33
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Cat. No. | Product Name | Target | Signaling Pathways |
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T0993 |
Methoxamine hydrochloride
Methoxamine HCl,盐酸甲氧明 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Methoxamine hydrochloride (Methoxamine HCl) 是一种 alpha1 肾上腺素能受体的选择性激动剂。它通过 Prazosin 敏感机制在兔肺动脉显著增加 ATP、ADP 和 AMP 的溢出,但不增加腺苷的溢出。它引起血管收缩和外周血管阻力增加。 | |||
T22459 |
Xanthinol Nicotinate
Angioamin,烟酸占替诺,Complamin |
Others | Others |
Xanthinol Nicotinate (Complamin) 是血管扩张剂,可直接作用于小动脉和毛细血管的平滑肌,能够扩大血管,改善血液流变学并降低外周血管阻力。 | |||
T1275 |
Phentolamine mesylate
Phentolamine methanesulfonate,甲磺酸酚妥拉明,Phentolamine mesilate |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Phentolamine mesylate (Phentolamine methanesulfonate) 是一种非选择性的、可逆的,具有口服活性的 α1 和 α2 肾上腺素能受体阻滞剂,能够扩张使血管,降低周围血管阻力。它可用于研究嗜铬细胞瘤相关的高血压,心力衰竭和勃起功能障碍。 | |||
T30615 |
Bupicomide
|
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Bupicomide is a vasodilator that significantly reduces systolic, diastolic, and means arterial pressure, as well as peripheral vascular resistance. | |||
T0712 |
Suloctidil
|
ATPase; Platelet aggregation | Membrane transporter/Ion channel; Others |
Suloctidil 是一种外周血管扩张剂,作用于大鼠脑突触, 影响Na+/ K+ ATP 酶活性和膜流动性,可治疗痴呆和血栓形成病症。 | |||
T9881 |
Benzoquinamide hydrochloride
3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride |
Others | Others |
Benzoquinamide hydrochloride (3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride) 是一种止吐剂,其增加动脉内压的作用是由于增加了外周血管阻力。 | |||
T0806 |
Flunarizine dihydrochloride
Flunarizine 2HCl,KW-3149,R14950,盐酸氟桂利嗪 |
Calcium Channel; Dopamine Receptor; Sodium Channel | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Flunarizine dihydrochloride (R14950) 是 Na+/Ca2+(T 型) 通道双重阻滞剂。它也是 D2多巴胺受体拮抗剂。它具有用于扩张外周血管和预防偏头痛的潜力。 | |||
T0957 |
Isradipine
PN 200-110,伊拉地平 |
Calcium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism |
Isradipine (PN 200-110) 是一种二氢吡啶类钙通道阻滞剂,具有抗高血压和血管扩张活性。它是一种具有口服活性的 L 型钙通道阻滞剂,也是一种潜在可行的帕金森病神经保护剂。 | |||
T0182L2 |
(±) Clopidogrel hydrogen sulfate
硫酸氢氯吡格雷,Plavix,Clopidogrel hydrogen sulfate,Iscover |
P2Y Receptor | GPCR/G Protein; Neuroscience |
(±) Clopidogrel hydrogen sulfate (Iscover) 是一种在药理学和结构上类似于ticlopidine 的抗血小板药物,用于抑制脑血管疾病、外周血管疾病和冠状动脉疾病等各种疾病中的血栓。 | |||
T1439 |
Lacidipine
SN-305,拉西地平,GX-1048,GR-43659X |
Apoptosis; Calcium Channel; Reactive Oxygen Species | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB |
Lacidipine (SN-305) 是一种L 型钙离子通道阻断剂。 | |||
T1081 |
Naftidrofuryl oxalate
萘呋胺酯 草酸盐,Nafronyl oxalate,Nafronyl oxalate salt |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Naftidrofuryl oxalate (Nafronyl oxalate) 是一种用于治疗外周和脑血管疾病的药物,可增加细胞氧化能力,也是一种 5-HT2 受体拮抗剂。 | |||
TP1918L1 |
Lys-[Des-Arg9]Bradykinin acetate
Lys-[Des-Arg9]Bradykinin acetate (71800-36-7 free base) |
Bradykinin Receptor | GPCR/G Protein |
Lys-[Des-Arg9]Bradykinin acetate (71800-36-7 free base) 是一种内源性强效和高选择性的缓激肽 B1 受体激动剂(对人 B1 和 B2 受体的 Ki 值分别为 0.12 和 > 30000 nM)。降低体内外周血管阻力的降压药。比 [Des-Arg9]-缓激肽强 16 倍。 | |||
TP1918L |
Lys-[Des-Arg9]Bradykinin,TFA
Lys-[Des-Arg9]Bradykinin,TFA 71800-36-7(fb-tfa) |
Bradykinin Receptor | GPCR/G Protein |
Lys-[Des-Arg9]Bradykinin,TFA (71800-36-7 free base) 是内源性强效和高选择性的缓激肽 B1 受体激动剂(对人 B1 和 B2 受体的 Ki 值分别为 0.12 和 > 30000 nM)。降低体内外周血管阻力的降压药。比 [Des-Arg9]-缓激肽强 16 倍。 | |||
T1050 |
Prazosin hydrochloride
Prazosin hydrochloride,哌唑嗪盐酸盐,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,盐酸哌唑嗪,Minipress |
Potassium Channel; MRP; Adrenergic Receptor; ABC; Autophagy | Autophagy; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience |
Prazosin hydrochloride (Vasoflex) 是一种选择性肾上腺素能 α-1 拮抗剂,可降低外周阻力并放松血管平滑肌。 它可用于研究高血压和酒精使用障碍。 它是一种合成哌嗪衍生物,具有降压抗肾上腺素能特性。它抑制有机阳离子转运蛋白 OCT-1 和 OCT-3,IC50分别为 1.8 和 13 μM 。 | |||
T11043 |
Dihydroergocristine mesylate
甲磺酸双氢麦角汀,DHEC (mesylate) |
Beta Amyloid | Neuroscience |
Dihydroergocristine mesylate (DHEC (mesylate)) 是一种 γ-secretase (GSI) 的抑制剂,能够阿尔茨海默氏病淀粉样蛋白 β 肽 (amyloid-β) 的产生,与 γ-secretase 和 Nicastrin 结合的平衡解离常数 (Kd) 值分别为 25.7 nM 和 9.8 μM。 | |||
T0712L |
Suloctidil HCl
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Suloctidil HCl is a peripheral vascular dilator. | |||
T0368L |
Cinepazide
Brendil,MD67350,Vasodistal,Cinepazide free base,MD-67350,MD 67350,NSC 291562 |
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Cinepazide is a vasodilator used for the treatment of cardiovascular, cerebrovascular, and peripheral vascular diseases. Cinepazide acts as a potentiator of adenosine A2 receptors. | |||
T69239 |
Nylidrin
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Nylidrin is a beta-adrenergic agonist. Nylidrin causes peripheral vasodilation, a positive inotropic effect, and increased gastric volume of gastric juice. It is used in the treatment of peripheral vascular disorders and premature labor. | |||
T5391L |
Bepridil free base
CERM1978,CERM 1978,Bepadin,CERM-1978,Angopril |
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Bepridil is a class IV anti-arrhythmic agent and calcium antagonist. Bepridil hydrochloride blocks calcium entry through membranous calcium channels of coronary and peripheral vascular smooth muscle, thereby dilating coronary arteries and peripheral arter | |||
T21392 |
Flunarizine
Flunarizinum,Flunarizin,Sibelium,Flunarizina,R-14950 |
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Flunarizine is a non-selective calcium entry blocker and a histamine H1 receptor blocker. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of | |||
T25848 |
Naftidrofuryl
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Naftidrofuryl is used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be spasmolytic. | |||
T69303 |
Isoxsuprine Free Base
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Isoxsuprine Free Base is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle. Its vasodilating actions are greater on the arteries supplying skeletal muscle than on those supplying skin. It is used in the treatment of peripheral vascular disease and in premature labor. | |||
T68825 |
Doxazosin HCl
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Doxazosin HCl is the salt form of Doxazosin Free Base which acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. | |||
T15560 |
Iloprost
ZK 36374,Ciloprost,伊洛前列素 |
Others | Others |
Iloprost is a synthetic analogue of prostacyclin PGI2. Iloprost commonly employed in the treatment of peripheral vascular disease and also indicated in the treatment of patients affected by systemic sclerosis (SSc) in the presence of severe Raynaud's phen | |||
T32833 |
Lobeline, (+)-
(+)-Lobeline |
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Lobeline, (+)- is an alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has been proposed for a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, a | |||
TP1918 |
Lys-[Des-Arg9]Bradykinin
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Endogenous potent and highly selective bradykinin B1 receptor agonist (Ki values are 0.12 and > 30000 nM at human B1 and B2 receptors respectively). Hypotensive agent that reduces peripheral vascular resistance in vivo. 16-fold more potent than [Des-Arg9] | |||
T68639 |
Ciprostene (free base)
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Ciprostene (free base) is a synthetic, chemically stable analog of prostacyclin (PGI2). In animal models, administration of ciprostene resulted in dose-dependent hypotension, tachycardia, and inhibition of ex vivo ADP-induced platelet aggregation. Ciprostene was evaluated in clinical trials in patients with peripheral vascular disease. It was found to reduce restenosis in patients with coronary artery disease undergoing therapeutic percutaneous transluminal coronary angioplasty. | |||
T29907 |
Alprostadil sodium
PGE1 sodium salt,Prostaglandin E1 sodium |
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Alprostadil sodium 是一种前列腺素受体配体,对小鼠 EP1、EP2、EP3、EP4和 IP 的 Ki 值分别为 36、10、1.1、2.1 和 33 nM。它诱导血管舒张并抑制血小板聚集,可作为血管扩张剂用于外周血管疾病的研究。 | |||
T17231 |
Vicagrel
|
Others | Others |
Vicagrel 是一种有效的、具有口服活性抗血小板化合物,通过不可逆地抑制 P2Y12 受体,降低代谢失活,增强了阿司匹林对啮齿类动物血小板聚集和血栓形成起抑制作用。Viagrel 可用于治疗冠状动脉疾病、外周血管疾病和脑血管疾病中血栓。 | |||
T63035 |
Izilendustat hydrochloride
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Izilendustat (hydrochloride) 是一种脯氨酰羟化酶 (prolyl hydroxylase) 的有效抑制剂,能够稳定缺氧诱导因子-1 α (HIF-1α) 和缺氧诱导因子-2 (HIF-2)。Izilendustat (hydrochloride) 具有潜力进行 HIF-1α 相关疾病的研究(包括外周血管疾病(PVD)、心力衰竭、冠状动脉疾病(CAD)、缺血、贫血、结肠炎和其他炎症性肠病)。 | |||
T83899 |
N-didesmethyl Loperamide
R 21345 |
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N-didesmethyl Loperamide是loperamide的一个活性代谢产物,属于周围μ1-阿片受体激动剂。它能抑制孤立的豚鼠肠膜丛中由电刺激引起的收缩(IC50 = 370 nM)。N-didesmethyl Loperamide还能增强对氯喹产生抗药性的P. falciparum菌株对氯喹的敏感性(EC50 = 482 nM),同时在A-10血管平滑肌细胞中未引起毒性(IC50 = >10,000 nM)。 | |||
T38128 |
Leukotriene D4
Leukotriene D4 MaxSpec® Standard,LTD4 |
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Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. It is the first cysteinyl-leukotriene metabolite of LTC4 . Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity. LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of... | |||
T35604 |
Osteocalcin (1-49) (human) (trifluoroacetate salt)
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Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D and plasma levels increase in diseases that induce dysregulated bone turnover such as osteoporosis, Paget's disease, and primary hyperparathyroidism. Osteocalcin (1-49) is positively correlated with insulin sensitivity and negatively correlated with high blood glucose levels in w... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T0070 |
Pentoxifylline
Oxpentifylline,PTX,己酮可可碱,BL-191 |
HIV Protease; PDE; Adenosine Receptor; Autophagy | Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Pentoxifylline (PTX) 是一种具有口服活性的磷酸二酯酶非选择性抑制剂,具有免疫调节、抗炎、抗纤溶、抗增殖和血液流变学改善作用。它可研究周围血管疾病、脑血管疾病和其他一些涉及局部微循环缺陷的疾病。 | |||
T22357 |
Lobeline sulfate
硫酸山梗菜碱,Lobelin sulphate |
Others | Others |
Lobelin sulphate is an alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has a variety of therapeutic uses including in insomnia, and smoking cessation, peripheral vascular disorders, respiratory disor |