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25

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T39472	NVP-CGM097 (stereoisomer) NVP-CGM097 (stereoisomer),CGM097 stereoisomer,(R)-Nvp-Cgm097
	NVP-CGM097 (stereoisomer) is a non-bioactive stereoisomer of NVP-CGM097, which is a potent and selective inhibitor of MDM2.
T10749	Cebranopadol ((1α,4α)stereoisomer) GRT6005 (1α,4α)stereoisomer	Others	Others
	Cebranopadol ((1α,4α)stereoisomer) is a stereoisomer of cebranopadol which is a potent ORL-1 agonist.
T15597L	ISA-2011B-P2
	ISA-2011B-P2 是 ISA-2011B 的立体异构体。ISA-2011B 是有效的 PIP5K1α 抑制剂，具有抗肿瘤活性。
T19618	(R)-(-)-JQ1 Enantiomer (R)-(-)2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂环庚烷-6-基)乙酸叔丁酯	Epigenetic Reader Domain	Chromatin/Epigenetic
	(R)-(-)-JQ1 Enantiomer 是 (+)-JQ1 的立体异构体。 (+)-JQ1 是一种 BET 溴结构域抑制剂，对BRD4(1/2)的IC50 为 77 和 33 nM。
T12628	(R)-MG-132 (S,R,S)-(-)-MG-132,N-[(苯基甲氧基)羰基]-L-亮氨酰-N-[(1S)-1-甲酰基-3-甲基丁基]-D-亮氨酰胺,Z-Leu-D-leu-leu-al	Proteasome	Proteases/Proteasome; Ubiquitination
	(R)-MG-132 (Z-Leu-D-leu-leu-al) 是一种 MG-132 的对映异构体，是一种蛋白酶体 (proteasome) 抑制剂，细胞毒性比 MG-132 弱，是一种比 MG-132 更有效的proteasome 抑制剂。
T22775	exo-IWR-1 exo-IWR 1	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	exo-IWR-1 (exo-IWR 1) 是一种 IWR-1 的阴性对照无活性异构体。其中IWR-1是一种端锚聚合酶抑制剂，能够抑制Wnt/β-catenin 信号传导途径。
T32137	Idonic acid L-Idonate,L-Idonic acid
	Idonic acid is a stereoisomer of gluconic acid.
T36949	Niaprazine	5-HT Receptor; Adrenergic Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Niaprazine 是有效的组胺 H1 受体拮抗剂，具有抗组胺和抗血清素活性。Niaprazine 在睡眠障碍方面有研究的价值。
T25333	Dilevalol Dilevalolum
	Dilevalol, the RR-stereoisomer of labetalol, is a non-cardioselective beta-adrenoceptor antagonist with substantial partial beta 2-agonist and negligible alpha 1-blocking activity.
T37899	UDP-β-D-Glucose (sodium salt)
	UDP-β-D-Glucose is the stereoisomer of UDP-α-D-glucose (sodium salt) . The activities of the UDP-β-D-glucose isomer are not known.
T35447	10(S)-PAHSA
	10(S)-PAHSA is a stereoisomer of 10-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs).
T36588	9(R)-PAHSA
	9(R)-PAHSA is a stereoisomer of 9-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs).
T35446	10(R)-PAHSA
	10(R)-PAHSA is a stereoisomer of 10-PAHSA , an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs).
T37455	C18 D-threo Ceramide (d18:1/18:0) C18 D-threo Ceramide (d18:1/18:0)
	C18 D-threoCeramide (d18:1/18:0) is a synthetic ceramide and stereoisomer of C18 ceramide .1It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50value of 16.6 μM.2[Matreya, LLC. Catalog No. 1855] 1.Koolath, S., Murai, Y., Suga, Y., et al.Chiral combinatorial preparation and biological evaluation of unique ceramides for inhibition of sphingomyelin synthaseChirality32(3)308-313(2019) 2.Usta, J., El Bawab, S., Roddy, P., et al.Structural requirements of ceramide and sphingosine bas...
T19114	(2S,4S)-Sacubitril Sacubitril Impurity C,LCZ 696杂质C	Others	Others
	(2S,4S)-Sacubitril (Sacubitril Impurity C) 是 Sacubitril 的杂质。其中 Sacubitril 是 NEP 抑制剂，可用于研究心力衰竭。
T37457	C18 L-threo Ceramide (d18:1/18:0) C18 L-threo Ceramide (d18:1/18:0)
	C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 0.21 mol% (16.8 μM).
T37456	C18 L-erythro Ceramide (d18:1/18:0) C18 L-erythro Ceramide (d18:1/18:0)
	C18 L-erythro Ceramide is a naturally occurring ceramide and stereoisomer of C18 ceramide . It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 0.11 mol% (8.8 μM).
T23296	(S)-CCG-1423	Others	Others
	(S)-CCG-1423 is a stereoisomer of CCG-1423. CCG-1423 is a Rho inhibitor involved in blocking signaling through myocardin-related transcription factor A and serum response factor.
T23221	(R)-CCG-1423	Others	Others
	(R)-CCG-1423 is a stereoisomer of CCG-1423. CCG-1423 is a Rho inhibitor involved in blocking signaling through myocardin-related transcription factor A (MRTF-A) and serum response factor (SRF).
T36621	Prostaglandin F2β
	Prostaglandin F2β (PGF2β) is the 9β-hydroxy stereoisomer of PGF2α. It is much less active than PGF2α in antifertility and bronchoconstrictor activities. PGF2β exhibits bronchodilating activity in guinea pigs and cats and antagonizes the bronchoconstrictor activity of PGF2α.
T37010	D-threo Sphinganine (d18:0) D-threo Sphinganine (d18:0)
	D-threo Sphinganine (d18:0) is a synthetic bioactive sphingolipid and stereoisomer of sphinganine (d18:0) and L-erythro sphinganine (d18:0) . It induces autophagy in HCT116 cells when used at a concentration of 12 μM. D-threo Sphinganine (d18:0) is metabolized via sphinganine N-acyltransferase and sphinganine kinase in vivo in rat liver.
T37665	Endosulfan I
	Endosulfan I is an organochlorine insecticide and a stereoisomer of endosulfan II . It is active against a variety of insects, including bollworms (LD50 = 0.63 mg/g). Endosulfan I binds to GABA receptors in rat brain membranes with an IC50 value of 30 nM and is toxic to rats (LD50 = 18 mg/kg).
TMIH-0469	Quinidine-d3
	Quinidine-d3 是 Quinidine 的氘代化合物。Quinidine 的 CAS 号为 56-54-2。Quinidine 是一种抗心律失常剂，也是 K+通道的有效阻断剂，其IC50值为 19.9 μM。它是一种选择性细胞色素 P450db 的有效抑制剂，也可研究疟疾。
T69060	Dextrallorphan
	Dextrallorphan (DXA) is an chemical of the morphinan class that is used in scientific research. It acts as a σ1 receptor agonist and NMDA receptor antagonist. It has no significant affinity for the σ2, μ-opioid, or δ-opioid receptor, or for the serotonin or norepinephrine transporter. As an NMDA receptor antagonist, in vivo, it is approximately twice as potent as dextromethorphan, and five-fold less potent than dextrorphan. Dextrallorphan was found to have a half maximal inhibitory concentration...
T60893	Ep vinyl quinidine
	Ep vinyl quinidine (3-Epiquinine) 是Quinidine 的一种乙烯基立体异构体。Quinidine 可用于研究疟疾，也是一种抗心律失常剂。Quinidine 是口服有效的、选择性细胞色素 P450db 抑制剂，以及钾通道的有效阻断剂，IC50值为 19.9 μM。

化合物

NVP-CGM097 (stereoisomer)

Cat.No: T39472

Synonym: NVP-CGM097 (stereoisomer),CGM097 stereoisomer,(R)-Nvp-Cgm097

Cebranopadol ((1α,4α)stereoisomer)

Cat.No: T10749

Synonym: GRT6005 (1α,4α)stereoisomer

Target: Others

Cat.No: T15597L

(R)-(-)-JQ1 Enantiomer

Cat.No: T19618

Synonym: (R)-(-)2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂环庚烷-6-基)乙酸叔丁酯

Target: Epigenetic Reader Domain

Cat.No: T12628

Synonym: (S,R,S)-(-)-MG-132,N-[(苯基甲氧基)羰基]-L-亮氨酰-N-[(1S)-1-甲酰基-3-甲基丁基]-D-亮氨酰胺,Z-Leu-D-leu-leu-al

Target: Proteasome

Cat.No: T22775

Synonym: exo-IWR 1

Target: Wnt/beta-catenin

Cat.No: T32137

Synonym: L-Idonate,L-Idonic acid

Cat.No: T36949

Target: 5-HT Receptor, Adrenergic Receptor, Histamine Receptor

Cat.No: T25333

Synonym: Dilevalolum

UDP-β-D-Glucose (sodium salt)

Cat.No: T37899

Cat.No: T35447

Cat.No: T36588

Cat.No: T35446

C18 D-threo Ceramide (d18:1/18:0)

Cat.No: T37455

Synonym: C18 D-threo Ceramide (d18:1/18:0)

(2S,4S)-Sacubitril

Cat.No: T19114

Synonym: Sacubitril Impurity C,LCZ 696杂质C

Target: Others

C18 L-threo Ceramide (d18:1/18:0)

Cat.No: T37457

Synonym: C18 L-threo Ceramide (d18:1/18:0)

C18 L-erythro Ceramide (d18:1/18:0)

Cat.No: T37456

Synonym: C18 L-erythro Ceramide (d18:1/18:0)

Cat.No: T23296

Target: Others

Cat.No: T23221

Target: Others

Prostaglandin F2β

Cat.No: T36621

D-threo Sphinganine (d18:0)

Cat.No: T37010

Synonym: D-threo Sphinganine (d18:0)

Cat.No: T37665

Cat.No: TMIH-0469

Cat.No: T69060

Ep vinyl quinidine

Cat.No: T60893

Cat. No.	Product Name	Target	Signaling Pathways
T6468	D-glutamine	Mitophagy; Ferroptosis; Endogenous Metabolite; GluR; Autophagy	Apoptosis; Autophagy; Metabolism; Neuroscience
	D-Glutamine 是有细胞渗透性谷氨酰胺的 D 型立体异构体，是标准遗传密码编码的20种氨基酸之一。
T3813	20(R)-Ginsenoside Rh2 20(R)-人参皂苷 RH2,(20R)Ginsenoside Rh2,Ginsenoside Rh2,20(R)-人参皂苷Rh2	Apoptosis; MMP; HSV	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	20(R)-Ginsenoside Rh2 (Ginsenoside Rh2) 是人参皂苷 Rh2 的次要立体异构体，具有基质金属蛋白酶抑制作用。它有抗癌、抗炎和抗氧化活性。
T7938	Quinidine 奎尼丁,奎宁树	Parasite	Microbiology/Virology
	Quinidine 是一种抗心律失常剂，也是 K+通道的有效阻断剂，其 IC50值为 19.9 μM。它是一种选择性细胞色素 P450db 的有效抑制剂，也可研究疟疾。
T3S0895	Spirostan-3-ol 剑麻皂苷元,Sarsaponin	Others	Others
	Spirostan-3-ol (Sarsaponin) 是 Sarsasapogenin 的立体异构体，是从植物材料中分离出来的类固醇糖苷，具有潜在的通过细胞凋亡的抗肿瘤活性。它可驱赶蜜蜂。
T1317	Cinchonidine 奎宁树,α-Quinidine,辛可尼丁,L-Cinchonidine	5-HT Receptor; Serotonin Transporter; Parasite	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Cinchonidine (L-Cinchonidine) 是在金鸡纳和角蒿中发现的一种生物碱，有抗疟活性。它是用于有机化学中不对称合成的砌块，是血清素转运蛋白的弱抑制剂。
T4751	(2R,3R)-Butane-2,3-diol (2R,3R)-(-)-2,3-Butanediol,levo-2,3-Butanediol,(2R,3R)-(-)-2,3-丁二醇	Others; Endogenous Metabolite	Metabolism; Others
	(2R,3R)-Butane-2,3-diol (levo-2,3-Butanediol) 是内源性代谢产物的一种。
T4429	Rauwolscine hydrochloride Corynanthidine hydrochloride,盐酸育亨宾碱,萝芙素盐酸盐,α-Yohimbine hydrochloride,Isoyohimbine hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Rauwolscine hydrochloride (Isoyohimbine hydrochloride) 是一种高选择性的 α2 adrenergic 受体拮抗剂，Ki=12 nM。
T5219	L-Alloisoleucine L-别异亮氨酸,L-allo-Isoleucine,(3R)-LS-Isoleucine,L(+)-Alloisoleucine	Others; Endogenous Metabolite	Metabolism; Others
	L-Alloisoleucine (L-allo-Isoleucine) 是 L-异亮氨酸的立体异构体，是一种支链氨基酸，是人血浆的常见成分 (尽管水平较低)。
T12789	S-1-Propenyl-L-cysteine	Others	Others
	S-1-Propenyl-L-cysteine, a stereoisomer of S-allyl-l-cysteine, exhibits immunomodulatory effects and has been shown to decrease blood pressure in hypertensive animal models.
T38036	Lumisterol
	Lumisterol (9β,10α-Ergosterol), a steroid compound, is the (9β,10α)-stereoisomer of Ergosterol. Lumisterol is a photoprotective agent against UVB-induced DNA damage and anti-proliferative activities[1]. [1]. Anyamanee Chaiprasongsuk, et al. Protective Effects of Novel Derivatives of Vitamin D 3 and Lumisterol Against UVB-induced Damage in Human Keratinocytes Involve Activation of Nrf2 and p53 Defense Mechanisms. Redox Biol. 2019 Jun;24:101206.
T4806	H-D-Trp-OH D-Tryptophan,D-色氨酸	Others; Endogenous Metabolite	Metabolism; Others
	H-D-Trp-OH (D-Tryptophan) 是一种色氨酸的 D 型异构体。它偶尔也会在自然界多肽中被发现，如海洋毒肽。

天然产物

Cat.No: T6468

Target: Mitophagy, Ferroptosis, Endogenous Metabolite, GluR, Autophagy

20(R)-Ginsenoside Rh2

Cat.No: T3813

Synonym: 20(R)-人参皂苷 RH2,(20R)Ginsenoside Rh2,Ginsenoside Rh2,20(R)-人参皂苷Rh2

Target: Apoptosis, MMP, HSV

Cat.No: T7938

Synonym: 奎尼丁,奎宁树

Target: Parasite

Cat.No: T3S0895

Synonym: 剑麻皂苷元,Sarsaponin

Target: Others

Cat.No: T1317

Synonym: 奎宁树,α-Quinidine,辛可尼丁,L-Cinchonidine

Target: 5-HT Receptor, Serotonin Transporter, Parasite

(2R,3R)-Butane-2,3-diol

Cat.No: T4751

Synonym: (2R,3R)-(-)-2,3-Butanediol,levo-2,3-Butanediol,(2R,3R)-(-)-2,3-丁二醇

Target: Others, Endogenous Metabolite

Rauwolscine hydrochloride

Cat.No: T4429

Synonym: Corynanthidine hydrochloride,盐酸育亨宾碱,萝芙素盐酸盐,α-Yohimbine hydrochloride,Isoyohimbine hydrochloride

Target: Adrenergic Receptor

L-Alloisoleucine

Cat.No: T5219

Synonym: L-别异亮氨酸,L-allo-Isoleucine,(3R)-LS-Isoleucine,L(+)-Alloisoleucine

Target: Others, Endogenous Metabolite

S-1-Propenyl-L-cysteine

Cat.No: T12789

Target: Others

Cat.No: T38036

Cat.No: T4806

Synonym: D-Tryptophan,D-色氨酸

Target: Others, Endogenous Metabolite

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