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Search Results for " analgesic effect "

16

抑制剂 & 化合物

15

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4351	DAMGO Dagol,DAGO,RX-783006	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	DAMGO (DAGO) 是一种阿片受体激动剂，Kd 值为 3.46 nM。它能够影响啮齿动物的运动活动，可作为镇痛剂。
T7416	WS-12	TRP/TRPV Channel	Membrane transporter/Ion channel
	WS-12 是有效的TRPM8激动剂，EC50为 39 nM。
T8410	ASP7663	TRP/TRPV Channel	Membrane transporter/Ion channel
	ASP7663 是口服有效的TRPA1选择性激动剂。ASP7663具有抗便秘和抗腹痛的功效。
T30824	Cgp 29030A Cgp29030A,Cgp-29030A	Others	Others
	CGP 29030A 是一种新的哌嗪衍生物，具有镇痛活性，对潜在的痛觉背角神经元有显著的抑制作用，可用于研究疼痛性疾病。
T40045	Sivopixant S-600918,Sivopixant	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	Sivopixant (S-600918) 是P2X3受体选择性拮抗剂 (P2X3IC50=4.2 nM; P2X2/3IC50=1100 nM)。Sivopixant 可用于缓解疼痛的研究。
T50030	1-(2,4-difluorophenyl)guanidine hydrochloride	Others	Others
	1-(2,4-difluorophenyl)guanidine hydrochloride 是一种化合物，是电压门控钠通道Nav1.7的强效选择性抑制剂，Nav1.7是疼痛信号传输的关键参与者，因此它能够减少疼痛信号的传递，从而产生镇痛作用。
T15360	Furobufen	Others	Others
	Furobufen is an anti-inflammatory agent. It produces antiarthritic and has antipyretic effects. Furobufen also has an analgesic effect in inflamed tissue.
T23944	DA 5018 DA-5018,DA5018
	DA 5018 is a capsaicin derivative and is also a new non-narcotic analgesic. It has an antipruritic effect.
T73339	Anrikefon HSK21542
	Anrikefon (HSK21542) 为 kappa 阿片受体（kappa opioid receptor）激动剂，具缓解疼痛作用。
TP1331	Super-TDU (1-31) TFA
	Super-tdu (1-31) TFA is an endogenous ligand of heptapeptide receptor and has a strong anti-analgesic effect.
T21843	GEMSA
	GEMSA 是一种有效的脑啡肽转化酶抑制剂 (enkephalin convertase,Ki=8.8 nM)，具有镇痛作用。
T25959	Pipebuzone LD-4644,LD 4644,LD4644,Pipebuzonum
	Pipebuzone 是一种抗炎、解热、镇痛药，用于治疗各种风湿性疾病。它在临床和病理上都具有良好的耐受性，并具有可靠的抗炎作用。
T11010	Detomidine carboxylic acid	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Detomidine carboxylic acid is the main urine metabolite of detomidine. Detomidine is a synthetic α2-adrenergic agonist and an animal analgesic. Detomidine also has heart and breathing effects, and has a diuretic effect.
T60526	N-Salicyloyltryptamine
	N-Salicyloyltryptamine(STP) 是一种色胺类似物，具有抗惊厥、抗炎、镇痛和血管舒张的作用。N-Salicyloyltryptamine 作为电压依赖性离子通道（包括Na+、Ca2+、K+离子通道）抑制剂，可抑制 K+电流，IC50值为 34.6 μM ( /to)。
T24692	QAQ dichloride
	QAQ dichloride is a photoswitchable compound that blocks voltage-gated Na v and K v channels. Its channel-blocking activity is observed in the trans form of the azobenzene photoswitch, while the cis form does not exhibit this effect. This compound is membrane-impermeant and selectively enters pain-sensing neurons expressing endogenous import channels. QAQ dichloride functions as a light-sensitive analgesic and provides a valuable tool for investigating signaling mechanisms involved in acute and ...
T71491	Enadoline (Free Base)
	Enadoline (Free Base) is a kappa-opioid receptor agonist; PD 129290 (CAM 570; CI 977) is the S,S(-)-enantiomer; PD 129289 (CAM 569) is the corresponding R,R(+)-enantiomer. In human studies, it produced visual distortions and feelings of dissociation, reminiscent of the effects of salvinorin A. It was studied as a potential analgesic, but abandoned because of the dose-limiting effects of dysphoria, which could be expected from a κ-opioid agonist. There was mention of its potential in treating com...

化合物

Cat.No: T4351

Synonym: Dagol,DAGO,RX-783006

Target: Opioid Receptor

Cat.No: T7416

Target: TRP/TRPV Channel

Cat.No: T8410

Target: TRP/TRPV Channel

Cat.No: T30824

Synonym: Cgp29030A,Cgp-29030A

Target: Others

Cat.No: T40045

Synonym: S-600918,Sivopixant

Target: P2X Receptor

1-(2,4-difluorophenyl)guanidine hydrochloride

Cat.No: T50030

Target: Others

Cat.No: T15360

Target: Others

Cat.No: T23944

Synonym: DA-5018,DA5018

Cat.No: T73339

Synonym: HSK21542

Super-TDU (1-31) TFA

Cat.No: TP1331

Cat.No: T21843

Cat.No: T25959

Synonym: LD-4644,LD 4644,LD4644,Pipebuzonum

Detomidine carboxylic acid

Cat.No: T11010

Target: Adrenergic Receptor

N-Salicyloyltryptamine

Cat.No: T60526

Cat.No: T24692

Enadoline (Free Base)

Cat.No: T71491

Cat. No.	Product Name	Target	Signaling Pathways
TN6989	Isotoosendanin 异川楝素,(1S,2S,4R,5S,6R,9S,10S,11R,13R,18S,20R)-20-(acetyloxy)-6-(furan-3-yl)-11,15,18-trihydroxy-5,10,14-trimethyl-3,8-dioxo-16-oxapentacyclo[12.3.3.01,13.02,1?.0?,?]icosan-4-yl acetate	Others	Others
	Isotoosendanin ((1S,2S,4R,5S,6R,9S,10S,11R,13R,18S,20R)-20-(acetyloxy)-6-(furan-3-yl)-11,15,18-trihydroxy-5,10,14-trimethyl-3,8-dioxo-16-oxapentacyclo[12.3.3.01,13.02,1?.0?,?]icosan-4-yl acetate) 是一种从楝树 Melia toosendan 果实中分离出的柠檬苦素类天然产物，具有抗炎和镇痛作用。
TN1517L	Cochinchinenin A	Others	Others
	Cochinchinenin A 是龙血镇痛作用的物质基础。
TN1517	1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one 剑叶龙血素A,Cochinchinenin A	Others	Others
	1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one (Cochinchinenin A) 是龙血镇痛作用的物质基础。
T8209	Saikosaponin b3 柴胡皂苷b3	Others	Others
	Saikosaponin b3 是从 Bupleurum falcatum L. 的根中分离得到的。Saikosaponin b3 抑制 ACTH 诱导的脂肪细胞中的脂肪分解并具有镇痛作用。
T3S0509	Gaultherin	COX	Immunology/Inflammation; Neuroscience
	Gaultherin 是一种分离自 Gaultheria yunnanensis 中的天然水杨酸酯衍生物。它是一种非甾体类抗炎药，具有止痛和抗炎作用，与 Aspirin 相比没有胃溃疡作用。
T1407	(-)-Menthol L-Menthol,Levomenthol,(-)-薄荷醇,薄荷冰,Menthomenthol,Menthacamphor	Opioid Receptor; Endogenous Metabolite; TRP/TRPV Channel	Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	(-)-Menthol (Levomenthol) 分离自薄荷油，L-Menthol 是瞬时受体电位 M8 (TRPM8)的激活剂，TRPM8 是 Ca2+-可渗透的非选择性阳离子通道，并增加 [Ca2+]i。L-Menthol 具有抗肿瘤活性。
T5S1889	Yunaconitine Guayewuanine B,滇乌头碱	Others	Others
	Yunaconitine (Guayewuanine B) 是一种乌头类生物碱，具有剧毒。
T6S1885	Benzoylmesaconine Mesaconine 14-benzoate,苯甲酰新乌头原碱	Others	Others
	Benzoylmesaconine (Mesaconine 14-benzoate) 是乌头汤最丰富的组分。其中乌头汤可用于研究类风湿性关节炎。
T5S0661	Koumine	Others	Others
	Koumine 是一种从钩吻中得到的生物碱，具有高效抗肿瘤活性，在肿瘤细胞中能够提高 Bax/Bcl-2 的蛋白比例和 caspase-3 的表达。在类风湿性关节炎动物模型中，它能够预防关节炎的发展。它具有抗焦虑、抗应激、抗银屑病作用，也可用于缓解疼痛的研究。
T5S0045	Isofraxidin 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶	MMP; ERK; p38 MAPK; TLR; COX	Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome
	Isofraxidin (Phytodolor) 是来自刺五加的香豆素成分，抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞，抑制ERK1/2磷酸化。它减弱iNOS 和COX-2表达，还抑制TLR4/髓样分化蛋白 2 复合物的形成。
T3929	Kaurenoic acid Kauren-19-Oic Acid,异贝壳杉烯酸,kaurenoate,kaur-16-en-18-oic acid	Others	Others
	Kaurenoic acid (kaurenoate) 是一种二萜，来源于 Sphagneticola trilobata 中，可以抑制细胞因子的产生和激活 NO–cyclic GMP–PKG–ATP- 敏感型钾通道信号通路，并抑制炎症疼痛。
TN4379	Kansuinine A	IL Receptor; STAT; Interleukin	Immunology/Inflammation; JAK/STAT signaling; Stem Cells
	Kansuinine A 对IL-6 诱导的 Stat3激活有作用。Kansuinine A 显示出抗病毒和抗肿瘤活性。
T6S1699	Shogaol [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol	Lipoxygenase; Autophagy	Autophagy; Metabolism
	6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物，具有抗癌、抗炎和抗氧化的多种生物活性。
TN2248	Sylvestroside I 林生续断苷I,匙羹藤皂苷 I	Others	Others
	Sylvestroside I may have analgesic effect.
TMA0805	Lupanine	ATPase; Potassium Channel; Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Lupanine has a weak sedative effect on the central nervous system, interaction with specific drugs used for treatment of the CNS and for analgesic activity. Lupanine improves glucose homeostasis by influencing KATP-channels of pancreatic beta cells.

天然产物

Cat.No: TN6989

Synonym: 异川楝素,(1S,2S,4R,5S,6R,9S,10S,11R,13R,18S,20R)-20-(acetyloxy)-6-(furan-3-yl)-11,15,18-trihydroxy-5,10,14-trimethyl-3,8-dioxo-16-oxapentacyclo[12.3.3.01,13.02,1?.0?,?]icosan-4-yl acetate

Target: Others

Cochinchinenin A

Cat.No: TN1517L

Target: Others

1-(2,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)propan-1-one

Cat.No: TN1517

Synonym: 剑叶龙血素A,Cochinchinenin A

Target: Others

Saikosaponin b3

Cat.No: T8209

Synonym: 柴胡皂苷b3

Target: Others

Cat.No: T3S0509

Target: COX

Cat.No: T1407

Synonym: L-Menthol,Levomenthol,(-)-薄荷醇,薄荷冰,Menthomenthol,Menthacamphor

Target: Opioid Receptor, Endogenous Metabolite, TRP/TRPV Channel

Cat.No: T5S1889

Synonym: Guayewuanine B,滇乌头碱

Target: Others

Benzoylmesaconine

Cat.No: T6S1885

Synonym: Mesaconine 14-benzoate,苯甲酰新乌头原碱

Target: Others

Cat.No: T5S0661

Target: Others

Cat.No: T5S0045

Synonym: 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶

Target: MMP, ERK, p38 MAPK, TLR, COX

Cat.No: T3929

Synonym: Kauren-19-Oic Acid,异贝壳杉烯酸,kaurenoate,kaur-16-en-18-oic acid

Target: Others

Cat.No: TN4379

Target: IL Receptor, STAT, Interleukin

Cat.No: T6S1699

Synonym: [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol

Target: Lipoxygenase, Autophagy

Sylvestroside I

Cat.No: TN2248

Synonym: 林生续断苷I,匙羹藤皂苷 I

Target: Others

Cat.No: TMA0805

Target: ATPase, Potassium Channel, Calcium Channel

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