70
18
4
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10503 |
ACAT-IN-1 cis isomer
|
Acyltransferase | Metabolism |
ACAT-IN-1 cis isomer是一种有效的 ACAT 抑制剂(IC50:100 nM),可用于研究免疫系统相关疾病。 | |||
T40552 |
ACAT-IN-10
|
||
ACAT-IN-10 is an acyl-Coenzyme A: cholesterol acyltransferase (ACAT) inhibitor. It inhibits NF-κB mediated transcription with a weak activity. | |||
T39412 |
ACAT-IN-5
|
||
ACAT-IN-5 (example 19) is a compound that functions as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). By inhibiting ACAT, this compound effectively suppresses the transcription mediated by NF-κB. | |||
T39415 |
ACAT-IN-9
|
||
ACAT-IN-9, acts as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). By doing so, it effectively suppresses NF-κB mediated transcription. | |||
T39414 | ACAT-IN-7 | ||
ACAT-IN-7 is a compound that acts as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT) enzyme. It effectively suppresses the transcription process mediated by NF-κB. | |||
T40551 |
ACAT-IN-3
|
||
ACAT-IN-3, a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT), effectively suppresses NF-κB dependent transcription. | |||
T39417 |
ACAT-IN-2
|
||
ACAT-IN-2 is a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). This compound effectively blocks NF-κB mediated transcription. | |||
T39411 |
ACAT-IN-10 dihydrochloride
|
||
ACAT-IN-10 dihydrochloride is a compound that serves as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT).ACAT-IN-10 dihydrochloride effectively hampers NF-κB mediated transcription, albeit to a lesser extent. | |||
T40554 | ACAT-IN-4 | ||
ACAT-IN-4 (Example 208) is a chemical compound that functions as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). Additionally, ACAT-IN-4 effectively inhibits the transcription process mediated by NF-κB. | |||
T40553 | ACAT-IN-6 | ||
ACAT-IN-6, an acyl-Coenzyme A: cholesterol acyltransferase (ACAT) inhibitor, displays potent inhibition of NF-κB mediated transcription. | |||
T39413 |
ACAT-IN-8
|
||
ACAT-IN-8 (example 206) is a compound that functions as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT), an enzyme involved in cholesterol modulation. This compound also possesses the ability to inhibit transcription mediated by NF-κB. | |||
T39416 |
ACAT-IN-4 hydrochloride
|
||
ACAT-IN-4 hydrochloride (Example 208) is a hydrochloride salt of a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). This compound effectively hinders NF-κB mediated transcription. | |||
T22665 |
PD 128042
CI 976 |
Acyltransferase | Metabolism |
PD 128042 (CI 976) 是口服有效的ACAT (酰基辅酶 A: 胆固醇酰基转移酶)选择性抑制剂。它也是LPAT(溶血磷脂酰基转移酶) 抑制剂。它抑制高尔基体相关 LPAT 活性 (IC50=15 μM)。它抑制多种膜运输步骤,包括在内吞和分泌途径中发现的步骤。 | |||
T2753 |
Avasimibe
PD-148515,阿伐麦布,CI-1011 |
P450; Acyltransferase | Metabolism |
Avasimibe (PD-148515) 是一种口服有效的酰基辅酶 A: 胆固醇酰基转移酶 (ACAT) 抑制剂,对 ACAT1和 ACAT2的 IC50分别为 24 和 9.2 µM。Avasimibe 在前列腺癌中有研究的价值。 | |||
T2320 |
Indacaterol
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Indacaterol 是一种超长效β-肾上腺素受体激动剂。 | |||
T1239 |
Indacaterol maleate
马来酸茚达特罗,QAB149 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Indacaterol maleate (QAB149) 是一种超长效的 β-肾上腺素受体激动剂。 | |||
T6035 |
Odanacatib
奥达卡替,奥当卡替,MK-0822 |
Cysteine Protease | Proteases/Proteasome |
Odanacatib 是组织蛋白酶K(人/兔)的选择性抑制剂,IC50分别为0.2 nM 和 1 nM。 | |||
T6078 |
Saracatinib
AZD0530,塞卡替尼 |
EGFR; Src; BTK; Autophagy | Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Saracatinib (AZD0530) 是一种有效的 Src 抑制剂,抑制 c-Src、Lck、c-YES、Lyn、Fyn、Fgr 和 Blk 的 IC50值在 2.7 到 11 nM 之间,对其他酪氨酸激酶具有选择性。 | |||
T26548 |
Acaterin
|
||
Acaterin, an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), inhibits synthesis of cholesteryl ester in macrophage J774. | |||
T40463 |
Relacatib
SB-462795 |
||
Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relacatib effectively inhibits endogenous cathepsin K in situ in human osteoclasts, as well as human osteoclast-mediated bone resorption, with IC 50 values of 45 nM and 70 nM, respectively. Additionally, in vitro studies demonstrate Relacatib's inhibitory effect on bone resorption in ... | |||
T31515 |
Dipentyl sebacate
Sebacinsaeurediphenylester,Diphenyl-sebacinat,Decandisaeure-diphenylester,Sebacinsaeure-diphenylester |
||
Dipentyl sebacate is a biochemical. | |||
T69475 |
Dinalbuphine sebacate
|
||
Dinalbuphine sebacate is a long-lasting prodrug of nalbuphine, acting as a moderate-efficacy partial agonist or antagonist of the μ-opioid receptor and as a high-efficacy partial agonist of the κ-opioid receptor. | |||
T34069 |
Piperazine sebacate
Nematorazine |
||
Piperazine sebacate has anthelminthic activity. it be studie for therapy of trichocephalosis. | |||
T31111 |
Cupric sebacate
|
||
Cupric sebacate is a biochemical. | |||
T71658 |
Indacaterol xinafoate
|
||
Indacaterol xinafoate is an ultra-long-acting beta-adrenoceptor agonist. | |||
T71340 |
Mizagliflozin sebacate
|
||
Mizagliflozin sebacate is a sodium-glucose transporter inhibitor. It is expected to improve postprandial hyperglycemia by suppressing glucose absorption from the intestine with a novel mechanism of action different from that of conventional alpha-glucosidase inhibitors. Mizagliflozin blocks intestinal glucose absorption and reduce GIP secretion in rats and humans, suggesting SGLT1 glucose transport is critical for GIP release. | |||
T21160 |
Dibenzyl sebacate
Sebacic Acid Dibenzyl Ester,Decanedioic Acid Dibenzyl Ester |
||
Dibenzyl sebacate is a biochemical. | |||
T30464 |
Bis(2-butoxyethyl) sebacate
ecanedioic acid, bis(2-butoxyethyl) ester,Dibutyoxyethyl sebacate,Decanedioic acid, 1,10-bis(2-butoxyethyl) ester |
||
Bis(2-butoxyethyl) sebacate is a biochemical. | |||
T71660 |
Indacaterol fumarate
|
||
Indacaterol fumarate is an ultra-long-acting beta-adrenoceptor agonist. | |||
T71659 |
Indacaterol acetate
|
||
Indacaterol acetate is an ultra-long-acting beta-adrenoceptor agonist. | |||
T68425 |
Saracatinib difumarate
|
||
Saracatinib difumarate is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities. | |||
T31506 |
Dioctyldodecyl sebacate
(+/-)-Dioctyldodecyl sebacate,Bis(2-octyldodecyl) sebacate |
||
Dioctyldodecyl sebacate is a biochemical. | |||
T131567 | Epicatechin (Epicatechol; Acacatechin; Kakaol) | ||
Epicatechin (Epicatechol; Acacatechin; Kakaol) 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131567。 | |||
T21236 |
Monomethyl sebacate
Decanoic acid, monomethyl ester,Methyl hydrogen sebacate |
||
Monomethyl sebacate is a biochemical. | |||
T31461 |
Dihexyldecyl sebacate
(+/-)-Dihexyldecyl sebacate,Decanedioic acid, bis(2-hexyldecyl) ester |
||
Dihexyldecyl sebacate is a biochemical. | |||
T21162 |
Diisooctyl sebacate
Decanedioic acid,diisooctyl ester |
||
Diisooctyl sebacate is a biochemical. | |||
T31528 |
Disodium sebacate
Sebacic Acid Disodium Salt,Decanedioic Acid Disodium Salt,Disodium Decanedioate |
||
Disodium sebacate is a 10-carbon-atom dicarboxylic acid, proposed as substrate for parenteral nutrition. It has low toxicity. | |||
T12767 |
RP 70676
|
Acyltransferase | Metabolism |
RP 70676 是ACAT 抑制剂,抑制大鼠和兔子中 ACAT 的IC50分别为 25 和 44 nM。 | |||
T13373 |
YM17E
|
Acyltransferase; AChR | Metabolism; Neuroscience |
YM17E 是一种 ACAT 抑制剂,在体外兔肝微粒体中的 IC50 为 44 nM。 | |||
T14523 |
Beauvericin
|
Others; Acyltransferase | Metabolism; Others |
Beauvericin 是一种镰刀菌霉菌毒素。Beauvericin 在大鼠肝微粒体酶实验中对酰基-CoA:胆固醇酰基转移酶(ACAT)有抑制作用,其 IC50 值为 3 μM。 | |||
T23550 |
YM-750
YM 750 |
Acyltransferase | Metabolism |
YM-750 是一种有效的酰基:胆固醇酰基转移酶(ACAT)抑制剂,IC50为0.18 μM。 | |||
T25635 |
Lateritin
Bassiatin |
Acyltransferase | Metabolism |
Lateritin (Bassiatin) 是一种酰基辅酶 A,是胆固醇酰基转移酶 (ACAT) 抑制剂和来自赤霉属菌丝饼的血小板聚集抑制剂。 Bassiatin 是 (3S,6R) 异构体。 | |||
T16928 |
SR144528
|
Cannabinoid Receptor | GPCR/G Protein |
SR144528 是 CB2 受体的拮抗剂 (Ki = 0.6 nM) 并抑制微粒体 ACAT 活性 (IC50 = 3.6 μM)。 | |||
T25651 |
Lecimibide
DuP128,DuP-128,DuP 128 |
Acyltransferase | Metabolism |
Lecimibide (DuP 128) 是一种有效且具有选择性的酰辅酶 A 胆固醇酰基转移酶(ACAT)抑制剂,可用于研究由于高脂带来的疾病。 | |||
T30961 |
CL 277082
CL277082,CL-277082,Ddpmhu |
Others | Others |
CL 277082 (Ddpmhu) 是一种酰基辅酶A:胆固醇O-酰基转移酶抑制剂,抑制肉芽肿组织 ACAT 活性。 | |||
T8314 |
RP-64477
RP64477 |
Acyltransferase | Metabolism |
RP-64477 是有效的胆固醇酯化酶酰基辅酶 A:胆固醇 O-酰基转移酶 (ACAT) 抑制剂。 | |||
T36126 |
TMP-153
|
||
Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and cholesterol accumulation in vascular tissues. ACAT inhibitors improve plasma lipid profile and ameliorate proteinuria in nephrotic animals. TMP-153 is a quinolyl derivative that inhibits ACAT with IC50 values of 5-10 nM in various animals. At 0.5-1.5 mg/kg, TMP-153 dose-dependently reduc... | |||
T23521 |
VULM 1457
|
Acyltransferase | Metabolism |
VULM 1457 是有效的胆固醇酰基转移酶抑制剂,具有显著的降血脂活性,并改善了整体心肌缺血再灌注损伤结果。VULM 1457 显著降低肾上腺髓质素的产生和分泌,并下调人肝母细胞上的 AM 受体。VULM 1457 具有研究糖尿病和高胆固醇血症的潜力。 | |||
T25828 |
Monatepil maleate
AJ2615 maleate,AJ-2615 maleate,AJ 2615 maleate |
Calcium Channel; Adrenergic Receptor; Acyltransferase | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Monatepil maleate (AJ-2615 maleate) 是一种具有口服活性的 Ca2+-通道和α1-肾上腺素受体拮抗剂,也是非竞争性肝酰辅酶A:胆固醇酰基转移酶(ACAT)抑制剂,具有抗高血压活性。Monatepil maleate 可用于研究高脂血症和动脉粥样硬化。 | |||
T28290 |
Pactimibe
CS 505,CS-505,CS505,Pactimibe free base,帕替麦布 |
||
Pactimibe is a ACAT inhibitor. It has anti-atherosclerotic activity. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8010 |
Dibutyl sebacate
Dibutyl decanedioate,癸二酸二丁酯 |
Others | Others |
Dibutyl sebacate (Dibutyl decanedioate) 是一种常作为塑料生产中的增塑剂的癸二酸二丁酯。 | |||
T21159 |
Bis(2-ethylhexyl) sebacate
Di(2-ethylhexyl) Sebacate,Dioctyl Sebacate |
||
Bis(2-ethylhexyl) sebacate is used as a plasticizer in preparing ion-selective electrodes. It is an important raw material and intermediate used in organic synthesis, agrochemicals, pharmaceuticals and dyestuff fields. | |||
T30683 |
Cadmium sebacate
|
||
Cadmium sebacate is a biochemical. | |||
TN1691 |
Glabrol
光甘草酚,光甘草醇 |
P450; NF-κB; NO Synthase; Acyltransferase | Immunology/Inflammation; Metabolism; NF-κB |
Glabrol 是分离自甘草根的乙醇提取物中的一种异戊二烯类黄酮,是一种有效且非竞争性的酰基辅酶 A:胆固醇酰基转移酶(ACAT)抑制剂,抑制大鼠肝脏微粒体 ACAT 的 IC50为 24.6 μM。 | |||
T75552 | Pomonic acid | ||
Pomonic酸,作为一种三萜化合物,能显著抑制胆固醇酯的积累,并降低酰基辅酶A:胆固醇酰基转移酶(ACAT)的活性。 | |||
T13678 |
Enniatin A
|
||
Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 22 μM in an enzyme assay using rat liver microsomes. | |||
T13679 |
Enniatin B
|
ERK | MAPK |
Enniatins B decreases the activation of ERK (p44/p42). Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113 μM in an enzyme assay using rat liver microsomes. | |||
T29329 |
24-Methylenecholesterol
24Methylenecholesterol,24 Methylenecholesterol,Chalinasterol,24-亚甲基胆固醇,Ostreasterol |
Acyltransferase | Metabolism |
24-Methylenecholesterol (24 Methylenecholesterol) 是一种天然海洋甾醇,可刺激人类巨噬细胞中的胆固醇酰基转移酶 (ACAT))。 | |||
T75696 | Ilexoside XLVIII | ||
Ilexoside XLVIII为一种三萜皂苷,自苦冬青叶片水提物分离而得,功能为抑制酰基辅酶A胆固醇酰基转移酶(ACAT)。 | |||
T36776 |
Terpendole C
|
||
Terpendole C is an indole diterpene alkaloid fungal metabolite originally isolated from A. yamanashiensis and an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 2.1 μM in rat liver microsomes). It also inhibits ACAT in J774 macrophages (IC50 = 0.46 μM) without affecting cell growth. | |||
T13680 |
Enniatin B1
恩镰孢菌素 B1 |
ERK | MAPK |
Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation.Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes. | |||
TN2834 |
27-p-Coumaroyloxyursolic acid
|
Others | Others |
27-trans-p-Coumaroyloxyursolic acid and 27-cis-p-coumaroyloxyursolic acid show potent inhibitory activity in the acyl CoA cholesteryl acyl transferase (ACAT) assay. | |||
T11201 |
Enniatin A1
恩镰孢菌素 A1 |
ERK | MAPK |
Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of 49 μM in rat liver microsomes. Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids. | |||
T36226 |
Beauveriolide I
|
||
Beauveriolide I is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.78 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 6 μM).2 1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific i... | |||
T36931 |
Penicillide
|
||
Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities. It is an inhibitor of calpain 2/m-calpain (IC50 = 7.1 μM) and acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 22.9 μM). It is also an antagonist of oxytocin receptors (IC50 = 67 μM). Penicillide inhibits RNA synthesis in P388 murine leukemia cells. | |||
T36329 |
Terpendole I
|
||
Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 |1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter... | |||
T37690 |
Phenylpyropene A
|
||
Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).1 Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver microsomes (IC50 = 78.7 μM). It induces mortality in 100% of M. persicae when used at a concentration of 5 ppm.3 |1. Kwon, O.E., Rho, M.C., Song, H.Y., et al. Phenylpyropene A and B, new inhibitors of ... | |||
T36227 |
Beauveriolide III
|
||
Beauveriolide III is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.41 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide III also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 5.5 μM).2Beauveriolide III (25 and 50 mg/kg) reduces the size of aortic ... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00875 |
ACAT1 Protein, Human, Recombinant (His)
EC:2.3.1.9,MAT,Acetyl-CoA acetyltransferase, mitochondrial,<... |
Human | E. coli |
ACAT1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 45.0 kDa and the accession number is P24752. | |||
TMPJ-01302 |
ACAT2 Protein, Human, Recombinant (His)
ACTL,Acetyl-CoA transferase-like protein,Acetyl-CoA acetyltr... |
Human | E. coli |
ACAT2 is a cytoplasmic enzyme which belongs to the thiolase family. ACAT2 takes part in lipid metabolism, lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. It is responsible for the synthesis of cholesteryl esters which are part of lipoproteins containing apoB. ACAT2 deficiency contributes to severe mental retardation and hypotonus. | |||
TMPY-06754 |
CES1 Protein, Human, Recombinant (His)
PCE-1,hCE-1,carboxylesterase 1,CE-1,TGH,HMSE,HMSE1,SES1,CEH,... |
Human | HEK293 Cells |
CES1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.08 kDa and the accession number is NP_001020365. | |||
TMPY-04813 |
ACAT2 Protein, Rat, Recombinant (His)
acetyl-CoA acetyltransferase 2 |
Rat | E. coli |
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two enzymes are involved in storing cholesteryl esters as lipid droplets, in macrophage foam-cell formation, in absorbing dietary cholesterol, and in supplying cholesteryl esters as part of the core lipid for lipoprotein synthesis and assembly. The key difference in tissue distributio... |