15
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Cat. No. | Product Name | Target | Signaling Pathways |
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T1613 |
Hydralazine hydrochloride
Hydralazine HCl,Apresoline,盐酸肼屈嗪 |
MAO; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Neuroscience |
Hydralazine hydrochloride (Apresoline) 是一种直接作用的血管舒张剂,可抗高血压。 | |||
T26745 |
BAY 73-1449
BAY-73-1449,BAY73-1449 |
Others | Others |
BAY 73-1449 是前列环素受体选择性拮抗剂,在人 HEL 细胞和大鼠 DRG 的 cAMP 分析中具有很高的效价,IC50小于 0.1 nM。BAY 73-1449在降血压方面有研究的价值。 | |||
T11918 |
Lysipressin
Lysine vasopressin,[Lys8]-Vasopressin,赖氨加压素 |
Others | Others |
Lysipressin ([Lys8]-Vasopressin) 是一种抗利尿激素,从猪身上发现,能够诱发兔膀胱平滑肌的收缩,激活腺苷酸环化酶。 | |||
T28817 |
SM4
SM-4,SM 4 |
Others | Others |
SM4 是一种SOX18小分子抑制剂,对HemSC血管在体内形成有抑制作用。 | |||
T27830 |
Lifarizine
RS 87476,RS 87476-000,RS-87476,RS-87476-000,RS87476 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Lifarizine (RS-87476) 是一种钙钠通道拮抗剂, 在简化的大鼠双血管闭塞存活模型中显示出神经保护活性。 | |||
T23016 |
MRS1220
MRS 1220 |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
MRS1220 是一种高效、选择性的人 A3 腺苷受体 (hA3AR) 拮抗剂,Ki 为 0.59 nM,可用于中枢神经系统疾病的研究。MRS1220 在体内还减少了胶质母细胞瘤的肿瘤大小和血管形成。 | |||
T2624 |
OSI-930
OSI 930,噻尔非尼 |
Apoptosis; c-Fms; Raf; VEGFR; FLT; CSF-1R; Src; c-Kit | Angiogenesis; Apoptosis; MAPK; Tyrosine Kinase/Adaptors |
OSI-930 是 Kit,KDR 和 CSF-1R (c-Fms)的口服选择性抑制剂,IC50分别为 80 nM,9 nM 和 15 nM。它具有抗肿瘤活性,靶向肿瘤中的癌细胞增殖和血管生成。它还适度抑制 Flt-1,c-Raf 和 Lck,并且对 PDGFRα/β,Flt-3和 Abl 具有较弱的抑制活性。 | |||
T0197 |
Terazosin hydrochloride
盐酸特拉唑嗪,Terazosin HCl,Terazosine,Blavin,Hytrin,Zayasel,Fosfomic |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Terazosin hydrochloride (Hytrin) 是一种竞争性和口服活性的 α1-肾上腺素受体拮抗剂,是一种喹唑啉衍生物。它通过舒张血管和打开膀胱来起作用。它可用于良性前列腺增生和高血压的研究。 | |||
T6695 |
Tasquinimod
他喹莫德,ABR-215050 |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Tasquinimod (ABR-215050) 是一种口服抗血管生成剂,有潜在的抗肿瘤活性。它也是 S100A9抑制剂,与 HDAC4Zn2+结合结构域结合的 Kd 值在10到30 nM 之间。 | |||
T1092 |
Zolmitriptan
佐米曲普坦,311C90,BW-311C90 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Zolmitriptan (311C90) 是一种5-HT1B/1D 受体部分激动剂,可用于偏头痛的研究,对 5-HT1B、5-HT1D、5-HT1F 受体的Ki 分别为 5.01、0.63 和 63.09 nM。 | |||
T36718 |
Tie2 Inhibitor 7
|
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Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 μM. This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization. | |||
T80127 |
FITC-Ahx-Gly-Arg-Gly-Asp-Ser-Pro
|
Integrin | Cytoskeletal Signaling |
FITC-Ahx-Gly-Arg-Gly-Asp-Ser-Pro为FITC标记的GRGDSP,后者为整联蛋白(integrin)抑制剂,能阻止肿瘤细胞与血管内皮细胞粘附,进而抑制肿瘤转移。 | |||
T70063 |
GYKI 52466 HCl
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GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 µM).2 GYKI 52466 (10 µM) reduces the amplitude of spontaneous excitatory postsynaptic currents (EPSCs) in the same cells. It increases the latency to seizure onset and reduces mortality in a rat model of general... | |||
T31396 |
Dexbrompheniramine maleate
D-Brompheniramine,Brompheniramine d-,Dexbrompheniraminum,Disophrol,Drixoral |
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Dexbrompheniramine is an antihistamine with anticholinergic properties. It is used to treat allergic diseases such as hay fever or urticaria. It can compete with histamine for H1 receptor sites on effector cells of the gastrointestinal tract, blood vessel | |||
T38171 | Ro 1138452 hydrochloride | ||
Selective prostacyclin IP receptor antagonist (pKi = 8.3). Exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. Demonstrates analgesic activity in rats. Orally bioavailable. Clark et al (2004) Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists. Bioorg.Med.Chem.Lett. 14 1053 PMID:15013022 |Jones et al (2006) Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1853 |
Lariciresinol
(+)-落叶松树脂醇 |
VEGFR; Antifection | Angiogenesis; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Lariciresinol 是一种肠木脂素前体,它通过破坏真菌质膜具有杀真菌活性,并具有作为治疗人类真菌感染性疾病的新型抗真菌剂的治疗潜力。膳食 lariciresinol 可以减缓乳腺肿瘤的生长并降低人 MCF-7 乳腺癌异种移植物和致癌物诱导的大鼠乳腺肿瘤的血管密度。 | |||
T4S1551 |
Cinnamaldehyde
Cinnamic Aldehyde,肉桂醛 |
HIF | Angiogenesis; Chromatin/Epigenetic |
Cinnamaldehyde (Cinnamic Aldehyde) 具有解热作用。 它是镇静剂。它抑制MDA-MB-435S 细胞的侵袭能力与下调miR-27a 的表达有关。它诱导活性氧的产生,发挥血管扩张和抗癌作用。 它似乎是一种有希望的候选药物,可作为与 5-氟尿嘧啶 (5-FU) 和奥沙利铂 (OXA) 这两种用于 CRC 治疗的化疗药物联合治疗的辅助剂。其作用的可能机制可能涉及药物代谢基因的调节。 它在抑制黑色素瘤的发生和发展方面具有一定的作用,其作用机制可能表现为抑制VEGF 和HIF-α的表达,从而使血管模拟和黑色素瘤细胞新生血管的形成,促进肿瘤的生长。 | |||
TN6038 |
1,2-Methylenedioxy-3,10,11-trimethoxynoraporphine
|
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1,2-Methylenedioxy-3,10,11-trimethoxyaporphine exerts moderate vessel-relaxing activities with the IC 50 value from 16.50 to 32.81 microM at the test concentrations. | |||
TN5234 |
Vindorosine
|
Calcium Channel; Sodium Channel | Membrane transporter/Ion channel; Metabolism |
Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular smooth muscles. | |||
T35624 |
Ajoene
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Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 µg/ml) and Gram-negative bacteria (MICs = 136-200 µg/ml), as well as yeasts (MICs = 10-20 µg/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 µM), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 µM).2It reduces... |