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11

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T36010	p38 MAPK Inhibitor	p38 MAPK	MAPK
	p38 MAPK Inhibitor 是p38 MAPK 激酶的有效抑制剂（IC50＝ 35 nM）。p38 MAPK Inhibitor 抑制癌基因RAS 诱导的衰老。
T12347	p38-α MAPK-IN-1	p38 MAPK; Autophagy	Autophagy; MAPK
	p38-α MAPK-IN-1 是一种 MAPK14 (p38-α) 抑制剂，在 EFC 置换试验和 HTRF 试验中 IC50 分别为 2300 nM 和 5500 nM。
T11241	p38 MAPK-IN-2	Others	Others
	p38 MAPK-IN-2 is an inhibitor of p38 kinase.
T16424	p38 MAPK-IN-1	p38 MAPK	MAPK
	p38 MAPK-IN-1 displays sustained levels, low clearance, and good bioavailability. p38 MAPK-IN-1 is a novel effective and selective inhibitor of p38 MAPK (IC50: 68 nM).
T12352	Oxidopamine hydrochloride 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride,6-羟基多巴胺盐酸盐	Mitophagy; Dopamine Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) 是一种神经递质多巴胺拮抗剂，可选择性地破坏多巴胺能神经元，是一种广泛使用的神经毒素。
T35420	(S)-p38 MAPK Inhibitor III (S)-p38 MAPK Inhibitor III
	(S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro). It is cell-permeable, potently blocking the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC50s = 0.37 and 0.044 μM, respectively).
T36011	p38 MAP Kinase Inhibitor IV p38 MAPK Inhibitor IV
	p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α and IL-1β cytokine production (IC50s = 22 and 44 nM, respectively) in human peripheral blood mononuclear cells.
T12352L	Oxidopamine hydrobromide 6-Hydroxydopamine hydrobromide,6-羟基多巴胺氢溴酸盐,6-OHDA hydrobromide	Mitophagy; Dopamine Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Oxidopamine hydrobromide (6-OHDA hydrobromide) 是一种神经递质多巴胺拮抗剂，可选择性地破坏多巴胺能神经元，是一种广泛使用的神经毒素。
T27787L	L-797,591 hydrochloride L-797,591 hydrochloride(217480-24-5 Free base)
	L-797,591 hydrochloride 对生长抑素受体亚型 1 (SSTR1)有活性。L-797,591 hydrochloride 常与 AG1478 联合使用来增强表达 SSTR1的细胞中 p-ERK5的表达。L-797,591 hydrochloride 在共转染的细胞中显著增强了 p38的磷酸化，这一作用在与 AG1478联合处理时被逆转。
T62514	HDAC-IN-46
	HDAC-IN-46 (compound 12c) 是一种 HDAC 的有效抑制剂，能够作用于 HDAC1 (IC50: 0.21 μM) 和 HDAC6 (IC50: 0.021 μM)的。HDAC-IN-46 在 MDA-MB-231 细胞中可以上调 p-p38，下调 Bcl-xL 和 cyclin D1。HDAC-IN-46 能够将细胞周期阻滞在 G2 期，并诱导细胞凋亡 (apoptosis)。HDAC-IN-46 能够用于三阴性乳腺癌 (TNBC) 的研究。
T35463	(±)14(15)-EET (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET
	(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage o...

化合物

p38 MAPK Inhibitor

Cat.No: T36010

Target: p38 MAPK

p38-α MAPK-IN-1

Cat.No: T12347

Target: p38 MAPK, Autophagy

Cat.No: T11241

Target: Others

Cat.No: T16424

Target: p38 MAPK

Oxidopamine hydrochloride

Cat.No: T12352

Synonym: 6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride,6-羟基多巴胺盐酸盐

Target: Mitophagy, Dopamine Receptor, Autophagy

(S)-p38 MAPK Inhibitor III

Cat.No: T35420

Synonym: (S)-p38 MAPK Inhibitor III

p38 MAP Kinase Inhibitor IV

Cat.No: T36011

Synonym: p38 MAPK Inhibitor IV

Oxidopamine hydrobromide

Cat.No: T12352L

Synonym: 6-Hydroxydopamine hydrobromide,6-羟基多巴胺氢溴酸盐,6-OHDA hydrobromide

Target: Mitophagy, Dopamine Receptor, Autophagy

L-797,591 hydrochloride

Cat.No: T27787L

Synonym: L-797,591 hydrochloride(217480-24-5 Free base)

Cat.No: T62514

Cat.No: T35463

Synonym: (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET

Cat. No.	Product Name	Target	Signaling Pathways
T4085	Paris saponin VII 重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII	Apoptosis; BCL; Others; PARP; p38 MAPK; Akt; Caspase; P-gp; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Membrane transporter/Ion channel; Neuroscience; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Paris saponin VII (Dioscini) 是从延龄草的根和根茎中分离的一种甾体皂苷。它减弱线粒体膜电位，增加凋亡相关蛋白的表达，并降低Bcl-2、caspase-9、caspase-3、PARP-1和p-Akt 的蛋白表达水平。它在 K562/ADR 细胞中诱导强烈的自噬，可研究白血病。
T10383	Asatone	NF-κB	NF-κB
	Asatone 是一种从细辛中分离到的活性成分，通过活化 NF-κB 及下调 p-MAPK (ERK，JNK 和 p38) 通路起作用，具有抗炎作用。
T2698	Asperosaponin VI Akebia saponin D,Asperosaponin Ⅵ,川续断皂苷 VI	Apoptosis; Others; Caspase	Apoptosis; Others; Proteases/Proteasome
	Asperosaponin VI (Akebia saponin D) 是一种来自续断壁的皂苷组分。它通过增加 Bcl-2/Bax 比值，降低活性 caspase-3 表达，以及增强 p-Akt 和 p-CREB，从而抑制缺氧诱导的心肌细胞凋亡。它通过 BMP-2/p38 和 ERK1/2 信号途径诱导成骨细胞分化。
TL0004	FERULIC ACID METHYL ESTER 阿魏酸甲酯,Methyl ferulate,Methyl 4'-hydroxy-3'-methoxycinnamate	p38 MAPK; Autophagy	Autophagy; MAPK
	FERULIC ACID METHYL ESTER (Methyl ferulate) 是从大百部中分到的阿魏酸衍生物，具有抗氧化和抗炎作用。在原发性骨髓源性巨噬细胞中，它抑制 COX-2 的表达，降低 p-p38和 p-JNK 的水平。它能够透过细胞膜和血脑屏障，清除自由基，可研究神经退行性疾病。
TN3839	Desoxo-narchinol A	ERK; IL Receptor; p38 MAPK; TNF; NOS; NF-κB; COX; Prostaglandin Receptor; JNK	Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; NF-κB
	Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity against LPS-induced NO production. Desoxo-narchinol A shows cytotoxic activity against P-388 cells.

天然产物

Paris saponin VII

Cat.No: T4085

Synonym: 重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII

Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy

Cat.No: T10383

Target: NF-κB

Asperosaponin VI

Cat.No: T2698

Synonym: Akebia saponin D,Asperosaponin Ⅵ,川续断皂苷 VI

Target: Apoptosis, Others, Caspase

FERULIC ACID METHYL ESTER

Cat.No: TL0004

Synonym: 阿魏酸甲酯,Methyl ferulate,Methyl 4'-hydroxy-3'-methoxycinnamate

Target: p38 MAPK, Autophagy

Desoxo-narchinol A

Cat.No: TN3839

Target: ERK, IL Receptor, p38 MAPK, TNF, NOS, NF-κB, COX, Prostaglandin Receptor, JNK

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