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28

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3635	IQ 1 IQ1,IQ-1	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	IQ 1 有多种作用，如保持小鼠ESCs 的多功能性、降低Wnt 刺激的磷酸化、阻止PP2A/Nkd 的相互作用等等。
T15199	Edicotinib JNJ-527,JNJ-40346527	c-Fms; FLT; CSF-1R; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Edicotinib (JNJ-527) 是能够透过血脑屏障的、口服具有活性的、选择性的CSF-1R 抑制剂 (IC50:3.2 nM)。它对 KIT (IC50:20 nM) 和 FLT3 (IC50:190 nM) 的抑制作用较小。它抑制小胶质细胞的扩张，减弱小胶质细胞的增殖和神经退行性变。它可用于研究阿尔茨海默病和类风湿性关节炎。
T6506	FPH1 BRD-6125	Others	Others
	FPH1 (BRD-6125) 在体外能够提高人肝原代细胞的活性及数量，并促进 iPS 细胞向肝系分化。
T3590	NSC23005	CDK	Cell Cycle/Checkpoint
	NSC23005 是一种 p18INK 抑制剂，可有效促进造血干细胞 (HSC) 扩增 (ED50: 5.21 nM)。
T3589	NSC23005 Sodium	CDK	Cell Cycle/Checkpoint
	NSC23005 sodium 是新型 p18 抑制剂 (ED50=5.21 nM)，在小鼠和人类模型中促进造血干细胞扩增。
T24580	P18IN003 P18IN 003,P18IN-003	CDK	Cell Cycle/Checkpoint
	P18IN003 是一种具有选择性和有效性的 p18(INK4C) 抑制剂，可抑制 p18 蛋白的活性可用于研究造血干细胞的体外扩增。
T24398	Lenaldekar LDK	Akt; IGF-1R; S6 Kinase	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Lenaldekar (LDK) 抑制 T 细胞扩增和自身免疫性脑脊髓炎。 Lenaldekar 导致 PI3 激酶/AKT/mTOR 通路成员的去磷酸化并延迟有丝分裂晚期的敏感细胞。
TQ0147	Arundic Acid ONO 2506,(R)-2-丙基辛酸,(R)-2-Propyloctanoic acid	Others	Others
	Arundic Acid (ONO 2506) 是星形胶质细胞调节剂，能够抑制 S-100β 的合成，并调节星形胶质细胞的活化，进而延缓脑梗塞的扩张。它对中风和阿尔茨海默病具有潜在的研究价值。
T77170	Siplizumab MEDI-507	Others	Others
	Siplizumab (MEDI-507) 是一种人源化靶向 CD2 的 IgG1 单克隆抗体。Siplizumab 在体外选择性地消耗效应记忆 T 细胞并促进同种异体反应性调节性 T 细胞的相对扩增。Siplizumab 可用于治疗斑块状银屑病。
T38861L	Tat-beclin 1 acetate Tat-beclin 1 acetate(1423821-88-8 free base)	HIV Protease; Autophagy	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Tat-beclin 1 acetate 是一种有效的自噬诱导剂，并与自噬的负调节因子 GAPR-1 相互作用。 Tat-beclin 1 acetate 减少聚谷氨酰胺扩增蛋白聚集体的积累和几种病原体（包括 HIV-1）的复制。
T14973	CITCO	Apoptosis; Others	Apoptosis; Others
	CITCO 是一种咪唑噻唑衍生物，也是一种选择性组成型雄甾烷受体激动剂。它抑制脑肿瘤干细胞的生长和扩增，其 EC50 比孕烷 X 受体为 49 nM
T27279	ER819762 ER-819762,ER 819762
	ER819762, an antagonist of the prostaglandin E2 EP4 receptor, inhibits Th1 differentiation and Th17 expansion.
T29166	XIE18-6 XIE186
	XIE18-6, a novel INK4C inhibitor, specifically blocks the bioactivity of p18 protein and promotes human and murine hematopoietic stem cell ex vivo expansion.
T32125	Hyperphyllin HP
	Hyperphyllin specifically mimics the branch defects of AMP1, including plastid reduction and expansion and proliferation of the branch meristem.
T71793	CDMG1
	CDMG1 is a novel Wnt inhibitor, promoting heart regeneration, injury repair, and myocardial hyperplasia through expansion of the cardiac progenitor cell population
T39650	Tadnersen IONIS-C9Rx,BIIB078
	Tadnersen (BIIB078) is an antisense oligonucleotide (ASO) designed for the selective targeting of C9ORF72 transcript variants 1 and 3, specifically those carrying the expansion.
T83072	Antifreeze Polypeptide 6 (winter flounder)
	Antifreeze Polypeptide 6 (winter flounder)为美洲拟鲽特有的抗冻多肽组成成分之一，主要作用是通过抑制冰核生长来降低血浆的凝固点。
TP2001	MM 54
	Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens survival time in a mouse xenograft model
T62859	MEIS-IN-1
	MEIS-IN-1 是一种有效的诱导小鼠和人类造血干细胞扩增的 MEIS 抑制剂。
T82642	Cyclo(RGDfK(Mal))
	Cyclo(RGDfK(Mal))为一种五肽，能促进人多能干细胞的附着与渗透，适用于三维干细胞培养及其扩增。
T38861	Tat-beclin 1
	Tat-beclin 1, a peptide derived from the autophagy protein beclin 1, is a powerful inducer of autophagy. It interacts with GAPR-1 (GLIPR2), a negative regulator of autophagy. Tat-beclin 1 effectively reduces the buildup of polyglutamine expansion protein aggregates and inhibits the replication of various pathogens, such as HIV-1, in laboratory experiments. In addition, it has demonstrated the ability to decrease mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV).
T82560	di-Ellipticine-RIBOTAC	PROTACs	PROTAC
	Di-Ellipticine-RIBOTAC是一款双功能小分子，在体外和体内肌萎缩侧索硬化（ALS）模型中能够减少c9ALS/FTD r(G4C2)的重复扩增。
T62137	ANKRD22-IN-1
	ANKRD22-IN-1 是一种 ANKRD22 的有效抑制剂。ANKRD22-IN-1 能够促进胃肠黏膜上皮干细胞的扩增，进而可以间接激活 Wnt 经典通路，对体内受损胃肠黏膜组织的恢复有益。
T83127	AMPK activator 13	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	AMPK activator13作为AMPK激活剂，通过激活AMPK通路有效抑制3T3-L1细胞的有丝分裂克隆扩增，并增加细胞线粒体耗氧量，适用于肥胖研究。
T78031	MOG peptide (35-55)
	MOG peptide (35-55) 是一段特定的髓鞘少突胶质细胞糖蛋白 (MOG) 免疫原肽的35至55氨基酸序列。该肽段具有针对CD4+T细胞的特异性活性，并可用于诱导实验性自身免疫性脑脊髓炎 (EAE) 的动物模型。
T76058	Tat-beclin 1 TFA
	Tat-beclin 1 TFA是一种来源于自噬蛋白区域(beclin 1)的肽，有效诱导自噬(autophagy)并与GAPR-1 (GLIPR2)发生相互作用，具有显著的自噬负调控作用。该化合物能有效减少体外聚谷氨酰胺扩增蛋白聚集体的积累，并抑制HIV-1等多种病原体的复制。同时，Tat-beclin 1 TFA能显著降低感染基孔肯雅病(CHIKV)或西尼罗河病毒(WNV)小鼠的死亡率。
T36578	Boc-Lys(Ac)-AMC
	Commendamide (N-acyl-3-hydroxypalmitoyl-glycine) is a newly discovered GPCR G2A/GPR132 agonist (EC50=11.8 μM) that isolated from Bacteroides vulgatus. [1] G2A/GPR132 belongs to the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. GPR132/G2A is first reported to be a transcriptional target for BCR-ABL tyrosine kinase attenuating B-cell expansion in vitro and arresting cells at G2 during mitosis. It has been involved in autoimmune disease and atherosclerosis. [1]...
T36648	Tucatinib hemiethanolate
	Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM. Tucatinib hemiethanolate has nanomolar activity against purified HER2 enzyme and is approximately 500-fold selective for HER2 versus EGFR in cell-based assays. Tucatinib selectively inhibits the receptor tyrosine kinase HER2 relative to EGFR[1].Tucatinib blocks proliferation and the phosphorylation of HER2 and its downstream effector, Akt in HER2 overexpressing cell lines. In the ...

化合物

Cat.No: T3635

Synonym: IQ1,IQ-1

Target: Wnt/beta-catenin

Cat.No: T15199

Synonym: JNJ-527,JNJ-40346527

Target: c-Fms, FLT, CSF-1R, c-Kit

Cat.No: T6506

Synonym: BRD-6125

Target: Others

Cat.No: T3590

Target: CDK

NSC23005 Sodium

Cat.No: T3589

Target: CDK

Cat.No: T24580

Synonym: P18IN 003,P18IN-003

Target: CDK

Cat.No: T24398

Synonym: LDK

Target: Akt, IGF-1R, S6 Kinase

Cat.No: TQ0147

Synonym: ONO 2506,(R)-2-丙基辛酸,(R)-2-Propyloctanoic acid

Target: Others

Cat.No: T77170

Synonym: MEDI-507

Target: Others

Tat-beclin 1 acetate

Cat.No: T38861L

Synonym: Tat-beclin 1 acetate(1423821-88-8 free base)

Target: HIV Protease, Autophagy

Cat.No: T14973

Target: Apoptosis, Others

Cat.No: T27279

Synonym: ER-819762,ER 819762

Cat.No: T29166

Synonym: XIE186

Cat.No: T32125

Synonym: HP

Cat.No: T71793

Cat.No: T39650

Synonym: IONIS-C9Rx,BIIB078

Antifreeze Polypeptide 6 (winter flounder)

Cat.No: T83072

Cat.No: TP2001

Cat.No: T62859

Cyclo(RGDfK(Mal))

Cat.No: T82642

Cat.No: T38861

di-Ellipticine-RIBOTAC

Cat.No: T82560

Target: PROTACs

Cat.No: T62137

AMPK activator 13

Cat.No: T83127

Target: AMPK

MOG peptide (35-55)

Cat.No: T78031

Tat-beclin 1 TFA

Cat.No: T76058

Boc-Lys(Ac)-AMC

Cat.No: T36578

Tucatinib hemiethanolate

Cat.No: T36648

Cat. No.	Product Name	Target	Signaling Pathways
T2230	Paeoniflorin 芍药苷,Peoniflorin	HSP; COX	Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience
	Paeoniflorin (Peoniflorin) 是从芍药根中提取的一种蒎烷单萜糖苷，具有抗癌作用、抗氧化应激、抗血小板聚集、血管扩张、降低血液粘度和抗炎活性等多种生物活性。它是一种热休克蛋白诱导剂，通过自噬途径保护 PC12 细胞免受 MPP+和酸性损伤。
T3S1471	Cucurbitacin IIA 葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA	Apoptosis; Survivin	Apoptosis
	Cucurbitacin IIA (Dihydrocucurbitacin Q1) 是从园果雪胆中分离得到的一种三萜烯，可诱导细胞凋亡和增强自噬，有助于葫芦素IIA 对炎症相关疾病的抗炎活性。它可降低癌细胞中生存素的表达，降低磷酸化组蛋白 H3 的水平，增加裂解的 PARP 的水平。

天然产物

Cat.No: T2230

Synonym: 芍药苷,Peoniflorin

Target: HSP, COX

Cucurbitacin IIA

Cat.No: T3S1471

Synonym: 葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA

Target: Apoptosis, Survivin

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