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Search Results for " adenylyl "

36

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T16333	NKY80 Adenylyl cyclase type V Inhibitor	Adenylyl cyclase	Neuroscience
	NKY80 调节心脏和肺组织中的腺苷酸环化酶催化活性。 NKY80 是腺苷酸环化酶 V 型亚型的非竞争性抑制剂（IC50 值：V、III 和 II 型分别为 8.3 µM、132 µM 和 1.7 mM）。
T83169	Adenylyl cyclase-IN-1
	Adenylyl cyclase-IN-1，一种Adenylyl cyclase抑制剂，具有潜在的应用价值于眼部张力减退研究领域。
T10066	2',5'-Dideoxyadenosine	Adenylyl cyclase; Adrenergic Receptor; AChR	GPCR/G Protein; Neuroscience
	2',5'-Dideoxyadenosine 是一种非竞争性腺苷酸环化酶抑制剂，通过结合 P 位点，IC50为 3 µM。它是核苷类似物，在心脏中发挥强大的抗肾上腺素作用。
T16938	ST034307	Adenylyl cyclase	Neuroscience
	ST034307 是一种选择性 adenylyl cyclase 1抑制剂，IC50值为 2.3 μM。
T15658	KH7	cAMP; AChR	GPCR/G Protein; Neuroscience
	KH7 是腺苷酸环化酶 (sAC) 特异性的可溶性抑制剂，也是一种 cAMP 抑制剂。它对重组纯化的人类 sACt 蛋白和细胞试验中异源表达的 sACt 的 IC50 为 3 到 10 μM 之间。
T63893	Adenylyl cyclase type 2 agonist-1
	Adenylyl cyclase type 2 agonist-1 是腺苷酸环化酶 2 型 (AC2) 有效的激动剂 (EC50: 90 nM)。Adenylyl cyclase type 2 agonist-1 能够抑制 Interleukin-6 的表达，是一种潜在的对抗呼吸系统疾病的先导化合物。
T0322	Fipexide	Dopamine Receptor; AChR	GPCR/G Protein; Neuroscience
	Fipexide 是对氯苯乙酸衍生物，是哌嗪化学类的精神活性药物，作为促智药物，有用于老年痴呆的研究潜力。它可降低了纹状体腺苷酸环化酶的活性，通过多巴胺能神经传递对认知表现出积极的作用。
T26869	BMS-986122 BMS 986122	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	BMS-986122 (BMS 986122) 是选择性 μ 阿片受体正变构调节剂，可增加 β-抑制蛋白募集、腺苷酸环化酶抑制和 G 蛋白活化的作用，还增强 DAMGO 介导的 [35S]GTPγS 在小鼠脑膜中的结合。
T16275	NB001 HTS 09836	Adenylyl cyclase	Neuroscience
	NB001 (HTS 09836) 是腺苷酸环化酶 1 的抑制剂，对神经和非神经疼痛有作用。
T60003	AC1-IN-1	Adenylyl cyclase	Neuroscience
	AC1-IN-1 是 1 型腺苷酸环化酶的选择性抑制剂（AC1，IC50 = 0.54 µM）。
T8702	SKF-83566	Dopamine Receptor; 5-HT Receptor; AChR	GPCR/G Protein; Neuroscience
	SKF-83566 是一种具有血脑渗透性和口服活性的 D1 样多巴胺受体拮抗剂和一种较弱的竞争性 5-HT2 受体拮抗剂，Ki 为 11 nM。它是竞争性多巴胺转运蛋白抑制剂，可用于研究帕金森氏症和对尼古丁渴望的缓解的相关研究。
T2172	SQ22536 9-(tetrahydrofuran-2-yl)-9h-purin-6-amine,SQ 22536	AChR	Neuroscience
	SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) 是一种腺苷酸环化酶抑制剂。
T11918	Lysipressin Lysine vasopressin,[Lys8]-Vasopressin,赖氨加压素	Others	Others
	Lysipressin ([Lys8]-Vasopressin) 是一种抗利尿激素，从猪身上发现，能够诱发兔膀胱平滑肌的收缩，激活腺苷酸环化酶。
T7813	α-MSH MSH, amide,CZEN-002,美拉诺坦,α-Melanocyte-Stimulating Hormone (MSH), amide	Melanocortin Receptor; Adenylyl cyclase	GPCR/G Protein; Neuroscience
	α-MSH (MSH, amide) 是一种内源性神经肽，是一种内源性黑皮质素受体 4 (MC4R) 激动剂，具有抗炎和解热活性。
T15787	LRE1	Adenylyl cyclase	Neuroscience
	LRE1是可溶性腺苷酸环化酶的特异性和变构抑制剂。
T8959	OS-3-106	Dopamine Receptor	GPCR/G Protein; Neuroscience
	OS-3-106 是一种新型芳酰胺苯基哌嗪，在腺苷酸环化酶抑制试验中作为 D3R 的部分激动剂。
T64355	TDI-10229	cAMP	GPCR/G Protein
	TDI-10229 是一种口服有效的可溶性腺苷酸环化酶 (sAC, ADCY10) 抑制剂 (IC50 值为 195 nM)。TDI-10229 在生化和细胞分析中都显示出对 sAC 的纳摩尔级抑制，并表现出足以保证其用作体内工具化合物的小鼠药代动力学特性。
T22615	BPIPP	Others	Others
	guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor
T22467	1,9-Dideoxyforskolin	Others	Others
	The compound is an inactive analog of forskolin(an adenylyl cyclase activator).
T23863	CB-6673567 CB 6673567
	CB-6673567 is a selective inhibitor of adenylyl cyclase.
T38782	Mant-GTPγS
	Mant-GTPγS, an effective GTP analog, displays strong competitive inhibition of adenylyl cyclase (AC). Additionally, it acts as a potent inhibitor of YdeH.
T26960	CB7833407
	CB7833407 is a selective Adenylyl Cyclase isoform-2 (AC2) inhibitor.
T28622	RU-0207148
	RU-0207148 is a novel allosteric soluble adenylyl cyclase (sAC) inhibitor.
T69543	CFM-1571(free base)
	CFM 1571 is the free base of CFM 1571 Hydrochloride (C291720), which acts as a soluble guanylyl cyclase (sGC) activator while ignoring adenylyl cyclase.
T83843	2'(3')-O-Anthraniloylguanosine-5'-O-triphosphate sodium 2'(3')-ANT-GTP
	2'(3')-O-Anthraniloylguanosine-5'-O-triphosphate（2'-ANT-GTP）及3'-ANT-GTP是荧光GTP衍生物，能够自发进行异构化。2'(3')-ANT-GTP在水中的激发波长为330 nm时，发射最大波长为428 nm。它抑制哺乳动物腺苷酸环化酶1（AC1；在锰存在下Ki=10 nM）、B. anthracis AC毒素水肿因子（在锰和镁存在下Kis分别为4.1 和 13 µM）及B. pertussis AC毒素CyaA（在锰存在下Ki=29 µM）。
T76657L	Human PTH-(1-31) amide
	Human PTH-(1-31) amide 是PTH类似物，能够刺激磷脂酰胆碱水解并促进腺苷酸环化酶的释放。
TP2033	[Des-His1,Glu9]-Glucagon amide des-His1-[Glu9]-Glucagon (1-29) amide
	Glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitro. Blocks added glucagon-induced hy
T73297	TDI-11861
	TDI-11861 是可溶性腺苷酸环化酶 (sAC) 的第二代抑制剂，具有解离率慢的特点。TDI-11861 抑制sAC 的IC50为 5.5 nM。
T71122	Carsatrin (free base)
	Carsatrin is purinylpiperazine derivative. as cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+, K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbine, or prazosin
T37131	MS 15203
	Potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of forskolin activated adenylyl cyclase activity in rat hypothalamic memebranes). Exhibits minimal binding to a panel of ~70 GPCRs and 10 other receptors (<22% of radioligand displaced from the target receptors). Increases neuronal activity in the paraventricular nucleus. Increases food intake and body weight in mice. Wardman et al (2016) Identification of a small-molecule ligand that activates the neuropeptide receptor GP...
T4411	DAMGO TFA (78123-71-4(Free base))	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	DAMGO TFA (78123-71-4(Free base)) 是Mu-opioid 受体的强效选择性激动剂。它也是镇痛药。它刺激钙激活的腺苷酸环化酶相关 cAMP 的产生。通过 TGF-beta1 表达趋化因子和趋化因子受体。增加老鼠的食物摄入量。
T36720	Deacetylforskolin
	Deacetylforskolin is a diterpene and a derivative of forskolin that has been found inC. forskohliiand has diverse biological activities.1,2,3,4It activates rat adipocyte adenylyl cyclase (IC50= 20 μM) and inhibits glucose transport in rat adipocyte plasma membranes.2Deactylforskolin (30-1,000 μg/kg) reduces blood pressure in spontaneously hypertensive rats.3It also attenuates hypercapnia-induced impairments in the passive avoidance response in mice.4 1.Gabetta, B., Zini, G., and Danieli, B.Minor...
T70975	Carsatrin succinate
	Carsatrin succinate is the salt form of Carsatin, a purinylpiperazine derivative used as a cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle without affecting the Na+, K+-ATPase, adenylyl cyclase, phosphodiesterase isozymes, or cardiac myofilaments. Carsatrin’s positive inotropic effect can be prevented by tetrodotoxin but not by the adrenergic antagonists timolol, yohimbi...
T37733	AMP-PNP tetralithium
	Non-hydrolyzable AMP analog. Kir6 (KATP) channel blocker. Inhibits fast axonal transport and stabilizes the interaction of membranous organelles with microtubules. Brady (1985) A novel brain ATPase with properties expected for the fast axonal transport motor. Nature 317 73 PMID:2412134 \|Yount et al (1971) Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P-N-P linkage. Biochemistry 10 2484 PMID:4326768 \|Hehl and Neumcke (1994) KATP channels of mouse skeletal muscle: mechan...
T83811	2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate sodium 2'(3')-ANT-ATP
	2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate（2'-ANT-ATP）与3'-ANT-ATP是荧光ATP衍生物，可自发地进行异构化。在水中，2'(3')-ANT-ATP的激发波长为330 nm时，发射最大波长为428 nm。它对哺乳动物腺苷酸环化酶（AC1）、AC2及AC5显示出抑制作用，抑制常数(Kis)分别为130、640和120 nM。此外，它还能抑制百日咳杆菌腺苷酸环化酶毒素CyaA（在锰和镁存在下，Kis分别为1.3和20 µM）、炭疽杆菌腺苷酸环化酶毒素水肿因子（在锰和镁存在下，Kis分别为0.44和5.15 µM）以及大肠杆菌重组酶A（RecA；Ki = 6.3 µM）。
T83820	TNP-GTP sodium TNP-Guanosine 5'-triphosphate
	TNP-GTP是一种荧光衍生物，源自蛋白质合成与糖异生的能量底物鸟苷三磷酸(GTP)。其在水中激发波长为410 nm时，发射最大波长为552 nm，而在40%和80%的N,N-二甲基甲酰胺中，其荧光强度增加，发射波长分别向544 nm和532 nm移动，这是因为N,N-二甲基甲酰胺的极性比水小。TNP-GTP是谷氨酸脱氢酶的抑制剂(Ki = 2.7 μM)。当与谷氨酸脱氢酶结合时，TNP-GTP的荧光强度增加，且发射波长从552 nm变为545 nm，此效果可以通过加入GTP来阻断。TNP-GTP还是嘌呤P2X2和P2X2/3受体的拮抗剂(IC50s分别为0.4和1.2 nM)。它还选择性抑制大鼠可溶性鸟苷酸环化酶(sGC; Ki = 11 nM)高于牛肝谷氨酸脱氢酶(GDH; Ki = 2.7 µM)以及钙调素依赖的B. pertussis腺苷酸环化酶(AC)毒素(Kis在存在锰或镁时分别为20和320 µM)。

化合物

Cat.No: T16333

Synonym: Adenylyl cyclase type V Inhibitor

Target: Adenylyl cyclase

Adenylyl cyclase-IN-1

Cat.No: T83169

2',5'-Dideoxyadenosine

Cat.No: T10066

Target: Adenylyl cyclase, Adrenergic Receptor, AChR

Cat.No: T16938

Target: Adenylyl cyclase

Cat.No: T15658

Target: cAMP, AChR

Adenylyl cyclase type 2 agonist-1

Cat.No: T63893

Cat.No: T0322

Target: Dopamine Receptor, AChR

Cat.No: T26869

Synonym: BMS 986122

Target: Opioid Receptor

Cat.No: T16275

Synonym: HTS 09836

Target: Adenylyl cyclase

Cat.No: T60003

Target: Adenylyl cyclase

Cat.No: T8702

Target: Dopamine Receptor, 5-HT Receptor, AChR

Cat.No: T2172

Synonym: 9-(tetrahydrofuran-2-yl)-9h-purin-6-amine,SQ 22536

Target: AChR

Cat.No: T11918

Synonym: Lysine vasopressin,[Lys8]-Vasopressin,赖氨加压素

Target: Others

Cat.No: T7813

Synonym: MSH, amide,CZEN-002,美拉诺坦,α-Melanocyte-Stimulating Hormone (MSH), amide

Target: Melanocortin Receptor, Adenylyl cyclase

Cat.No: T15787

Target: Adenylyl cyclase

Cat.No: T8959

Target: Dopamine Receptor

Cat.No: T64355

Target: cAMP

Cat.No: T22615

Target: Others

1,9-Dideoxyforskolin

Cat.No: T22467

Target: Others

Cat.No: T23863

Synonym: CB 6673567

Cat.No: T38782

Cat.No: T26960

Cat.No: T28622

CFM-1571(free base)

Cat.No: T69543

2'(3')-O-Anthraniloylguanosine-5'-O-triphosphate sodium

Cat.No: T83843

Synonym: 2'(3')-ANT-GTP

Human PTH-(1-31) amide

Cat.No: T76657L

[Des-His1,Glu9]-Glucagon amide

Cat.No: TP2033

Synonym: des-His1-[Glu9]-Glucagon (1-29) amide

Cat.No: T73297

Carsatrin (free base)

Cat.No: T71122

Cat.No: T37131

DAMGO TFA (78123-71-4(Free base))

Cat.No: T4411

Target: Opioid Receptor

Deacetylforskolin

Cat.No: T36720

Carsatrin succinate

Cat.No: T70975

AMP-PNP tetralithium

Cat.No: T37733

2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate sodium

Cat.No: T83811

Synonym: 2'(3')-ANT-ATP

Cat.No: T83820

Synonym: TNP-Guanosine 5'-triphosphate

Cat. No.	Product Name	Target	Signaling Pathways
T2939	Forskolin 毛喉素,Coleonol,Colforsin	FXR; Adenylyl cyclase; AChR; Autophagy	Autophagy; Metabolism; Neuroscience
	Forskolin (Coleonol) 属于天然产物，是一种腺苷酸环化酶激活剂 (EC50=0.5 μM)。Forskolin 可以增加 cAMP 水平，可以激活 PXR 和 FXR，也可以诱导细胞自噬。Forskolin 对心脏产生正性肌力作用，具有血小板抗凝集和降压作用。
T1083	Theophylline Theo-24,1,3-Dimethylxanthine,茶碱	Endogenous Metabolite; HDAC; PDE; Adenosine Receptor; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Theophylline (1,3-Dimethylxanthine) 是茶中的甲基黄嘌呤衍生物，具有利尿、平滑肌松弛、支气管扩张、心脏和中枢神经系统兴奋作用。
T0853L	Adenosine 5'-monophosphate monohydrate 5'-AMP,腺苷-5'-单磷酸一水合物,5'-AMP monohydrate,5'-Adenylic acid	AMPK; Adenosine Receptor; HSV	Chromatin/Epigenetic; GPCR/G Protein; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling
	Adenosine 5'-monophosphate monohydrate (5'-AMP) 是一种核苷酸，用作 RNA 中的单体。它是一个腺苷 A1受体激动剂，对HSV-1和HSV-2具有显著的抗病毒活性。

天然产物

Cat.No: T2939

Synonym: 毛喉素,Coleonol,Colforsin

Target: FXR, Adenylyl cyclase, AChR, Autophagy

Cat.No: T1083

Synonym: Theo-24,1,3-Dimethylxanthine,茶碱

Target: Endogenous Metabolite, HDAC, PDE, Adenosine Receptor, Autophagy

Adenosine 5'-monophosphate monohydrate

Cat.No: T0853L

Synonym: 5'-AMP,腺苷-5'-单磷酸一水合物,5'-AMP monohydrate,5'-Adenylic acid

Target: AMPK, Adenosine Receptor, HSV

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