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Search Results for " ht29 "

31

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9966	GSK-1520489A	Wee1	Cell Cycle/Checkpoint
	GSK-1520489 A 是一种活性 PKMYT1 抑制剂。
T6255	Bromosporine	Epigenetic Reader Domain; CDK	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Bromosporine 是广谱 BRD2/4/9 和 CECR2 溴结构域抑制剂，IC50为0.41、0.29、0.122和0.017 μM。
T6967	RHPS4 RHPS 4 methosulfate,NSC714187	Apoptosis; Telomerase	Apoptosis; DNA Damage/DNA Repair
	RHPS4 (RHPS 4 methosulfate) 是 DNA 损伤诱导剂，是一种有效的亚微摩尔端粒酶抑制剂，IC50为0.33 μM。
T2617	SNS-314 Mesylate SNS-314	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	SNS-314 Mesylate (SNS-314) 是一种有效且特异性的极光激酶抑制剂，对极光激酶 A、B、C 的 IC50值分别为 9，31 和 3 nM。
T16961	Supinoxin RX-5902	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Supinoxin (RX-5902) 是磷酸化 p68 RNA 解旋酶的强效口服活性抑制剂，是一种抗肿瘤试剂。它与 Y593 磷酸化的 p68 相互作用并减弱 β-catenin 的核穿梭性。它诱导细胞凋亡并抑制 TNBC 癌细胞系的生长，IC50的范围为 10 nM 至 20 nM。
T13009	STAT3-IN-1	Apoptosis; STAT	Apoptosis; JAK/STAT signaling; Stem Cells
	STAT3-IN-1 是一种选择性的、口服有效的 STAT3的强效抑制剂，可诱导肿瘤细胞凋亡，其在 HT29 和MDA-MB 231 细胞中的IC50值分别为1.82 μM 和2.14 μM。
T78156	MC4033	Apoptosis	Apoptosis
	MC4033是一种选择性的，可逆的KAT8赖氨酸乙酰转移酶抑制剂，IC50为12.1μM，具有抗癌活性，并能诱导凋亡(apoptosisautophagy)。
T68896	Daniquidone NSC 320846,BAY-H 2049	Topoisomerase	DNA Damage/DNA Repair
	Daniquidone (Batracylin) 是一种有效的 DNA 拓扑异构酶 I 和 DNA 拓扑异构酶 II 双重抑制剂，具有细胞毒性和抗增殖活性，可诱导 DNA 断裂，可用于研究肿瘤、免疫系统疾病和淋巴系统疾病。
T20882	4-Nitrobenzoic acid Kyselina p-nitrobenzoova,4Nitrobenzoic acid,Nitrodracylic acid,4 Nitrobenzoic acid
	4-Nitrobenzoic acid (4Nitrobenzoic acid) 是一种药物中间体，常在叶酸、DABA、PABA 和染料的生产中出现。
T11369	GB-110	Others	Others
	GB-110 selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist.
T2283	PX-12 2-[(1-甲基丙基)二硫代]-1H-咪唑,IV-2,PX12	Thioredoxin	Metabolism
	PX-12 (PX12) 是一种可逆的硫氧还蛋白-1(Trx-1)抑制剂，能够抑制 MCF-7 细胞(IC50:1.9 μM)和HT-29 细胞(IC50:2.9 μM)的生长。
T73854	GB-110 hydrochloride
	GB-110 hydrochloride 是一种有效的，具有口服活性的，非肽类的 protease activated receptor2 (PAR2)激动剂。GB-110 hydrochloride 选择性诱导 PAR2介导的 HT29 细胞内 Ca2+释放，EC50值为 0.28 μM。
T12259	NSC 601980	Others	Others
	NSC 601980 酵母筛选实验结果中显示了抗肿瘤活性, 能够在COLO 205 and HT29细胞株里很好的抑制细胞增殖，Log GI 50分别是-6.6和 -6.9。
T62922	Tubulin inhibitor 25
	Tubulin inhibitor 25 是一种微管蛋白 (tubulin) 的有效抑制剂 (IC50: 0.98 μM)，能够显著抑制 HT29 细胞。Tubulin inhibitor 25 对细胞迁移和微管形成具有抑制作用，有助于抗血管生成。
T11369L	GB-110 hydrochloride (1252806-70-4 free base) GB-110 hydrochloride	Others	Others
	GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist.
T3437	Lys05 Lys01 trihydrochloride	lysosomal autophagy; Autophagy	Autophagy
	Lys05 是一种有效的水溶性溶酶体自噬抑制剂，具有抗肿瘤活性。在 MTT 试验中，对1205Lu、c8161、LN229 和 HT-29细胞系的IC50值分别为3.6、3.8、6 和7.9 μM。
T61532	Tubulin polymerization-IN-6
	Tubulin polymerization-IN-6 (compound 5f) is a potent inhibitor of tubulin polymerization, with an IC50 of 1.09 μM. It not only inhibits cell migration and tube formation but also has anti-angiogenic properties. Additionally, Tubulin polymerization-IN-6 has been found to effectively hinder tumor growth in HT29 xenograft Balb/c nude mice [1].
T72525	Antitumor agent-48
	Antitumor agent-48 是一种具有抗肿瘤活性的 2,3-dehydrosilybin 衍生物。Antitumor agent-48 对 MCF-7、NCI-H1299、HepG2 和 HT29 细胞具有细胞毒活性，IC50值分别为 8.06 µM、13.1 µM、16.51 µM 和 12.44 µM。
T79353	P-gp/BCRP-IN-2
	P-gp/BCRP-IN-2（化合物15）为恶二唑衍生物，作为ABC转运蛋白P-glycoprotein（IC50：1.6 nM）及BCRP（IC50：600 nM）的双重抑制剂。该化合物增强了Doxorubicin针对耐药型人腺癌结肠癌细胞系HT29/DX及MDCK-MDR1细胞的抗增殖效果。
T72524	Antitumor agent-47
	Antitumor agent-47 是一种具有抗肿瘤活性的水飞蓟宾衍生物。Antitumor agent-47 对 NCI-H1299 和 HT29 细胞具有细胞毒活性，IC50值分别为 8.07 µM 和 6.27 µM。
T21749	4-iodo-SAHA
	4-Iodo-SAHA (1k) 是一种具有口服活性的I 类和II 类histone deacetylase (HDAC)抑制剂，对 Skbr3、 HT29、 U937、 JA16 和 HL60细胞的EC50值分别为1.1、0.95、0.12、0.24、0.85和1.3 μM。4-Iodo-SAHA (1k) 可用于癌症的研究。
T41189	AY 254
	AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50= 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+release). Reduces cytoKi ne-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cellsin vitro.
T36704	CCT241533 dihydrochloride CCT 241533 dihydrochloride
	Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes. Caldwell et al (2011) Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J.Med.Chem. 54 580 PMID:21186793
T78855	Anticancer agent 157	NO Synthase	Immunology/Inflammation
	Anticanceragent 157（compound 15）是一种NO抑制剂，具有抗炎和抗癌特性，IC50值为0.62 μg/mL。它能够与iNOS和caspase 8结合，进而导致核断裂和染色质浓缩，从而诱导细胞凋亡。此外，Anticanceragent 157在不同癌细胞系中展现出显著的抑制活性，对HT29结肠癌细胞的IC50为2.45 μg/mL，对Hep-G2肝癌细胞的IC50为3.25 μg/mL，以及对B16-F10鼠黑色素瘤细胞的IC50为3.84 μg/mL。
T79388	Anticancer agent 154	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Anticanceragent 154 (Compound 8h) 增加活性氧水平、导致线粒体损伤，并诱导细胞凋亡和 DNA 损伤。此外，该化合物通过降低 GSH 和 GPX4 水平，增加脂质过氧化，进而诱导铁死亡。Anticanceragent 154 对多种癌细胞株（HT29、H1975、A549 及 MCF-7）显示抑制作用，IC50 值在 1.0-1.9 μM 范围。
T60793	Tubulin inhibitor 26
	Tubulin inhibitor 26 (compound 3c) 是一种吲唑衍生物，是微管蛋白抑制剂，对 HepG2、HCT116、SW620、HT29 和 A549 癌细胞系具有显著的低纳摩尔效力。Tubulin inhibitor 26 抑制G2/M 期肿瘤细胞，并且诱导细胞凋亡。Tubulin inhibitor 26 在体内抑制肿瘤生长，并且不影响小鼠体重。
T79598	Anti-inflammatory agent 52	COX	Immunology/Inflammation; Neuroscience
	Anti-inflammatory agent 52 (compound 7j) 是一种口服有效的选择性COX-2抑制剂，它不仅抑制HT29细胞迁移并诱导G2/M期的细胞周期停滞，而且在大鼠胃肠道安全性良好，并对炎症具有中等程度的抑制作用。此外，Anti-inflammatory agent 52 在携带艾利希实体癌的小鼠模型中表现出抗肿瘤活性。
T79599	Anti-inflammatory agent 53	COX	Immunology/Inflammation; Neuroscience
	Anti-inflammatory agent 53（compound 7c）是口服有效及选择性的COX-2抑制剂。Anti-inflammatory agent 52展现了抗HT29细胞迁移的特性，能够促使细胞周期在S期与G2/M期停滞。此外，该化合物对大鼠胃肠道安全，对炎症具有中等程度的抑制效应。在携带艾利希实体瘤的小鼠模型中，Anti-inflammatory agent 52能够抑制肿瘤生长，显示出潜在的抗癌活性。
T71382	KRC-108
	KRC-108 is a multiple kinase inhibitor. KRC-108 is a potent inhibitor of Ron, Flt3 and TrkA as well as c-Met. KRC-108 inhibited oncogenic c-Met M1250T and Y1230D more strongly than wild type c-Met. The anti-proliferative activity of KRC-108 was measured by performing a cytotoxicity assay on a panel of cancer cell lines. The GI(50) values (i.e., 50% inhibition of cell growth) for KRC-108 ranged from 0.01 to 4.22 μM for these cancer cell lines. KRC-108 was also effective for the inhibition of tumo...
T41070	LP-184
	LP-184 (Compound 6), referred to as an acylfulvene analog, demonstrates the ability to inhibit tumor growth with noteworthy anti-cancer efficacy observed across multiple cell lines, including ovarian, colon, prostate, and pancreatic.
T13782	MS432	MEK	MAPK
	MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.

化合物

Cat.No: T9966

Target: Wee1

Cat.No: T6255

Target: Epigenetic Reader Domain, CDK

Cat.No: T6967

Synonym: RHPS 4 methosulfate,NSC714187

Target: Apoptosis, Telomerase

SNS-314 Mesylate

Cat.No: T2617

Synonym: SNS-314

Target: Aurora Kinase

Cat.No: T16961

Synonym: RX-5902

Target: Apoptosis, DNA/RNA Synthesis

Cat.No: T13009

Target: Apoptosis, STAT

Cat.No: T78156

Target: Apoptosis

Cat.No: T68896

Synonym: NSC 320846,BAY-H 2049

Target: Topoisomerase

4-Nitrobenzoic acid

Cat.No: T20882

Synonym: Kyselina p-nitrobenzoova,4Nitrobenzoic acid,Nitrodracylic acid,4 Nitrobenzoic acid

Cat.No: T11369

Target: Others

Cat.No: T2283

Synonym: 2-[(1-甲基丙基)二硫代]-1H-咪唑,IV-2,PX12

Target: Thioredoxin

GB-110 hydrochloride

Cat.No: T73854

Cat.No: T12259

Target: Others

Tubulin inhibitor 25

Cat.No: T62922

GB-110 hydrochloride (1252806-70-4 free base)

Cat.No: T11369L

Synonym: GB-110 hydrochloride

Target: Others

Cat.No: T3437

Synonym: Lys01 trihydrochloride

Target: lysosomal autophagy, Autophagy

Tubulin polymerization-IN-6

Cat.No: T61532

Antitumor agent-48

Cat.No: T72525

Cat.No: T79353

Antitumor agent-47

Cat.No: T72524

Cat.No: T21749

Cat.No: T41189

CCT241533 dihydrochloride

Cat.No: T36704

Synonym: CCT 241533 dihydrochloride

Anticancer agent 157

Cat.No: T78855

Target: NO Synthase

Anticancer agent 154

Cat.No: T79388

Target: Reactive Oxygen Species

Tubulin inhibitor 26

Cat.No: T60793

Anti-inflammatory agent 52

Cat.No: T79598

Target: COX

Anti-inflammatory agent 53

Cat.No: T79599

Target: COX

Cat.No: T71382

Cat.No: T41070

Cat.No: T13782

Target: MEK

Cat. No.	Product Name	Target	Signaling Pathways
T13629	Cyclo(Ala-Gly)	Others	Others
	Cyclo (Ala-Gly) is a mangrove endophytic fungus, a metabolite of Penicillium thomi, which is cytotoxic to A549, HepG2 and HT29 cells. The IC50 value is in the range of 9.5-18.1 μM.
TN4132	Germanicol
	Germanicol induces selective growth inhibitory effects in human colon HCT-116 and HT29 cancer cells through induction of apoptosis, cell cycle arrest and inhibition of cell migration. Germanicol may have anti-inflammatory effects .
TN1324	6-O-Nicotinoylscutebarbatine G	Others	Others
	6-O-Nicotinoylscutebarbatine G shows cytotoxic activities against three human tumor cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC50 values in the range of 2.1 5.7 μM.
TN3812	Dehydrovomifoliol	AChR	Neuroscience
	Dehydrovomifoliol could be a marker of Polish heather honey. Dehydrovomifoliol exhibits moderate acetylcholinesterase (AChE) inhibitory activities. Dehydrovomifoliol shows significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and the IC(50) values in the range 3.7-8.1 microM.
TN3300	8alpha-Tigloyloxyhirsutinolide 13-O-acetate	NADPH-oxidase; P450; MAO	Immunology/Inflammation; Metabolism; Neuroscience
	8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has anti-cancer activity, it is active against both cancer cell lines (IC50 = 3.50 microM for HT29

天然产物

Cat.No: T13629

Target: Others

Cat.No: TN4132

6-O-Nicotinoylscutebarbatine G

Cat.No: TN1324

Target: Others

Dehydrovomifoliol

Cat.No: TN3812

Target: AChR

8alpha-Tigloyloxyhirsutinolide 13-O-acetate

Cat.No: TN3300

Target: NADPH-oxidase, P450, MAO

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