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Search Results for " immune modulator "

19

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10696	CB2 modulator 1	Cannabinoid Receptor	GPCR/G Protein
	CB2 modulator 1 是一种有效的 CB2 调节剂。可用于免疫疾病、骨质疏松症、炎症、肾缺血的研究。
T62204	NR2F6 modulator-1	Others	Others
	NR2F6 modulator-1 是一种核受体亚族 2，F 组第 6 号成员 (NR2F6) 的有效调节剂。NR2F6 modulator-1 能够用于研究免疫调节和肿瘤干细胞活性的调节。
T16792	Rovazolac ALX-101	Liver X Receptor	Metabolism
	Rovazolac (ALX-101) 是一种肝脏x受体 (LXR)调节剂，可用于研究免疫系统疾病和特应性皮炎。
T36522	Isoallolithocholic acid Alloisolithocholic Acid,AILCA,3β-Hydroxy-5α-cholanic acid	Others	Others
	Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) 是一种 T 细胞调节剂，是一种胆汁酸代谢物，具有抗炎活性，与人类免疫稳态有关。
T72482	Dazostinag disodium	STING	Immunology/Inflammation
	Dazostinag disodium (TAK-676) 是一种新型干扰素基因刺激剂（STING）激动剂，也是一种免疫系统调节剂，具有抗肿瘤活性，可激活树突状细胞、自然杀伤细胞和 T 细胞。
T10824	cis-Urocanic acid cis-UCA,(Z)-Imidazole-4-acrylic acid,(Z)-Urocanic acid,(E)-Urocanic acid,(Z)-3-(1H-Imidazol-5-yl)acrylic acid,顺式-尿刊酸	5-HT Receptor	GPCR/G Protein; Neuroscience
	cis-Urocanic acid ((E)-Urocanic acid) 是一种 5-HT2A 受体激动剂，cis-Urocanic acid 与 5-HT 受体结合的Kd 为 4.6 nM。cis-Urocanic acid 是一种免疫调节剂，通过与 5-HT2A 受体结合而诱导免疫抑制。
T2539	Fingolimod hydrochloride Fingolimod (FTY720) HCl,FTY720,盐酸芬戈莫德	TRP/TRPV Channel; S1P Receptor; PAK; LPL Receptor	Cytoskeletal Signaling; GPCR/G Protein; Membrane transporter/Ion channel
	Fingolimod hydrochloride (FTY720) 是一种新型免疫调节剂，是一种 1-磷酸鞘氨醇(S1P) 拮抗剂，作用于 K562 和 NK 细胞，IC50为 0.033 nM。它诱导 S1P1 的内化，从而抑制 S1P 活性。它被鞘氨醇激酶磷酸化，尤其是被 SK2 磷酸化，从而可与 S1PR1、3、4 和 5 结合
T61025	GSK-1482160	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	GSK-1482160是一种CNS-渗透的P2X7受体负变构调节剂，具有口服活性。P2X7受体参与中枢和外周免疫细胞产生促炎细胞因子，因此GSK-1482160具有研究炎症性疾病的潜力。GSK-1482160具有出色的体外效价(在包括人类在内的多种物种的重组和初始P2X7受体的功能和电生理测试中)和交叉靶标选择性。
T13182	Toll-like receptor modulator	TLR	Immunology/Inflammation
	Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.
T12378L	CA-170 PD-1-IN-1	Others	Others
	PD-1-IN-1 is a programmed cell dealth-1inhibitor. PD-1-IN-1 can be used as an immune modulator.
T12387	PD1-PDL1-IN 1	Others	Others
	PD1-PDL1-IN 1 is a potent inhibitor of programmed cell death 1 (PD-1),and used as immune modulator.
TP1076	AUNP-12 NP-12
	AUNP-12, a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway.
T40355	IL-17A modulator-2
	IL-17A modulator-2, exhibits inhibitory properties towards IL-17A, with a pIC50 of 8.3. Its effectiveness lies in attenuating the biological effects associated with IL-17A activity. IL-17A modulator-2 finds utility in the study of diseases and disorders characterized by dysregulated IL-17A modulation, such as those involving immune dysfunction, autoimmune pathology, cancer, and neurodegenerative conditions.
T72986	IMD-ferulic
	IMD-ferulic 是一种共价连接的 NF-κB 调节剂，可提高小分子免疫增强剂的佐剂性。
T40354	IL-17A modulator-1
	IL-17A modulator-1 is an effective inhibitor of IL-17A activity, exhibiting a pIC 50 value of 8.2. This compound holds great promise for studying diseases and disorders that involve the modulation of IL-17A, such as immune-related diseases, autoimmune pathologies, cancer, and neurodegenerative disorders.
T73630	PD1-PDL1-IN 1 TFA
	PD1-PDL1-IN 1 TFA（compound 16）是一种高效的程序性细胞死亡1（PD-1）抑制剂，具有免疫调节作用。
T61390	D18
	D18 is an immune modulator that acts as a dual agonist for TLR7/8 (with EC50 values of 24 nM for hTLR7 and 10 nM for hTLR8, respectively). It enhances the expression of PD-L1 through epigenetic regulation, thereby increasing the sensitivity of tumors to PD-1/PD-L1 blockade. Additionally, D18 functions as a cytotoxin for ADC synthesis, specifically for the ADC HE-S2 [1].
T37548	azido-FTY720 azido-FTY720
	FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). Down-regulation of S1P1 recept...
T80653	Larixol (+)-Larixol	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Larixol作为一种fMLP抑制剂，在免疫调节作用上，能够抑制Src激酶、ERK1/2、p38以及AKT的磷酸化信号。它能够通过干扰fMLP受体Gi蛋白的βγ亚基与下游分子之间的作用，抑制fMLP引发的呼吸爆发。此外，Larixol可有效降低由fMLP (0.1 μM) 诱导的超氧阴离子生成（IC50: 1.98 μM）、组织蛋白酶G的释放（IC50: 2.76 μM）及趋化反应，有助于缓解中性粒细胞的过度激活，减少炎症或组织损伤。Larixol衍生物对FSGS相关TRPC6功能突变有显著的抑制效果。

化合物

CB2 modulator 1

Cat.No: T10696

Target: Cannabinoid Receptor

NR2F6 modulator-1

Cat.No: T62204

Target: Others

Cat.No: T16792

Synonym: ALX-101

Target: Liver X Receptor

Isoallolithocholic acid

Cat.No: T36522

Synonym: Alloisolithocholic Acid,AILCA,3β-Hydroxy-5α-cholanic acid

Target: Others

Dazostinag disodium

Cat.No: T72482

Target: STING

cis-Urocanic acid

Cat.No: T10824

Synonym: cis-UCA,(Z)-Imidazole-4-acrylic acid,(Z)-Urocanic acid,(E)-Urocanic acid,(Z)-3-(1H-Imidazol-5-yl)acrylic acid,顺式-尿刊酸

Target: 5-HT Receptor

Fingolimod hydrochloride

Cat.No: T2539

Synonym: Fingolimod (FTY720) HCl,FTY720,盐酸芬戈莫德

Target: TRP/TRPV Channel, S1P Receptor, PAK, LPL Receptor

Cat.No: T61025

Target: P2X Receptor

Toll-like receptor modulator

Cat.No: T13182

Target: TLR

Cat.No: T12378L

Synonym: PD-1-IN-1

Target: Others

Cat.No: T12387

Target: Others

Cat.No: TP1076

Synonym: NP-12

IL-17A modulator-2

Cat.No: T40355

Cat.No: T72986

IL-17A modulator-1

Cat.No: T40354

PD1-PDL1-IN 1 TFA

Cat.No: T73630

Cat.No: T61390

Cat.No: T37548

Synonym: azido-FTY720

Cat.No: T80653

Synonym: (+)-Larixol

Target: Akt

Cat. No.	Product Name	Target	Signaling Pathways
T0983	Penicillamine 青霉胺,d-penicillamin,Dimethyl Cysteine,D-青霉胺,Artamine,D-(-)-Penicillamine	Antibiotic	Microbiology/Virology
	Penicillamine (Artamine) 是一种 penicillin 的代谢降解产物，是一种螯合剂，可作用于威尔逊氏病。
T34295	Resiniferatoxin RTX,[3H]resiniferatoxin,树脂毒素	IL Receptor	Immunology/Inflammation
	Resiniferatoxin ([3H]resiniferatoxin) 抑制 Th1 细胞因子的产生，有助于防御 T.spiralis 感染，并可用于免疫反应调节剂的研究。
T14046	Anandamide 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide	Cannabinoid Receptor; Endogenous Metabolite	GPCR/G Protein; Metabolism
	Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide) 是一种免疫调节剂，通过大麻素受体 CB1 和 CB2 起作用，还通过中枢神经系统中的其他靶点起作用，如 GPR18/GPR55。
TN1879	Lucideric acid A Lucidenic acid A,赤芝酸A	MMP; p38 MAPK; JNK	MAPK; Proteases/Proteasome
	Lucideric acid A (Lucidenic acid A) 是分离自灵芝的天然产物，可抑制 PMA 诱导的MMP-9活性，具有抵抗肝癌细胞侵袭的作用。
TN1420	Bacopaside I	Others	Others
	Bacopaside I 是一种皂苷，分离自 Bacopa monniera 中，具有抗氧化活性和清除自由基的功能，有抗抑郁作用。
TN1790	Isopteropodine Uncarine E	5-HT Receptor; Antibacterial; AChR	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Isopteropodine (Uncarine E) 是从 Hamelia patens micropropagated 分离得到的一种异育亨宾型辛吲哚生物碱.具有抗菌活性，可刺激机体免疫系统。Isopteropodine 是 M1 型毒蕈碱乙酰胆碱 (muscarinic M1) 受体及 5-HT2 受体的正向调节剂，是PXR激活剂，可诱导大鼠子宫肌层收缩。

天然产物

Cat.No: T0983

Synonym: 青霉胺,d-penicillamin,Dimethyl Cysteine,D-青霉胺,Artamine,D-(-)-Penicillamine

Target: Antibiotic

Resiniferatoxin

Cat.No: T34295

Synonym: RTX,[3H]resiniferatoxin,树脂毒素

Target: IL Receptor

Cat.No: T14046

Synonym: 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide

Target: Cannabinoid Receptor, Endogenous Metabolite

Lucideric acid A

Cat.No: TN1879

Synonym: Lucidenic acid A,赤芝酸A

Target: MMP, p38 MAPK, JNK

Cat.No: TN1420

Target: Others

Cat.No: TN1790

Synonym: Uncarine E

Target: 5-HT Receptor, Antibacterial, AChR

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