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Cat. No.	Product Name	Target	Signaling Pathways
T1866	AT-56	Others; PGE Synthase	Immunology/Inflammation; Others
	AT56 是口服有活性的脂钙蛋白型前列腺素 D 合酶 (L-PGDS) 选择性抑制剂，其IC50=95 μM，Ki=75 μM。它能够特异性地抑制L-PGDS 催化的 PGD2介导的嗜睡或疼痛反应。
T4309	CIL56 CA3	Ferroptosis; ROS	Apoptosis; Immunology/Inflammation
	CIL56 (CA3) 是一种选择性铁死亡诱导剂，可通过产生铁依赖性活性氧来诱导细胞铁死亡。
T4066	FIN56	Ferroptosis	Apoptosis
	FIN56 是一种铁死亡特异性诱导剂，能结合并激活角鲨烯合酶，可通过诱导 GPX4 降解来诱导铁死亡。
T3960	T56-LIMKi T5601640	LIM Kinase	Cell Cycle/Checkpoint
	T56-LIMKi (T5601640) 是一种选择性LIMK2抑制剂，抑制Panc-1细胞生长的IC50值为35.2 μM。
T7795	RIPA-56	RIP kinase	Apoptosis; NF-κB
	RIPA-56 是一种高效选择和代谢稳定的受体相互作用蛋白 1 抑制剂，可研究全身炎症反应综合征，IC50为 13 nM。
T12216	NF-56-EJ40	GPR	Endocrinology/Hormones; GPCR/G Protein
	NF-56-EJ40 是一种有效且高度特异性的人 SUCNR1 拮抗剂，IC50 为 25 nM，Ki 为 33 nM。
T12216L	NF-56-EJ40 hydrochloride	GHSR	GPCR/G Protein
	NF-56-EJ40 hydrochloride 是一种有效，高亲和力和高度选择性的人 SUCNR1 (GPR91) 拮抗剂，IC50 为 25 nM，Ki 为 33.5 nM，对大鼠 SUCNR1 几乎没有活性。 NF-56-EJ40 hydrochloride 对人源化大鼠 SUCNR1 具有高亲和力，Ki 值为 17.4 nM。
TP2131L	Rac1 Inhibitor W56 acetate(1095179-01-3 free base)	Rho	Cell Cycle/Checkpoint
	Rac1 Inhibitor W56 acetate(1095179-01-3 free base) 包含 Rac1 的鸟嘌呤核苷酸交换因子 (GEF) 识别/激活位点的残基 45-60 的肽；选择性抑制 Rac1 与 Rac1 特异性 GEF TrioN、GEF-H1 和 Tiam1 的相互作用。
TP2132L	26RFa acetate	Others	Others
	26RFa acetate 是一种在哺乳动物中具有促食欲活性的下丘脑神经肽。
TP2186L	PalMitoyl Tripeptide-1 Acetate(147732-56-7 Free base) PalMitoyl Tripeptide-1 Acetate(147732-56-7 Free base)	Others	Others
	PalMitoyl Tripeptide-1 Acetate 是一种含有棕榈酸的细胞外基质衍生肽。
T36107	YW3-56 YW3-56
	YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor, with an IC50 of 1-5 μM for PAD4. Compared with Cl-amidine, YW3-56 shows >60-fold increase in cell growth inhibition efficacy (IC50 about 2.5 μM) but only 5-fold increase in PAD4 inhibition (IC sub>50 about 1-5 μM). At 2-4 μM concentrations, YW3-56 displays mainly cytostatic effects by slowing cell division, whereas at higher concentrations, it exerts cytotoxic effects by altering cell morphology and killing cells[1]. [1]. Wang Y, et ...
T35913	EMI56
	EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].
T38881	Antibacterial agent 56
	Antibacterial agent 56 (example 22) is a antibacterial agent.
T68341	HS56
	HS56 是一种 ATP 竞争性 Pim/DAPK3双重抑制剂，对 DAPK3、Pim-3、Pim-1和 Pim-2 的 Ki 值分别为 0.26、0.208、2.94 和＞100 μM。 HS56 抑制 LC20 磷酸化和平滑肌收缩。HS56 降低自发性高血压小鼠的血压。HS56可用于高血压研究。
T62458	EGFR-IN-56
	EGFR-IN-56 (Compound 13a) 是一种 EGFR 的有效抑制剂，能够作用于 EGFRT790M (IC50: 541.7 nM) 和 EGFRT790M/L858R (IC50: 132.1 nM)。EGFR-IN-56 能够将癌细胞的细胞周期阻滞在 G2/M 期，并诱导细胞凋亡 (apoptosis)。
T79670	Anti-inflammatory agent 56	COX	Immunology/Inflammation; Neuroscience
	Anti-inflammatory agent 56 (Compound 9) 是一种选择性COX-2抑制剂，IC50值为0.54 μM。该化合物展现出显著的抗氧化和抗炎效果，并能有效抑制氧化应激引起的细胞死亡。通过抑制Keap1、COX-2和iNOS，Anti-inflammatory agent 56减轻氧化应激及神经炎症。此外，其在小鼠中的急性毒性较低，LD50为1000 mg/kg。
T79329	SARS-CoV-2-IN-56	SARS-CoV	Microbiology/Virology
	SARS-CoV-2-IN-56（Compound 63）是具有抗病毒活性的SARS-CoV-2抑制剂，能在Vero E6 细胞中抑制SARS-CoV-2，其IC50为0.7 μM。
T80922	Tubulin polymerization-IN-56
	Tubulin polymerization-IN-56（compound 8l），一种吲唑衍生的微管蛋白聚合抑制剂，通过与秋水仙碱位点的相互作用，能够引发细胞周期停滞与细胞凋亡。该化合物还能降低细胞迁移并在体内更有效地抑制肿瘤生长。
T61768	FY-56
	FY-56 是一种高效的具有选择性LSD1/KDM1A 抑制剂 (IC50=42 nM)，比 MAO-A/B 具有高选择性. FY-56 诱导 MOLM-13 和 MV4-11 细胞分化，具有急性髓系白血病 AML 研究潜力。
T61673	Anticancer agent 56
	Anticancer agent 56 (compound 4d) is a powerful anti-cancer compound with favorable drug-like properties. It shows significant anticancer activity against multiple cancer cell lines, with an IC50 value of less than 3 μM. Anticancer agent 56 exerts its effects by causing cell cycle arrest at the G2/M phase and activating the mitochondrial apoptosis pathway. Mechanistically, it induces the accumulation of reactive oxygen species (ROS), upregulates BAX, downregulates Bcl-2, and triggers the activat...
T75179	Antifungal agent 56
	Antifungal agent 56 (compound A09) 是一种抗氟康唑耐药菌株的强效抗真菌剂。Antifungal agent 56 比咪康唑更有效。Antifungal agent 56 抑制白色念珠菌的 MIC 值为 0.03-0.25 μg/mL。
T39831	PSMA-ALB-56
	PSMA-ALB-56是通过结合谷氨酸脲基 psma 结合实体、DOTA 螯合剂和基于4-(对碘苯基)-片段或 p(tolyl)-片段的白蛋白结合剂而设计的一种 PSMA-targeting 放射性配体,具有抗肿瘤活性。
T64128	Antitumor agent-56
	Antitumor agent-56 是一种口服具有活力的 triptolide 衍生物，能够明显抑制黑色素瘤的生长，表现出抗肿瘤、抗炎和 NO 释放作用。
T77852	INX-SM-56
	INX-SM-56是一种用于合成抗VISTA抗体活性分子偶联物的cytotoxin。VISTA代指含V区域免疫球蛋白的T细胞活化抑制因子。
T36108	YW3-56 (hydrochloride) (technical grade) YW3-56 (hydrochloride) (technical grade)
	YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.2 1.Wang, Y., Li, P., Wang, S., et al.Anticancer pept...
T78979	HIV-1 inhibitor-56
	HIV-1 inhibitor-56 (compound 12126065)为一有效HIV-1非核苷逆转录酶抑制剂，其在TZM细胞中对野生型HIV-1显示出高效的抗病毒活性，EC50仅为0.24 nM，并能穿透血脑屏障。
T71818	SOD1-Derlin-1 Inhibitor 56-26
	SOD1-Derlin-1 Inhibitor 56-26 is a potent inhibitor of SOD1-Derlin-1 interaction.
T76389	Prepro-ANF (56-92), human
	Prepro-ANF (56-92), human，是一种人类心房利钠因子的前体，同时也作为鸟苷酸环化酶的激活剂，有助于提升肾膜和肾单位微粒鸟苷酸环化酶的活性。
T72356	KRAS G12C inhibitor 56
	KRAS G12C inhibitor 56（化合物IC-6），作为一种SOS1抑制剂，显示出1.6 nM的IC50值，表明其对于癌症研究的潜在应用价值。
T75932	Rac1 Inhibitor W56 TFA
	Rac1 Inhibitor W56 TFA，为Rac1中残基45-60的抑制剂，能够阻止Rac1与鸟嘌呤核苷酸交换因子TrioN、GEF-H1及Tiam的相互作用。
T83770	Klotho-derived Peptide 1 (56-87) (human) TFA KP1 (56-87)
	Klotho衍生肽1（KP1）(56-87)是从人类Klotho蛋白质中衍生的肽，具有扰乱TGF-β信号传导的作用。它与TGF-β受体类型1（TGFBR2）和TGF-β受体类型2（TGFBR2；Kds分别为1.41和14.6µM）结合。KP1（10 µg/ml）的预孵育抑制TGF-β在NRK-49F大鼠成纤维细胞中诱导的纤维连接蛋白和α-平滑肌肌动蛋白（α-SMA）水平的增加。在体内，KP1（每天1 mg/kg）选择性地定位于受损的肾脏，并减少血清肌酐和血尿素氮水平，这些是肾功能的标志物，同时也减少了小鼠单侧输尿管阻塞（UUO）和单侧缺血-再灌注损伤诱导的肾脏纤维化模型中的肾纤维化。
T80119	Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)	Thrombin	Proteases/Proteasome
	Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) 是一种具有高亲和力的Hirugen类肽，其与凝血酶的KD值小于100 nM。作为抗血栓剂，它能有效抑制凝血酶诱导的纤维蛋白凝块生成，其IC50值为0.087 μM。
T22126	Org 25543 hydrochloride	GlyT	Neuroscience
	Org 25543 hydrochloride 是一种有效的选择性甘氨酸转运蛋白 2 型 (GlyT2) 抑制剂（hGlyT2 的 IC50 = 16 nM）。在 CHO 细胞的甘氨酸摄取测定中，对 GlyT1 或 56 种其他常见生物靶标 (≥ 100 μM) 没有显示活性。
T15032	CYM50308	S1P Receptor; LPL Receptor	GPCR/G Protein
	CYM50308 是选择性和高亲和力的鞘氨醇-1-磷酸受体 4 激动剂，EC50为 56 nM。它对 S1P4-R 的选择性比 S1P5-R 高 37 倍。
T4019	Cambinol SIRT1/2 Inhibitor IV,NSC 112546	Apoptosis; Phospholipase; Sirtuin	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Cambinol (SIRT1/2 Inhibitor IV) 是一种SIRT1和SIRT2的抑制剂，IC50值分别为 56 μM 和 59 μM。它是中性鞘磷脂酶的外泌体抑制剂。
T38192	Unifiram	Others	Others
	Unifiram 是一种认知增强剂。 Unifiram 诱导大鼠海马 CA1 区场兴奋性突触后电位 (fEPSP) 幅度的持久增加 (EC50= 27 nM) 并增加大鼠大脑皮层中乙酰胆碱 (ACh) 的释放。
T83363	3-Acetyl-6-bromocoumarin
	3-Acetyl-6-bromocoumarin，一种香豆素，具有约56%的强抗氧化活性。
T36144	11β-Prostaglandin E2 11β-PGE2,11β-Prostaglandin E2
	11β-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM.[1] 11β-PGE2 also stimulates bone resorption in rats at concentrations of 10-8 to 10-6 M which is similar to PGE2.2 11β-PGE2 inhibits PGE2 binding to the prostaglandin transporter protein with a Ki of 56 nM.[3] .
T81831	MDL-811	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	MDL-811为SIRT6的异构激活剂，有效促进SIRT6对组蛋白H3的去乙酰化作用（H3K9Ac, H3K18Ac, 和 H3K56Ac）。该化合物在结肠癌研究中有应用价值。
T70168	Tofacitinib HCl
	Tofacitinib HCl, also known as tasocitinib, CP-690550, is a Janus kinase (JAK) inhibitor. Tofacitinib HCl modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. JAK enzymes transmit cytokine signaling through pairing of JAKs (e.g., JAK1/JAK3, JAK1/JAK2, JAK1/TyK2, JAK2/JAK2). Tofacitinib HCl inhibited the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50 of 406, 56, and 1377 nM, respectively.
T70538	PD-85639
	PD-85639 is a voltage-gated sodium (Na+) channel blocker (75% in 10 min & >95% in 25 min blockage of Na+ current by 25 μM PD85,639; whole-cell patch clamp using primary rat brain neurons) that is shown to target rat brain Nav1.2 with simultaneous high- and low-affinity modes of binding (EC50 = 56 nM/40% & 20 μM/60% at pH 9.0, 5 nM/28% & 3 μM/72% at pH 7.4, against 2 nM [3H]-PD85,639 for binding rat brain synaptosomes; EC50 = 17 nM/39% & 10 μM/61% using at pH 9.0 using rat brain synaptosome membr...
T69958	Tofacitinib maleate
	Tofacitinib maleate, also known as tasocitinib, CP-690550, is a Janus kinase (JAK) inhibitor. Tofacitinib maleate modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. JAK enzymes transmit cytokine signaling through pairing of JAKs (e.g., JAK1/JAK3, JAK1/JAK2, JAK1/TyK2, JAK2/JAK2). Tofacitinib maleate inhibited the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50 of 406, 56, and 1377 nM, respectively.
T38269	Purfalcamine
	Purfalcamine is an orally active, selective Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) inhibitor with an IC50 of 17 nM and an EC50 of 230 nM. Purfalcamine has antimalarial activity and causes malaria parasites developmental arrest at the schizont stage[1][2]. Purfalcamine has low activity against Toxoplasma gondii calcium-dependent protein kinase 3 (TgCDPK3)[1]. Purfalcamine (225, 450 nM) has no effect on the parasitemia in the first 32 hours. After about 40 hours, paras...
T37847	Zonisamide-13C2,15N Zonisamide-13C2,15N
	Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...
T36649	AN3661
	AN3661, a potent antimalarial lead compound, targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue subunit 3 (PfCPSF3). AN3661 inhibits Plasmodium falciparum laboratory-adapted strains, Ugandan field isolates, and murine P. berghei and P. falciparum infections[1]. AN3661 is active at nanomolar (IC50=20-56 nM) concentrations against P. falciparum laboratory strains known to be sensitive (3D7) or resistant (W2, Dd2, K1, HB3, FCR3 and TM90C2B), and AN3661 is simi...
T37094	(S)-UFR2709 hydrochloride (S)-UFR2709 hydrochloride
	(S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 (hydrochloride) decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 (hydrochloride) acts as an anxiolytic agent and can be used for the study of nicotine addiction[1][2]. Brain nicotinic acetylcholine receptors (nAChRs) is a heterogeneous family of pentameric acetylcholine-gated cation channels, whi...

化合物

Cat.No: T1866

Target: Others, PGE Synthase

Cat.No: T4309

Synonym: CA3

Target: Ferroptosis, ROS

Cat.No: T4066

Target: Ferroptosis

Cat.No: T3960

Synonym: T5601640

Target: LIM Kinase

Cat.No: T7795

Target: RIP kinase

Cat.No: T12216

Target: GPR

NF-56-EJ40 hydrochloride

Cat.No: T12216L

Target: GHSR

Rac1 Inhibitor W56 acetate(1095179-01-3 free base)

Cat.No: TP2131L

Target: Rho

Cat.No: TP2132L

Target: Others

PalMitoyl Tripeptide-1 Acetate(147732-56-7 Free base)

Cat.No: TP2186L

Synonym: PalMitoyl Tripeptide-1 Acetate(147732-56-7 Free base)

Target: Others

Cat.No: T36107

Synonym: YW3-56

Cat.No: T35913

Antibacterial agent 56

Cat.No: T38881

Cat.No: T68341

Cat.No: T62458

Anti-inflammatory agent 56

Cat.No: T79670

Target: COX

SARS-CoV-2-IN-56

Cat.No: T79329

Target: SARS-CoV

Tubulin polymerization-IN-56

Cat.No: T80922

Cat.No: T61768

Anticancer agent 56

Cat.No: T61673

Antifungal agent 56

Cat.No: T75179

Cat.No: T39831

Antitumor agent-56

Cat.No: T64128

Cat.No: T77852

YW3-56 (hydrochloride) (technical grade)

Cat.No: T36108

Synonym: YW3-56 (hydrochloride) (technical grade)

HIV-1 inhibitor-56

Cat.No: T78979

SOD1-Derlin-1 Inhibitor 56-26

Cat.No: T71818

Prepro-ANF (56-92), human

Cat.No: T76389

KRAS G12C inhibitor 56

Cat.No: T72356

Rac1 Inhibitor W56 TFA

Cat.No: T75932

Klotho-derived Peptide 1 (56-87) (human) TFA

Cat.No: T83770

Synonym: KP1 (56-87)

Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)

Cat.No: T80119

Target: Thrombin

Org 25543 hydrochloride

Cat.No: T22126

Target: GlyT

Cat.No: T15032

Target: S1P Receptor, LPL Receptor

Cat.No: T4019

Synonym: SIRT1/2 Inhibitor IV,NSC 112546

Target: Apoptosis, Phospholipase, Sirtuin

Cat.No: T38192

Target: Others

3-Acetyl-6-bromocoumarin

Cat.No: T83363

11β-Prostaglandin E2

Cat.No: T36144

Synonym: 11β-PGE2,11β-Prostaglandin E2

Cat.No: T81831

Target: Sirtuin

Tofacitinib HCl

Cat.No: T70168

Cat.No: T70538

Tofacitinib maleate

Cat.No: T69958

Cat.No: T38269

Zonisamide-13C2,15N

Cat.No: T37847

Synonym: Zonisamide-13C2,15N

Cat.No: T36649

(S)-UFR2709 hydrochloride

Cat.No: T37094

Synonym: (S)-UFR2709 hydrochloride

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