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79

抑制剂 & 化合物

11

天然产物

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Cat. No. Product Name Target Signaling Pathways
T8354 Triazavirin

Nucleoside Antimetabolite/Analog; Influenza Virus; DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
Triazavirin 是一种核酸的核苷类似物和抗病毒剂,通过抑制病毒 RNA 和 DNA 的合成以及基因组片段的复制而起作用。在流感传播阶段,它可作为保护剂。
T23513 VU10010

VU 10010

AChR Neuroscience
VU10010 (VU 10010) 是一种高度选择性的M4mAChR 变构增强剂,EC50为 400 nM。它与 M4mAChR 的变构位点结合,增强与 G 蛋白偶联,增加对乙酰胆碱的亲和力,还会增加卡巴胆碱引起的兴奋性传导抑制。
T1234 5,5-Dimethyloxazolidine-2,4-dione

Dimethadion,Dimethadione,二甲双酮,Dimethyloxazolidinedione

Calcium Channel Membrane transporter/Ion channel; Metabolism
5,5-Dimethyloxazolidine-2,4-dione (Dimethadione) 是抗惊厥药,是 TRIMETHADIONE 的活性代谢物。
T9988 Wnt/β-catenin agonist 3

Wnt/beta-catenin Cytoskeletal Signaling; Stem Cells
Wnt/β-catenin agonist 3是一种Wnt/beta-catenin 信号通路激动剂。
TP1559L Ziconotide Acetate (107452-89-1 free base)

醋酸齐考诺肽,Prialt,Ziconotide Acetate

Calcium Channel Membrane transporter/Ion channel; Metabolism
Ziconotide Acetate (107452-89-1 free base) (Prialt) 是一种镇痛剂,已用于治疗神经性和非神经性疼痛。 Ziconotide 通过与位于伤害感受通路初级传入神经元末端部分的 N 型钙通道结合起作用,因此通过有效的镇痛作用减少突触传递。
T3280 Clodronate disodium tetrahydrate

clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,氯屈膦酸二钠(四水合物),Clodronate disodium

IL Receptor; TNF Apoptosis; Immunology/Inflammation
Clodronate disodium tetrahydrate (Clastoban) 是一种选择性、高效的,可逆、Cl-竞争性的囊泡核苷酸转运体阻滞剂(IC50:15.6 nM)。是一种双膦酸盐,具有抗骨质疏松、抗炎作用,可用于缓解疼痛的研究。它可抑制神经元释放囊泡 ATP,缓解慢性神经病理性疼痛和炎症性疼痛。
T22963 McN-A 343

AChR Neuroscience
McN-A 343 is a selective M1 muscarinic agonist known for its ability to stimulate muscarinic transmission in sympathetic ganglia. It has been found to effectively reduce inflammation and oxidative stress in experimental models of ulcerative colitis.
T7115 Pymetrozine

CGA 215944,吡蚜酮

Antibacterial Microbiology/Virology
Pymetrozine (CGA 215944) is a Homoptera feeding inhibitor that effectively prevents transmission of the cauliflower mosaic caulimovirus by the aphid species Myzus persicae.
T0924 Benzocaine

苯唑卡因,苯佐卡因

Others; MRP; Sodium Channel Immunology/Inflammation; Membrane transporter/Ion channel; Others
Benzocaine 作用电压门控 Na+通道的共同受体,+30 mV 下的 IC50为0.8 mM。
TP1868 Proctolin

直肠肽

Others Others
Proctolin 是内源性五肽,也是兴奋性神经调节剂。
T16697 Pyronaridine tetraphosphate

Topoisomerase DNA Damage/DNA Repair
Pyronaridine tetraphosphate 是一种具有口服活性的、含甘露醇的DNA 拓扑异构酶 2 的抑制剂和红细胞裂殖杀灭剂,具有抗疟活性和抗肿瘤活性。Pyronaridine tetraphosphate 可治疗 P. falciparum 和 Echinococcus granulosus感染,可减轻埃博拉病毒传播。
T27400L Ganaplacide phosphate

Ganaplacide phosphate (1261113-96-5 Free base)

Others Others
Ganaplacide phosphate 对疟原虫症状性无性血期感染具有多阶段抗疟活性,并且能够在动物模型中预防传播和阻断感染。
T0166 Pancuronium dibromide

Pancuronium bromide,Pavulon,泮库溴铵

AChR Neuroscience
Pancuronium dibromide (Pavulon) 是一种双季基类固醇,是一种神经肌肉松弛剂。它通过与乙酰胆碱竞争 nACh 受体上的结合位点来抑制神经肌肉传递。它还可抑制心脏毒蕈碱受体并具有拟交感神经作用。
T13102 TCMDC-135051

Others Others
TCMDC-135051 是一种高选择性和有效性的蛋白激酶 PfCLK3 抑制剂,具有低的靶外毒性。TCMDC-135051 可以防止滋养体到裂殖体的转变,破坏转录并减少向蚊子载体的传播。TCMDC-135051 具有抗寄生虫活性 (EC50=320 nM)。
T67765 MenA-IN-2

Others Others
MenA-IN-2是一种有效的 1,4-二羟基-2-萘甲酸酯异戊二烯转移酶 (MenA) 抑制剂,对 MenA 的 IC50 值为 22 µM,对结核分枝杆菌 (Mtb) 的 GIC50 值为 10 µM。MenA-IN-2 Mtb 的持续传播具有抑制作用。
T1065 Baclofen

巴氯芬,Lioresal

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Baclofen (Lioresal) 是 γ-氨基丁酸 (GABA) 的亲脂性衍生物,是可口服的选择性代谢型 GABA-B 受体激动剂,具有高血脑屏障渗透率,用于治疗因脊髓损伤和多发性硬化引起的痉挛。
T50008 2,2-Dimethyl-5-(2,5-xylyloxy)valeramide

5-(2,5-二甲基苯氧基)-2,2-二甲基戊酰胺,5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide

Others Others
2,2-Dimethyl-5-(2,5-xylyloxy)valeramide (5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide) 是一种苯氧基家族化合物。它已被证明对神经系统具有刺激作用,包括神经元放电率的增加、突触传递的增加和神经递质释放的增加;还被证明对心血管系统有刺激作用,包括提高心率和血压。
T8630 Baclofen hydrochloride

4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Baclofen hydrochloride (4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride) 是一种 GAMMA-AMINOBUTYRIC ACID 衍生物,是一种特异性 GABA-B 受体激动剂。它用于治疗肌肉痉挛,尤其是由于脊髓损伤引起的肌肉痉挛。其治疗效果来自于脊髓和脊髓上部位的作用,通常是减少兴奋性传递。
T1092 Zolmitriptan

佐米曲普坦,311C90,BW-311C90

5-HT Receptor GPCR/G Protein; Neuroscience
Zolmitriptan (311C90) 是一种5-HT1B/1D 受体部分激动剂,可用于偏头痛的研究,对 5-HT1B、5-HT1D、5-HT1F 受体的Ki 分别为 5.01、0.63 和 63.09 nM。
T25616 Lanepitant 2HCl

LY303870 dihydrochloride,LY 303870 dihydrochloride,LY-303870 dihydrochloride,Lanepitant dihydrochloride

Neurokinin receptor GPCR/G Protein; Neuroscience
Lanepitant 2HCl 是一种非肽类神经激肽-1 受体拮抗剂,具有镇痛和抗炎活性。Lanepitant 2HCl 抑制 P 物质与神经激肽-1 受体的结合,抑制神经源性炎症和疼痛传递,可用于研究偏头痛等疼痛性神经病变类疾病。
TP2505L LAH4 acetate

KKALLALALHHLAHLALHLALALKKA acetate,LAH4 acetate(184776-51-0 Free base)

Antibacterial Microbiology/Virology
LAH4 acetate 是所设计的两性肽抗生素的α -螺旋结构,能够与DNA 络合,与细胞表面膜结合后被包裹在核内体中,随着pH 值的下降破坏核内体膜。具有强大的抗菌、核酸转染和细胞渗透活性。LAH4 acetate 具有较高的质粒DNA 传递能力。LAH4 acetate 对细菌膜外膜中的阴离子脂具有很强的亲和力。
T69043 GJH-166

GJH-166 is an analog of dopamine that has been shown to inhibit adrenergic transmission in canines.
T71952 DDD01035881

DDD01035881 is a novel transmission blocker of antimalarials, targeting male gametes.
T26230 Stilbamidine dihydrochloride

NSC 35605,NCI 174

Stilbamidine dihydrochloride is a blocker of neuromuscular transmission and axonal conduction used to study the distribution of the drug in the organs and tissues of rats following intravenous injection.
T69804 Nicotine monomethiodide

Nicotine monomethiodide is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
T69439 Nicotine tartrate

Nicotine tartrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
T34458 Ryanodol

Ryanodol is a complex diterpenoid that modulates intracellular calcium-ion release at ryanodine receptors, ion channels critical for skeletal and cardiac muscle excitation-contraction coupling and synaptic transmission.
T24450 Mephenoxalone

Lenetran Lenetran,TAB Lenetranat

Mephenoxalone is a muscle relaxant and mild anxiolytic. It inhibits neuron transmission and relaxing skeletal muscles by inhibiting the reflex arc.
TP1471 Ziconotide TFA (107452-89-1 free base)

Ziconotide TFA

Ziconotide TEA acts by binding to N-type calcium channels situated on the terminal part of primary afferent neurons of the nociceptive pathway therefore reducing synaptic transmission with potent antinociceptive effects.
T69964 Bornaprine

Bornaprine is an anticholinergic drug used to treat Parkinson's disease due to inhibition of muscarinic or nicotinic transmission.
T60950 Pirepemat fumarate

Pirepemat (IRL752) fumarate 可用于研究帕金森病。Pireemat fumarate 是一种偏向皮质的儿茶酚胺传递剂和认知促进剂。
T69165 Methiothepin methanesulfonate

Methiothepin methanesulfonate is an inhibitor of HCV infection and cell-to-cell transmission that acts by targeting the HCV E2 glycoprotein.
T31903 Galphimine B

Galphimine B is a cyclodesiccated triterpenoid from Galphimia Glauca, which can regulate the synaptic transmission of dopaminergic ventral tegmental neurons and has a sedative effect.
T68289 Nicotine hemicitrate

Nicotine hemicitrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
T68439 Nicotine dicitrate

Nicotine dicitrate is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
T24839 Stampidine

HI-113,HI 113,HI113

Stampidine can prevent the sexual transmission of HIV-1. It exhibited remarkable subnanomolar to low nanomolar in vitro antiretroviral potency against nucleoside reverse transcriptase inhibitor-resistant primary clinical HIV isolates, non-nucleoside RT-re
T71531 Metamizil hydrochloride

Metamizil hydrochloride is a cholinolytic agent -- an agent that blocks the transmission of excitation from cholinergic nerve fibers -- and an antagonist of the mediator acetylcholine.
T62410 Hydroxyethylamine

Hydroxyethylamine (Compd VII) 是一种 SARS-CoV-2 3CLpro 抑制剂,在传播试验中的IC50为 ~10 μM。Hydroxyethylamine 表现出显著的抗病毒效果。
T69012 Cinnarizine clofibrate

Cinnarizine clofibrate is a calcium channel protein inhibitor as well as an antihistamine channel blocker. The compound is a drug derivative of piperazine. Cinnarizine is used for the control of vomiting due to motion sickness. It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus
T70075 KDS2010 mesylate

KDS2010 is a potent, highly selective, and reversible MAO-B inhibitor which shows 12,500-fold selectivity over MAO-A. KDS2010 overcomes the disadvantages of the irreversible MAO-B inhibitor and significantly attenuates increased astrocytic GABA levels and astrogliosis, thereby enhancing synaptic transmission, and rescuing learning and memory impairments in APP/PS1 mice.
T68811 Trimetaphan camsilate

Trimetaphan camsilate is a drug that counteracts cholinergic transmission at the ganglion type of nicotinic receptors of the autonomic ganglia and therefore blocks both the sympathetic nervous system and the parasympathetic nervous system. It acts as a non-depolarizing competitive antagonist at the nicotinic acetylcholine receptor, is short-acting, and is given intravenously.
T6782 Benzocaine hydrochloride

Benzocaine HCl,Ethyl p-aminobenzoate hydrochloride,Ethyl 4-aminobenzoate hydrochloride

Sodium Channel Membrane transporter/Ion channel
Benzocaine hydrochloride (Ethyl 4-aminobenzoate hydrochloride) 是一种表面麻醉剂,通过阻止脉冲沿神经纤维和神经末梢传递而起作用。
T17306 (R)-Baclofen hydrochloride

Arbaclofen hydrochloride,(R)-巴氯芬盐酸盐

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Arbaclofen hydrochloride, a Gamma-Aminobutyric Acid derivative, is a specific agonist of GABA-B receptors, it is used to treat spasticity, especially that due to spinal cord damage. It acts at spinal and supraspinal sites, generally reduces excitatory tra
T81511 Peptide F, bovine

Peptide F, bovine,是源自牛大脑和肾上腺髓质的前脑啡肽F,与脑啡能系统的疼痛传导过程相关。
TD0005 SYBR GREEN II

SUPER Green II RNA gel stain *10,000× concentrate in DMSO* (Electrophoresis Grade),SUPER Green II (效果同SYBR Green II)RNA染料(10,000× DMSO溶液)(电泳级)

1) Non-toxicity: belong to flower-stem dye, easy to biodegrade, no carcinogenic toxicity. 2) High sensitivity: at least 100pg ssDNA or RNA can be detected, which is 25 ~ 100 times higher than EB staining. 3) High SIGNal-to-noise ratio: the sample fluorescence signal is strong, while the background signal is low. 4) Simple operation: like EB, the dye does not degrade in the prefabricated gel and electrophoresis process;The dyeing process after electrophoresis takes only 30 minutes without decolor...
TP2077 α-Bungarotoxin

Neurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs). Prevents opening of nicotinic receptor-associated ion channels and is selective for α7 receptors over α3β4 receptors (IC50 values are 1.6 nM
T75710 Ziconotide TFA

Ziconotide TFA (SNX-111 TFA),一种肽类化合物,作为高效且选择性的N型钙通道拮抗剂,能减少突触传递,适用于慢性疼痛的研究。
T73466 Pulixin

Pulixin 阻碍了 FREP1 与恶性疟原虫感染细胞的裂解物的结合,防止传播至蚊子,其中EC50值为11 µM。同时,Pulixin 抑制无性期恶性疟原虫的增殖,EC50值达47 nM。
T76568 Aminopeptidase N Ligand (CD13) NGR peptide

AminopeptidaseN Ligand (CD13) NGR peptide 是靶向CD13的多肽,常见于癌症研究中,用作细胞内传递的载体介质。
T36783 BPIQ-II (hydrochloride)

BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM). It is selective for EGFR over an assortment of other tyrosine and serine/threonine kinases. Cellular studies indicate that BPIQ-II can enter cells and very selectively shut down EGF-stimulated signal transmission by binding competitively at the ATP site of EGFR.

化合物

Triazavirin
Cat.No: T8354
Synonym:
Target: Nucleoside Antimetabolite/Analog, Influenza Virus, DNA/RNA Synthesis
VU10010
Cat.No: T23513
Synonym: VU 10010
Target: AChR
5,5-Dimethyloxazolidine-2,4-dione
Cat.No: T1234
Synonym: Dimethadion,Dimethadione,二甲双酮,Dimethyloxazolidinedione
Target: Calcium Channel
Wnt/β-catenin agonist 3
Cat.No: T9988
Synonym:
Target: Wnt/beta-catenin
Ziconotide Acetate (107452-89-1 free base)
Cat.No: TP1559L
Synonym: 醋酸齐考诺肽,Prialt,Ziconotide Acetate
Target: Calcium Channel
Clodronate disodium tetrahydrate
Cat.No: T3280
Synonym: clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,氯屈膦酸二钠(四水合物),Clodronate disodium
Target: IL Receptor, TNF
McN-A 343
Cat.No: T22963
Synonym:
Target: AChR
Pymetrozine
Cat.No: T7115
Synonym: CGA 215944,吡蚜酮
Target: Antibacterial
Benzocaine
Cat.No: T0924
Synonym: 苯唑卡因,苯佐卡因
Target: Others, MRP, Sodium Channel
Proctolin
Cat.No: TP1868
Synonym: 直肠肽
Target: Others
Pyronaridine tetraphosphate
Cat.No: T16697
Synonym:
Target: Topoisomerase
Ganaplacide phosphate
Cat.No: T27400L
Synonym: Ganaplacide phosphate (1261113-96-5 Free base)
Target: Others
Pancuronium dibromide
Cat.No: T0166
Synonym: Pancuronium bromide,Pavulon,泮库溴铵
Target: AChR
TCMDC-135051
Cat.No: T13102
Synonym:
Target: Others
MenA-IN-2
Cat.No: T67765
Synonym:
Target: Others
Baclofen
Cat.No: T1065
Synonym: 巴氯芬,Lioresal
Target: GABA Receptor
2,2-Dimethyl-5-(2,5-xylyloxy)valeramide
Cat.No: T50008
Synonym: 5-(2,5-二甲基苯氧基)-2,2-二甲基戊酰胺,5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide
Target: Others
Baclofen hydrochloride
Cat.No: T8630
Synonym: 4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride
Target: GABA Receptor
Zolmitriptan
Cat.No: T1092
Synonym: 佐米曲普坦,311C90,BW-311C90
Target: 5-HT Receptor
Lanepitant 2HCl
Cat.No: T25616
Synonym: LY303870 dihydrochloride,LY 303870 dihydrochloride,LY-303870 dihydrochloride,Lanepitant dihydrochloride
Target: Neurokinin receptor
LAH4 acetate
Cat.No: TP2505L
Synonym: KKALLALALHHLAHLALHLALALKKA acetate,LAH4 acetate(184776-51-0 Free base)
Target: Antibacterial
GJH-166
Cat.No: T69043
Synonym:
Target:
DDD01035881
Cat.No: T71952
Synonym:
Target:
Stilbamidine dihydrochloride
Cat.No: T26230
Synonym: NSC 35605,NCI 174
Target:
Nicotine monomethiodide
Cat.No: T69804
Synonym:
Target:
Nicotine tartrate
Cat.No: T69439
Synonym:
Target:
Ryanodol
Cat.No: T34458
Synonym:
Target:
Mephenoxalone
Cat.No: T24450
Synonym: Lenetran Lenetran,TAB Lenetranat
Target:
Ziconotide TFA (107452-89-1 free base)
Cat.No: TP1471
Synonym: Ziconotide TFA
Target:
Bornaprine
Cat.No: T69964
Synonym:
Target:
Pirepemat fumarate
Cat.No: T60950
Synonym:
Target:
Methiothepin methanesulfonate
Cat.No: T69165
Synonym:
Target:
Galphimine B
Cat.No: T31903
Synonym:
Target:
Nicotine hemicitrate
Cat.No: T68289
Synonym:
Target:
Nicotine dicitrate
Cat.No: T68439
Synonym:
Target:
Stampidine
Cat.No: T24839
Synonym: HI-113,HI 113,HI113
Target:
Metamizil hydrochloride
Cat.No: T71531
Synonym:
Target:
Hydroxyethylamine
Cat.No: T62410
Synonym:
Target:
Cinnarizine clofibrate
Cat.No: T69012
Synonym:
Target:
KDS2010 mesylate
Cat.No: T70075
Synonym:
Target:
Trimetaphan camsilate
Cat.No: T68811
Synonym:
Target:
Benzocaine hydrochloride
Cat.No: T6782
Synonym: Benzocaine HCl,Ethyl p-aminobenzoate hydrochloride,Ethyl 4-aminobenzoate hydrochloride
Target: Sodium Channel
(R)-Baclofen hydrochloride
Cat.No: T17306
Synonym: Arbaclofen hydrochloride,(R)-巴氯芬盐酸盐
Target: GABA Receptor
Peptide F, bovine
Cat.No: T81511
Synonym:
Target:
SYBR GREEN II
Cat.No: TD0005
Synonym: SUPER Green II RNA gel stain *10,000× concentrate in DMSO* (Electrophoresis Grade),SUPER Green II (效果同SYBR Green II)RNA染料(10,000× DMSO溶液)(电泳级)
Target:
α-Bungarotoxin
Cat.No: TP2077
Synonym:
Target:
Ziconotide TFA
Cat.No: T75710
Synonym:
Target:
Pulixin
Cat.No: T73466
Synonym:
Target:
Aminopeptidase N Ligand (CD13) NGR peptide
Cat.No: T76568
Synonym:
Target:
BPIQ-II (hydrochloride)
Cat.No: T36783
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T4S0554 Theaflavine-3,3'-digallate

TFBG,theaflavin digallate,3,3’-二没食子酸酯茶黄素

Others Others
Theaflavine-3,3'-digallate (theaflavin digallate) 和乳酸一起可以减少单纯疱疹病毒的传播。
T9299 D-Leucine

D-亮氨酸,(R)-Leucine

Endogenous Metabolite Metabolism
D-Leucine ((R)-Leucine) 具有抗癫痫特性,活性比L-leucine,能够有效终止癫痫发作。在体外,它能够抑制长期点位,但基底突触传递无影响。
TN1202 (-)-α-Pinene

左旋-α-蒎烯,左旋-alpha-蒎烯,(1S)-(-)-Alpha-Pinene

Virus Protease; GABA Receptor; Endogenous Metabolite; Antibacterial Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) 是一种单萜类化合物,通过延长 GABAergic 突触传递、作为 GABAA-BZD 受体的部分调节剂并直接与 GABAA 受体的 BZD 结合位点结合来增强 NREMS 的数量而不影响 NREMS 的强度。
T0958 Penicillin G sodium salt

青霉素钠,Penicillin G Sodium,Benzylpenicillin sodium salt,Benzylpenicillin Sodium

GABA Receptor; Antibacterial; Antibiotic Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
Penicillin G sodium(Benzylpenicillin sodium) salt 是一种 β-内酰胺类抗生素。
T0894 Thiamine hydrochloride

盐酸硫胺素,Vitamin B1,Vitamin B1 hydrochloride,Thiamine HCl,盐酸硫胺(维生素B1),Thiamine chloride hydrochloride

Apoptosis; HBV; Endogenous Metabolite Apoptosis; Metabolism; Microbiology/Virology
Thiamine hydrochloride (Vitamin B1) 是一种必需的微量营养素,是许多中枢代谢酶的辅因子。
T3606 γ-Oryzanol

谷维素,Gamma-Oryzanol,Oliver,γ-谷维素,Gammariza

DNA Methyltransferase Chromatin/Epigenetic
γ-Oryzanol (Gamma-Oryzanol) 是一种从米糠油中分离出来的营养提取物,是含有甾醇和阿魏酸的混合物,有助于破坏皮肤中的自由基。它有效抑制小鼠纹状体中的 DNA 甲基转移酶(DNMTs)。 它抑制DNMT1和DNMT3a,IC50分别为 3.2 和 22.3 μM。
T83454 13-Hydroxylupanine hydrochloride

Hydroxylupanine hydrochloride

13-Hydroxylupanine是甜羽扇豆中一种典型的生物碱。它具有阻断神经节传递、降低心肌收缩力以及收缩子宫平滑肌的作用。
TN6028 Gardneramine

Gardneramine has a mild central depressive effect. Gardneramine and hirsutine show a local anesthetic action, they also can inhibit the ganglionic transmission of the dog urinary bladder and that the blockade of the nicotinic receptor plays a main role.
T75447 Asperaculane B

Asperaculane B,一种真菌代谢产物,以IC50 7.89 µM抗恶性疟原虫传播,同时以IC50 3 µM抑制无性恶性疟原虫的发育,对人类细胞无毒。
T82003 Juniferdin

Juniferdin是一种抑制Protein disulfide isomerase (PDI),IC50为3.5 μM,旨在阻断HIV传播的化合物。此外,Juniferdin展现出细胞毒性并能抑制血小板聚集。
TN3472 Axillaridine A

Others Others
Axillaridine A is a new cholinesterase inhibitors, it may act as potential leads in the discovery of clinically useful inhibitors for nervous-system disorders, particularly by reducing memory deficiency in Alzheimer's disease patients by potentiating and

天然产物

Theaflavine-3,3'-digallate
Cat.No: T4S0554
Synonym: TFBG,theaflavin digallate,3,3’-二没食子酸酯茶黄素
Target: Others
D-Leucine
Cat.No: T9299
Synonym: D-亮氨酸,(R)-Leucine
Target: Endogenous Metabolite
(-)-α-Pinene
Cat.No: TN1202
Synonym: 左旋-α-蒎烯,左旋-alpha-蒎烯,(1S)-(-)-Alpha-Pinene
Target: Virus Protease, GABA Receptor, Endogenous Metabolite, Antibacterial
Penicillin G sodium salt
Cat.No: T0958
Synonym: 青霉素钠,Penicillin G Sodium,Benzylpenicillin sodium salt,Benzylpenicillin Sodium
Target: GABA Receptor, Antibacterial, Antibiotic
Thiamine hydrochloride
Cat.No: T0894
Synonym: 盐酸硫胺素,Vitamin B1,Vitamin B1 hydrochloride,Thiamine HCl,盐酸硫胺(维生素B1),Thiamine chloride hydrochloride
Target: Apoptosis, HBV, Endogenous Metabolite
γ-Oryzanol
Cat.No: T3606
Synonym: 谷维素,Gamma-Oryzanol,Oliver,γ-谷维素,Gammariza
Target: DNA Methyltransferase
13-Hydroxylupanine hydrochloride
Cat.No: T83454
Synonym: Hydroxylupanine hydrochloride
Target:
Gardneramine
Cat.No: TN6028
Synonym:
Target:
Asperaculane B
Cat.No: T75447
Synonym:
Target:
Juniferdin
Cat.No: T82003
Synonym:
Target:
Axillaridine A
Cat.No: TN3472
Synonym:
Target: Others
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