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Search Results for " xanthine oxidase "

52

抑制剂 & 化合物

30

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T76104	Xanthine oxidase 黄嘌呤氧化酶
	Xanthine oxidase 是一种黄嘌呤氧化还原酶，可产生活性氧 (ROS)，催化次黄嘌呤氧化为黄嘌呤，进一步催化黄嘌呤氧化为尿酸。
T10509	Xanthine oxidase-IN-1 4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acid	Xanthine Oxidase	Metabolism
	Xanthine oxidase-IN-1是一种有效的黄嘌呤氧化酶抑制剂(IC50值:6.5 nM),是一种利用核酸和核苷酸介质降解产生的生物活性核苷酸在嘌呤分解代谢中起核心作用的化合物，
T78984	Xanthine oxidase-IN-10 XO8 analog	ROS	Immunology/Inflammation
	Xanthine oxidase-IN-10 (XO8 analog) 是一种黄嘌呤氧化酶 (XO) 抑制剂，可用于研究痛风。
T8337	Nequinate	Xanthine Oxidase; Parasite	Metabolism; Microbiology/Virology
	Nequinate 是一种喹啉化合物，是一种抗球虫剂，可预防球虫病。它抑制黄嘌呤氧化还原酶活性。
T1274	Benzbromarone Desuric,Normurat,苯溴马隆,Urinorm	Apoptosis; P450; Xanthine Oxidase	Apoptosis; Metabolism
	Benzbromarone (Desuric) 是一种高效的，耐受性良好的非竞争性黄嘌呤氧化酶抑制剂，用作排尿酸剂，研究痛风。
T22304	Desciclovir BW A515U,地昔洛韦,6-Deoxyacyclovir,DCV	Antifection	Microbiology/Virology
	Desciclovir (DCV) 是抗疱疹药物阿昔洛韦的前药，口服有活性，在体内被黄嘌呤氧化酶转化成为阿昔洛韦。
T2397	Topiroxostat 托匹司他,FYX-051	P450; ROS; Xanthine Oxidase	Immunology/Inflammation; Metabolism
	Topiroxostat (FYX-051) 是一种有效的口服黄嘌呤氧化还原酶 (XOR) 抑制剂，IC50=5.3 nM，Ki=5.7 nM。它还表现出弱的CYP3A4抑制活性 (18.6%)。它有用于高尿酸血症的研究潜力。
T72409	Xanthine oxidase-IN-6
	Xanthine oxidase-IN-6 是一种强效的、具有口服活性的黄嘌呤氧化酶 (XOD) 混合型抑制剂，其IC50值为1.37 µM。Xanthine oxidase-IN-6 具有很强的抗高尿酸血症 (anti-hyperuricemia) 和肾保护活性。
T60626	Xanthine oxidase-IN-7
	Xanthine oxidase-IN-7 (compound1h) 是一种口服的黄嘌呤氧化酶(XO)抑制剂 (IC50 = 0.36 μM)。Xanthine oxidase-IN-7 可有效降低血清尿酸水平，在高尿酸血症和痛风的研究中具有潜力。
T61092	Xanthine oxidase-IN-5
	Xanthine oxidase-IN-5, a powerful and orally active inhibitor of xanthine oxidase (XO), exhibits an IC50 value of 0.70 μM. It possesses favorable drug-like characteristics, with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Moreover, Xanthine oxidase-IN-5 showcases significant hypouricemic effects in a hyperuricemic rat model [1].
T80767	Xanthine oxidase-IN-12	Xanthine Oxidase	Metabolism
	Xanthine oxidase-IN-12 (Compound 11), 作为一种高效的黄嘌呤氧化酶 (XO) 抑制剂，其IC50值达到91 nM。此外，Xanthine oxidase-IN-12 亦展现出抗氧化活性，能降低细胞内活性氧种 (ROS) 的水平。
T78985	Xanthine oxidase-IN-11	Xanthine Oxidase	Metabolism
	Xanthine oxidase-IN-11 (XO8 analog) 是一种有效的黄嘌呤氧化酶 (XO) 抑制剂。
T60632	Xanthine oxidase-IN-4
	Xanthine oxidase-IN-4 (化合物 19a) 是一种具有口服活性的有效黄嘌呤氧化酶 (XO) 抑制剂，IC50值为0.039 μM，可用于高尿酸血症和痛风的研究。Xanthine oxidase-IN-4 在氧嗪酸钾诱导的高尿酸血症大鼠中表现出降尿酸能力。
T0692	Allopurinol Zyloric,别嘌醇,Zyloprim,Lopurin,别嘌呤醇	ROS; Xanthine Oxidase	Immunology/Inflammation; Metabolism
	Allopurinol (Zyloric) 是一种黄嘌呤氧化酶(XO)抑制剂，IC50=7.82±0.12 μM。
T0773	Febuxostat 非布索坦,TMX 67,非布司他,TEI 6720	ROS; Xanthine Oxidase	Immunology/Inflammation; Metabolism
	Febuxostat (TEI 6720) 是一种选择性黄嘌呤氧化酶(XO)抑制剂，Ki=0.6 nM。
T6376	Allopurinol Sodium 1H-吡唑并[3,4-D]嘧啶-4-醇单钠盐,Allopurinol sodium salt,Sodium allopurinol	ROS	Immunology/Inflammation
	Allopurinol Sodium 是黄嘌呤氧化酶抑制剂，其IC50= 0.2~50 μM。它能够抗利什曼原虫，也可用于研究痛风以及高尿酸血症。
T33676	Niraxostat Y 700,Y700,Y-700	Xanthine Oxidase	Metabolism
	Niraxostat (Y-700) 是作为黄嘌呤氧化酶抑制剂的异胞嘧啶衍生物之一。
T9366	Pyrazoloadenine 4-Aminopyrazolo[3,4-d]pyrimidine	ROS	Immunology/Inflammation
	Pyrazoloadenine (4-Aminopyrazolo[3,4-d]pyrimidine) 是人黄嘌呤氧化酶的抑制剂。
T8567	amflutizole	Xanthine Oxidase	Metabolism
	amflutizole 用于治疗痛风，是一种黄嘌呤氧化酶抑制剂。
T20042	8-Azaadenine NSC 32797,NSC32797,NSC-32797	Xanthine Oxidase	Metabolism
	8-Azaadenine (NSC-32797) 是一种黄嘌呤氧化酶抑制剂，IC50 为 0.54 μM，Ki 为 0.66 μM。
T20347	Deoxybenzoin 二苯基乙酮,2-Phenylacetophenone,Benzyl phenyl ketone,NSC-131456,NSC131456,NSC 131456	Others	Others
	Deoxybenzoin (2-Phenylacetophenone) 用于靶向免疫传感器和黄嘌呤氧化酶。它用于治疗痛风。
T60625	Tigulixostat
	Tigulixostat 是吲哚基杂芳羧酸的新型衍生物。Tigulixostat 是一种非嘌呤选择性的黄嘌呤氧化酶抑制剂，可降低尿酸的生成。
TP1886L1	NoxA1ds acetate(1435893-78-9 free base)	NADPH-oxidase	Immunology/Inflammation
	NoxA1ds acetate(1435893-78-9 free base) 是一种有效的选择性 NADPH 氧化酶 1 (NOX1) 抑制剂 (IC50 : 20 nM)。对 NOX1 的选择性优于对 NOX2、NOX4、NOX5 和黄嘌呤氧化酶的选择性。它抑制 HT-29 人结肠癌细胞中 NOX1 衍生的 O2 产生。在体外缺氧条件下减弱 VEGF 诱导的人肺动脉内皮细胞迁移。
T50059	6-ethenylquinoline	Others	Others
	6-ethenylquinoline 是一种结构独特的芳香杂环化合物，是生产其他芳香族化合物的重要中间体，并被用作合成各种药物的起始材料，包括抗真菌剂、抗寄生虫剂和抗病毒剂。它已被证明是多种参与药物代谢的酶的抑制剂，包括细胞色素P450、醛氧化酶和黄嘌呤氧化酶等。
T69247	Febuxostat hemihydrate
	Febuxostat hemihydrate is a xanthine oxidase inhibitor used to treat hyperuricemia and chronic gout.
T26058	Renierol
	Renierol is a natural xanthine oxidase inhibitor with hypouricemic effects isolated from marine sponge Halicdona.SP.
T39012	O-Desisobutyl-O-n-propyl Febuxostat
	O-Desisobutyl-O-n-propyl Febuxostat, an xanthine oxidase inhibitor.
T32905	LSPN451 LSPN 451,LSPN-451
	LSPN451 is an effective xanthine oxidase inhibitor and may be used to treat hyperuricemia and gout.
T68437	Febuxostat 67M-1
	Febuxostat 67M-1 is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and reduces the risk of gout or kidney stone formation.
T11270	Febuxostat D9 非布司他D9	Others	Others
	Febuxostat D9 is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.
T73969	Febuxostat impurity 6
	Febuxostat impurity 6 是 Febuxostat 一种杂质。Febuxostat 是选择性黄嘌呤氧化酶 (XO) 抑制剂，Ki 为 0.6 nM。
T69282	Febuxostat 67M-2
	Febuxostat 67M-2 is a derivative compound of Febuxostat 67M-1 which is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and also used to reduce the risk of gout or kidney stone formation.
T75949	NoxA1ds TFA
	NoxA1ds TFA is a potent and selective inhibitor of NADPH oxidase 1 (NOX1), with an inhibition concentration (IC50) of 20 nM, demonstrating selectivity over NOX2, NOX4, NOX5, and xanthine oxidase. It effectively inhibits NOX1-derived O2- production in HT-29 human colon cancer cells and attenuates VEGF-induced migration of human pulmonary artery endothelial cells under hypoxic conditions in vitro.
T73965	Febuxostat n-butyl isomer
	Febuxostat n-butyl isomer 是 Febuxostat 一种杂质。Febuxostat 是选择性黄嘌呤氧化酶 (XO) 抑制剂，Ki 为 0.6 nM。
T73970	Febuxostat dicarboxylic acid impurity
	Febuxostat dicarboxylic acid impurity 是 Febuxostat 一种杂质。Febuxostat 是选择性黄嘌呤氧化酶 (XO) 抑制剂，Ki 为 0.6 nM。
T73967	Febuxostat impurity 7
	Febuxostat impurity 7 是 Febuxostat 一种杂质。Febuxostat 是选择性黄嘌呤氧化酶 (XO) 抑制剂，Ki 为 0.6 nM。
T73971	Febuxostat amide impurity
	Febuxostat amide impurity 是 Febuxostat 一种杂质。Febuxostat 是选择性黄嘌呤氧化酶 (XO) 抑制剂，Ki 为 0.6 nM。
T73960	Febuxostat isopropyl isomer
	Febuxostat isopropyl isomer 是 Febuxostat 一种杂质。Febuxostat 是选择性黄嘌呤氧化酶 (XO) 抑制剂，Ki 为 0.6 nM。
T73968	Febuxostat impurity 8
	Febuxostat impurity 8 是 Febuxostat 一种杂质。Febuxostat 是选择性黄嘌呤氧化酶 (XO) 抑制剂，Ki 为 0.6 nM。
T69281	Febuxostat 67M-4
	Febuxostat 67M-4 is a derivative compound of Febuxostat 67M-1 which is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and reduces the risk of gout or kidney stone formation.
TP1886	NoxA1ds
	Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary
T73966	Febuxostat sec-butoxy acid
	Febuxostat sec-butoxy acid 是 Febuxostat 一种杂质。Febuxostat 是选择性黄嘌呤氧化酶 (XO) 抑制剂，Ki 为 0.6 nM。
T61060	Febuxostat sodium
	Febuxostat (TEI 6720) sodium 在痛风和高尿酸血症研究中具有潜力，它是一种有效的、选择性的、非嘌呤的黄嘌呤氧化酶 (XO)抑制剂，Ki 值为 0.6 nM。
T79177	URAT1&XO inhibitor 2	Xanthine Oxidase	Metabolism
	URAT1&XO inhibitor 2 (Compound BDEO)是一种针对xanthine oxidase (黄嘌呤氧化酶) 及URAT1的双重抑制剂，对xanthine oxidase展现出优异的抑制效果，IC50值为3.3 μM。该化合物在表达URAT1的HEK293细胞中显著抑制尿酸的摄取，其Ki值达到0.145 μM。在动物模型中，URAT1&XO inhibitor 2有效降低高尿酸血症小鼠的血清尿酸水平，并增加尿酸的排泄。该化合物主要用于高尿酸血症的研究。
T35976	6-Formylpterin
	Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen. 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic acid. It binds to one of two active sites on XO nearly quantitatively and irreversibly and prevents the metabolism of other substrates at the second site, resulting in hetero-substrate" inhibition at nanomolar concentrations. However
T62350	XO/COX/LOX-IN-1
	XO/COX/LOX-IN-1 是一种黄嘌呤氧化酶/环氧酶/脂氧合酶 XO/COX/LOX 的有效抑制剂。XO/COX/LOX-IN-1 能够用于研究炎症、癌症以及代谢性疾病。
T75501	Morin 3-O-β-D-glucopyranoside
	Morin 3-O-β-D-glucopyranoside 是一种天然类黄酮，具有抗真菌、抗癌和抗氧化活性。Morin 3-O-β-D-glucopyranoside 抑制逆转录酶、蛋白酪氨酸激酶和黄嘌呤氧化酶，还具有抗 HIV、抗动脉硬化和超氧化物清除活性。
T79331	Antioxidant agent-13	Xanthine Oxidase	Metabolism
	Antioxidant agent-13（Compound 5f）为一种效能显著的抗氧化剂，其抑制DPPH和FRAP的IC50值分别为80.33 μM和85.69 μM；同时，Antioxidant agent-13对LOX和XO酶的抑制作用亦强，对应IC50值为16.85 μM及23.01 μM。
T36501	CYPMPO RR 071
	CYPMPO is a free radical spin trap with excellent trapping capabilities toward hydroxyl and superoxide radicals in biological and chemical systems. Decay of the superoxide adduct of CYPMPO proceeds in an apparent first order fashion with half-lives of 15 and 51 minutes in a UV-illuminated hydrogen peroxide solution and a hypoxanthine/xanthine oxidase system, respectively. CYPMPO traps superoxide radicals generated by bovine neutrophils as effectively as DEPMPO.[1] The high melting point (126°C),...
T79175	URAT1&XO inhibitor 1	Xanthine Oxidase	Metabolism
	URAT1&XO inhibitor 1（化合物29）是一种对URAT1(IC50≈10μM)和黄嘌呤氧化酶(IC50=1.01μM)具有双重抑制作用的抑制剂。该化合物能够在氧酸钾引起的高尿酸血症大鼠模型中降低血尿酸水平，已广泛应用于高尿酸血症的研究。

化合物

Xanthine oxidase

Cat.No: T76104

Synonym: 黄嘌呤氧化酶

Xanthine oxidase-IN-1

Cat.No: T10509

Synonym: 4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acid

Target: Xanthine Oxidase

Xanthine oxidase-IN-10

Cat.No: T78984

Synonym: XO8 analog

Target: ROS

Cat.No: T8337

Target: Xanthine Oxidase, Parasite

Cat.No: T1274

Synonym: Desuric,Normurat,苯溴马隆,Urinorm

Target: Apoptosis, P450, Xanthine Oxidase

Cat.No: T22304

Synonym: BW A515U,地昔洛韦,6-Deoxyacyclovir,DCV

Target: Antifection

Cat.No: T2397

Synonym: 托匹司他,FYX-051

Target: P450, ROS, Xanthine Oxidase

Xanthine oxidase-IN-6

Cat.No: T72409

Xanthine oxidase-IN-7

Cat.No: T60626

Xanthine oxidase-IN-5

Cat.No: T61092

Xanthine oxidase-IN-12

Cat.No: T80767

Target: Xanthine Oxidase

Xanthine oxidase-IN-11

Cat.No: T78985

Target: Xanthine Oxidase

Xanthine oxidase-IN-4

Cat.No: T60632

Cat.No: T0692

Synonym: Zyloric,别嘌醇,Zyloprim,Lopurin,别嘌呤醇

Target: ROS, Xanthine Oxidase

Cat.No: T0773

Synonym: 非布索坦,TMX 67,非布司他,TEI 6720

Target: ROS, Xanthine Oxidase

Allopurinol Sodium

Cat.No: T6376

Synonym: 1H-吡唑并[3,4-D]嘧啶-4-醇单钠盐,Allopurinol sodium salt,Sodium allopurinol

Target: ROS

Cat.No: T33676

Synonym: Y 700,Y700,Y-700

Target: Xanthine Oxidase

Pyrazoloadenine

Cat.No: T9366

Synonym: 4-Aminopyrazolo[3,4-d]pyrimidine

Target: ROS

Cat.No: T8567

Target: Xanthine Oxidase

Cat.No: T20042

Synonym: NSC 32797,NSC32797,NSC-32797

Target: Xanthine Oxidase

Cat.No: T20347

Synonym: 二苯基乙酮,2-Phenylacetophenone,Benzyl phenyl ketone,NSC-131456,NSC131456,NSC 131456

Target: Others

Cat.No: T60625

NoxA1ds acetate(1435893-78-9 free base)

Cat.No: TP1886L1

Target: NADPH-oxidase

6-ethenylquinoline

Cat.No: T50059

Target: Others

Febuxostat hemihydrate

Cat.No: T69247

Cat.No: T26058

O-Desisobutyl-O-n-propyl Febuxostat

Cat.No: T39012

Cat.No: T32905

Synonym: LSPN 451,LSPN-451

Febuxostat 67M-1

Cat.No: T68437

Cat.No: T11270

Synonym: 非布司他D9

Target: Others

Febuxostat impurity 6

Cat.No: T73969

Febuxostat 67M-2

Cat.No: T69282

Cat.No: T75949

Febuxostat n-butyl isomer

Cat.No: T73965

Febuxostat dicarboxylic acid impurity

Cat.No: T73970

Febuxostat impurity 7

Cat.No: T73967

Febuxostat amide impurity

Cat.No: T73971

Febuxostat isopropyl isomer

Cat.No: T73960

Febuxostat impurity 8

Cat.No: T73968

Febuxostat 67M-4

Cat.No: T69281

Cat.No: TP1886

Febuxostat sec-butoxy acid

Cat.No: T73966

Febuxostat sodium

Cat.No: T61060

URAT1&XO inhibitor 2

Cat.No: T79177

Target: Xanthine Oxidase

Cat.No: T35976

XO/COX/LOX-IN-1

Cat.No: T62350

Morin 3-O-β-D-glucopyranoside

Cat.No: T75501

Antioxidant agent-13

Cat.No: T79331

Target: Xanthine Oxidase

Cat.No: T36501

Synonym: RR 071

URAT1&XO inhibitor 1

Cat.No: T79175

Target: Xanthine Oxidase

Cat. No.	Product Name	Target	Signaling Pathways
T16685	Purpurogallin 红倍酚,红陪酚	Xanthine Oxidase	Metabolism
	Purpurogallin 是一种从栎属植物中提取的天然酚，具有显著的黄嘌呤氧化酶抑制作用，其IC50=0.2 µM，具有抗氧化和抗炎作用。
T1694	Oxypurinol Oxipurinol,羟基嘌呤	ROS; Xanthine Oxidase; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Oxypurinol 是一种黄嘌呤氧化酶 (xanthine oxidase) 抑制剂，是 Allopurinol 的主要特性代谢产物。它能够用于调节血尿酸水平，有潜力用于痛风的研究。
TMA0958	Forsythoside F 连翘酯苷F,Arenarioside,三糖苯丙素苷	Xanthine Oxidase	Metabolism
	Forsythoside F (Arenarioside) 是一种黄嘌呤氧化酶 (xanthine oxidase) 抑制剂，具有抗高尿酸活性。
T2858	Baicalein 5,6,7-Trihydroxyflavone,黄芩素,黄芩黄素	Ferroptosis; Influenza Virus; ROS; Xanthine Oxidase	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology
	Baicalein (5,6,7-Trihydroxyflavone) 是一种黄嘌呤氧化酶抑制剂，其IC50值为 3.12 μM。
T2971	Phytic acid Inositol hexaphosphate,inositol hexakisphosphate,inositol polyphosphate,myo-Inositol, hexakis(dihydrogen phosphate),植酸,Fytic Acid	Xanthine Oxidase; Endogenous Metabolite	Metabolism
	Phytic acid (Fytic Acid) 是种子和谷粒的磷储存化合物。它被称为食品抑制剂，具有很强的螯合多价金属离子的能力，特别是钙，铁，锌和蛋白质残留物。它抑制超氧化物来源黄嘌呤氧化酶并具有抗氧化，抗炎以及神经保护作用。
T12564	Prudomestin 3,5,7-Trihydroxy-4',8-dimethoxyflavone,3,5,7-三羟基-8,4'-二甲氧基黄酮	Xanthine Oxidase	Metabolism
	Prudomestin (3,5,7-Trihydroxy-4',8-dimethoxyflavone) 是一种分离自 Prunus domestica 心材中，具有很强的黄嘌呤氧化酶(XO)抑制活性(IC50≈6 µM)。
T75504	Xanthine oxidase-IN-8
	Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) 是一种 XOD 抑制剂，IC50值为 29.71 μM。
T75505	Xanthine oxidase-IN-9
	Xanthine oxidase-IN-9 (Icarisids E) (Compound 2)，一种黄嘌呤氧化酶 (XOD) 高效抑制剂，具有31.81 μM 的 IC50 值。
T16527	Phytic acid dodecasodium salt hydrate 植酸十二钠盐,myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate,Inositol hexaphosphate dodecasodium salt hydrate	Others; Xanthine Oxidase; Endogenous Metabolite	Metabolism; Others
	Phytic acid dodecasodium salt hydrate (myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate) 是种子和谷物的磷储存化合物。 Phytic acid dodecasodium salt hydrate 抑制酶促超氧化物源黄嘌呤氧化酶，IC50 为 6 mM，并具有抗氧化、神经保护和抗炎作用。
T1363	N-Demethylricinine 4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile,吉莫斯特中间体二	ROS	Immunology/Inflammation
	N-Demethylricinine (4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile) 被报道为 xanthine oxidase 抑制剂。
TN1002	Blumeatin	ROS	Immunology/Inflammation
	Blumeatin 是从Blumea balsamiferaDC 中分离得到，对 CCl4 和硫代乙酰胺 (TAA) 所致的肝损伤表现出保护活性。
T3750	4-Hydroxyacetophenone 对羟基苯乙酮,4-Acetylphenol,Piceol,p-Acetylphenol,4'-Hydroxyacetophenone	HBV; Xanthine Oxidase	Metabolism; Microbiology/Virology
	4-Hydroxyacetophenone (4-Acetylphenol) 是蒿属植物和木香属植物中的一种黄嘌呤氧化酶抑制剂，具有保肝促胆、抗乙型肝炎病毒和抗炎作用。
T0665	Xanthine 2,6-Dihydroxypurine,海生丁（黄嘌呤）,黄嘌呤,Isoxanthine	Endogenous Metabolite; Adenosine Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Xanthine (Isoxanthine) 是一种植物生物碱，存在于茶、咖啡和可可中。Xanthine 是温和的中枢神经系统激活剂，也是嘌呤降解途径的中间产物。
T5S0281	Tubuloside A	NOS	Immunology/Inflammation
	Tubuloside A 是一种苯乙醇苷，具有抗氧化活性和保肝活性。
TN1962	Myricetin 3-O-galactoside Myricetin 3-O-beta-D-galactopyranoside	NOS; Xanthine Oxidase	Immunology/Inflammation; Metabolism
	Myricetin 3-O-galactoside (Myricetin 3-O-beta-D-galactopyranoside) 可抑制黄嘌呤氧化酶 (xanthine oxidase; XO) 活性，脂质过氧化并清除自由基。杨梅素3- o -半乳糖苷具有很多作用包括细胞毒性、抗氧化、抗基因毒性、抗感染性、抗炎作用和抗氧化活性，其主要作用是抑制诱导型一氧化氮合酶(iNOS)的合成。Myricetin 3-O-galactoside 抑制脂质过氧化的 IC50 为 160 μg/mL。
T0617	Nicotinamide N-oxide Nicotinamide-N-oxide,Nicotinamide 1-oxide,N-氧代烟酰胺,烟酰胺-N-氧化物,1-oxynicotinamide	c-Myc; Endogenous Metabolite; CXCR; Drug Metabolite	Autophagy; Cell Cycle/Checkpoint; GPCR/G Protein; Immunology/Inflammation; Metabolism
	Nicotinamide N-oxide (Nicotinamide 1-oxide) 是生物体内烟酰胺分解代谢物，是高效选择性CXCR2受体拮抗剂。
T0626	Uric Acid 尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate	Reactive Oxygen Species; Endogenous Metabolite; Phosphorylase	Immunology/Inflammation; Metabolism; NF-κB
	Uric Acid (Lithic acid) 是一种重要的抗氧化剂。Uric acid 能清除活性氧(ROS) ，如单线态氧和过氧亚硝酸盐，抑制脂质过氧化。Uric acid 有助于维持血压的稳定和抗氧化应激。
T1362	Hypoxanthine 次黄嘌呤,6-羟基嘌呤,6-Hydroxypurine,Purin-6-ol,Sarcine,Sarkin	Others; Endogenous Metabolite	Metabolism; Others
	Hypoxanthine (Purin-6-ol)，也被称为 purine-6-ol 或 Hyp，是一种天然存在的嘌呤衍生物，是腺苷代谢和核苷酸补救途径形成核酸的反应中间体。在正常情况下，Hypoxanthine 很容易转化为尿酸。Hypoxanthine 首先被氧化为黄嘌呤，黄嘌呤再被黄嘌呤氧化酶氧化为尿酸。
T4746	Purine 7H-Imidazo(4,5-d)pyrimidine,嘌呤	Others; Endogenous Metabolite	Metabolism; Others
	Purine (7H-Imidazo(4,5-d)pyrimidine) 是内源性代谢产物的一种。
TN5670	Protosappanin A dimethyl acetal
	Protosappanin A dimethyl acetal shows significant xanthine oxidase inhibitory activity in a concentration-dependent manner.
TN2180	Sappanchalcone 苏木查耳酮	IL Receptor; BCL; TNF	Apoptosis; Immunology/Inflammation
	Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
TN4080	Fraxamoside	Xanthine Oxidase	Metabolism
	Fraxamoside is a xanthine oxidase inhibitor (XOI) comparable in potency in vitro to the standard antigout drug allopurinol. It shows significant free radical scavenging effect against DPPH(EC50=62.6 uM).
TN3208	7,3',4'-Trihydroxy-3-benzyl-2H-chromene	ROS	Immunology/Inflammation
	7,3',4'-Trihydroxy-3-benzyl-2H-chromene is a potential xanthine oxidase inhibitor.
T38777	Ilexoside O
	Ilexoside O, a triterpene saponin derived from Ilex pubescens roots, demonstrates modest inhibition of xanthine oxidase (XOD) activity with an IC50 value of 53.05 μM.
T75546	Ellagic acid 4-O-β-D-xylopyranoside
	Ellagic acid 4-O-β-D-xylopyranoside，天然鞣花单宁，展现抗菌活性。同时，作为黄嘌呤氧化酶 (xanthine oxidase) 抑制剂，其50为 2.1 μg/mL。
TN1503	Cistanoside F 肉苁蓉苷F,肉苁蓉苷 F	NADPH-oxidase	Immunology/Inflammation
	Cistanoside F shows vasorelaxant, and antioxidative effects, it shows a strong free radical scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and xanthine/xanthine oxidase (XOD) generated superoxide anion radical (O2-.).
TN4433	Licoarylcoumarin	cAMP; HIV Protease; Antifection	GPCR/G Protein; Microbiology/Virology; Proteases/Proteasome
	Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effects on xanthine oxidase.
TN3473	Axillarin
	Axillarin has antioxidant activity, it shows xanthine oxidase inhibitory activity ( IC(50) :36.0 uM). Axillarin can strongly protect primary cultured neurons against glutamate-induced oxidative stress.
T82649	Cyanidin
	Cyanidin，作为一种抗氧化剂，能够保护 DNA 免受裂解，有效清除自由基，并显著抑制 XO 活性。
T72594	Broussochalcone A
	Broussochalcone A 是一种具有抗氧化和抑制黄嘌呤氧化酶（IC50=2.21 μM）功能的化合物，能清除自由基，抑制铁诱导的脂质过氧化和脂多糖（LPS）激活的巨噬细胞中一氧化氮（NO）的合成。此外，Broussochalcone A 通过增加ROS水平和激活FOXO3信号通路，诱导人肾癌细胞的凋亡（Apoptosis）。

天然产物

Cat.No: T16685

Synonym: 红倍酚,红陪酚

Target: Xanthine Oxidase

Cat.No: T1694

Synonym: Oxipurinol,羟基嘌呤

Target: ROS, Xanthine Oxidase, Endogenous Metabolite

Cat.No: TMA0958

Synonym: 连翘酯苷F,Arenarioside,三糖苯丙素苷

Target: Xanthine Oxidase

Cat.No: T2858

Synonym: 5,6,7-Trihydroxyflavone,黄芩素,黄芩黄素

Target: Ferroptosis, Influenza Virus, ROS, Xanthine Oxidase

Cat.No: T2971

Synonym: Inositol hexaphosphate,inositol hexakisphosphate,inositol polyphosphate,myo-Inositol, hexakis(dihydrogen phosphate),植酸,Fytic Acid

Target: Xanthine Oxidase, Endogenous Metabolite

Cat.No: T12564

Synonym: 3,5,7-Trihydroxy-4',8-dimethoxyflavone,3,5,7-三羟基-8,4'-二甲氧基黄酮

Target: Xanthine Oxidase

Xanthine oxidase-IN-8

Cat.No: T75504

Xanthine oxidase-IN-9

Cat.No: T75505

Phytic acid dodecasodium salt hydrate

Cat.No: T16527

Synonym: 植酸十二钠盐,myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate,Inositol hexaphosphate dodecasodium salt hydrate

Target: Others, Xanthine Oxidase, Endogenous Metabolite

N-Demethylricinine

Cat.No: T1363

Synonym: 4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile,吉莫斯特中间体二

Target: ROS

Cat.No: TN1002

Target: ROS

4-Hydroxyacetophenone

Cat.No: T3750

Synonym: 对羟基苯乙酮,4-Acetylphenol,Piceol,p-Acetylphenol,4'-Hydroxyacetophenone

Target: HBV, Xanthine Oxidase

Cat.No: T0665

Synonym: 2,6-Dihydroxypurine,海生丁（黄嘌呤）,黄嘌呤,Isoxanthine

Target: Endogenous Metabolite, Adenosine Receptor

Cat.No: T5S0281

Target: NOS

Myricetin 3-O-galactoside

Cat.No: TN1962

Synonym: Myricetin 3-O-beta-D-galactopyranoside

Target: NOS, Xanthine Oxidase

Nicotinamide N-oxide

Cat.No: T0617

Synonym: Nicotinamide-N-oxide,Nicotinamide 1-oxide,N-氧代烟酰胺,烟酰胺-N-氧化物,1-oxynicotinamide

Target: c-Myc, Endogenous Metabolite, CXCR, Drug Metabolite

Cat.No: T0626

Synonym: 尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate

Target: Reactive Oxygen Species, Endogenous Metabolite, Phosphorylase

Cat.No: T1362

Synonym: 次黄嘌呤,6-羟基嘌呤,6-Hydroxypurine,Purin-6-ol,Sarcine,Sarkin

Target: Others, Endogenous Metabolite

Cat.No: T4746

Synonym: 7H-Imidazo(4,5-d)pyrimidine,嘌呤

Target: Others, Endogenous Metabolite

Protosappanin A dimethyl acetal

Cat.No: TN5670

Cat.No: TN2180

Synonym: 苏木查耳酮

Target: IL Receptor, BCL, TNF

Cat.No: TN4080

Target: Xanthine Oxidase

7,3',4'-Trihydroxy-3-benzyl-2H-chromene

Cat.No: TN3208

Target: ROS

Cat.No: T38777

Ellagic acid 4-O-β-D-xylopyranoside

Cat.No: T75546

Cat.No: TN1503

Synonym: 肉苁蓉苷F,肉苁蓉苷 F

Target: NADPH-oxidase

Licoarylcoumarin

Cat.No: TN4433

Target: cAMP, HIV Protease, Antifection

Cat.No: TN3473

Cat.No: T82649

Broussochalcone A

Cat.No: T72594

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