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Search Results for " gastric ulcer "

27

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T38612	Linaprazan glurate	Others	Others
	Linaprazan glurate 抑制外源性或内源性刺激的胃酸分泌。 Linaprazan glurate 可用于胃肠道炎症性疾病和消化性溃疡疾病的研究。
T15500	HPi1	Others; Antibacterial	Microbiology/Virology; Others
	HPi1 是一种有口服活性的，针对幽门螺杆菌的选择性抗菌剂，IC50为 0.24 μM，MIC 为 0.08-0.16 μg/mL。
T6710	Troxipide 曲昔派特,曲昔匹特,Aplace	Others	Others
	Troxipide (Aplace) 是非分泌型胃保护剂，是口服具有活力的胃炎和胃溃疡的防御因子的增强剂，具有抗溃疡、抗炎和粘液分泌作用。
T1562	Rebamipide Proamipide,OPC12759,瑞巴派特	Free radical scavengers; COX; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience; oxidation-reduction
	Rebamipide (OPC12759) 是一种粘膜保护剂，可诱导COX-2表达，增加PGE2水平，并以 COX-2 依赖性方式增强胃粘膜防御。
T0157	Roxatidine Acetate hydrochloride HOE 760,盐酸罗沙替丁醋酸酯,Roxatidine Acetate HCl	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Roxatidine Acetate hydrochloride (HOE 760) 是一种特异性和竞争性的组胺 H2 受体拮抗剂，能抑制胃酸分泌，可用于胃溃疡和十二指肠溃疡的研究。
T8388	Vonoprazan TAK-438 (free base),沃诺拉赞	Proton pump	Membrane transporter/Ion channel
	Vonoprazan (TAK-438 (free base)) 是一种质子泵抑制剂，是口服活性钾竞争性酸阻断剂，有抗分泌作用。在 pH 为 6.5 时，它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性，IC50值为 19 nM。它可用于研究胃酸相关疾病。
T21254	Vonoprazan Fumarate TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞	Proton pump	Membrane transporter/Ion channel
	Vonoprazan Fumarate (TAK438) 是质子泵的有效抑制剂，是口服有效的高效钾竞争性酸阻断剂，具有抗分泌活性。在 pH 为 6.5 时，它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性，IC50为 19 nM。它被开发用于研究酸相关疾病，如消化性溃疡和胃食管反流病。
T19763	Cetraxate hydrochloride DV-1006,DV 1006,Cetraxate HCl,盐酸西曲酸酯,DV1006	Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism
	Cetraxate hydrochloride (DV10062) 是一种有效的顶体蛋白酶 (acrosomal proteinase acrosin) 抑制剂，Ki 和 IC50分别为 0.94 μM 和 3.3 μM。它是一种口服有活性的抗溃疡试剂 (anti-ulcer)，具有粘膜保护作用，可用于研究胃溃疡。
T28665	Saviprazole Hoe731,Hoe 731,Hoe-731	Proton pump	Membrane transporter/Ion channel
	Saviprazole (Hoe-731) 是一种质子泵抑制剂，可用于治疗胃溃疡。
T6548	Irsogladine Dicloguamine,伊索拉定	PDE; AChR	Metabolism; Neuroscience
	Irsogladine (Dicloguamine) 是抗胃溃疡剂，通过 M1 毒蕈碱乙酰胆碱受体结合促进间隙连接细胞间通讯。
T77618	COX-2-IN-34	COX	Immunology/Inflammation; Neuroscience
	COX-2-IN-34 是一种选择性的、口服有效的 COX-2 抑制剂，在小鼠实验过程中显示出抗炎活性且无胃溃疡毒性。
T21385	Cinitapride 西尼必利,Paxapride,Cidine,cinitapride tartrate,Blaston,Cintapro,Cinmove	5-HT Receptor	GPCR/G Protein; Neuroscience
	Cinitapride (Blaston) 是一种促胃药。它减缓肌肉的活动，以减轻诸如胃酸反流、胃排空延迟和溃疡性消化不良等病症的症状。 Cinitapride 作为 5-HT2 受体的拮抗剂和 5-HT1 和 5-HT4 受体的激动剂。
T16865	SCH28080	ATPase; Proton pump	Membrane transporter/Ion channel
	SCH28080 是一种可逆且具有 K+ 竞争性的胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂，IC50 值为 20 nM (家兔微粒体膜)。SCH28080 在体内是有效的酸分泌抑制剂，具有抗溃疡活性、抗分泌和细胞保护活性。
T34087	Plaunotol Kelnac,Plaunotolum
	Plaunotol is a gastric protective agent that increases prostaglandins in the gastric mucosa and accelerates ulcer healing.
T68200	Roxatidine hydrochloride
	Roxatidine hydrochloride is an anti-ulcer agent and histamine antagonist that suppresses gastric acid secretion. It effectively heals duodenal and gastric ulcers and reduces ulcer pain. Roxatidine acetate has an improved safety profile compared to other similar drugs, in part because lower doses of roxatidine acetate are therapeutically effective.
T10008	BTM-1086	Others	Others
	BTM-1086 is a potent gastric secretory inhibitor and an anti-ulcer agent.
T69801	AU-461
	AU-461 is a gastric H(+)/K(+) ATPase inhibitor which acts as an anti-ulcer agent.
T69805	AU-006
	AU-006 is an anti-ulcer drug which is effective in the treatment of gastric ulcers by inhibiting gastric acid secretion.
T70428	Nepaprazole sodium
	Nepaprazole Na is the salt form of Nepaprazole Free Base, also known as TY-11345, is a proton pump inhibitor potentially for treatment of gastric ulcer. TY-11345 potently inhibited H+/K(+)-ATPase activity in isolated rabbit gastric mucosal microsomes; and the inhibitory effect was enhanced under weak acid conditions, the IC50 (concentrations that inhibit the enzyme activity by 50%) being 5.8 microM and 9.9 microM at pH 6.0 and pH 7.4, respectively. TY-11345 should be useful for the clinical tre...
T81074	Sucrose octasulfate sodium
	Sucrose octasulfate为硫糖铝组分，能直接刺激胃粘膜D细胞以促进生长抑素样免疫反应(SLI)的释放，进而发挥内源性胃生长抑素的溃疡愈合功能，适用于抗胃溃疡研究。
T0157L	Roxatidine acetate
	Roxatidine acetate is an anti-ulcer agent and histamine antagonist that inhibits gastric acid secretion. Compared to other similar drugs, Roxatidine acetate has an improved safety profile, in part because lower doses of roxatidine acetate are therapeutica
T25576	KF 392 KF392,KF-392
	KF 392 is antiulcer. It was found that KF-392 given orally to rats at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions.
T33314	Methantheline Bromide Frenogastrico,Dixamone bromide,Banthine,Asabaine,Methanthelinium bromide
	Methantheline Bromide is a synthetic spasmolytic used to relieve cramps or spasms of the stomach, bowel, and bladder. It is also useful for intestinal or gastric ulcers (peptic ulcer disease), intestinal problems, pancreatitis, gastritis, biliary dysmotil
T26366L	Prasterone sulfate sodium hydrate Sodium dehydroepiandrosterone sulfate,Prasterone sulfate sodium salt dihydrate,5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate
	Prasterone is an endogenous steroid hormone. Prasterone acts as an agonist at ERβ, NMDA, and σ1 receptors, a partial agonist at ERα and AR, and antagonist at GABA-A receptors. It displays a variety of biologocial activities, including enhancing working me
T38045	Cholesterol β-D-Glucoside
	Cholesterol β-D-glucoside is a derivative of cholesterol that contains β-D-glucose . It is formed from cholesterol and glucosylceramide by β-glucosidase 1. It activates heat shock transcription factor 1 (Hsf1) in response to heat shock, which increases the expression of heat shock protein 70 (Hsp70) in TIG-3 human fetal lung fibroblasts when used at a concentration of 10 μM. Cholesterol β-D-glucoside (100 mg/kg) prevents ulcer formation following cold-restraint stress and increases Hsf1 activity...
T78218	Ilaprazole sodium hydrate IY-81149 sodium hydrate	Proton pump	Membrane transporter/Ion channel
	Ilaprazole (IY-81149) sodium hydrate是一种具有口服活性的质子泵抑制剂，可以量依赖性地不可逆抑制H+/K+-ATPase，并在兔壁细胞制剂中展示出IC50为6μM的效力。该化合物主要用于胃溃疡的研究，并已证实是一种有效的T细胞起源蛋白激酶(TOPK)抑制剂。
T61643	Vonoprazan hydrochloride
	Vonoprazan hydrochloride 是一种高效且具口服活性的质子泵抑制剂 (PPI) 和钾竞争性酸阻断剂 (potassium-competitive acid blocker, P-CAB)，展示出优秀的抗分泌活性。在 pH 为 6.5 的条件下，该化合物可抑制猪胃微粒体内 H+,K+-ATPase 的酶活性，呈现出 19 nM 的 IC50 值。Vonoprazan hydrochloride 主要应用于胃酸相关疾病的研究，包括胃食管反流病和消化性溃疡，并可用于根除幽门螺杆菌。

化合物

Linaprazan glurate

Cat.No: T38612

Target: Others

Cat.No: T15500

Target: Others, Antibacterial

Cat.No: T6710

Synonym: 曲昔派特,曲昔匹特,Aplace

Target: Others

Cat.No: T1562

Synonym: Proamipide,OPC12759,瑞巴派特

Target: Free radical scavengers, COX, Prostaglandin Receptor

Roxatidine Acetate hydrochloride

Cat.No: T0157

Synonym: HOE 760,盐酸罗沙替丁醋酸酯,Roxatidine Acetate HCl

Target: Histamine Receptor

Cat.No: T8388

Synonym: TAK-438 (free base),沃诺拉赞

Target: Proton pump

Vonoprazan Fumarate

Cat.No: T21254

Synonym: TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞

Target: Proton pump

Cetraxate hydrochloride

Cat.No: T19763

Synonym: DV-1006,DV 1006,Cetraxate HCl,盐酸西曲酸酯,DV1006

Target: Serine/threonin kinase

Cat.No: T28665

Synonym: Hoe731,Hoe 731,Hoe-731

Target: Proton pump

Cat.No: T6548

Synonym: Dicloguamine,伊索拉定

Target: PDE, AChR

Cat.No: T77618

Target: COX

Cat.No: T21385

Synonym: 西尼必利,Paxapride,Cidine,cinitapride tartrate,Blaston,Cintapro,Cinmove

Target: 5-HT Receptor

Cat.No: T16865

Target: ATPase, Proton pump

Cat.No: T34087

Synonym: Kelnac,Plaunotolum

Roxatidine hydrochloride

Cat.No: T68200

Cat.No: T10008

Target: Others

Cat.No: T69801

Cat.No: T69805

Nepaprazole sodium

Cat.No: T70428

Sucrose octasulfate sodium

Cat.No: T81074

Roxatidine acetate

Cat.No: T0157L

Cat.No: T25576

Synonym: KF392,KF-392

Methantheline Bromide

Cat.No: T33314

Synonym: Frenogastrico,Dixamone bromide,Banthine,Asabaine,Methanthelinium bromide

Prasterone sulfate sodium hydrate

Cat.No: T26366L

Synonym: Sodium dehydroepiandrosterone sulfate,Prasterone sulfate sodium salt dihydrate,5-Androsten-3β-ol-17-one sulfate sodium salt dihydrate

Cholesterol β-D-Glucoside

Cat.No: T38045

Ilaprazole sodium hydrate

Cat.No: T78218

Synonym: IY-81149 sodium hydrate

Target: Proton pump

Vonoprazan hydrochloride

Cat.No: T61643

Cat. No.	Product Name	Target	Signaling Pathways
TN6577	Bletilloside A 3-Methoxyshancigusin I	Others	Others
	Bletilloside A（3-Methoxyshancigusin I）是从条纹苜蓿的块茎中分离出一种新型葡萄糖苷，具有抗胃溃疡活性。
T21651	Lansoprazole sodium 兰索拉唑钠,Lansoprazole (sodium), AG-1749 sodium	Proton pump; Phospholipase; Antibacterial	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology
	Lansoprazole sodium (Lansoprazole (sodium)) 是一种质子泵抑制剂，是中性鞘磷脂酶的外泌体抑制剂，能抑制胃酸生成。
TN3852	Dihydrolicoisoflavone	Antifection	Microbiology/Virology
	Dihydrolicoisoflavone A possesses weaker anti-H. pylori activity, it may be useful chemopreventive agents for peptic ulcer or gastric cancer in H. pylori-infected individuals.
TN1302	6,8-Diprenylorobol 6,8-二异戊烯基香豌豆苷元	Others; HIV Protease; Antifection	Microbiology/Virology; Others; Proteases/Proteasome
	6,8-Diprenylorobol possesses weaker anti-H. pylori activity, it may be a useful chemopreventive agent for peptic ulcer or gastric cancer in H. pylori-infected individuals.
TN1913	Marmin	Calcium Channel; Antifection; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Marmin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and secondarily due to the prevention of the effects of endogenous acetylcholine and histamine.
TN4223	Homopterocarpin	Antifection	Microbiology/Virology
	Homopterocarpin and Pterocarpus extract offer gastroprotection against indomethacin- induced ulcer by antioxidative mechanism and the modulation of gastric homeostasis, homopterocarpin may be responsible for, or contribute to the antiulcerogenic property

天然产物

Cat.No: TN6577

Synonym: 3-Methoxyshancigusin I

Target: Others

Lansoprazole sodium

Cat.No: T21651

Synonym: 兰索拉唑钠,Lansoprazole (sodium), AG-1749 sodium

Target: Proton pump, Phospholipase, Antibacterial

Dihydrolicoisoflavone

Cat.No: TN3852

Target: Antifection

6,8-Diprenylorobol

Cat.No: TN1302

Synonym: 6,8-二异戊烯基香豌豆苷元

Target: Others, HIV Protease, Antifection

Cat.No: TN1913

Target: Calcium Channel, Antifection, Histamine Receptor

Homopterocarpin

Cat.No: TN4223

Target: Antifection

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