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9

抑制剂 & 化合物

2

天然产物

19

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T82890	bFGF (119-126)
	bFGF (119-126) 为具备生物活性的肽段，对应人类、牛(119-126)、小鼠、大鼠(118-125)以及肝素结合生长因子2(118-125)的相应残基。该肽能够抑制bFGF受体的二聚化及其激活作用。
T1843	XMD8-92	ERK; BMI-1; Epigenetic Reader Domain	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK
	XMD8-92 是 ERK5 (BMK1)/BRD4的有效抑制剂，Kd 分别为80和190 nM。它抑制 DCAMKL2、PLK4 和 TNK1的 Kd 分别为190、600和890nm，具有抗癌活性。
T3714	SUN11602 SUN 11602	ERK; FGFR	Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
	SUN11602 是新型的碱性苯胺化合物，具有成纤维细胞生长因子特性。
T10870L	CP-547632	VEGFR; FGFR; PDGFR; BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	CP-547632是一种可口服且具有有效性、ATP 竞争性的血管内皮生长因子受体2（VEGFR-2 ）和碱性成纤维细胞生长因子（FGF）激酶F 双重抑制剂，IC50 分别为 11 nM 和 9 nM。CP-547632具有选择性，对 VEGFR2 和 bFGF 的选择性高于 EGFR，PDGFRβ 和相关的酪氨酸激酶 (TKs) 。 CP-547632具有抗肿瘤活性。
T2160	Suramin Sodium Salt 苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060	Apoptosis; Phosphatase; SARS-CoV; Sirtuin; Reverse Transcriptase; Topoisomerase; Parasite	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Suramin Sodium Salt (BAY-205) 是可逆的竞争性蛋白酪氨酸磷酸酶抑制剂。它抑制 IP5K，是抗寄生虫，抗肿瘤和抗血管生成剂。它是sirtuins 的有效抑制剂，也是 SARS-CoV-2 RNA 依赖性 RNA 聚合酶抑制剂。
T37820	Brain-Derived Basic Fibroblast Growth Factor (1-24) (bovine) (trifluoroacetate salt)
	Brain-derived basic fibroblast growth factor (1-24) (brain-derived bFGF) is a peptide fragment of brain-derived bFGF. bFGF is a peptide produced in bovine brain that is protective in a rat model of pressure-induced retinal ischemia. bFGF (1-24) corresponds to amino acid residues 1-24 of the full length peptide.
T67442	CGP-53716
	The growth factors, platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) play major roles in enhanced smooth muscle cells growth in rodent blood vessels after vascular injury. Tyrosine kinase inhibition has been shown to be effective in blocking tyrosine phosphorylation at the PDGF and bFGF receptors in cultured fibroblast and vascular smooth muscle cells which in turn inhibits their proliferation[1]. CGP 53716 is a specific PDGFR tyrosine kinase inhibitor on SMC (smoo...
T74000	CP-547632 TFA	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	CP-547632 TFA是一款口服效果显著的ATP競爭性抑制劑，针对VEGFR-2和FGF激酶具有高度选择性，IC50值分别为11 nM和9 nM。该化合物相较于EGFR和PDGFRβ，对VEGFR2和bFGF展现出更高的选择性，优于相关的酪氨酸激酶（TKs）。CP-547632 TFA还显示了显著的抗肿瘤活性。
T69599	ABT-510
	ABT-510 is synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8).

化合物

bFGF (119-126)

Cat.No: T82890

Cat.No: T1843

Target: ERK, BMI-1, Epigenetic Reader Domain

Cat.No: T3714

Synonym: SUN 11602

Target: ERK, FGFR

Cat.No: T10870L

Target: VEGFR, FGFR, PDGFR, BTK

Suramin Sodium Salt

Cat.No: T2160

Synonym: 苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060

Target: Apoptosis, Phosphatase, SARS-CoV, Sirtuin, Reverse Transcriptase, Topoisomerase, Parasite

Brain-Derived Basic Fibroblast Growth Factor (1-24) (bovine) (trifluoroacetate salt)

Cat.No: T37820

Cat.No: T67442

Cat.No: T74000

Target: VEGFR

Cat.No: T69599

Cat. No.	Product Name	Target	Signaling Pathways
T5S1103	Isoliensinine 异莲心碱,Isoliensinin	Apoptosis; Antioxidant	Apoptosis; oxidation-reduction
	Isoliensinine (Isoliensinin) 是从水芙蓉种子胚中提取的一种双苄基异喹啉生物碱，能诱导三阴性乳腺癌细胞凋亡，具有抗氧化、抗炎、抗癌活性。
T2787	Picroside I 6'-Cinnamoylcatalpol,胡黄连苦苷I	MMP; STAT	JAK/STAT signaling; Proteases/Proteasome; Stem Cells
	Picroside I (6'-Cinnamoylcatalpol) 是胡黄连的一种天然产物，是有肝脏保护作用的代谢成分，可用于哮喘研究，有减轻炎症作用，还下调 pSTAT6 和 GATA3 表达。

天然产物

Cat.No: T5S1103

Synonym: 异莲心碱,Isoliensinin

Target: Apoptosis, Antioxidant

Cat.No: T2787

Synonym: 6'-Cinnamoylcatalpol,胡黄连苦苷I

Target: MMP, STAT

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00210	FGF-2 Protein, Mouse, Recombinant (His) Fgfb,bFGF,Fgf-2,fibroblast growth factor 2 (basic)	Mouse	E. coli
	FGF-2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 18.5 kDa and the accession number is P15655.
TMPY-00749	FGF-2 Protein, Human, Recombinant fibroblast growth factor 2 (basic),FGF-2,FGFB,HBGF-2,BFG...	Human	E. coli
	FGF-2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16.5 kDa and the accession number is P09038-4.
TMPJ-00037	FGF-2 Protein, Mouse, Recombinant Fibroblast Growth Factor 2,bFGF,HBGF-2,Basic Fibrob...	Mouse	E. coli
	FGF basic is one of 22 mitogenic proteins of the FGF family, which show 35-60% amino acid conservation. Unlike other FGFs, FGF acidic and basic lack signal peptides and are secreted by an alternate pathway. The 17 kDa mouse sequence has 98% aa identity with rat, and 95% identity with human, bovine, and sheep FGF basic. Binding of FGF to heparin or cell surface HSPG is necessary for binding, dimerization and activation of tyrosine kinase FGF receptors. FGF basic binds other proteins, polysacchari...
TMPJ-00842	FGF-2 Protein, Rat, Recombinant bFGF,Heparin-Binding Growth Factor 2,FGFB,Fibroblas...	Rat	E. coli
	FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family. The family constitutes a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. They act on several cell types to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, neurotrophic effects, and tissue repair. FGF-basic is a non-glycosylated heparin binding g...
TMPY-01011	FGFR1 Protein, Human, Recombinant (His) KAL2,FLT2,FGFBR,HRTFDS,OGD,FLG,HBGFR,bFGF-R-1,CD331...	Human	HEK293
	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glyc...
TMPY-06034	FGFR1 Protein, Human, Recombinant (beta (IIIb), His) FLG,CD331,N-SAM,HBGFR,HRTFDS,BFGFR,OGD,KAL2,fibrobl...	Human	HEK293
	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glyc...
TMPY-06036	FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) FGFR-1,FLG,CD331,HH2,FLT2,KAL2,FGFBR,HBGFR,CEK,HRTFDS,fibrob...	Human	HEK293
	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glyc...
TMPK-00392	FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi) CD331,FGFR-1,FLT-2,BFGFR,N-sam,FGFR1 β (IIIc),b...	Human	HEK293
	Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment.
TMPK-00394	FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated FGFR1 β (IIIc),N-sam,FLT-2,BFGFR,bFGF-R-1,...	Human	HEK293
	Fibroblast growth factor receptor 1 (FGFR1) transmits signals through the plasma membrane regulating essential cellular processes like division, motility, metabolism, and death. Overexpression of FGFR1 is observed in numerous tumors and thus constitutes an attractive molecular target for selective cancer treatment.
TMPY-01782	FGFR1 Protein, Mouse, Recombinant (hFc) Hspy,fibroblast growth factor receptor 1,bFGF-R-1,A...	Mouse	HEK293
	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glyc...
TMPY-01781	FGFR1 Protein, Mouse, Recombinant (His) Flt-2,FLG,fibroblast growth factor receptor 1,bFGF-...	Mouse	HEK293
	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glyc...
TMPJ-00039	FGF-2 Protein, Human, Recombinant (K128N) FGF2,bFGF,FGFB,Heparin-binding growth factor 2,HBGF...	Human	E. coli
	Fibroblast growth factors (FGF) are a family of heparin-binding secreted proteins that stimulate cell proliferation and differentiation in a wide variety of tissues. FGFs play important roles in diverse biological functions both in vivo and in vitro, including mitogenesis, cellular migration, differentiation, angiogenesis, and wound healing. Human embryonic stem cell (hESC) cultures require FGF basic (also known as FGF-2 or bFGF) in cell culture media to remain in an undifferentiated and pluripo...
TMPJ-00040	FGF-2 Protein, Human,Recombinant (Q65I, C96S, N111G) FGF-2,Fibroblast growth factor 2,Heparin-binding growth fact...	Human	E. coli
	Fibroblast growth factors (FGF) are a family of heparin-binding secreted proteins that stimulate cell proliferation and differentiation in a wide variety of tissues. FGFs play important roles in diverse biological functions both in vivo and in vitro, including mitogenesis, cellular migration, differentiation, angiogenesis, and wound healing. Human embryonic stem cell (hESC) cultures require FGF basic (also known as FGF-2 or bFGF) in cell culture media to remain in an undifferentiated and pluripo...
TMPY-04371	FGFR1 Protein, Human, Recombinant (His & GST) HRTFDS,CEK,OGD,FLG,FLT2,FGFBR,bFGF-R-1,N-SAM,fibrob...	Human	Baculovirus-Insect Cells
	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glyc...
TMPY-05761	FGFR1 Protein, Human, Recombinant (His), Biotinylated FLT-2,KAL2,FGFBR,HRTFDS,BFGFR,fibroblast growth fac...	Human	HEK293
	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glyc...
TMPY-05777	FGFR1 Protein, Human, Recombinant (hFc) N-SAM,OGD,HH2,HBGFR,FLT2,CEK,FLG,FGFR-1,FGFBR,HRTFDS,FLT-2,<...	Human	HEK293
	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glyc...
TMPY-06033	FGFR1 Protein, Human, Recombinant (beta (IIIb), hFc) HBGFR,BFGFR,bFGF-R-1,FLG,FGFR-1,fibroblast...	Human	HEK293
	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glyc...
TMPY-06035	FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) KAL2,OGD,N-SAM,CEK,FLT2,HH2,FLG,CD331,BFGFR,HBGFR,F...	Human	HEK293
	FGFR1, also known as CD331, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. Fibroblast growth factors (FGFs) (FGF1 - 10 and 16 - 23) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGFs bind heparan sulfate glyc...
TMPY-05004	FGF-4 Protein, Human, Recombinant HST-1,KFGF,fibroblast growth factor 4,HSTF1,K-FGF,HST,HBGF-4	Human	E. coli
	FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) a...

重组蛋白

FGF-2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00210

Species: Mouse

Expression System: E. coli

FGF-2 Protein, Human, Recombinant

Cat.No: TMPY-00749

Species: Human

Expression System: E. coli

FGF-2 Protein, Mouse, Recombinant

Cat.No: TMPJ-00037

Species: Mouse

Expression System: E. coli

FGF-2 Protein, Rat, Recombinant

Cat.No: TMPJ-00842

Species: Rat

Expression System: E. coli

FGFR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01011

Species: Human

Expression System: HEK293

FGFR1 Protein, Human, Recombinant (beta (IIIb), His)

Cat.No: TMPY-06034

Species: Human

Expression System: HEK293

FGFR1 Protein, Human, Recombinant (alpha (IIIb), His)

Cat.No: TMPY-06036

Species: Human

Expression System: HEK293

FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00392

Species: Human

Expression System: HEK293

FGFR1 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00394

Species: Human

Expression System: HEK293

FGFR1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01782

Species: Mouse

Expression System: HEK293

FGFR1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01781

Species: Mouse

Expression System: HEK293

FGF-2 Protein, Human, Recombinant (K128N)

Cat.No: TMPJ-00039

Species: Human

Expression System: E. coli

FGF-2 Protein, Human,Recombinant (Q65I, C96S, N111G)

Cat.No: TMPJ-00040

Species: Human

Expression System: E. coli

FGFR1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04371

Species: Human

Expression System: Baculovirus-Insect Cells

FGFR1 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05761

Species: Human

Expression System: HEK293

FGFR1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05777

Species: Human

Expression System: HEK293

FGFR1 Protein, Human, Recombinant (beta (IIIb), hFc)

Cat.No: TMPY-06033

Species: Human

Expression System: HEK293

FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc)

Cat.No: TMPY-06035

Species: Human

Expression System: HEK293

FGF-4 Protein, Human, Recombinant

Cat.No: TMPY-05004

Species: Human

Expression System: E. coli

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