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36

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T39789	BMS-986235 BMS-986235,LAR-1219	Others	Others
	BMS-986235 (LAR-1219) 是一种特异性和口服活性的甲酰肽受体 2 (FPR2) 激动剂，对 hFPR2 和 mFPR2 的 EC50 分别为 0.41 nM 和 3.4 nM。 BMS-986235 可用于预防心力衰竭的研究。
T11069	DO-264	Others	Others
	DO-264 是一种自水解酶结构域 12 (ABHD12) 的抑制剂(IC50：11 nM)，也是一种细胞LysoPS降解抑制剂，可增强 LPS 诱导的吞噬作用。
T68166L	Traxanox TFA Traxanox TFA(58712-69-9 Free base)	Others	Others
	Traxanox TFA 是一种可口服的利尿剂。Traxanox TFA 在体外增强小鼠腹膜巨噬细胞或大鼠腹膜多形核白细胞对酵母颗粒的吞噬作用。Traxanox TFA 对抑制BALB/c小鼠抗体产生的恢复作用。
T4982	Benznidazol 苄哒唑,苄硝唑,Radanil,Benznidazole,Ro 71051,Ro 07-1051	Antibiotic; Parasite	Microbiology/Virology
	Benznidazol (Benznidazole) 是一种抗寄生虫药物，对哥伦比亚 T. cruzi 菌株的 IC50值为 20.35 μM，有潜力研究美洲锥虫病。
T39308	Boc-Asp(OMe)-fluoromethyl ketone Boc-Asp(OMe)-fluoromethyl ketone,Boc-Asp(OMe)-FMK	Caspase	Apoptosis; Proteases/Proteasome
	Boc-Asp(OMe)-fluoromethyl ketone (Boc-Asp(OMe)-FMK) 是广谱的 caspase 抑制剂，可抑制 Fas 介导的吞噬作用和氧化破裂抑制，但对 IL-8 的趋化活性无影响。
T68166	Traxanox	Others	Others
	Traxanox 是一种可口服的利尿剂。Traxanox 在体外增强小鼠腹膜巨噬细胞或大鼠腹膜多形核白细胞对酵母颗粒的吞噬作用。Traxanox 对抑制BALB/c小鼠抗体产生的恢复作用。
T77362	Vorsetuzumab SGN-70	Immunology/Inflammation related	Immunology/Inflammation
	Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) 是靶向 CD70 抗体的单克隆抗体。Vorsetuzumab 具有抗癌活性，能够加强肾癌细胞巨噬相关吞噬作用，抑制 Burkitt 淋巴瘤。
T33613	NCGC00135472 NCGC 00135472,DRV1 (GPR32) agonist C2A,C2A,NCGC-00135472	Others	Others
	NCGC00135472 (DRV1 (GPR32) agonist C2A)是具有促分解功能的人Resolvin D1受体激动剂,可在β阻滞素和 cAMP 测定中激活人溶解蛋白 D1 受体 DRV1/GPR32 受体，EC50 分别为 0.37 uM 和 0.05 uM。NCGC00135472在过表达重组DRV1的细胞中引起快速阻抗变化，刺激血清处理的酶聚糖的吞噬作用。
T72024	ZIM
	ZIM，一种从4-Aminoantipyrine衍生的降冰片烯，有效诱导DNA损伤，造成基因组及染色体损害，进而引发细胞死亡和激活吞噬。其化疗潜力适用于癌症研究。
TP1042	Palmitoyl Tetrapeptide-3 Rigin,棕榈酰四肽-7/棕榈酰四肽-3	Others	Others
	Palmitoyl Tetrapeptide-3 (Rigin) 是一种具有刺激吞噬活性的合成多肽，对应人免疫球蛋白重链的第 341-344 氨基酸序列。
T76703	Tislelizumab 替雷利珠
	Tislelizumab 是一种对PD-1受体具有高结合亲和力的单克隆抗体，可减少 Fcγ 受体与巨噬细胞的结合，从而消除抗体依赖性吞噬作用，这是一种 T 细胞清除机制，可对抗PD-1研究的潜在耐药性。Tislelizumab 可用于晚期鳞状非小细胞肺癌的研究。
T34917	Traxanox sodium Y 12141,Y12141,Y-12141
	Traxanox sodium 是一种可口服的利尿剂。Traxanox sodium 在体外增强小鼠腹膜巨噬细胞或大鼠腹膜多形核白细胞对酵母颗粒的吞噬作用。Traxanox sodium 对抑制BALB/c小鼠抗体产生的恢复作用。
T77065	Ligufalimab
	Ligufalimab (AK 117) 是一种人源化 IgG4抗 CD47 单克隆抗体 Ligufalimab 不诱导 RBC 血凝，而诱导吞噬作用。Ligufalimab 具有抗肿瘤活性。
T37907	DL 175
	Potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis.
T73564	DMUP
	DMUP 是一种有效的 CD47-SIRPα axis 抑制剂。DMUP 在 A549 细胞中诱导细胞凋亡 (apoptosis) 并增加巨噬细胞的吞噬作用。DMUP 降低 CD47 和 SIRPα 的蛋白表达水平。DMUP 显示出抗肿瘤活性。
T78323	Letaplimab IBI-188
	Letaplimab (IBI-188) 是一种人源化IgG4单克隆抗CD47抗体，克隆标的CD47在癌细胞上过表达并作为SIRPα的配体。该药物通过增强对肿瘤细胞的吞噬作用发挥功效。
T76677	Dacetuzumab
	Dacetuzumab (SGN-40) 是一种人源化的 IgG1，抗 CD40单克隆抗体，具有抗淋巴瘤活性。Dacetuzumab 通过免疫效应作用(抗体依赖性细胞毒性和吞噬作用[ADCC/ADCP]) 杀死肿瘤细胞。Dacetuzumab ((SGN-40) 可用于多发性骨髓瘤研究。
T78552	PB118
	PB118是一种新型组蛋白去乙酰化酶 6（HDAC6）抑制剂，具备穿越血脑屏障的能力，可用于AD治疗。PB118 对 HDAC6 的 IC50 为 5.6 nM。
T82994	Anzurstobart BMS-986351,CC-95251
	Anzurstobart (CC-95251; BMS-986351) 是具有高亲和力的SIRPα全人源单克隆抗体，能够阻断CD47与SIRPα的结合。联合应用抗体利妥昔单抗时，Anzurstobart能增强巨噬细胞在共培养模型中对DLBCL细胞系的吞噬作用，显示出在实体和血液恶性肿瘤研究中的应用潜力。
T78277	ATG-031
	ATG-031是一款人源化抗CD24单克隆抗体，能有效激活巨噬细胞介导的吞噬作用，阻断多种癌症细胞表面的“不要吃我”信号，诱导癌细胞清除。此抗体适用于血液恶性肿瘤和实体瘤研究。
T35773	Gliotoxin-13C13 Gliotoxin-13C13
	Gliotoxin-13C13is intended for use as an internal standard for the quantification of gliotoxin by GC- or LC-MS. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains ofAspergillusand other fungi with diverse biological activities.1,2,3,4,5,6,7,8It inhibits 20S proteasomal chymotrypsin activity (IC50= 10 μM), blocking the degradation of IκBα and preventing the activation of NF-κB.2,3Gliotoxin induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutr...
T37259	14(S)-HDHA
	Docosahexaenoic acid is a nutritionally-derived ω-3 fatty acid that is abundant in the brain and the retina and is thought to be important in early development and for therapeutic approaches to inflammatory disorders and cancer. 14(S)-HDHA is an oxygenation product of DHA that serves as a precursor to maresin 1 , an anti-inflammatory, pro-resolving mediator that prevents polymorphonuclear neutrophil (PMN) infiltration and stimulates macrophage phagocytosis. At doses as low as 0.2 ng/mouse 14(S)-...
T80762	XmAb 5592
	XmAb 5592 是一款人源化Fc工程化的抗HM1.24抗体，通过增强与 FcγRIIIa 及 FcγRIIIb 受体的结合能力，增强了对HM1.24特异性多发性骨髓瘤（MM）细胞的抗体依赖性细胞毒性（ADCC）和抗体依赖性细胞吞噬（ADCP）作用，从而促进了体外裂解效果。
T63139	Glutaminyl cyclases-IN-1
	Glutaminyl cyclases-IN-1 (IsoQC-IN-1) 是一种谷氨酰胺酰基环化酶 (glutaminyl cyclases, QC) 的有效抑制剂，作用于人 QC (IC50: 12 nM) 和 isoQC (IC50: 73 nM)。Glutaminyl cyclases-IN-1 能够抑制 isoQC，进而选择性的阻碍 CD47/SIRPα 的相互作用，也可以提高 THP-1 和 U937 巨噬细胞的吞噬作用。
T81605	Ontorpacept TTI-621
	Ontorpacept (TTI-621)为一种由人SIRPα的N端(1-118)与人IgG1的Fc区域构建的可溶性融合蛋白。该N端片段为CD47结合域，而CD47为巨噬细胞吞噬作用的负调控器。作为CD47阻断剂和检查点抑制剂，Ontorpacept展现出抗肿瘤活性。
T37503	Maresin 2 3R,14S-diHDHA
	Docosahexaenoic acid is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.[1] [2] Maresin 2 (MaR2) is a 13R,14S-dihydroxy DHA formed by recombinant human macrophage 12-lipoxygenase and soluble epoxide hydrolase co-incubated with DHA. [3] At 1 ng/mouse, MaR2 was shown to reduce neutrophil infiltration by 40% in a mouse model of peritonitis, and at 10 pM, MaR2 can enhance human macrophage phagocytosis of zymosan A by 90%. [3] Analytica...
T37505	MCTR1 MCTR1
	Maresin conjugates in tissue regeneration 1 (MCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is then converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase. MCTR1 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR1 (50 ng/mouse, i.p.) prior to E. coli administration reduces neutrophil infiltration, shortens the inflam...
T38042	Resolvin D4 Resolvin D4,RvD4
	Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid . [1] It has been detected in human milk, in the dorsal pouch of mice before and after infection with S. aureus, and in untreated tissues from humans, mice, and sardines.[2][3] RvD4, at 10 ng/mouse, reduces neutrophil infiltration in zymosan A-induced peritonitis and, at 200 ng/mouse, diminishes neutrophil infiltration in response to S. aureus infection. [3] With isolated cells, RvD4 promotes phagocytosi...
T37506	MCTR2 MCTR2
	Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase then to MCTR2 by γ-glutamyl transferase. MCTR2 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR2 prior to E. coli administration reduces neutrophil infiltration, shor...
T37606	Resolvin D5 7(S),17(S)-diHDHA
	Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid . [1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D5 (RvD5) is a DHA-derived resolvin generated by a double dioxygenation mechanism.[3] RvD5 has been identified in media from ionophore-stimulated trout brain cells, in human synovial fluid from patients with rheumatoid arthritis, and in...
T78450	4-Di-1-ASP
	4-Di-1-ASP是一种苯乙烯基染料，适用于标记活脑组织中的神经胶质瘤细胞，常用于分析细胞的结构、活性、增殖以及内吞作用、胞吐和吞噬作用。同时，该染料也被用于观察活细胞的线粒体结构。在显微镜观察下，4-Di-1-ASP能够发射绿色荧光（λex/λem= 475/606 nm）。
T83661	17(R,S)-Benzo-Resolvin D1 17(R,S)-Benzo-RvD1,Benzo-RvD1
	17(R,S)-Benzo-resolvin D1 (benzo-RvD1) 是专门的分辨介质 (SPM) RvD1 的衍生物。在10和100 nM的浓度下，它能减少PDGF-BB诱导的人类血管平滑肌细胞 (VSMCs) 的细胞骨架变化，并抑制PDGF诱导的这些细胞的迁移。Benzo-RvD1 (10 nM) 抑制人脐静脉内皮细胞 (HUVECs) 中的p65核转位。它还提高了RAW 264.7对S. aureus和zymosan颗粒的吞噬作用。
T37507	MCTR3 MCTR3
	Maresin conjugates in tissue regeneration 3 (MCTR3) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages. DHA is oxidized to maresin 1 , which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase, then to MCTR2 by γ-glutamyl transferase, and to MCTR3 by dipeptidase. MCTR3 accelerates tissue regeneration in planaria (1 and 100 nM) approximately as potently as MCTR2 and more potently than MCTR1. Pretreatment with MCTR3 pri...
T37166	RCTR1
	Resolvin conjugate in tissue regeneration 1 (RCTR1) is a specialized pro-resolving mediator (SPM) biosynthesized from docosahexaenoic acid by isolated human macrophages and apoptotic polymorphonuclear (PMN) neutrophils.1It has been found in human spleen and bone marrow.2RCTR1 is produced via lipoxygenase-mediated oxidation of DHA to 7(S)-8-epoxy-17(S)-HDHA, which is conjugated to glutathione.1,2,3RCTR1 (10 nM) increases phagocytosis ofE. colior apoptotic neutrophils in isolated human monocyte-de...
T83847	SP-A (196-215) (human) TFA Surfactant Protein A,SPA4
	表面活性蛋白A（SP-A）（196-215）是一种合成肽，与人类SP-A的C末端碳水化合物识别域的196至215氨基酸序列相对应。当浓度为1和10 µM时，它能抑制JAWSII鼠树突细胞中由LPS诱导的TNF-α释放。SP-A（196-215）（75 µM）促使JAWSII细胞吞噬P. aeruginosa。通过气管内给药，SP-A（196-215）（50 µg/动物）降低了小鼠P. aeruginosa感染模型的疾病严重程度和肺部形成菌落数。
T36679	Rp-cAMPS sodium salt
	Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6]. A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic t...

化合物

Cat.No: T39789

Synonym: BMS-986235,LAR-1219

Target: Others

Cat.No: T11069

Target: Others

Cat.No: T68166L

Synonym: Traxanox TFA(58712-69-9 Free base)

Target: Others

Cat.No: T4982

Synonym: 苄哒唑,苄硝唑,Radanil,Benznidazole,Ro 71051,Ro 07-1051

Target: Antibiotic, Parasite

Boc-Asp(OMe)-fluoromethyl ketone

Cat.No: T39308

Synonym: Boc-Asp(OMe)-fluoromethyl ketone,Boc-Asp(OMe)-FMK

Target: Caspase

Cat.No: T68166

Target: Others

Cat.No: T77362

Synonym: SGN-70

Target: Immunology/Inflammation related

Cat.No: T33613

Synonym: NCGC 00135472,DRV1 (GPR32) agonist C2A,C2A,NCGC-00135472

Target: Others

Cat.No: T72024

Palmitoyl Tetrapeptide-3

Cat.No: TP1042

Synonym: Rigin,棕榈酰四肽-7/棕榈酰四肽-3

Target: Others

Cat.No: T76703

Synonym: 替雷利珠

Traxanox sodium

Cat.No: T34917

Synonym: Y 12141,Y12141,Y-12141

Cat.No: T77065

Cat.No: T37907

Cat.No: T73564

Cat.No: T78323

Synonym: IBI-188

Cat.No: T76677

Cat.No: T78552

Cat.No: T82994

Synonym: BMS-986351,CC-95251

Cat.No: T78277

Gliotoxin-13C13

Cat.No: T35773

Synonym: Gliotoxin-13C13

Cat.No: T37259

Cat.No: T80762

Glutaminyl cyclases-IN-1

Cat.No: T63139

Cat.No: T81605

Synonym: TTI-621

Cat.No: T37503

Synonym: 3R,14S-diHDHA

Cat.No: T37505

Synonym: MCTR1

Cat.No: T38042

Synonym: Resolvin D4,RvD4

Cat.No: T37506

Synonym: MCTR2

Cat.No: T37606

Synonym: 7(S),17(S)-diHDHA

Cat.No: T78450

17(R,S)-Benzo-Resolvin D1

Cat.No: T83661

Synonym: 17(R,S)-Benzo-RvD1,Benzo-RvD1

Cat.No: T37507

Synonym: MCTR3

Cat.No: T37166

SP-A (196-215) (human) TFA

Cat.No: T83847

Synonym: Surfactant Protein A,SPA4

Rp-cAMPS sodium salt

Cat.No: T36679

Cat. No.	Product Name	Target	Signaling Pathways
T13864	Resolvin D1 RvD1	Apoptosis	Apoptosis
	Resolvin D1 (RvD1) 是一种内源性促进炎症消解介质，可通过调节肌动蛋白聚合阻断促进炎症的中性粒细胞迁移，减少 TNF-α 介导的炎症在巨噬细胞中的作用，并增强巨噬细胞对凋亡细胞的吞噬作用。
T4706	Uridine-5'-diphosphate disodium salt UDP disodium salt,Uridine 5'-diphosphate disodium salt hyd,尿苷-5'-二磷酸二钠盐	DNA/RNA Synthesis; Endogenous Metabolite; P2Y Receptor	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Uridine-5'-diphosphate disodium salt (UDP disodium salt) 是一种选择性 P2Y6受体激动剂，EC50为300 nM，对人 P2Y6受体的 pEC50为6.52。它可刺激炎症介质的产生、吞噬作用和血管收缩，催化多种底物的葡糖醛酸糖化反应，用于核酸生物合成。
TL0007	Bisdemethoxycurcumin 双去甲氧基姜黄素,Curcumin III,Didemethoxycurcumin	Epigenetic Reader Domain; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; Stem Cells
	Bisdemethoxycurcumin (Curcumin III) 是一种具有抗炎及抗氧化作用的姜黄素。
T65269	L-Aspartic acid potasium salt Aspartic acid potasium salt,Potassium L-aspartate	Others	Others
	L-aspartic acid potasium salt（VX-548）是一种广泛存在于动植物体内的氨基酸。L-aspartic acid potasium salt驱动氮氧化物的产生，从而促进吞噬作用，有助于提高鱼类的成活率。L-aspartic acid potasium salt 可对抗生素产生刺激，刺激作用可能与参与天冬氨酸-4-半醛生物合成的前体有关。
T3229	Cytochalasin D	ATPase; p38 MAPK; Calcium Channel; Akt; PI3K	Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit
TN5880	Mesuol
	Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical; it also has immunomodulatory activity, can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and phagocytosis in carbon clearance assay. Mesuol can suppress HIV-1 replication in Jurkat T cells, it inhibits TNFα-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-κB (NF-κB) pathway.
TN3125	5-Methoxycanthin-6-one	Others	Others
	5-Methoxycanthin-6-one displays moderate cytotoxic activity against the human prostate cancer cell PC-3 line, with IC50 values ranging from 13.5-15.4 uM versus doxorubicine with IC50 = 1.5 uM. It also exhibits a clear suppressive effect on the phagocytosi

天然产物

Cat.No: T13864

Synonym: RvD1

Target: Apoptosis

Uridine-5'-diphosphate disodium salt

Cat.No: T4706

Synonym: UDP disodium salt,Uridine 5'-diphosphate disodium salt hyd,尿苷-5'-二磷酸二钠盐

Target: DNA/RNA Synthesis, Endogenous Metabolite, P2Y Receptor

Bisdemethoxycurcumin

Cat.No: TL0007

Synonym: 双去甲氧基姜黄素,Curcumin III,Didemethoxycurcumin

Target: Epigenetic Reader Domain, Wnt/beta-catenin

L-Aspartic acid potasium salt

Cat.No: T65269

Synonym: Aspartic acid potasium salt,Potassium L-aspartate

Target: Others

Cat.No: T3229

Target: ATPase, p38 MAPK, Calcium Channel, Akt, PI3K

Cat.No: TN5880

5-Methoxycanthin-6-one

Cat.No: TN3125

Target: Others

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