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Cat. No. | Product Name | Target | Signaling Pathways |
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T1482 |
Ciclopirox
环吡酮,HOE296b,环吡酮胺 |
ATPase; Ferroptosis; Antibacterial; Autophagy; Antifungal | Apoptosis; Autophagy; Membrane transporter/Ion channel; Microbiology/Virology |
Ciclopirox (HOE296b) 是一种合成的抗真菌剂,可研究浅表真菌病。 | |||
T0825 |
Ebselen
SPI-1005,PZ-51,依布硒,CCG-39161 |
Phosphatase; Virus Protease; Calcium Channel; COX; HIV Protease | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物,是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒,是HIV-1衣壳 CTD 二聚化的抑制剂,具有抗炎、抗癌和抗氧化活性。 | |||
T50032 |
5-(2-furyl)-N-propylisoxazole-3-carboxamide
|
Others | Others |
5-(2-furyl)-N-propylisoxazole-3-carboxamide 是一种用作分子结构单元的化合物,被认为是 NMDA 受体的调节剂,已被证明对神经元细胞中谷氨酸诱导的兴奋性毒性和氧化应激具有保护作用。它也被发现具有抗炎活性,使其成为阿尔茨海默病和帕金森病等疾病的潜在治疗剂。 | |||
T38240 |
2,6-Dichlorodiphenylamine
|
Antibacterial | Microbiology/Virology |
2,6-Dichlorodiphenylamine 是双氯芬酸钠的一种结构类似物,显示出抗白色念珠菌活性。2,6-Dichlorodiphenylamine 是非选择性抗炎剂,为COX 的抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的IC50分别为 4 和 1.3 nM。 | |||
T71264 |
Tenidap Sodium
|
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Tenidap Sodium is a COX/5-LOX inhibitor and cytokine-modulating anti-inflammatory agent. | |||
T8775 |
Lisuride maleate
R-(+)-LISURIDE HYDROGEN MALEATE |
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Lisuride maleate is an agonist of Dopamine receptor and anti-Parkinson's agent. Displays high affinity for D2, D3 and D4 receptors along with 5-HT1A. Exhibits some 5-HT2B receptor antagonist properties. Decreases prolactin release; reduces inflammatory me | |||
T72412 | Antimicrobial agent-5 | ||
Antimicrobial agent-5 是一种强效抗菌剂,对革兰氏阳性菌/阴性菌展示出良好的细胞选择性。通过阻断LPS与CD14/TLR4受体之间的交互作用,Antimicrobial agent-5 显示出抗炎活性并能缓解LPS引发的炎症反应。 | |||
T79389 |
LTB4-IN-2
|
FLAP | Immunology/Inflammation |
LTB4-IN-2(Compound 6x)是一种选择性的5-脂氧合酶激活蛋白(FLAP)抑制剂,旨在抑制白三烯B4(LTB4)的形成(IC50:1.15 μM),适用于抗炎研究。 | |||
T35708 | N-acetyl-5-Aminosalicylic Acid | ||
N-acetyl-5-Aminosalicylic acid is a metabolite of the anti-inflammatory agent 5-aminosalicylic acid and its prodrug form, sulfasalazine . It is formed in the liver, intestinal lumen, and colonic epithelial cells via N-acetyltransferases. It reduces IFN-γ binding to colonic epithelial cells by 24% when used at a concentration of 10 mM. N-acetyl-5-Aminosalicylic acid (100 μM) scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay and inhibits base hydroxylation in DNA stimulated by ... | |||
T36660 |
Olsalazine-13C6
Olsalazine-13C6 |
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Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50= 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of ... | |||
T60417 |
Fenspiride
|
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Fenspiride 是 H1-组胺受体的拮抗剂。 Fenspiride 是一种具有口服活性的非甾体类抗炎药,可用于治疗呼吸道感染和中耳炎。 Fenspiride 抑制磷酸二酯酶 4 和磷酸二酯酶 3 的活性,-logIC50 值分别为 4.16+/-0.09 和 3.44+/-0.12。 磷酸二酯酶 5 活性也受到抑制,-logIC50 值约为 3.8。 | |||
T60292 |
Ibuprofen sodium
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Ibuprofen ((±)-Ibuprofen) sodium 是一种口服活性的选择性COX-1抑制剂,IC50值为 13 μM。Ibuprofen sodium 抑制细胞增殖、血管生成,并诱导细胞凋亡 (apoptosis)。Ibuprofen sodium 是一种非甾体抗炎剂和一氧化氮 (NO) 供体。Ibuprofen sodium 可用于疼痛、肿胀、炎症、感染、免疫学、癌症的研究。 | |||
T22242 |
Amodiaquine hydrochloride
|
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Amodiaquine dihydrochloride (Amodiaquin dihydrochloride) 是一种4-氨基喹啉类抗疟剂,是一种有效的口服活性的组胺 N-甲基转移酶 (histamine N-methyltransferase) 抑制剂,Ki 值为 18.6 nM。Amodiaquine dihydrochloride 也是一种Nurr1激动剂,可特异性结合Nurr1的配体结合域,EC50约为20 μM,具有抗炎作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T83056 |
Anti-inflammatory agent 5
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5 是一种抗炎剂,对由 LPS 诱导的 BV-2 小胶质细胞中 NO 的生成显示出显著的抑制活性。 | |||
T0646 |
5-Aminosalicylic Acid
Mesalazine,5-ASA,5-氨基水杨酸,Mesalamine |
NF-κB; Lipoxygenase; COX; Glutathione Peroxidase; Endogenous Metabolite; PAK; PPAR | Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB |
5-Aminosalicylic Acid (5-ASA) 是一种特异性的PPARγ激动剂,还抑制 p21-激活激酶1(PAK1) 和NF-κB,具有抗炎活性。 | |||
T4S2126 |
Ginkgetin
银杏双黄酮,银杏素 |
Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells |
Ginkgetin 是从银杏叶中分离得到的一种双黄酮,具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂,IC50值为 5.92 μM。 | |||
T2830 |
Betulinic acid
白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid |
Apoptosis; Mitophagy; NF-κB; HIV Protease; Topoisomerase; Endogenous Metabolite; Aminopeptidase; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
Betulinic acid (ALS-357) 是从白桦树皮中分离出来的一种五环三萜类天然产物,是真核细胞拓扑异构酶 I 的抑制剂,IC50值为 5 μM,具有抗逆转录病毒、抗疟疾、抗癌和抗炎特性。 | |||
T3794 |
Pentagalloylglucose
Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖 |
Influenza Virus | Microbiology/Virology |
1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中,具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。 | |||
T4S0969 |
Obtusifolin
决明蒽醌,决明蒽醌;美决明子素 |
Antioxidant; NF-κB | NF-κB; oxidation-reduction |
Obtusifolin 是分离自决明子的种子中,能够抑制NF-kB 通路,调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。 | |||
T83060 |
Anti-inflammatory agent 30
|
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Compound 5(Anti-inflammatory agent 30)是一种具备肝脏保护作用的抗炎药物。 | |||
T14317 |
ar-Turmerone
(+)-ar-Turmerone |
Others | Others |
ar-Turmerone ((+)-ar-Turmerone) is a major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities[1][2][3]. ar-Turmerone ((+)-ar-Turmerone) exerts positive modulation on murine DCs, induces NSC proliferation. |