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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T8133	SulfadiMethoxine sodium	Anti-infection; Antibacterial; Antibiotic	Microbiology/Virology
	SulfadiMethoxine sodium 是一种磺胺类抗生素，可研究由多种感染引起的疾病。
T1078	Sulfadimethoxine Sulphadimethoxine,磺胺二甲氧嗪	Antibacterial; Antibiotic	Microbiology/Virology
	Sulfadimethoxine (Sulphadimethoxine) 是一种磺胺类抗生素，用于多种感染引起的疾病的研究。
T7808	Alacepril Cetapril,阿拉普利,DU-1219	RAAS	Endocrinology/Hormones
	Alacepril (DU-1219) 是一种具有口服活性血管紧张素转换酶 (ACE) 抑制剂，具有长效抗高血压作用。
T12732	Rezafungin 棘白菌素,SP-3025,CD101,Biafungin	Others; Antifungal	Microbiology/Virology; Others
	Rezafungin (SP-3025) 是一种长效的广谱棘皮菌素，对念珠菌、曲霉和肺孢子菌具有强效抗真菌活性。
T5376	Aranidipine 阿雷地平,MPC1304	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Aranidipine (MPC1304) 是一种钙通道拮抗剂，具有强效和持久的抗高血压作用。
T22316	Doxazosin UK 33274,多沙唑嗪	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Doxazosin (UK 33274) 是选择性的拮抗突触后的α1肾上腺素受体。
T1470L	Fexofenadine hydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Fexofenadine hydrochloride 是 terfenadine 的羧化代谢衍生物和长效选择性组胺 H1 受体拮抗剂，具有抗组胺活性。
T27636	Ispronicline AZD-3480,RJR-1734,AZD 3480,TC 1734,AZD3480,TC-01734,TC-1734-112	AChR	Neuroscience
	Ispronicline (TC-1734) 是一种具有口服活性、选择性和有效性的 α4β2 nAChR 部分激动剂，具有抗抑郁、神经保护和持久的认知作用。Ispronicline 对 α4β2 nAChR 具有很高的亲和力，Ki= 11 nM。
T0231	Amlodipine Besylate Amlodipine benzenesulfonate,苯磺酸氨氯地平	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Amlodipine Besylate (Amlodipine benzenesulfonate) 是可口服的二氢吡啶钙通道阻滞剂，有抗心绞痛作用。它通过阻断电压依赖性的 L 型钙通道，从而抑制钙离子内流，用于高血压和癌症的研究。
T3407L	Rapastinel acetate Rapastinel acetate (117928-94-6 Free base)	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Rapastinel acetate 是 N-甲基-D-天冬氨酸 (NMDA) 受体的调节剂和甘氨酸位点的部分激动剂，具有长效抗抑郁作用。
T8536	Filastatin	Antifungal	Microbiology/Virology
	Filastatin 是一种长效的白色念珠菌丝状体抑制剂，具有强大的抗真菌作用。它抑制真菌与聚苯乙烯和人类细胞的粘附，从酵母到菌丝的形态转变，抑制菌丝特异性 HWP1 启动子。
T6999	Teneligliptin hydrobromide Teneligliptin hydrobromide anhydrous,MP-513 (hydrobromide)	Others; Proteasome; DPP-4	Others; Proteases/Proteasome; Ubiquitination
	Teneligliptin hydrobromide (MP-513(hydrobromide)) 是β2肾上腺素能受体 (β2AR) 阻滞剂，具有抗高血压、抗氧化、清除自由基的活性。
T2180	Hexythiazox	Parasite	Microbiology/Virology
	Hexythiazox 是一种螨类生长调节剂和噻唑烷类杀螨剂，对多种螨类具有长效杀虫作用，适用于植物从萌芽到结果的任何生长阶段。
T24932	Vatanidipine AE-0047,AE 0047,AE0047	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Vatanidipine (AE0047) 是一种新型的双氢吡啶(DHP)型钙通道阻滞剂，具有缓慢起效的药理作用。在各种实验性高血压模型中观察到缓慢起效和持久的降压作用。
T15432	GSK256073	GPR; Others	Endocrinology/Hormones; GPCR/G Protein; Others
	GSK256073 是一种口服有活性的GPR109A 选择性激动剂，也是一种持久的人HCA2激动剂(pEC50:7.5) 。它能够减少脂降解，而显著改善葡萄糖稳态，对 2 型糖尿病和血脂异常具有潜在的研究价值。
T68129L1	Picumeterol FA Picumeterol FA(130641-36-0 Free base)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	picumeterol FA 是一种有效的选择性β2肾上腺素能受体激动剂。在体外和体内试验中，picumeterol FA 可产生持久的气道平滑肌松弛作用。picumeterol FA 是一种纯 R 对映异构体，可用于改善哮喘患者的肺功能和降低气道高反应性。
T38192	Unifiram	Others	Others
	Unifiram 是一种认知增强剂。 Unifiram 诱导大鼠海马 CA1 区场兴奋性突触后电位 (fEPSP) 幅度的持久增加 (EC50= 27 nM) 并增加大鼠大脑皮层中乙酰胆碱 (ACh) 的释放。
T6707	Tiotropium Bromide hydrate BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物	AChR	Neuroscience
	Tiotropium Bromide hydrate (BA-679 BR hydrate) 是长效的毒蕈碱受体拮抗剂，可用于治疗慢性阻塞性气道疾病 (COPD)。
T22659	Chlorisondamine diiodide	Others	Others
	long lasting nicotinic antagonist
T28914	Tak 187 Tak-187,Tak187
	Tak 187 is a long-lasting inhibitor of ergosterol biosynthesis.
T71189	RX 809055AX
	RX 809055AX is a long lasting opioid antagonist at mu and delta receptors.
T23965	DAT 582 DAT582,DAT-582
	DAT 582 is a novel serotonin3 receptor antagonist. It is also an effective and long-lasting antiemetic agent
T26305	U 67827E N-Ac-Asp-tyr(So3H)-nle-gly-trp-nle-asp-phe-NH2,U-67827E,U67827E
	U 67827E is a long-lasting cholecystokinin agonist. It acts by decreases food intake.
T11755	KF 13218	Histone Demethylase	Chromatin/Epigenetic
	KF 13218 is a selective, potent and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM.
T29182	YM-358 potassium hydrate YM-358,YM358,YM 358
	YM-358 potassium hydrate is an orally active and long-lasting antagonist of angiotensin type 1 receptor.
T70749	TY 11223
	TY 11223 is a chemically stable homoisocarbacyclin analog. It has showed potent and long-lasting activities in inhibiting platelet aggregation and a good selectivity in biological activities.
T71229	NA 0346
	NA 0346 is a derivative of SF 2370 that shows long lasting antihypertensive action as well as potent protein kinases inhibitory activity.
T70294	KAA-276 free base
	KAA-276 free base is a novel potent and long-lasting histamine HI-receptor antagonist with less-topical irritation, and can be topically administered by inhalation for the treatment of bronchial asthma.
T25669	Lercanidipine, (S)- (S)-Lercanidipine,(+)-Lercanidipine
	Lercanidipine, (S)-是 Lercanidipine 的异构体，一种降压化合物。Lercanidipine 是二氢吡啶类的钙通道阻滞剂，具有持久的降压作用和肾脏保护作用。
T68066	Eptastigmine
	Eptastigmine，一种有效且持久的胆碱酯酶抑制剂，用于治疗与年龄相关的记忆缺陷。
T69475	Dinalbuphine sebacate
	Dinalbuphine sebacate is a long-lasting prodrug of nalbuphine, acting as a moderate-efficacy partial agonist or antagonist of the μ-opioid receptor and as a high-efficacy partial agonist of the κ-opioid receptor.
T13121	Teneligliptin D8 MP-513 D8	Others	Others
	Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4.
T12732L	Rezafungin acetate Biafungin acetate,SP-3025 acetate,CD101 acetate	Others	Others
	Rezafungin acetate is an advanced echinocandin compound that exhibits broad-spectrum antifungal activity against Candida spp, Aspergillus spp, and Pneumocystis spp. This long-lasting next-generation medication showcases potent efficacy in combating fungal infections.
T70293	KAA-276 HCl
	KAA-276 HCl is the salt form of KAA-276 free base, a novel potent and long-lasting histamine HI-receptor antagonist with less-topical irritation, and can be topically administered by inhalation for the treatment of bronchial asthma.
TP1202	Calcitonin Gene Related Peptide (CGRP) II, rat CGRP II, rat
	Calcitonin Gene Related Peptide II is a potent, long-lasting vasodilator; activation of CGRP receptors on pancreatic β-cells increases plasma levels of pancreatic enzymes.
T63434	Abiraterone decanoate
	Abiraterone decanoate 是 Abiraterone 的前药，能够利用肌肉内 (IM) 递送提供 Abiraterone 的受控释放和长效 CYP17 抑制。
T41006	TFAX 488,TFP
	TFAX 488,TFP is a green fluorescent dye that demonstrates pH-insensitivity across an extensive range (pH 4-10). It provides highly intense and long-lasting conjugates with proteins or antibodies, such as goat anti-mouse IgG and streptavidin.
T61300	RBP4 inhibitor 1
	RBP4 inhibitor 1 (compound 43b) is an orally active and potent inhibitor of retinol-binding protein 4 (RBP4), exhibiting IC50 values of 28 nM and 110 nM for human and mouse RBP4, respectively. It effectively reduces blood RBP4 levels in mice, providing a long-lasting effect [1].
TP1885	[(pF)Phe4]Nociceptin(1-13)NH2
	Highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80). Displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronociceptive, hypotensive, negative inotrop
T25819	ML350 SR-2311,SR 2311,SR2311,ML-350,ML 350
	ML350 (CYM-50202) is a KOR (IC50: 12.6 nM) antagonist with good and moderate selectivity against the DOR and MOR. CYM-50202 displayed high solubility and excellent CNS penetration. CYM-50202 did not display long-lasting pharmacodynamic effects observed wi
T37748	Ivermectin B1b
	Ivermectin B1b is the minor component . It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening and very long-lasting hyperpolarization/depolarization of the neuron/muscle cell, thereby blocking further function.
T26452	A 80b A80b,A-80b
	A-80b is a synthesized pyridazino[4,5-b]indole derivate with potent and long-lasting antihypertensive activity. The decrease in diastolic pressure was greater than the decrease in systolic pressure and cardiac frequency was not modified significantly. A-8
T61654	PI3Kα-IN-9
	PI3Kα-IN-9 (compound 27) is a highly specific, orally active, and long-lasting inhibitor of PI3Kα, demonstrating potent inhibitory effects with IC50 values of 4.4, 128, 146, and 153 nM against PI3Kα, PI3Kγ, PI3Kδ, and PI3Kβ, respectively. Additionally, PI3Kα-IN-9 exhibits antiproliferative properties and effectively induces apoptosis. Given its characteristics, PI3Kα-IN-9 holds great potential for cancer research [1].
TP2012	JMV 449
	Potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analg
T41250	Teneligliptin hydrobromide hydrate
	Teneligliptin hydrobromide hydrate 是一种有效的 DPP-4抑制剂，可在体外竞争性抑制人血浆、大鼠血浆和重组人 DPP-4 ，IC50值约为 1 nM。
T18680	SD-36	Others	Others
	SD-36, a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), exhibits high specificity for STAT3 over other STAT members. It effectively targets both wild-type and mutated STAT3 proteins in cells, inhibiting their transcriptional activity (IC50=10 nM). The compound, consisting of the STAT3 inhibitor SI-109, a linker, and a CRBN ligand Lenalidomide analog for E3 ubiquitin ligase[1], demonstrates significant anti-tumor effects and achieves complete, long-lasting tumor regression in mouse mod...
T27799	LAS191859 LAS-191859,LAS 191859
	LAS191859 is a CRTH2/DP2 antagonist with IC50 values of 7.6, 9.58, 14 and 15.5nM for recombinant guinea pig, human, rat and mouse CRTH2/DP2 receptors, respectively. LAS191859 has a residence time half-life of 21h at CRTh2 that translates into a long-lasti
T75919	PL-017 TFA
	PL-017 TFA 是高效、选择性的 μ 阿片受体(μopioid receptor)激动剂，具有 5.5 nM 对125I-FK 33,824 与 μ 位点结合的 IC50 值。该化合物在大鼠中展现出持久且可逆的缓解疼痛效果。
T62985	Cofrogliptin
	Cofrogliptin (HSK7653) (compound 2) 是一种四氢吡喃衍生物，是一种口服具有活力的 DPP-4 抑制剂，具有长效降糖作用。Cofrogliptin (compound 2) 具有潜力进行 2 型糖尿病 (T2DM) 的研究。
T27595	Imarikiren HCl TAK-272 hydrochloride,TAK-272 HCl. Imarikiren HCl \|,TAK272,TAK 272,TAK-272
	Imarikiren is a potent, selective and orally active direct renin inhibitor. TAK-272 shows potent inhibitory activity against human renin (IC50 = 2.1 nM) in hPRA assay and excellent selectivity against other aspartic proteases, such as cathepsin D (IC50 >

化合物

SulfadiMethoxine sodium

Cat.No: T8133

Target: Anti-infection, Antibacterial, Antibiotic

Sulfadimethoxine

Cat.No: T1078

Synonym: Sulphadimethoxine,磺胺二甲氧嗪

Target: Antibacterial, Antibiotic

Cat.No: T7808

Synonym: Cetapril,阿拉普利,DU-1219

Target: RAAS

Cat.No: T12732

Synonym: 棘白菌素,SP-3025,CD101,Biafungin

Target: Others, Antifungal

Cat.No: T5376

Synonym: 阿雷地平,MPC1304

Target: Calcium Channel

Cat.No: T22316

Synonym: UK 33274,多沙唑嗪

Target: Adrenergic Receptor

Fexofenadine hydrochloride

Cat.No: T1470L

Target: Histamine Receptor

Cat.No: T27636

Synonym: AZD-3480,RJR-1734,AZD 3480,TC 1734,AZD3480,TC-01734,TC-1734-112

Target: AChR

Amlodipine Besylate

Cat.No: T0231

Synonym: Amlodipine benzenesulfonate,苯磺酸氨氯地平

Target: Calcium Channel

Rapastinel acetate

Cat.No: T3407L

Synonym: Rapastinel acetate (117928-94-6 Free base)

Target: NMDAR, iGluR

Cat.No: T8536

Target: Antifungal

Teneligliptin hydrobromide

Cat.No: T6999

Synonym: Teneligliptin hydrobromide anhydrous,MP-513 (hydrobromide)

Target: Others, Proteasome, DPP-4

Cat.No: T2180

Target: Parasite

Cat.No: T24932

Synonym: AE-0047,AE 0047,AE0047

Target: Calcium Channel

Cat.No: T15432

Target: GPR, Others

Cat.No: T68129L1

Synonym: Picumeterol FA(130641-36-0 Free base)

Target: Adrenergic Receptor

Cat.No: T38192

Target: Others

Tiotropium Bromide hydrate

Cat.No: T6707

Synonym: BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物

Target: AChR

Chlorisondamine diiodide

Cat.No: T22659

Target: Others

Cat.No: T28914

Synonym: Tak-187,Tak187

Cat.No: T71189

Cat.No: T23965

Synonym: DAT582,DAT-582

Cat.No: T26305

Synonym: N-Ac-Asp-tyr(So3H)-nle-gly-trp-nle-asp-phe-NH2,U-67827E,U67827E

Cat.No: T11755

Target: Histone Demethylase

YM-358 potassium hydrate

Cat.No: T29182

Synonym: YM-358,YM358,YM 358

Cat.No: T70749

Cat.No: T71229

KAA-276 free base

Cat.No: T70294

Lercanidipine, (S)-

Cat.No: T25669

Synonym: (S)-Lercanidipine,(+)-Lercanidipine

Cat.No: T68066

Dinalbuphine sebacate

Cat.No: T69475

Teneligliptin D8

Cat.No: T13121

Synonym: MP-513 D8

Target: Others

Rezafungin acetate

Cat.No: T12732L

Synonym: Biafungin acetate,SP-3025 acetate,CD101 acetate

Target: Others

Cat.No: T70293

Calcitonin Gene Related Peptide (CGRP) II, rat

Cat.No: TP1202

Synonym: CGRP II, rat

Abiraterone decanoate

Cat.No: T63434

Cat.No: T41006

RBP4 inhibitor 1

Cat.No: T61300

[(pF)Phe4]Nociceptin(1-13)NH2

Cat.No: TP1885

Cat.No: T25819

Synonym: SR-2311,SR 2311,SR2311,ML-350,ML 350

Cat.No: T37748

Cat.No: T26452

Synonym: A80b,A-80b

Cat.No: T61654

Cat.No: TP2012

Teneligliptin hydrobromide hydrate

Cat.No: T41250

Cat.No: T18680

Target: Others

Cat.No: T27799

Synonym: LAS-191859,LAS 191859

Cat.No: T75919

Cat.No: T62985

Cat.No: T27595

Synonym: TAK-272 hydrochloride,TAK-272 HCl. Imarikiren HCl |,TAK272,TAK 272,TAK-272

Cat. No.	Product Name	Target	Signaling Pathways
T68746	Chaetochromin
	Chaetochromin also known as 4548-G05 and NSC 345647, is an orally active, small-molecule, selective agonist of the insulin receptor. It has potent and long-lasting antidiabetic activity in vivo in mice.

天然产物

Cat.No: T68746

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