51
9
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12225L |
Nevanimibe hydrochloride
PD-132301 hydrochloride,ATR101 hydrochloride |
Apoptosis; Acyltransferase | Apoptosis; Metabolism |
Nevanimibe hydrochloride (PD-132301 hydrochloride) 是一种口服有效的,选择性酰基辅酶 A:胆固醇 O-酰基转移酶 1 抑制剂,EC50为 9 nM。它抑制 ACAT2,EC50为 368 nM。它诱导细胞凋亡,具有抗肾上腺皮质癌的潜力。 | |||
T7164 |
Levalbuterol tartrate
左旋沙丁胺醇酒石酸盐,Levosalbutamol tartrate |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Levalbuterol tartrate (Levosalbutamol tartrate) 是一种短效的β2肾上腺素受体激动剂,是一种 salbutamol 的 R 型对映体。 | |||
T1545 |
Levamlodipine
左旋氨氯地平,(S)-Amlodipine,S-amlodipine |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Levamlodipine (S-amlodipine) 是一种二氢吡啶钙通道阻滞剂,具有舒张血管的作用,可用于高血压和心绞痛的研究。 | |||
T68055 |
Devapamil
Devapamilo,Devapamilum |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Devapamil (Devapamilo) 是一种苯烷基胺,以使用依赖性方式阻断来自膜细胞内侧的 L 型钙电流。 | |||
TQ0166 |
Tesevatinib
KD-019,XL-647,EXEL-7647 |
EGFR; VEGFR; FLT; Ephrin Receptor | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Tesevatinib (XL-647) 是一种口服的多靶点酪氨酸激酶抑制剂,对 EGFR、ErbB2、KDR、Flt4和 EphB4的 IC50值分别为 0.3、16、1.5、8.7和 1.4 nM。 | |||
T9904 |
Bevacizumab
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Bevacizumab 是一种人源化单克隆抗体,能以高亲和力与所有血管内皮生长因子-A 异构体特异性结合。 | |||
T37596 |
Terevalefim
|
c-Met/HGFR | Tyrosine Kinase/Adaptors |
Terevalefim 是干细胞生长因子的一种类似物,对c-Met 受体有选择性激活作用。 | |||
T8143 |
Bevantolol hydrochloride
贝凡洛尔盐酸盐,NC-1400 hydrochloride,盐酸贝凡洛尔 |
Calcium Channel; Adrenergic Receptor | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Bevantolol hydrochloride (NC-1400 hydrochloride) 是一种 β1-肾上腺素受体拮抗剂,可治疗心绞痛和高血压,在大鼠大脑皮层中的pKi 值分别为 7.83、6.9。 | |||
T15259 |
Evatanepag
CP-533536 free acid,2-[3-[N-(4-叔丁基苄基)-N-(吡啶-3-基磺酰基)氨基甲基]苯氧基]乙酸 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Evatanepag (CP-533536 free acid) 是一种 EP2 受体选择性前列腺素 E2 (PGE2) 激动剂,可诱导局部骨形成,EC50 为 0.3 nM。它在大鼠骨折愈合模型中以单剂量局部给药时表现出愈合骨折的能力。 | |||
T6262 |
Evacetrapib
LY2484595 |
CETP | Metabolism |
Evacetrapib (LY2484595) 是 CETP 的选择性抑制剂,在人血浆中,抑制人重组 CETP 蛋白 (IC50:5.5 nM) 和 CETP (IC50:36 nM) 活性。 | |||
T4284 |
Levamlodipine besylate
左旋氨氯地平,(S)-Amlodipine Besylate (103129-82-4(free base)) |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Levamlodipine besylate ((S)-Amlodipine Besylate(103129-82-4(free base))) 是一种二氢吡啶钙通道阻滞剂,具有舒张血管的作用,可用于高血压和心绞痛的研究。 | |||
T2405 |
Revaprazan hydrochloride
盐酸瑞伐拉赞,YH1885 |
ATPase; COX; Antibacterial | Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience |
Revaprazan hydrochloride (YH1885) 是一种新型酸泵拮抗剂,可降低COX-2的表达,在幽门螺杆菌感染中,显著抑制炎症。 | |||
T0313 |
Evans blue
Direct Blue 53,C.I. 23860,伊文思蓝 |
GluR | Neuroscience |
Evans blue (C.I. 23860) 是一种突触泡谷氨酸吸收的有效抑制剂,同时也是一种AMPA/kainate 受体拮抗剂。 | |||
T20660 |
Revaprazan
SB-641257,SB 641257,SB641257 |
||
Revaprazan is a novel, selective potassium-competitive acid blocker, to be specific, it reversibly inhibits gastric H(+)/K(+)-ATPase and shows effective acid suppression comparable to PPIs. | |||
T75270 |
Genevant CL1
|
||
Genevant CL1 是一种脂质,可用于 mRNA 脂质纳米颗粒 (LNP) 疫苗递送。 | |||
T36814 |
Chevalone B
|
||
Chevalone B is a meroterpenoid originally isolated from the fungus E. chevalieri. It is cytotoxic to KB and NCI-H187 cells with IC50 values of 2.9 and 9.8 μg/ml, respectively. | |||
T39074 |
(Rac)-Zevaquenabant
(Rac)-MRI-1867,(Rac)-Zevaquenabant |
||
(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of the cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), exhibiting a binding affinity (Ki) of 5.7 nM specifically for CB1R. Due to its characteristics, (Rac)-Zevaquenabant holds promise as an investigative tool in liver fibrosis research. | |||
T69639 |
Sevasemten
|
||
Sevasemten为骨骼肌肌球蛋白(Myosin)的变构抑制剂,具有选择性抑制作用,其IC50值对骨骼肌球蛋白 ≤ 10 μM,而对心脏肌球蛋白则 >100 μM。 | |||
T25691 |
Levamlodipine gentisate
(S)-Amlodipine gentisate,(S)-(-)-Amlodipine gentisate |
||
Levamlodipine gentisate is a pharmacologically active enantiomer of amlodipine. Amlodipine is the dihydropyridine calcium channel blocker used as an antihypertensive and antianginal drug. | |||
T124525 |
Cevadine
|
||
T82222 |
H-D-MeAla-EtVaI-VaI-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVaI-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe
|
||
H-D-MeAla-EtVal-Val-MeLeu-AIa-D-AIa-MeLeu-MeLeu-MeVal-MeBmt(OAc)-Abu-O-CH2-CH2-NHMe 是一种非免疫抑制性的环孢菌素A衍生物,具备研究先天性肌营养不良症潜力[1]。 | |||
T75156 | Bevasiranib | ||
Bevasiranib 是一种siRNA,可沉默产生血管内皮生长因子(VEGF)的基因。VEGF 在脉络膜新生血管形成(choroidal neo-vascularization, CNV)的发病机制中起着关键作用,而CNV 是湿性年龄相关性黄斑变性(wet age-related macular degeneration, wet AMD)的前兆。 | |||
T79855 |
Nevadistinel
NYX-458,NYX-3054 |
iGluR | Membrane transporter/Ion channel; Neuroscience |
Nevadistinel (NYX-458; NYX-3054) 是一种NMDA受体的正变构调节剂,主要应用于抑制与神经退行性疾病相关的认知障碍,疾病包括轻度认知障碍、轻度阿尔茨海默病、帕金森病和路易体病。 | |||
T20276 |
Kelevan
Despirol,Caswell No. 436C |
||
Kelevan is an insecticide. | |||
T31729 |
Evariquinone
|
||
Evalliquinone is a biologically active isolate of Metarhizium anisopliae derived from the sponge. | |||
T69755 |
Evatanepag sodium
|
||
Evatanepag, also known as CP-533536, is an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. CP-533536 demonstrated the ability to heal fractures when administered locally as a single dose in rat models of fracture healing. | |||
T124478 |
Cannabichromevarinic acid
|
||
Cannabichromevarinic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124478。 | |||
T68423 |
Revamilast sodium
|
||
Revamilast sodium, also known as GRC4039 sodium, is a phosphodiesterase IV inhibitor for potentially treating of asthma and rheumatoid arthritis | |||
T68424 |
Revamilast
|
||
Revamilast, also known as GRC4039, is a phosphodiesterase IV inhibitor for potentially treating of asthma and rheumatoid arthritis | |||
T72531 |
6-Fluoromevalonate
Tetrahydro-4-fluoromethyl-4-hydroxy-2H-pyran-2-one |
||
6-Fluoromevalonate 是甲羟戊酸-焦磷酸脱羧酶抑制剂。 | |||
T15101 |
Devazepide
L-364,718,地伐西匹,MK-329 |
Others | Others |
Devazepide is a competitive and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor (IC50s: 81 pM, 45 pM, and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively). | |||
T28523 |
Revatropate
UK-112 166,UK 112166,UK-112,166 |
||
Revatropate, a selective muscarinic antagonist, is an antimuscarinic drug. | |||
T39410 |
Zevaquenabant
(S)-MRI-1867 |
||
Zevaquenabant ((S)-MRI-1867), a dual cannabinoid CB1 receptor and inducible NOS (iNOS) antagonist, is orally bioavailable and peripherally restricted. It effectively mitigates obesity-induced chronic kidney disease (CKD). | |||
T78287 |
Alsevalimab
|
||
Alsevalimab为针对B7-H4的人源化单克隆抗体。 | |||
T12225 |
Nevanimibe
ATR-101,PD-132301 |
Others | Others |
Nevanimibe is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM). | |||
T34717 |
Stevastelin B3
NK374186B3,NK 374186B3,Antibiotic NK 374186B3,NK-374186B3 |
||
Stevastelin B3 is a depsipeptide isolated from Penicillium. | |||
T34026 |
Phevamine A
PHVA |
Others | Others |
Phevamine A (PHVA) 是植物免疫反应的抑制剂。 | |||
T71657 |
Evandamine
|
||
Evandamine is a Lipooxygenase Inhibitor | |||
T82426 |
Evazarsen
ISIS-757456 |
||
Evazarsen为血管紧张素原合成抑制剂,展现抗高血压特性。 | |||
T40425 |
Levalbuterol
(R)-Albuterol,左沙丁胺醇,Levosalbutamol,(R)-Salbutamol |
||
Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD. | |||
T32692 |
Levamlodipine hydrobromide
Levamlodipine HBr |
||
Levamlodipine hydrobromide is a medication used to lower blood pressure and prevent chest pain. | |||
T75156L | Bevasiranib sodium | ||
Bevasiranib sodium 是一种siRNA,可沉默产生血管内皮生长因子(VEGF)的基因。VEGF 在脉络膜新生血管形成(choroidal neo-vascularization, CNV)的发病机制中起着关键作用,而CNV 是湿性年龄相关性黄斑变性(wet age-related macular degeneration, wet AMD)的前兆。 | |||
T23579 |
13-Hydroxystevane
Kauran-13-ol |
||
13-Hydroxystevane shows an inhibitory action on oxidative phosphorylation. | |||
T32690 |
Levallorphan
Levallorphanum,Lorfan,Levallorphane,Levalorfano,Naloxiphan |
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Levorphane (levorphane tartrate) is an opioid modulator of the Morphan family that acts as an antagonist for μ-opioid receptor (MOR) and an agonist for κ-opioid receptor (KOR). | |||
T20396 |
Levadopa Related Compound A
6-Hydroxydopa, L-,L-Hydroxydopa |
||
Levadopa Related Compound A is the 6-hydroxy derivative of the amino acid L-DOPA with neurotoxic properties. Exogenously administered 6-Hydroxy-L-DOPA is biotransformed by an amino acid decarboxylase to the highly potent and catecholamine-selective neurot | |||
T32691 |
Levamlodipine hydrochloride
|
||
Levamlodipine hydrochloride is a medication used to lower blood pressure and prevent chest pain. | |||
T25333 |
Dilevalol
Dilevalolum |
||
Dilevalol, the RR-stereoisomer of labetalol, is a non-cardioselective beta-adrenoceptor antagonist with substantial partial beta 2-agonist and negligible alpha 1-blocking activity. | |||
T32825 |
L-Mevalonic acid
(S)-Mevalonic acid |
Others | Others |
L-Mevalonic acid ((S)-Mevalonic acid) 是胆固醇的远源前体,是甲羟戊酸途径的代谢产物,可用于研究自身免疫性疾病、动脉粥样硬化和阿尔茨海默病。 | |||
T61138 |
Bevantolol
|
||
Bevantolol, a selective β-1 adrenoceptor antagonist, is utilized for the investigation of angina pectoris and hypertension [1]. | |||
T25690 |
Levallorphan tartrate
Lorfan |
||
Levallorphan tartrate is an opioid antagonist with properties similar to those of NALOXONE. Levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid ce |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TJP2872 |
Acevaltrate
Acevaltratum,乙酰缬草三酯,Acetoxyvaltrate |
ATPase; Others | Membrane transporter/Ion channel; Others |
Acevaltrate (Acevaltratum) 对人小细胞肺癌细胞系 GLC(4) 和人结肠直肠癌细胞系 COLO 320 具有高细胞毒性,IC50 值为 1-6 uM。它抑制大鼠肾和脑半球中 Na+/K+-ATP 酶活性,IC50分别为 22.8 和 42.3 μM。 | |||
T0683 |
Mevastatin
Compactin,ML236B,美伐他汀 |
Apoptosis; Antibacterial; Antibiotic; HMG-CoA Reductase; Autophagy; Lipid | Apoptosis; Autophagy; Metabolism; Microbiology/Virology |
Mevastatin (ML236B) 是他汀类 HMG-CoA 还原酶抑制剂。它是一种降脂药,可诱导细胞凋亡,将癌细胞阻滞在 G0/G1期。它还可增加内皮型一氧化氮合酶的 mRNA 和蛋白质水平。它有抗肿瘤活性,用于心血管疾病的研究。 | |||
T1353 |
DL-Mevalonolactone
甲瓦龙酸内酯,Mevalonolactone |
Others; Endogenous Metabolite | Metabolism; Others |
DL-Mevalonolactone (Mevalonolactone),一种人内源性代谢物,是甲羟戊酸的 δ-lactone 形式,甲羟戊酸途径的一个前体。它能够降低大脑中线粒体膜电位(∆Ψm),Ca2+的保留能力和 NAD (P) H 的含量 , 而且还诱导线粒体肿胀。 | |||
T5722 |
Nevadensin
Pedunculin,石吊兰素,5,7-二羟基-6,8,4'-三甲氧基黄酮 |
Anti-infection; Antibacterial | Microbiology/Virology |
Nevadensin 是一种重要的草本成分,可抑制雌二醇的生物活化。 它具有抗结核分枝杆菌、镇咳、抗炎、抗高血压等多种药理作用。 | |||
T36815 | Chevalone C | ||
Chevalone C is a meroterpenoid fungal metabolite originally isolated from E. chevalieri. It is active against M. tuberculosis H37Ra (MIC = 6.3 μg/ml) and is cytotoxic to BC1 human breast cancer cells (IC50 = 8.7 μg/ml). Chevalone C inhibits the growth of multidrug-resistant isolates of E. coli, S. aureus, and E. faecium in a disc diffusion assay when used at a concentration of 15 μg/disc. It also induces cell death in HCT116 colorectal carcinoma cells. | |||
T22923 |
Levatin
|
Others | Others |
Levatin is extracted from Croton laevigatus Vahl. | |||
T19426 |
Mevalonic acid lithium salt
|
Others | Others |
Mevalonic acid lithium salt, is essential for cell growth and proliferation. | |||
T19427 | Mevalonic acid | Others | Others |
Mevalonic acid is essential for cell growth and proliferation,Mevalonic acid is a precursor in the mevalonate pathway. | |||
T38478 |
Mevalonic acid 5-pyrophosphate tetralithium
Mevalonicacid5-diphosphatetetralithium,Mevalonic acid 5-pyrophosphate tetralithium,5-Diphosphomevalonic acid tetralithium |
||
Mevalonic acid 5-pyrophosphate (also known as 5-Diphosphomevalonic acid) tetralithium is an endogenous metabolite involved in the mevalonate pathway. |
Cat. No. | Product Name | Species | Expression System |
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TMPK-00737 |
EVA-1/MPZL2 Protein, Human, Recombinant (hFc)
Eva,Mpzl2,EVA-1,EVA 1,EVA |
Human | HEK293 Cells |
MPZL2 encodes myelin protein zero-like 2, an adhesion molecule that mediates epithelial cell-cell interactions in several (developing) tissues.Deleterious variants of Mplz2/MPZL2 affect adhesion of the inner-ear epithelium and result in loss of structural integrity of the organ of Corti and progressive degeneration of hair cells, supporting cells, and spiral ganglion neurons. EVA-1/MPZL2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecu... | |||
TMPK-00738 |
EVA-1/MPZL2 Protein, Mouse, Recombinant (hFc)
EVA 1,Mpzl2,Epithelial V-like antigen 1,EVA |
Mouse | HEK293 Cells |
MPZL2 encodes myelin protein zero-like 2, an adhesion molecule that mediates epithelial cell-cell interactions in several (developing) tissues.Deleterious variants of Mplz2/MPZL2 affect adhesion of the inner-ear epithelium and result in loss of structural integrity of the organ of Corti and progressive degeneration of hair cells, supporting cells, and spiral ganglion neurons. EVA-1/MPZL2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecu... | |||
TMPH-00163 |
Levanase Protein, Bacillus sp., Recombinant (His & SUMO)
|
Bacillus | E. coli |
Catalyzes the hydrolysis of levan with endo-type specificity. The products of levan hydrolysis are a mixture of fructose and a series of fructooligosaccharides up to 12-mer, with levantriose being the major oligosaccharide obtained. Is not active towards sucrose. Levanase Protein, Bacillus sp., Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 30.3 kDa and the accession number is O31411. | |||
TMPH-00168 |
Levanase Protein, Bacillus subtilis, Recombinant (His)
|
Bacillus subtilis | E. coli |
Exo-fructosidase that can hydrolyze both levan and inulin, leading to the production of free fructose. Is also able to hydrolyze sucrose and to a small extent raffinose, but not melezitose, stachylose, cellobiose, maltose, and lactose. Levanase Protein, Bacillus subtilis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 77.2 kDa and the accession number is P05656. |