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26

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10851	CMP-Sialic acid sodium salt CMP-Neu5Ac sodium salt	Others	Others
	CMP-Sialic acid sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. It provides a substrate for Golgi sialyltransferases. UDP-GlcNAc 2-epimerase initiates sialic acid synthesis.
T10850	CMP-5	Antiviral; Histone Methyltransferase	Chromatin/Epigenetic; Immunology/Inflammation
	CMP-5 是一种具有选择性的 PRMT5 抑制剂，是刺突蛋白、神经纤毛蛋白受体和 ACE2 的强结合剂,抑制 PRMT5 甲基转移酶活性。CMP-5 具有抗病毒活性，可用于研究SARS病毒感染。
T10850L	CMP-5 2HCl	Others	Others
	CMP-5 2HCl 是一种驱虫剂。CMP-5 2HCl 体外抗H. contortus 的EC100为5μM。
T14987	CMP8	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	CMP8 是一种雌激素受体的选择性配体，可结合到雌激素受体配体结合域。它能够作用于突变型 MGERα (IC50:29 nM)、MGRERα (IC50:41 nM)和野生型 hERα (IC50:1100 nM)、hERβ (IC50:2200 nM)。
T27606	Indantadol HCl CHF-3381,CMP-3381,GT-3381,V-3381,CNP-3381,Indantadol	MAO; NMDAR	Metabolism; Neuroscience
	Indantadol HCl (CHF-3381) 是一种 NMDA 拮抗剂和非选择性 MAO 抑制剂。
T3080	Pyridone 6 Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,吡啶酮6,JAK Inhibitor I	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Pyridone 6 (JAK Inhibitor) 是一种泛JAK 抑制剂，有效抑制 JAK 激酶家族，对JAK2、TYK2、JAK3和JAK1的IC50分别为 1、1、5 和 15 nM。
T19243	CMP-5 hydrochloride	Others	Others
	CMP-5 hydrochloride is a potent and selective PRMT5 inhibitor, while displays no activity against PRMT1/4/7 enzymes. It selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations.
T27052	CMP3a CMP-3a,CMP 3a
	CMP3a is a NEK2 kinase inhibitor. CMP3a efficiently attenuated GBM growth in a mouse model and exhibited a synergistic effect with radiotherapy. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase E
T83629	Smurf-1 modulator CMP Example 20 Smurf-1-IN-20	Others	Others
	Smurf-1 modulator CMP Example 20 (Smurf-1-IN-20) 是一种有效的 Smurf-1 调节剂。
T39750	CMP98	PROTACs	PROTAC
	CMP98, a proteolysis targeting chimera (PROTAC), exhibits a lack of VHL degradation efficacy. It can function as a negative control compound in comparison to CM11. CMP98 comprises two von Hippel-Lindau ligands operating within their active domains.
T73747	CMP-Sialic acid
	CMP-Sialic acid (CMP-Neu5Ac) 是 UDP-GlcNAc 2-epimerase 的变构抑制剂。CMP-Sialic acid 可为高尔基体唾液酸转移酶提供底物。CMP-Sialic acid 是唾液酸及其结合物的生物合成中的重要糖类核苷酸。
T68490	CMPF	Microtubule Associated	Cytoskeletal Signaling
	CMPF是一种微管蛋白抑制剂，可用于研究肿瘤。
T14989	CMPD101	ROCK; GRK; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; GPCR/G Protein; Stem Cells
	CMPD101 是膜透性的 GRK2/3高选择性小分子抑制剂，IC50分别为 18 nM 和 5.4 nM。它针对 GRK1、GRK5 ROCK-2 和 PKCα 的选择性较小，IC50值分别为 3.1 μM，2.3 μM，1.4 μM 和 8.1 μM，可研究心衰疾病。
T14988	CMPD1	MAPK	MAPK
	CMPD1 是非 ATP 竞争性 p38 MAPK 介导的 MK2磷酸化选择性抑制剂(Ki:330 nM)。
T74481	m7GpppCmpG
	m7GpppCmpG 是 M7GpppNpG 三核苷酸帽类似物的一种寡核苷酸，用于合成带有 cap 0 或 cap 1 结构的 RNA。
T25267	Cmpd 339509 Cmpd339509,Cmpd-339509
	Cmpd 339509 is a DprE1 inhibitor. DprE1 is an epimerase required for cell wall biosynthesis.
T70628	Cmpd-A
	Cmpd-A is a time-dependent CENP-E inhibitor with potent antitumor activity. Cmpd-A inhibits the ATPase activity of the CENP-E motor domain, acting as a time-dependent inhibitor with an ATP-competitive-like behavior. Cmpd-A causes chromosome misalignment on the metaphase plate, leading to prolonged mitotic arrest. Treatment with Cmpd-A induces antiproliferation in multiple cancer cell lines.
T39771	nAChR agonist CMPI hydrochloride
	nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4) 3 (β2) 2 nAChR to ACh (10 μM) with an EC 50 of 0.26 μM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity.
T37293	CMPI hydrochloride
	Potent positive allosteric modulator of α4β2 nAChRs (EC50 values are 20 and 18 nM for rat and human, respectively). Selective for hα4β2 over hα3β2, hα3β4 and hα7. Inhibits (α4)2(β2)3, muscle-type and Torpedo nAChRs (IC50 values are 0.5, 0.7 and 0.2 μM, respectively), but not (α4)3(β2)2 receptors. Exhibits ability to photoincorporate into aliphatic and nucleophilic amino acid side chains. Hamouda (2016) Photolabeling a nicotinic acetylcholine receptor (nAChR) with an (α4)3(β2)2 nAChR-selective p...
TQ0114	CMPDA	GluR	Neuroscience
	CMPDA is a positive allosteric modulator of AMPA receptors (EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor).
T82702	CMPD167 MRK-1	CCR	Immunology/Inflammation; Microbiology/Virology
	CMPD167 (MRK-1)为口服活性CCR5抑制剂，体外显示出高效的抗病毒能力。
T8735	Sulbactum Sodium 5'-CDP,Cytidine-5′-diphosphate,胞苷-5'-二磷酸	Others	Others
	Sulbactum Sodium (5'-CDP) 由胞苷一磷酸 (CMP) 或尿苷一磷酸 (UMP) 通过磷酸基团的转移在尿苷酸激酶 (UMPK) 酶的催化下合成。
T83296	5-Azacytidine 5′-triphosphate
	5-Azacytidine 5′-triphosphate (5-aza-CMP) 为一种胞苷类似物，可抑制 DNA 依赖性 RNA 聚合酶反响中的 [3H]CTP 并入 RNA，而不影响 [3H]UTP 的并入。
T75395	alpha-2-3,6-sialidase (BiNanH2)
	alpha-2-3,6-sialidase (BiNanH2) 为一种生化研究常用的唾液酸转移酶，催化 α-2,3/2,6-唾液酸从 CMP-Neu5Ac 转移到半乳糖苷受体。
T36300	Uridine-5’-monophosphate (sodium salt hydrate)
	Uridine-5’-monophosphate (UMP) is a ribonucleotide.1It is formedviadecarboxylation of orotidine-5’-monophosphate (5’-OMP) by OMP decarboxylase. UMP is further phosphorylated by UMP-CMP kinase to form UDP and UTP during nucleic acid biosynthesis. Formulations containing UMP have been used as dietary supplements. 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide BiosynthesisBiochemistry(2002)
T74706	Vidutolimod
	Vidutolimod 是一种CpG-A 类寡核苷酸，是TLR9的激动剂。Vidutolimod 激活浆细胞样树突状细胞(pDCs)并触发IFNα的释放，导致抗肿瘤免疫作用。

化合物

CMP-Sialic acid sodium salt

Cat.No: T10851

Synonym: CMP-Neu5Ac sodium salt

Target: Others

Cat.No: T10850

Target: Antiviral, Histone Methyltransferase

Cat.No: T10850L

Target: Others

Cat.No: T14987

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Cat.No: T27606

Synonym: CHF-3381,CMP-3381,GT-3381,V-3381,CNP-3381,Indantadol

Target: MAO, NMDAR

Cat.No: T3080

Synonym: Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,吡啶酮6,JAK Inhibitor I

Target: Tyrosine Kinases, JAK

CMP-5 hydrochloride

Cat.No: T19243

Target: Others

Cat.No: T27052

Synonym: CMP-3a,CMP 3a

Smurf-1 modulator CMP Example 20

Cat.No: T83629

Synonym: Smurf-1-IN-20

Target: Others

Cat.No: T39750

Target: PROTACs

CMP-Sialic acid

Cat.No: T73747

Cat.No: T68490

Target: Microtubule Associated

Cat.No: T14989

Target: ROCK, GRK, PKC

Cat.No: T14988

Target: MAPK

Cat.No: T74481

Cat.No: T25267

Synonym: Cmpd339509,Cmpd-339509

Cat.No: T70628

nAChR agonist CMPI hydrochloride

Cat.No: T39771

CMPI hydrochloride

Cat.No: T37293

Cat.No: TQ0114

Target: GluR

Cat.No: T82702

Synonym: MRK-1

Target: CCR

Sulbactum Sodium

Cat.No: T8735

Synonym: 5'-CDP,Cytidine-5′-diphosphate,胞苷-5'-二磷酸

Target: Others

5-Azacytidine 5′-triphosphate

Cat.No: T83296

alpha-2-3,6-sialidase (BiNanH2)

Cat.No: T75395

Uridine-5’-monophosphate (sodium salt hydrate)

Cat.No: T36300

Cat.No: T74706

Cat. No.	Product Name	Target	Signaling Pathways
TMO2752	Cytidine 5'-monophosphate 5'-Cytidylic acid,5'-CMP,胞苷酸,Cytidylic Acid	Others; Endogenous Metabolite	Metabolism; Others
	Cytidine 5'-monophosphate (5'-Cytidylic acid) 是一种核苷酸，是组成 RNA 的基本单位之一。它由核碱基胞嘧啶，戊糖核糖和磷酸基团组成。
T1591	Ancitabine hydrochloride NSC 145668 HCl,盐酸环胞苷,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C	Others; DNA/RNA Synthesis; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	Ancitabine hydrochloride (NSC 145668 HCl) 是一种天然的抗白血病药物。
T40426	Cytidine 5'-diphosphate trisodium salt CDP,胞苷5'-二磷酸三钠盐水合物,胞苷-5-二磷酸三钠盐,胞苷-5'-二磷酸三钠盐	Others	Others
	Cytidine 5'-diphosphate trisodium salt (CDP) 可通过尿苷单磷酸激酶 (UMPK) 催化将磷酸基从 ATP 转移到胞苷一磷酸 (CMP) 生成用于合成 DNA 和 RNA 的胞苷三磷酸。
T4731	2'-Deoxycytidine-5'-monophosphoric acid dCMP,2'-脱氧胞苷 5'-单磷酸,2'-Deoxycytidine 5'-monophosphate	Others; Endogenous Metabolite	Metabolism; Others
	2'-Deoxycytidine-5'-monophosphoric acid (2'-Deoxycytidine 5'-monophosphate) 被用作尿苷单磷酸(UMP)或胞苷单磷酸(CMP)激酶的底物，形成 dCDP，在磷酸化成 dCTP 后支持 DNA 的生物合成。
T4703	(2-Aminoethyl)phosphonic acid 2-Aminoethylphosphonic acid,2-氨基乙基膦酸,Ciliatine,2-AEP	Others; Endogenous Metabolite	Metabolism; Others
	(2-Aminoethyl)phosphonic acid (2-Aminoethylphosphonic acid) 主要在尿液中检测到。(2-Aminoethyl)phosphonic acid 参与许多酶促反应，也是其他转化产物的母体化合物，包括但不限于神经酰胺 2-(甲氨基)乙基膦酸酯、N-(2-膦乙基)胆酰胺和 CMP-2-氨基乙基膦酸酯。

天然产物

Cytidine 5'-monophosphate

Cat.No: TMO2752

Synonym: 5'-Cytidylic acid,5'-CMP,胞苷酸,Cytidylic Acid

Target: Others, Endogenous Metabolite

Ancitabine hydrochloride

Cat.No: T1591

Synonym: NSC 145668 HCl,盐酸环胞苷,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C

Target: Others, DNA/RNA Synthesis, Autophagy

Cytidine 5'-diphosphate trisodium salt

Cat.No: T40426

Synonym: CDP,胞苷5'-二磷酸三钠盐水合物,胞苷-5-二磷酸三钠盐,胞苷-5'-二磷酸三钠盐

Target: Others

2'-Deoxycytidine-5'-monophosphoric acid

Cat.No: T4731

Synonym: dCMP,2'-脱氧胞苷 5'-单磷酸,2'-Deoxycytidine 5'-monophosphate

Target: Others, Endogenous Metabolite

(2-Aminoethyl)phosphonic acid

Cat.No: T4703

Synonym: 2-Aminoethylphosphonic acid,2-氨基乙基膦酸,Ciliatine,2-AEP

Target: Others, Endogenous Metabolite

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