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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T8133	SulfadiMethoxine sodium	Anti-infection; Antibacterial; Antibiotic	Microbiology/Virology
	SulfadiMethoxine sodium 是一种磺胺类抗生素，可研究由多种感染引起的疾病。
T1078	Sulfadimethoxine Sulphadimethoxine,磺胺二甲氧嗪	Antibacterial; Antibiotic	Microbiology/Virology
	Sulfadimethoxine (Sulphadimethoxine) 是一种磺胺类抗生素，用于多种感染引起的疾病的研究。
T7808	Alacepril Cetapril,阿拉普利,DU-1219	RAAS	Endocrinology/Hormones
	Alacepril (DU-1219) 是一种具有口服活性血管紧张素转换酶 (ACE) 抑制剂，具有长效抗高血压作用。
T12732	Rezafungin 棘白菌素,SP-3025,CD101,Biafungin	Others; Antifungal	Microbiology/Virology; Others
	Rezafungin (SP-3025) 是一种长效的广谱棘皮菌素，对念珠菌、曲霉和肺孢子菌具有强效抗真菌活性。
T5376	Aranidipine 阿雷地平,MPC1304	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Aranidipine (MPC1304) 是一种钙通道拮抗剂，具有强效和持久的抗高血压作用。
T22316	Doxazosin UK 33274,多沙唑嗪	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Doxazosin (UK 33274) 是选择性的拮抗突触后的α1肾上腺素受体。
T1470L	Fexofenadine hydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Fexofenadine hydrochloride 是 terfenadine 的羧化代谢衍生物和长效选择性组胺 H1 受体拮抗剂，具有抗组胺活性。
T27636	Ispronicline AZD-3480,RJR-1734,AZD 3480,TC 1734,AZD3480,TC-01734,TC-1734-112	AChR	Neuroscience
	Ispronicline (TC-1734) 是一种具有口服活性、选择性和有效性的 α4β2 nAChR 部分激动剂，具有抗抑郁、神经保护和持久的认知作用。Ispronicline 对 α4β2 nAChR 具有很高的亲和力，Ki= 11 nM。
T3407L	Rapastinel acetate Rapastinel acetate (117928-94-6 Free base)	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Rapastinel acetate 是 N-甲基-D-天冬氨酸 (NMDA) 受体的调节剂和甘氨酸位点的部分激动剂，具有长效抗抑郁作用。
T0231	Amlodipine Besylate Amlodipine benzenesulfonate,苯磺酸氨氯地平	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Amlodipine Besylate (Amlodipine benzenesulfonate) 是可口服的二氢吡啶钙通道阻滞剂，有抗心绞痛作用。它通过阻断电压依赖性的 L 型钙通道，从而抑制钙离子内流，用于高血压和癌症的研究。
T8536	Filastatin	Antifungal	Microbiology/Virology
	Filastatin 是一种长效的白色念珠菌丝状体抑制剂，具有强大的抗真菌作用。它抑制真菌与聚苯乙烯和人类细胞的粘附，从酵母到菌丝的形态转变，抑制菌丝特异性 HWP1 启动子。
T6999	Teneligliptin hydrobromide Teneligliptin hydrobromide anhydrous,MP-513 (hydrobromide)	Others; Proteasome; DPP-4	Others; Proteases/Proteasome; Ubiquitination
	Teneligliptin hydrobromide (MP-513(hydrobromide)) 是β2肾上腺素能受体 (β2AR) 阻滞剂，具有抗高血压、抗氧化、清除自由基的活性。
T2180	Hexythiazox	Parasite	Microbiology/Virology
	Hexythiazox 是一种螨类生长调节剂和噻唑烷类杀螨剂，对多种螨类具有长效杀虫作用，适用于植物从萌芽到结果的任何生长阶段。
T24932	Vatanidipine AE-0047,AE 0047,AE0047	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Vatanidipine (AE0047) 是一种新型的双氢吡啶(DHP)型钙通道阻滞剂，具有缓慢起效的药理作用。在各种实验性高血压模型中观察到缓慢起效和持久的降压作用。
T15432	GSK256073	GPR; Others	Endocrinology/Hormones; GPCR/G Protein; Others
	GSK256073 是一种口服有活性的GPR109A 选择性激动剂，也是一种持久的人HCA2激动剂(pEC50:7.5) 。它能够减少脂降解，而显著改善葡萄糖稳态，对 2 型糖尿病和血脂异常具有潜在的研究价值。
T38192	Unifiram	Others	Others
	Unifiram 是一种认知增强剂。 Unifiram 诱导大鼠海马 CA1 区场兴奋性突触后电位 (fEPSP) 幅度的持久增加 (EC50= 27 nM) 并增加大鼠大脑皮层中乙酰胆碱 (ACh) 的释放。
T68129L1	Picumeterol FA Picumeterol FA(130641-36-0 Free base)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	picumeterol FA 是一种有效的选择性β2肾上腺素能受体激动剂。在体外和体内试验中，picumeterol FA 可产生持久的气道平滑肌松弛作用。picumeterol FA 是一种纯 R 对映异构体，可用于改善哮喘患者的肺功能和降低气道高反应性。
T6707	Tiotropium Bromide hydrate BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物	AChR	Neuroscience
	Tiotropium Bromide hydrate (BA-679 BR hydrate) 是长效的毒蕈碱受体拮抗剂，可用于治疗慢性阻塞性气道疾病 (COPD)。
T22659	Chlorisondamine diiodide	Others	Others
	long lasting nicotinic antagonist
T28914	Tak 187 Tak-187,Tak187
	Tak 187 is a long-lasting inhibitor of ergosterol biosynthesis.
T71189	RX 809055AX
	RX 809055AX is a long lasting opioid antagonist at mu and delta receptors.
T23965	DAT 582 DAT582,DAT-582
	DAT 582 is a novel serotonin3 receptor antagonist. It is also an effective and long-lasting antiemetic agent
T11755	KF 13218	Histone Demethylase	Chromatin/Epigenetic
	KF 13218 is a selective, potent and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM.
T26305	U 67827E N-Ac-Asp-tyr(So3H)-nle-gly-trp-nle-asp-phe-NH2,U-67827E,U67827E
	U 67827E is a long-lasting cholecystokinin agonist. It acts by decreases food intake.
T70749	TY 11223
	TY 11223 is a chemically stable homoisocarbacyclin analog. It has showed potent and long-lasting activities in inhibiting platelet aggregation and a good selectivity in biological activities.
T29182	YM-358 potassium hydrate YM-358,YM358,YM 358
	YM-358 potassium hydrate is an orally active and long-lasting antagonist of angiotensin type 1 receptor.
T71229	NA 0346
	NA 0346 is a derivative of SF 2370 that shows long lasting antihypertensive action as well as potent protein kinases inhibitory activity.
T13121	Teneligliptin D8 MP-513 D8	Others	Others
	Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4.
T70294	KAA-276 free base
	KAA-276 free base is a novel potent and long-lasting histamine HI-receptor antagonist with less-topical irritation, and can be topically administered by inhalation for the treatment of bronchial asthma.
T25669	Lercanidipine, (S)- (S)-Lercanidipine,(+)-Lercanidipine
	Lercanidipine, (S)-是 Lercanidipine 的异构体，一种降压化合物。Lercanidipine 是二氢吡啶类的钙通道阻滞剂，具有持久的降压作用和肾脏保护作用。
T68066	Eptastigmine
	Eptastigmine，一种有效且持久的胆碱酯酶抑制剂，用于治疗与年龄相关的记忆缺陷。
T69475	Dinalbuphine sebacate
	Dinalbuphine sebacate is a long-lasting prodrug of nalbuphine, acting as a moderate-efficacy partial agonist or antagonist of the μ-opioid receptor and as a high-efficacy partial agonist of the κ-opioid receptor.
T70293	KAA-276 HCl
	KAA-276 HCl is the salt form of KAA-276 free base, a novel potent and long-lasting histamine HI-receptor antagonist with less-topical irritation, and can be topically administered by inhalation for the treatment of bronchial asthma.
T12732L	Rezafungin acetate Biafungin acetate,SP-3025 acetate,CD101 acetate	Others	Others
	Rezafungin acetate is an advanced echinocandin compound that exhibits broad-spectrum antifungal activity against Candida spp, Aspergillus spp, and Pneumocystis spp. This long-lasting next-generation medication showcases potent efficacy in combating fungal infections.
TP1202	Calcitonin Gene Related Peptide (CGRP) II, rat CGRP II, rat
	Calcitonin Gene Related Peptide II is a potent, long-lasting vasodilator; activation of CGRP receptors on pancreatic β-cells increases plasma levels of pancreatic enzymes.
T41006	TFAX 488,TFP
	TFAX 488,TFP is a green fluorescent dye that demonstrates pH-insensitivity across an extensive range (pH 4-10). It provides highly intense and long-lasting conjugates with proteins or antibodies, such as goat anti-mouse IgG and streptavidin.
T63434	Abiraterone decanoate
	Abiraterone decanoate 是 Abiraterone 的前药，能够利用肌肉内 (IM) 递送提供 Abiraterone 的受控释放和长效 CYP17 抑制。
T61300	RBP4 inhibitor 1
	RBP4 inhibitor 1 (compound 43b) is an orally active and potent inhibitor of retinol-binding protein 4 (RBP4), exhibiting IC50 values of 28 nM and 110 nM for human and mouse RBP4, respectively. It effectively reduces blood RBP4 levels in mice, providing a long-lasting effect [1].
TP1885	[(pF)Phe4]Nociceptin(1-13)NH2
	Highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80). Displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronociceptive, hypotensive, negative inotrop
T25819	ML350 SR-2311,SR 2311,SR2311,ML-350,ML 350
	ML350 (CYM-50202) is a KOR (IC50: 12.6 nM) antagonist with good and moderate selectivity against the DOR and MOR. CYM-50202 displayed high solubility and excellent CNS penetration. CYM-50202 did not display long-lasting pharmacodynamic effects observed wi
T26452	A 80b A80b,A-80b
	A-80b is a synthesized pyridazino[4,5-b]indole derivate with potent and long-lasting antihypertensive activity. The decrease in diastolic pressure was greater than the decrease in systolic pressure and cardiac frequency was not modified significantly. A-8
T37748	Ivermectin B1b
	Ivermectin B1b is the minor component . It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening and very long-lasting hyperpolarization/depolarization of the neuron/muscle cell, thereby blocking further function.
T61654	PI3Kα-IN-9
	PI3Kα-IN-9 (compound 27) is a highly specific, orally active, and long-lasting inhibitor of PI3Kα, demonstrating potent inhibitory effects with IC50 values of 4.4, 128, 146, and 153 nM against PI3Kα, PI3Kγ, PI3Kδ, and PI3Kβ, respectively. Additionally, PI3Kα-IN-9 exhibits antiproliferative properties and effectively induces apoptosis. Given its characteristics, PI3Kα-IN-9 holds great potential for cancer research [1].
T41250	Teneligliptin hydrobromide hydrate
	Teneligliptin hydrobromide hydrate 是一种有效的 DPP-4抑制剂，可在体外竞争性抑制人血浆、大鼠血浆和重组人 DPP-4 ，IC50值约为 1 nM。
TP2012	JMV 449
	Potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analg
T18680	SD-36	Others	Others
	SD-36, a potent and efficacious PROTAC STAT3 degrader (Kd=~50 nM), exhibits high specificity for STAT3 over other STAT members. It effectively targets both wild-type and mutated STAT3 proteins in cells, inhibiting their transcriptional activity (IC50=10 nM). The compound, consisting of the STAT3 inhibitor SI-109, a linker, and a CRBN ligand Lenalidomide analog for E3 ubiquitin ligase[1], demonstrates significant anti-tumor effects and achieves complete, long-lasting tumor regression in mouse mod...
T75919	PL-017 TFA
	PL-017 TFA 是高效、选择性的 μ 阿片受体(μopioid receptor)激动剂，具有 5.5 nM 对125I-FK 33,824 与 μ 位点结合的 IC50 值。该化合物在大鼠中展现出持久且可逆的缓解疼痛效果。
T27799	LAS191859 LAS-191859,LAS 191859
	LAS191859 is a CRTH2/DP2 antagonist with IC50 values of 7.6, 9.58, 14 and 15.5nM for recombinant guinea pig, human, rat and mouse CRTH2/DP2 receptors, respectively. LAS191859 has a residence time half-life of 21h at CRTh2 that translates into a long-lasti
T62985	Cofrogliptin
	Cofrogliptin (HSK7653) (compound 2) 是一种四氢吡喃衍生物，是一种口服具有活力的 DPP-4 抑制剂，具有长效降糖作用。Cofrogliptin (compound 2) 具有潜力进行 2 型糖尿病 (T2DM) 的研究。
T75868	JMV 449 acetate
	JMV 449 acetate 是一种有效的神经降压素受体 (neurotensin receptor) 激动剂。JMV 449 acetate 显示抑制125I-neurotensin 与新生小鼠脑结合的 IC50为 0.15 nM，对收缩豚鼠回肠的 EC50为 1.9 nM。JMV 449 acetate 对小鼠具有高效、持久的降温和缓解疼痛作用。

化合物

SulfadiMethoxine sodium

Cat.No: T8133

Target: Anti-infection, Antibacterial, Antibiotic

Sulfadimethoxine

Cat.No: T1078

Synonym: Sulphadimethoxine,磺胺二甲氧嗪

Target: Antibacterial, Antibiotic

Cat.No: T7808

Synonym: Cetapril,阿拉普利,DU-1219

Target: RAAS

Cat.No: T12732

Synonym: 棘白菌素,SP-3025,CD101,Biafungin

Target: Others, Antifungal

Cat.No: T5376

Synonym: 阿雷地平,MPC1304

Target: Calcium Channel

Cat.No: T22316

Synonym: UK 33274,多沙唑嗪

Target: Adrenergic Receptor

Fexofenadine hydrochloride

Cat.No: T1470L

Target: Histamine Receptor

Cat.No: T27636

Synonym: AZD-3480,RJR-1734,AZD 3480,TC 1734,AZD3480,TC-01734,TC-1734-112

Target: AChR

Rapastinel acetate

Cat.No: T3407L

Synonym: Rapastinel acetate (117928-94-6 Free base)

Target: NMDAR, iGluR

Amlodipine Besylate

Cat.No: T0231

Synonym: Amlodipine benzenesulfonate,苯磺酸氨氯地平

Target: Calcium Channel

Cat.No: T8536

Target: Antifungal

Teneligliptin hydrobromide

Cat.No: T6999

Synonym: Teneligliptin hydrobromide anhydrous,MP-513 (hydrobromide)

Target: Others, Proteasome, DPP-4

Cat.No: T2180

Target: Parasite

Cat.No: T24932

Synonym: AE-0047,AE 0047,AE0047

Target: Calcium Channel

Cat.No: T15432

Target: GPR, Others

Cat.No: T38192

Target: Others

Cat.No: T68129L1

Synonym: Picumeterol FA(130641-36-0 Free base)

Target: Adrenergic Receptor

Tiotropium Bromide hydrate

Cat.No: T6707

Synonym: BA-679 BR hydrate,BA 679BR,噻托溴铵一水合物

Target: AChR

Chlorisondamine diiodide

Cat.No: T22659

Target: Others

Cat.No: T28914

Synonym: Tak-187,Tak187

Cat.No: T71189

Cat.No: T23965

Synonym: DAT582,DAT-582

Cat.No: T11755

Target: Histone Demethylase

Cat.No: T26305

Synonym: N-Ac-Asp-tyr(So3H)-nle-gly-trp-nle-asp-phe-NH2,U-67827E,U67827E

Cat.No: T70749

YM-358 potassium hydrate

Cat.No: T29182

Synonym: YM-358,YM358,YM 358

Cat.No: T71229

Teneligliptin D8

Cat.No: T13121

Synonym: MP-513 D8

Target: Others

KAA-276 free base

Cat.No: T70294

Lercanidipine, (S)-

Cat.No: T25669

Synonym: (S)-Lercanidipine,(+)-Lercanidipine

Cat.No: T68066

Dinalbuphine sebacate

Cat.No: T69475

Cat.No: T70293

Rezafungin acetate

Cat.No: T12732L

Synonym: Biafungin acetate,SP-3025 acetate,CD101 acetate

Target: Others

Calcitonin Gene Related Peptide (CGRP) II, rat

Cat.No: TP1202

Synonym: CGRP II, rat

Cat.No: T41006

Abiraterone decanoate

Cat.No: T63434

RBP4 inhibitor 1

Cat.No: T61300

[(pF)Phe4]Nociceptin(1-13)NH2

Cat.No: TP1885

Cat.No: T25819

Synonym: SR-2311,SR 2311,SR2311,ML-350,ML 350

Cat.No: T26452

Synonym: A80b,A-80b

Cat.No: T37748

Cat.No: T61654

Teneligliptin hydrobromide hydrate

Cat.No: T41250

Cat.No: TP2012

Cat.No: T18680

Target: Others

Cat.No: T75919

Cat.No: T27799

Synonym: LAS-191859,LAS 191859

Cat.No: T62985

JMV 449 acetate

Cat.No: T75868

Cat. No.	Product Name	Target	Signaling Pathways
T68746	Chaetochromin
	Chaetochromin also known as 4548-G05 and NSC 345647, is an orally active, small-molecule, selective agonist of the insulin receptor. It has potent and long-lasting antidiabetic activity in vivo in mice.

天然产物

Cat.No: T68746

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