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113

抑制剂 & 化合物

2

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Cat. No. Product Name Target Signaling Pathways
T38260 SP 600125, negative control

JNK Inhibitor II, negative control

SP 600125, negative control 是 SP 600125 的甲基化类似物,可用作SP 600125的阴性对照,对 DTP3和GADD45β/MKK7(生长停滞和 DNA 损伤诱导型 β/介原活化蛋白激酶激酶 7)具有抑制作用,能够恢复活化。SP 600125, negative control 对 JNK2 和 JNK3 的 IC50s 分别为 18 和 24 μM。
T39317 ELA-14 negative control

ELA-14 negative control is an inactive peptide that serves as a negative control for ELA-14.
T41227 ARCC 4 negative control

ARCC 4 negative control is a negative control for ARCC 4. Binds androgen receptors (AR) without inducing degradation.
TP2203 Bax inhibitor peptide, negative control

Others Others
The compound is a negative control peptide for the Bax inhibitor peptides V5 and P5.
T23150 PHGDH-inactive

Others Others
PHGDH-inactive 对 PHGDH 无活性,IC50大于57 μM,可用作 NCT-502 和 NCT-503 的阴性对照。
T71316 ERK Inhibitor II (Negative control)

ERK InhibitorII (Negative control)为高效的细胞外信号调节激酶(ERK)抑制剂,能抑制胰岛素受体(Insulin Receptor)激活,适用于糖尿病研究。
T19578 TH-263

Others Others
TH-263 是二芳基磺酰胺衍生物,可用作 TH-257 的阴性对照,对 LIMK1 和 LIMK2 均无抑制活性。
T24677 PS47

PS 47,PS-47

PDK PI3K/Akt/mTOR signaling
PS-47(PS 47) 是一种 PS48 的非活性 E-异构体。其中 PS48 是一种 PDK1 的激活剂。PS47 (PS 47) 可用作 PS48 的阴性对照。
T74869 SiRNA Negative Control

SiRNA Negative Control 是 21个核苷酸的 siRNA,可作为阴性对照使用。
T41214 (S)-BAY-293

BAY 294,BAY 293 Negative Control

Ras GPCR/G Protein; MAPK
(S)-BAY-293 是一种有效的 pan-KRAS 抑制剂,可用于研究原发性非小肺癌和胰腺癌。
T71314 GL-V9

GL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.
T10608 BRD5648

(R)-BRD0705

GSK-3 PI3K/Akt/mTOR signaling; Stem Cells
BRD5648 ((R)-BRD0705) 是 BRD0705 的 阴性对照,BRD0705 是旁系选择性和口服有效的 GSK3α 抑制剂,Kd 为 4.8 μM,IC50为 66 nM。与 GSK3β (IC50为 515 nM) 相比,BRD0705 对 GSK3α 的选择性更高 (8 倍)。BRD0705 可用于急性髓细胞性白血病。
T23176 PP 3

Src Angiogenesis; Tyrosine Kinase/Adaptors
PP 3 是 Src 激酶抑制剂 PP 2 的阴性对照
T23237L RLLFT-NH2 acetate

Others Others
RLLFT-NH2 acetate 是 TFLLR-NH2 的反向氨基酸序列阴性对照肽。
T23160 PIR 3.5

6,6′-Dithiodi(2-naphthol),双(6-羟基-2-萘)二硫

PAK Cytoskeletal Signaling
PIR 3.5 (6,6′-Dithiodi(2-naphthol)) 是 IPA 3 的阴性对照,IPA 3 是 Pak1 抑制剂。
T35478 cis VH 032, amine dihydrochloride

(S,S,S)-AHPC

cis VH 032, amine dihydrochloride ((S,S,S)-AHPC) 是 功能性 VHL ligand VH 032, amine 的阴性对照.
T9554 SN-008

STING Immunology/Inflammation
SN-008 是 SN-011 的低活性类似物,可作为阴性对照。
T22175L ZIP (SCRAMBLED) Acetate

ZIP (SCRAMBLED) Acetate(908012-18-0 Free Base)

Others Others
ZIP (SCRAMBLED) Acetate (ZIP (SCRAMBLED) Acetate (908012-18-0 Free Base)) 是一种乱序肽,可用作 zeta 抑制肽 (ZIP) 的阴性对照。
T7157 XY1

N-2-萘基-N'-[2-氧代-2-(1-吡咯烷基)乙基]脲

Histone Methyltransferase Chromatin/Epigenetic
XY1是 SGC707的类似物,SGC707是选择性PRMT3抑制剂,IC50值为31 nM。
T30579 BRD4097

HDAC Chromatin/Epigenetic; DNA Damage/DNA Repair
BRD4097是HDAC1/2/3/8检测中的阴性对照品,是一种选择性组蛋白去乙酰化酶(HDAC3)抑制剂,可用于保护b 细胞和改善胰岛素抵抗,有助于促进认知功能和增强学习和记忆的形成。
T2035 WHI-P258

EGFR; JAK; JNK Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Stem Cells; Tyrosine Kinase/Adaptors
WHI-P258 是喹唑啉化合物,结合到JAK3的活性位点(Ki:72 µM)。甚至当WHI-P258到达 100 μM 时也不会抑制 JAK3 ,且对凝血酶诱导的血小板聚集无影响。
T22775 exo-IWR-1

exo-IWR 1

Wnt/beta-catenin Cytoskeletal Signaling; Stem Cells
exo-IWR-1 (exo-IWR 1) 是一种 IWR-1 的阴性对照无活性异构体。其中IWR-1是一种端锚聚合酶抑制剂,能够抑制Wnt/β-catenin 信号传导途径。
T13877 (S,S,S)-AHPC hydrochloride

(S,S,S)-VH032-NH2 hydrochloride,(S,S,S)-AHPC盐酸盐

Ligand for E3 Ligase PROTAC
(S,S,S)-AHPC hydrochloride ((S,S,S)-VH032-NH2 hydrochloride) 是 von Hippel-Lindau (VHL) 氨基砌块。(S,S,S)-AHPC (Compound 27) 常作为 (S,R,S)-AHPC 的阴性对照。(S,R,S)-AHPC 是基于 VH032 的 VHL 配体,可用于募集 VHL 蛋白。
TP1330 Cyclo(RADfK)

Integrin Cytoskeletal Signaling
Cyclo(RADfK) 是选择性 α(v)β(3) 整合素配体,广泛用于新血管生成的研究、治疗和诊断。它是 cyclo (-RGDfK-) 的阴性对照, RGD 肽。 RGD 肽是细胞粘附的调节剂,并被整合素家族的几个成员识别。
TQ0159 U-73343

U 73343

Phospholipase Metabolism
U-73343 是一种 U-73122 的无活性类似物,能够剂量依赖性的抑制酸分泌,可作为 U-73122 的阴性对照。其中 U 73122 是一种有效的磷脂酶 C (phospholipase C) 和 5-脂氧合酶 (5-LO (5-lipoxygenase)) 抑制剂,对磷脂酶 C 的 IC50值约为 1-2.1 µM。
T30578 BRD3067

BRD-3067,BRD 3067

BRD3067 is a negative control for tubastatin A.
T32823 LM11A-36

LM11A36,LM11A 36,LM 11 A 36,LM-11-A-36

LM11A-36 is an LM11A-24 negative control.
T41228 CG 428-Neg

Negative control for CG 428.
T41167 CG 858-Neg

Negative control for CG 858
T41215 LC 2 Epimer

Negative control for LC 2.
T41181 iP300v

iP300v is a negative control for iP300w
T31558 DO53

DO53 is a negative control for DO34, not inhibiting DAGL.
T34998 UNC0737

UNC-0737,UNC 0737

UNC0737 is a negative control of UNC0638
T36255 dTAGV-1-NEG

Negative control for dTAGV-1.
T36252 dTAG-13-NEG

Negative control for dTAG-13.
T34890 TL13-27

TL13 27

TL13-27 is a negative control for TL12-186.
T23484 U0124

Others Others
Inactive analog of U0126(MEK-1/2 inhibitor), used as a negative control
T34629 SGC3027N

SGC-3027N,SGC 3027N

SGC3027N is a negative control for SGC3027 (GLXC-12451).
T31832 FM-476

FM-476 is a negative control for FM-381.
T41229 MD15

MD15

MD15 is a negative control for MD13.
T34133 Primordazine NC-6364997

Primordazine NC 6364997,Primordazine NC6364997

Primordazine NC-6364997 is a negative control for Primordazine A and Primordazine B.
T41201 cis-VZ 185

cis-VZ 185 is a negative control for VZ 185.
T41199 cis-SIM1

cis-SIM1

cis-SIM1 is the negative control for SIM1.
T34631 SGC-GAK-1N

SGC-GAK1N,SGCGAK1N,SGCGAK-1N

SGC-GAK-1N is a negative control for SGC-GAK-1.
T41203 1R,3R-RSL3

1R,3R-RSL3

1R,3R-RSL3 is a negative control for1S, 3R-RSL3.
T26222 SR-140603

(R)-Nolpitantium Chloride

SR-140603, the less potent enantiomer of SR 140333, is used as the negative control.
T31234 DDR-TRK-1N

DDR-TRK1N,DDRTRK-1N,DDRTRK1N,DDR-TRK 1N,DDR TRK-1N

DDR-TRK-1N is a negative control for DDR-TRK-1.
T32012 GSK984

GSK984 is a negative control probe for GSK983 (GLXC-08449).
T40957 Adeninobananin

Adeninobananin, a negative control tool, exhibits no inhibitory activity against the SARS Coronavirus helicase.
T41200 cis MZ 1

cis MZ 1 is a negative Control for MZ1. Exhibits no significant VHL binding affinity.

化合物

SP 600125, negative control
Cat.No: T38260
Synonym: JNK Inhibitor II, negative control
Target:
ELA-14 negative control
Cat.No: T39317
Synonym:
Target:
ARCC 4 negative control
Cat.No: T41227
Synonym:
Target:
Bax inhibitor peptide, negative control
Cat.No: TP2203
Synonym:
Target: Others
PHGDH-inactive
Cat.No: T23150
Synonym:
Target: Others
ERK Inhibitor II (Negative control)
Cat.No: T71316
Synonym:
Target:
TH-263
Cat.No: T19578
Synonym:
Target: Others
PS47
Cat.No: T24677
Synonym: PS 47,PS-47
Target: PDK
SiRNA Negative Control
Cat.No: T74869
Synonym:
Target:
(S)-BAY-293
Cat.No: T41214
Synonym: BAY 294,BAY 293 Negative Control
Target: Ras
GL-V9
Cat.No: T71314
Synonym:
Target:
BRD5648
Cat.No: T10608
Synonym: (R)-BRD0705
Target: GSK-3
PP 3
Cat.No: T23176
Synonym:
Target: Src
RLLFT-NH2 acetate
Cat.No: T23237L
Synonym:
Target: Others
PIR 3.5
Cat.No: T23160
Synonym: 6,6′-Dithiodi(2-naphthol),双(6-羟基-2-萘)二硫
Target: PAK
cis VH 032, amine dihydrochloride
Cat.No: T35478
Synonym: (S,S,S)-AHPC
Target:
SN-008
Cat.No: T9554
Synonym:
Target: STING
ZIP (SCRAMBLED) Acetate
Cat.No: T22175L
Synonym: ZIP (SCRAMBLED) Acetate(908012-18-0 Free Base)
Target: Others
XY1
Cat.No: T7157
Synonym: N-2-萘基-N'-[2-氧代-2-(1-吡咯烷基)乙基]脲
Target: Histone Methyltransferase
BRD4097
Cat.No: T30579
Synonym:
Target: HDAC
WHI-P258
Cat.No: T2035
Synonym:
Target: EGFR, JAK, JNK
exo-IWR-1
Cat.No: T22775
Synonym: exo-IWR 1
Target: Wnt/beta-catenin
(S,S,S)-AHPC hydrochloride
Cat.No: T13877
Synonym: (S,S,S)-VH032-NH2 hydrochloride,(S,S,S)-AHPC盐酸盐
Target: Ligand for E3 Ligase
Cyclo(RADfK)
Cat.No: TP1330
Synonym:
Target: Integrin
U-73343
Cat.No: TQ0159
Synonym: U 73343
Target: Phospholipase
BRD3067
Cat.No: T30578
Synonym: BRD-3067,BRD 3067
Target:
LM11A-36
Cat.No: T32823
Synonym: LM11A36,LM11A 36,LM 11 A 36,LM-11-A-36
Target:
CG 428-Neg
Cat.No: T41228
Synonym:
Target:
CG 858-Neg
Cat.No: T41167
Synonym:
Target:
LC 2 Epimer
Cat.No: T41215
Synonym:
Target:
iP300v
Cat.No: T41181
Synonym:
Target:
DO53
Cat.No: T31558
Synonym:
Target:
UNC0737
Cat.No: T34998
Synonym: UNC-0737,UNC 0737
Target:
dTAGV-1-NEG
Cat.No: T36255
Synonym:
Target:
dTAG-13-NEG
Cat.No: T36252
Synonym:
Target:
TL13-27
Cat.No: T34890
Synonym: TL13 27
Target:
U0124
Cat.No: T23484
Synonym:
Target: Others
SGC3027N
Cat.No: T34629
Synonym: SGC-3027N,SGC 3027N
Target:
FM-476
Cat.No: T31832
Synonym:
Target:
MD15
Cat.No: T41229
Synonym: MD15
Target:
Primordazine NC-6364997
Cat.No: T34133
Synonym: Primordazine NC 6364997,Primordazine NC6364997
Target:
cis-VZ 185
Cat.No: T41201
Synonym:
Target:
cis-SIM1
Cat.No: T41199
Synonym: cis-SIM1
Target:
SGC-GAK-1N
Cat.No: T34631
Synonym: SGC-GAK1N,SGCGAK1N,SGCGAK-1N
Target:
1R,3R-RSL3
Cat.No: T41203
Synonym: 1R,3R-RSL3
Target:
SR-140603
Cat.No: T26222
Synonym: (R)-Nolpitantium Chloride
Target:
DDR-TRK-1N
Cat.No: T31234
Synonym: DDR-TRK1N,DDRTRK-1N,DDRTRK1N,DDR-TRK 1N,DDR TRK-1N
Target:
GSK984
Cat.No: T32012
Synonym:
Target:
Adeninobananin
Cat.No: T40957
Synonym:
Target:
cis MZ 1
Cat.No: T41200
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T4592 TOMATIDINE HYDROCHLORIDE

Tomatidine,Tomatidine HCl,盐酸番茄碱

Others; NF-κB; JNK; Autophagy Autophagy; MAPK; NF-κB; Others
Tomatidine hydrochloride (Tomatidine HCl) 是一种甾体生物碱,可防止肌肉萎缩并促进肌肉生长。它通过阻断 NF-κB 和JNK 信号发挥抗炎作用,可激活哺乳动物细胞或秀丽隐杆线虫中的自噬。
T36563 (E)-Guggulsterone

Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy...

天然产物

TOMATIDINE HYDROCHLORIDE
Cat.No: T4592
Synonym: Tomatidine,Tomatidine HCl,盐酸番茄碱
Target: Others, NF-κB, JNK, Autophagy
(E)-Guggulsterone
Cat.No: T36563
Synonym:
Target:
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