R,S)-AHPC 是基于 VH032 的 VHL 配体,可用于募集 VHL 蛋白。 | |||
TP1330 |
Cyclo(RADfK)
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Integrin | Cytoskeletal Signaling |
Cyclo(RADfK) 是选择性 α(v)β(3) 整合素配体,广泛用于新血管生成的研究、治疗和诊断。它是 cyclo (-RGDfK-) 的阴性对照, RGD 肽。 RGD 肽是细胞粘附的调节剂,并被整合素家族的几个成员识别。 | |||
TQ0159 |
U-73343
U 73343 |
Phospholipase | Metabolism |
U-73343 是一种 U-73122 的无活性类似物,能够剂量依赖性的抑制酸分泌,可作为 U-73122 的阴性对照。其中 U 73122 是一种有效的磷脂酶 C (phospholipase C) 和 5-脂氧合酶 (5-LO (5-lipoxygenase)) 抑制剂,对磷脂酶 C 的 IC50值约为 1-2.1 µM。 | |||
T30578 |
BRD3067
BRD-3067,BRD 3067 |
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BRD3067 is a negative control for tubastatin A. | |||
T32823 |
LM11A-36
LM11A36,LM11A 36,LM 11 A 36,LM-11-A-36 |
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LM11A-36 is an LM11A-24 negative control. | |||
T41228 | CG 428-Neg | ||
Negative control for CG 428. | |||
T41167 |
CG 858-Neg
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Negative control for CG 858 | |||
T41215 |
LC 2 Epimer
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Negative control for LC 2. | |||
T41181 | iP300v | ||
iP300v is a negative control for iP300w | |||
T31558 |
DO53
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DO53 is a negative control for DO34, not inhibiting DAGL. | |||
T34998 |
UNC0737
UNC-0737,UNC 0737 |
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UNC0737 is a negative control of UNC0638 | |||
T36255 |
dTAGV-1-NEG
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Negative control for dTAGV-1. | |||
T36252 |
dTAG-13-NEG
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Negative control for dTAG-13. | |||
T34890 |
TL13-27
TL13 27 |
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TL13-27 is a negative control for TL12-186. | |||
T23484 |
U0124
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Others | Others |
Inactive analog of U0126(MEK-1/2 inhibitor), used as a negative control | |||
T34629 |
SGC3027N
SGC-3027N,SGC 3027N |
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SGC3027N is a negative control for SGC3027 (GLXC-12451). | |||
T31832 |
FM-476
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FM-476 is a negative control for FM-381. | |||
T41229 |
MD15
MD15 |
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MD15 is a negative control for MD13. | |||
T34133 |
Primordazine NC-6364997
Primordazine NC 6364997,Primordazine NC6364997 |
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Primordazine NC-6364997 is a negative control for Primordazine A and Primordazine B. | |||
T41201 |
cis-VZ 185
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cis-VZ 185 is a negative control for VZ 185. | |||
T41199 |
cis-SIM1
cis-SIM1 |
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cis-SIM1 is the negative control for SIM1. | |||
T34631 |
SGC-GAK-1N
SGC-GAK1N,SGCGAK1N,SGCGAK-1N |
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SGC-GAK-1N is a negative control for SGC-GAK-1. | |||
T41203 |
1R,3R-RSL3
1R,3R-RSL3 |
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1R,3R-RSL3 is a negative control for1S, 3R-RSL3. | |||
T26222 |
SR-140603
(R)-Nolpitantium Chloride |
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SR-140603, the less potent enantiomer of SR 140333, is used as the negative control. | |||
T31234 |
DDR-TRK-1N
DDR-TRK1N,DDRTRK-1N,DDRTRK1N,DDR-TRK 1N,DDR TRK-1N |
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DDR-TRK-1N is a negative control for DDR-TRK-1. | |||
T32012 |
GSK984
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GSK984 is a negative control probe for GSK983 (GLXC-08449). | |||
T40957 |
Adeninobananin
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Adeninobananin, a negative control tool, exhibits no inhibitory activity against the SARS Coronavirus helicase. | |||
T41200 |
cis MZ 1
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cis MZ 1 is a negative Control for MZ1. Exhibits no significant VHL binding affinity. |
Cat. No. | Product Name | Target | Signaling Pathways |
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T4592 |
TOMATIDINE HYDROCHLORIDE
Tomatidine,Tomatidine HCl,盐酸番茄碱 |
Others; NF-κB; JNK; Autophagy | Autophagy; MAPK; NF-κB; Others |
Tomatidine hydrochloride (Tomatidine HCl) 是一种甾体生物碱,可防止肌肉萎缩并促进肌肉生长。它通过阻断 NF-κB 和JNK 信号发挥抗炎作用,可激活哺乳动物细胞或秀丽隐杆线虫中的自噬。 | |||
T36563 |
(E)-Guggulsterone
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Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy... |