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Search Results for " inotropic "

56

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5033	Olprinone 奥普力农,Loprinone	PDE	Metabolism
	Olprinone (Loprinone) 是一种有效的磷酸二酯酶(PDE) 3抑制剂，对 PDE1，PDE2，PDE3，PDE4 的IC50分别为 150、100、0.35 和 14 μM，具有抗炎活性。它具有正性肌力和血管扩张作用，可用于心力衰竭的研究。
T1265	Amrinone Inamrinone,Inocor,氨力农,Wincoram	TNF; PDE	Apoptosis; Metabolism
	Amrinone (Inocor) 是一种正性肌力血管扩张剂，是一种具有口服活性的，非糖苷和非儿茶酚胺的强心剂，也是一种选择性磷酸二酯酶 III (phosphodiesterase III) 抑制剂，能够防止环磷酸腺苷分解，从而增加环磷酸腺苷水平。
T15050	Danicamtiv MYK-491,SAR 440181	Myosin	Cytoskeletal Signaling
	Danicamtiv (MYK-491) 是一种正性肌力药物，也是一种心肌肌球蛋白的选择性变构激活剂，可增加心脏收缩功能并保持机械效率。
T3465	Vesnarinone 维司力农,OPC-8212,Arkin,Piteranometozine	HIV Protease; PDE	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Vesnarinone (Arkin) 是一种喹啉酮衍生物，可抑制磷酸二酯酶III 活性，增加钙通量和减小钾通量。
T1320	Disopyramide Triombrin,Hypaque sodium,amidotrizoate sodium,达舒平	Potassium Channel; Sodium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Disopyramide (Triombrin) 是用于研究房性和室性心律失常的 IA 类抗心律失常试剂。它阻断心肌快速内向钠电流，延长心肌动作电位持续时间。它抑制 HERG 编码的钾通道。它也表现出复杂的蛋白质结合，并具有强大的负性肌力作用。
T33806	Opc 18750 Opc18750,Opc-18750	Others	Others
	Opc 18750 是一种具有选择性和正性肌力作用的化合物。
T33589	Nanterinone UK-61260,UK61260,UK 61260	PDE	Metabolism
	Nanterinone (UK 61260) 是一种口服的部分磷酸二酯酶抑制剂，是一种新型的正性肌力和平衡血管扩张化合物。Nanterinone 口服后，可使急性血流动力学得到明显改善，这可能取决于先前存在的左心室充盈压。
T21457	Carbazeran UK-31557,UK31,557,UK-31,557,UK31557,UK 31557,卡巴折伦,UK 31,557	PDE	Metabolism
	Carbazeran (UK-31,557) 是 PDE2 和 PDE3 的抑制剂，可用于代谢疾病的研究。 Carbazeran 在体内显示出正性肌力和变时性作用 (EC50 = 100 μM)。
T71744	Imazodan	PDE	Metabolism
	Imazodan 是一种具有正性肌力活性的小分子化合物，是选择性III型磷酸二酯酶抑制剂，可用于研究心力衰竭。
T83974	OPC18750 HCl	PDE	Metabolism
	OPC18750 HCl 是一种潜在的磷酸二酯酶抑制剂，具有正肌力作用，可用于研究哮喘、癌症、糖尿病和精神疾病。
T14507	Bay 60-7550 BAY 607550	PDE	Metabolism
	Bay 60-7550 是一种具有选择性和高效性的 PDE2 抑制剂（Ki：3.8 nM），通过增加 PKA 介导的磷酸化来发挥大鼠心脏的正性肌力作用，可用于改善认知障碍和记忆障碍。
TP2044L	α-CGRP (human) acetate 人类降钙素基因相关肽 1,α-CGRP (human) acetate (90954-53-3 free base)	Others	Others
	α-CGRP (human) acetate 是一种由 37 个氨基酸组成的调节性神经肽。它是一种有效的血管扩张剂，具有正性肌力作用和变时性作用。
T2189	Sodium orthovanadate Sodium vanadate,钒酸钠,Trisodium vanadate,Sodium pervanadate	ATPase; Phosphatase	Membrane transporter/Ion channel; Metabolism
	Sodium orthovanadate 是一种蛋白酪氨酸磷酸酶，碱性磷酸酶和一些ATP 酶的抑制剂，有可能充当磷酸盐类似物。它具有胰岛素样作用、对心室肌的正性肌力作用和其他代谢作用。
T27205	DPI 201-106 DPI-201-106	Sodium Channel	Membrane transporter/Ion channel
	DPI 201-106对电压门控钠通道的有心脏选择性调节活性，从而产生正性肌力作用。DPI 201-106 具有协同肌膜和细胞内作用机制。
T3465L	Vesnarinone HCl Synonym 2,OPC-8212 HCl,Vesnarinone HCl(81840-15-5 Free base)	Potassium Channel; Calcium Channel; PDE	Membrane transporter/Ion channel; Metabolism
	Vesnarinone HCl (OPC-8212 HCl) 是一种具有口服活性的 phosphodiesterase 3 (PDE3) 抑制剂。Vesnarinone HCl 可对钙离子和钾离子进行调节，增加钙通量，减少钾通量。Vesnarinone HCl 是一种新的正性肌力化合物，可增强心肌收缩力，可用于心力衰竭的研究。
T0871	Noradrenaline bitartrate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Noradrenaline bitartrate 直接作用于 α 和 β 肾上腺素能受体。它是去甲肾上腺素的酒石酸氢盐，去甲肾上腺素是一种合成苯乙胺，可模拟内源性去甲肾上腺素的拟交感神经作用。临床上，去甲肾上腺素用作外周血管收缩剂，通过其α-肾上腺素能作用导致动脉和静脉床收缩。它还被用作通过其 β-1 肾上腺素能作用介导的强效正性肌力和变时性心脏刺激剂。
T32829	Lnd 623 Lnd-623,Lnd623
	Lnd 623 is an inotropic aminosteroid.
T33807	Opc 8490 Opc-8490,Opc8490
	Opc 8490 is a positive inotropic agent.
T30286	BA 41899 BA41899,BA-41899
	BA 41899 is a positive inotropic Ca(2+)-sensitizing agent.
T15714	LAS-31180	Others	Others
	LAS-31180 is a phosphodiesterase 3 inhibitor. It also has positive inotropic and vasodilator properties.
T30197	ATI-22-107 ATI22-107
	ATI-22-107 is a positive cardiac inotropic agent which may affect myocyte calcium cycling and contractility.
T33805	OPC 18692 OPC-18692,OPC18692
	OPC 18692 is a metabolite of Vesnarinone, a positive inotropic drug developed for congestive heart failure.
T30956	CK 3197 CK3197,CK-3197
	CK 3197 is a selective positive inotropic agent for the treatment of congestive heart failure. It has hemodynamic and myocardial energetic effects.
T68979	Prenalterol (free base)
	Prenalterol (free base) is a selective inotropic beta-adrenoceptor agonist. It is used as a cardiac stimulant.
T27833	Liguzinediol
	Liguzinediol, a potent positive inotropic agent, inhibits myocardial cell apoptosis.
T70975	Carsatrin succinate
	Carsatrin succinate is the salt form of Carsatin, a purinylpiperazine derivative used as a cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+, K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbi...
T32997	LY 249933 LY249933,LY-249933
	LY 249933 is a cardioselective 1, 4-dihydropyridine with positive inotropic activity.
T68742	Inamrinone lactate
	Inamrinone lactate is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
T80461	Anthopleurin-C	Sodium Channel	Membrane transporter/Ion channel
	Anthopleurin-C (APE 2-1)为一种正性肌力作用显著的强心多肽。
T71122	Carsatrin (free base)
	Carsatrin is purinylpiperazine derivative. as cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+, K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbine, or prazosin
T14967	Cimlanod BMS-986231,CXL-1427	Others	Others
	Cimlanod is a second-generation Nitroxyl (HNO) donor for heart failure with positive lusitropic and inotropic as well as vasodilatory effects. Cimlanod delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloo
T33589L	Nanterinone mesylate UK61260,UK-61260,UK 61260
	Nanterinone Mesylate is the mesylate form of Nanterinone that is a novel positive inotropic and balanced vasodilator.
T21424	Disopyramide phosphate SC13957,SC 13957,SC-13957
	Disopyramide, a sodium channel blocker in the Class of 1a anti-arrhythmic agent, is used in the treatment of Ventricular Tachycardia. Disopyramide has a negative inotropic effect on the ventricular myocardium, resulting in a significant decrease in contra
T68782	Ono 11006
	Ono 11006 is a thromboxane agonist that dose dependently reduced the positive inotropic effect induced by field stimulation.
T16769	Ro 363	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	RO 363 is an effective inotropic stimulant and is a cardiovascular modulator that decreases diastolic blood pressure and pronounces increases in myocardial contractility. Ro 363 is an effective and highly selective β1-adrenoceptor agonist.
T11609	ICI 153110	Others	Others
	ICI 153110 is an orally active phosphodiesterase inhibitor with both inotropic and vasodilating properties. It is designed for the treatment of congestive cardiac failure.
T68600	Enoximone sulfoxide
	Enoximone sulfoxide is a selective phosphodiesterase III (PDE3) inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. Enoximone prevents the degradation of cAMP by PDE, which prolongs signal transduction and its subsequent effects. It is used in patients with congestive heart failure.
T69239	Nylidrin
	Nylidrin is a beta-adrenergic agonist. Nylidrin causes peripheral vasodilation, a positive inotropic effect, and increased gastric volume of gastric juice. It is used in the treatment of peripheral vascular disorders and premature labor.
T69107	Doxaminol
	Doxaminol is a synthetic partial beta-adrenergic agonist with sympathomimetic activity. Doxaminol may bind to and stimulate beta-1-adrenergic receptors located in the myocardium. As a result, it leads to a positive inotropic effect and increases in cardiac output.
T69084	Mabuterol, (R)-
	Mabuterol, (R)- is a D isoform of Mabuterol, which is a selective β2 adrenoreceptor agonist. Mabuterol has been found to decrease the blood pressure in rats and increase heart rate and contractile force in guinea pigs. Mabuterol inhibited the positive inotropic effect of isoprenaline but has no effect on alpha-adrenergic, acetylcholine and histamine receptors.
T69000	Prenalterol hydrochloride
	Prenalterol hydrochloride is a partial adrenergic agonist with functional beta 1-receptor specificity and inotropic effect. It is effective in the treatment of acute cardiac failure, postmyocardial infarction low-output syndrome, shock, and reducing orthostatic hypotension in the Shy-Drager syndrome.
T69085	Mabuterol, (S)-
	Mabuterol, (S)- is a D isoform of Mabuterol, which is a selective β2 adrenoreceptor agonist. Mabuterol has been found to decrease the blood pressure in rats and increase heart rate and contractile force in guinea pigs. Mabuterol inhibited the positive inotropic effect of isoprenaline but has no effect on alpha-adrenergic, acetylcholine and histamine receptors.
T68242	D-Mabuterol hydrochloride
	D-Mabuterol hydrochloride is a D isoform of Mabuterol, which is a selective β2 adrenoreceptor agonist. Mabuterol has been found to decrease the blood pressure in rats and increase heart rate and contractile force in guinea pigs. Mabuterol inhibited the positive inotropic effect of isoprenaline but has no effect on alpha-adrenergic, acetylcholine and histamine receptors.
T27970	Mabuterol free base Mabuterol,PB 868Cl	Others	Others
	Mabuterol is a selective agonist of β2 adrenoreceptor with no beta 1-stimulation. Mabuterol inhibited the positive inotropic effect of isoprenaline at 10(-7) g/ml and decreased the maximum driving frequency at 3 X 10(-6) g/ml. Mabuterol was 3 times more p
TP1885	[(pF)Phe4]Nociceptin(1-13)NH2
	Highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80). Displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronociceptive, hypotensive, negative inotrop
TP2000	MM 07
	Apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in vitro. Shows positive inotropic an
T69119	Disopyramide HCl
	Disopyramide HCl is the salt form of Disopyramide, an antiarrhythmic medication used in the treatment of ventricular tachycardia. It is a sodium channel blocker and therefore classified as a Class 1a anti-arrhythmic agent. Disopyramide has a negative inotropic effect on the ventricular myocardium, significantly decreasing the contractility. Disopyramide also has an anticholinergic effect on the heart which accounts for many adverse side effects. Disopyramide is available in both oral and intrave...
T61918	Ro 363 hydrochloride
	Ro 363 hydrochloride 是一种有效的，高度选择性的 β1 肾上腺素受体 (β1-adrenoceptor) 激动剂。Ro 363 hydrochloride 是有效的正性肌力活化剂。Ro 363 hydrochloride 是心血管调节剂，可降低舒张压，显著增加心肌收缩力。
T69975	Istaroxime oxalate
	Istaroxime, also known as PST-2744, is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase). Na+/K+ ATPase inhibition increases intracellular sodium levels, which reverses the driving force of the sodium/calcium exchanger, inhibiting calcium extrusion and possibly facilitating calcium entry. Additionally, Istaroxime increases intracellular calcium by improving the efficacy by which intracellular calcium triggers sarco...
T36547	Quazinone
	Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties.1,2 It induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 μM).1 Quazinone (10-300 μg/kg) increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner, as well as decreases systolic and diastolic blood pressure.2 It also inhibits DNA synthesis induced by the PDGF isoform PDGF-BB in bovine coronary artery smoot...

化合物

Cat.No: T5033

Synonym: 奥普力农,Loprinone

Target: PDE

Cat.No: T1265

Synonym: Inamrinone,Inocor,氨力农,Wincoram

Target: TNF, PDE

Cat.No: T15050

Synonym: MYK-491,SAR 440181

Target: Myosin

Cat.No: T3465

Synonym: 维司力农,OPC-8212,Arkin,Piteranometozine

Target: HIV Protease, PDE

Cat.No: T1320

Synonym: Triombrin,Hypaque sodium,amidotrizoate sodium,达舒平

Target: Potassium Channel, Sodium Channel, AChR

Cat.No: T33806

Synonym: Opc18750,Opc-18750

Target: Others

Cat.No: T33589

Synonym: UK-61260,UK61260,UK 61260

Target: PDE

Cat.No: T21457

Synonym: UK-31557,UK31,557,UK-31,557,UK31557,UK 31557,卡巴折伦,UK 31,557

Target: PDE

Cat.No: T71744

Target: PDE

Cat.No: T83974

Target: PDE

Cat.No: T14507

Synonym: BAY 607550

Target: PDE

α-CGRP (human) acetate

Cat.No: TP2044L

Synonym: 人类降钙素基因相关肽 1,α-CGRP (human) acetate (90954-53-3 free base)

Target: Others

Sodium orthovanadate

Cat.No: T2189

Synonym: Sodium vanadate,钒酸钠,Trisodium vanadate,Sodium pervanadate

Target: ATPase, Phosphatase

Cat.No: T27205

Synonym: DPI-201-106

Target: Sodium Channel

Vesnarinone HCl

Cat.No: T3465L

Synonym: Synonym 2,OPC-8212 HCl,Vesnarinone HCl(81840-15-5 Free base)

Target: Potassium Channel, Calcium Channel, PDE

Noradrenaline bitartrate

Cat.No: T0871

Target: Adrenergic Receptor

Cat.No: T32829

Synonym: Lnd-623,Lnd623

Cat.No: T33807

Synonym: Opc-8490,Opc8490

Cat.No: T30286

Synonym: BA41899,BA-41899

Cat.No: T15714

Target: Others

Cat.No: T30197

Synonym: ATI22-107

Cat.No: T33805

Synonym: OPC-18692,OPC18692

Cat.No: T30956

Synonym: CK3197,CK-3197

Prenalterol (free base)

Cat.No: T68979

Cat.No: T27833

Carsatrin succinate

Cat.No: T70975

Cat.No: T32997

Synonym: LY249933,LY-249933

Inamrinone lactate

Cat.No: T68742

Cat.No: T80461

Target: Sodium Channel

Carsatrin (free base)

Cat.No: T71122

Cat.No: T14967

Synonym: BMS-986231,CXL-1427

Target: Others

Nanterinone mesylate

Cat.No: T33589L

Synonym: UK61260,UK-61260,UK 61260

Disopyramide phosphate

Cat.No: T21424

Synonym: SC13957,SC 13957,SC-13957

Cat.No: T68782

Cat.No: T16769

Target: Adrenergic Receptor

Cat.No: T11609

Target: Others

Enoximone sulfoxide

Cat.No: T68600

Cat.No: T69239

Cat.No: T69107

Mabuterol, (R)-

Cat.No: T69084

Prenalterol hydrochloride

Cat.No: T69000

Mabuterol, (S)-

Cat.No: T69085

D-Mabuterol hydrochloride

Cat.No: T68242

Mabuterol free base

Cat.No: T27970

Synonym: Mabuterol,PB 868Cl

Target: Others

[(pF)Phe4]Nociceptin(1-13)NH2

Cat.No: TP1885

Cat.No: TP2000

Disopyramide HCl

Cat.No: T69119

Ro 363 hydrochloride

Cat.No: T61918

Istaroxime oxalate

Cat.No: T69975

Cat.No: T36547

Cat. No.	Product Name	Target	Signaling Pathways
T3920	Pseudoginsenoside F11 Ginsenoside A1,拟人参皂苷 F11,拟人参皂苷F11	Others; Endogenous Metabolite	Metabolism; Others
	Pseudoginsenoside F11 (Ginsenoside A1) 从人参根和叶中分离得到。PF11在一系列心血管和中枢神经系统疾病中具有广泛的保护作用。
T8149	Dobutamine hydrochloride 盐酸多巴酚丁胺,Dobutamine (hydrochloride)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Dobutamine hydrochloride (Dobutamine(hydrochloride)) 是一种合成的儿茶酚胺，可作用于肾上腺素能受体α1-AR、β1-AR 和β2-AR，是一种选择性的 β1-AR 受体激动剂，对 α1-AR 和 β2-AR 作用相对较弱。它能够增加心输出量，矫正低灌注。
T2939	Forskolin 毛喉素,Coleonol,Colforsin	FXR; Adenylyl cyclase; AChR; Autophagy	Autophagy; Metabolism; Neuroscience
	Forskolin (Coleonol) 属于天然产物，是一种腺苷酸环化酶激活剂 (EC50=0.5 μM)。Forskolin 可以增加 cAMP 水平，可以激活 PXR 和 FXR，也可以诱导细胞自噬。Forskolin 对心脏产生正性肌力作用，具有血小板抗凝集和降压作用。
T3S0629	Delsoline Belsoline,硬飞燕草碱	Others	Others
	Delsoline (Belsoline) 是一种还亮草的主要生物碱，具有类似箭毒的效果和神经节阻滞作用，可用于肌肉紧张或运动过度的缓解。其中还亮草具有祛风除湿，止痛，活络的功效，可用于风湿，偏瘫，消化不良和咳嗽的研究。
TN6519	Saucerneol
	Saucerneol has significant cardiovascular effects such as vasorelaxant and negative inotropic actions.
TN4616	N-Methyltaxol C	Others	Others
	N-methyltaxol C and paclitaxel can produce a positive inotropic effect in papillary muscle, without alterations in the action potential. They can induced conduction arrhythmias and reduce coronary flow and left ventricular systolic pressure in the isolate
T4S0823	Astragaloside	Others	Others
	Astragaloside 能够保护大鼠海马形态结构，恢复乙酰胆碱水平，并能够使脑电图正常化改善脑功能。

天然产物

Pseudoginsenoside F11

Cat.No: T3920

Synonym: Ginsenoside A1,拟人参皂苷 F11,拟人参皂苷F11

Target: Others, Endogenous Metabolite

Dobutamine hydrochloride

Cat.No: T8149

Synonym: 盐酸多巴酚丁胺,Dobutamine (hydrochloride)

Target: Adrenergic Receptor

Cat.No: T2939

Synonym: 毛喉素,Coleonol,Colforsin

Target: FXR, Adenylyl cyclase, AChR, Autophagy

Cat.No: T3S0629

Synonym: Belsoline,硬飞燕草碱

Target: Others

Cat.No: TN6519

N-Methyltaxol C

Cat.No: TN4616

Target: Others

Cat.No: T4S0823

Target: Others

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