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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1038 |
Fludarabine
NSC 118218,Fludarabinum,氟达拉宾,氟达拉滨,F-ara-A |
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; STAT | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; JAK/STAT signaling; Stem Cells |
Fludarabine (Fludarabinum) 是一种氟化嘌呤类似物,一种核酸合成抑制剂和 STAT1 激活抑制剂。Fludarabine 具有抗肿瘤活性,可以用于治疗白血病和淋巴瘤。 | |||
T2168 |
2-(1,8-naphthyridin-2-yl)phenol
|
STAT | JAK/STAT signaling; Stem Cells |
2-NP 是选择性的STAT1转录增强剂。它能够增强 IFN-γ 的功能,提高对人乳腺癌和纤维肉瘤细胞增殖的抑制能力。 | |||
T2505 |
S3I-201
S3I 201,S3I201 |
STAT | JAK/STAT signaling; Stem Cells |
S3I-201 (S3I-201) 是一种选择性Stat3抑制剂,IC50为 86 μM。 | |||
T35544 |
ML115
|
STAT | JAK/STAT signaling; Stem Cells |
ML115 是一种有效且选择性的转录 3 (STAT3) 激活剂,abn EC50 为 2.0 nM,对相关的 STAT1 和 NFκB 抗靶点无活性。 | |||
T1563 |
Nifuroxazide
Diarlidan,硝呋齐特,Nifuroxazid,Dicoferin,硝呋酚酰肼 |
Antibacterial; Antibiotic; STAT | JAK/STAT signaling; Microbiology/Virology; Stem Cells |
Nifuroxazide (Diarlidan) 是STAT3抑制剂,具有抗转移和抗癌活性。 | |||
T72029 |
CDK8-IN-13
|
Apoptosis; CDK | Apoptosis; Cell Cycle/Checkpoint |
CDK8-IN-13是一种 CDK8抑制剂(IC50:51.9 nM),具有强效性、选择性和口服活性。CDK8-IN-13能诱导细胞凋亡,降低了 p-STAT1 S727和p-STAT5 S726的表达。CDK8-IN-13表现出抗肿瘤活性。 | |||
TQ0037 |
Abrocitinib
PF-04965842 |
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Abrocitinib (PF-04965842) 是可口服、选择性的JAK1抑制剂,可用于自身免疫症的研究,对 JAK1 和 JAK2 的IC50值分别为 29 和 803 nM。它可抑制 TYK2 的活性,IC50为1.253 μM, 也可抑制刺激后 STAT1、STAT3 和 STAT5 的磷酸化水平。 | |||
T26895 |
BRD0476
BRD-0476,ML 187,ML187,ML-187,BRD 0476 |
||
BRD0476 is a suppressor of pancreatic β-cell apoptosis. BRD0476 inhibits interferon-gamma (IFN-γ)-induced Janus kinase 2 (JAK2) and signal transducer and activation of transcription 1 (STAT1) signaling to promote β-cell survival. BRD0476 inhibits JAK-STAT | |||
T21501 | 5,15-DPP | ||
5,15-Diphenylporphyrin (5,15-DPP) 是一种选择性STAT3-SH2拮抗剂,其对于STAT3 和 STAT1 的IC50值分别为 0.28 μM 和 10 μM。 | |||
T73472 | Erasin | ||
Erasin 是一种有效的 Erlotinib 抗性STAT3抑制剂,对STAT3和STAT1的IC50分别为 9.7 和 24 μM。Erasin 诱导癌细胞凋亡(apoptosis)。 | |||
T61779 |
STAT3-IN-9
|
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STAT3-IN-9, a potent inhibitor of STAT3 activation at Tyr705, exhibits no impact on the phosphorylation of STAT1 at Tyr 701. Additionally, this compound efficiently induces apoptosis and cell cycle arrest specifically at the G2/M phase [1]. | |||
T71156 |
Poloxipan
|
||
Poloxipan is a potent and pan-specific PLK1 inhibitor. In vitro, Poloxipan has IC50 3.2 uM (Plk1); 1.7 uM (Plk2); and 3 uM (Plk3). Poloxipan showed minor inhibition over FHA dommain of Chk2, S2 domian of STAT1, STAT5b, Lck, etc. | |||
T26936 |
C188
Cpd188,STAT3-IN-C188,Cpd-188,C 188,C-188 |
||
C188 is a cell-permeable naphthol compound and a STAT3 inhibitor. C188 inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket, while exhibiting little effect agai | |||
T77038 | Interferon alfa | ||
Interferon alfa 是 I 型干扰素,可激活新基因,对靶细胞产生有效抗病毒和抗增殖活性。Interferon alfa 的信号传导需要 Stat1和 Stat2 的受体依赖性激活,形成异源二聚化 STAT。STAT 复合物与 DNA 结合蛋白 IRF-9 (p48) 结合并形成 ISGF-3 (IFN 刺激基因因子 3)。随后由 ISGF-3 进一步激活驱动基因,实现抗病毒功能。 | |||
T74784 | LL-K8-22 | ||
LL-K8-22 是一款高效且具有选择性和持久性的 CDK8-cyclin C 双重降解剂,其DC50值分别为2.52 μM和2.64 μM。该化合物还能抑制STAT1Ser 727的磷酸化,并能抑制由E2F 和 MYC 驱动的致癌转录程序,适用于三阴性乳腺癌 (TNBC) 的研究。 | |||
T36645 |
CAY10763
CAY10763 |
||
CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50= 46 nM) and STAT3 activation.1It binds to STAT3 (Kd= 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position 705 (STAT3Y705) over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells when used at a concentration of 500 nM. It also inhibits STAT3 nuclear translocation in SKOV3 cells. CAY10763 is cytotoxic to HCT116, SKOV3, A549, and HepG2 cancer cells (IC50s = 37, 28, 33, and 12 nM... | |||
T68182 |
3-Hydroxykynurenamine
|
||
3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the IFN-γ mediated STAT1/NF-κΒ pathway in both mouse and human dendritic cells (DCs) with a consequent decrease in the release of pro-inflammatory chemokines and cytokines, most notably TNF, IL-6, and IL12p70. 3-HKA has protective effects in an experimental mouse model of psoriasis ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T14854 |
Caerulomycin A
浅蓝霉素,Cerulomycin,Caerulomycin |
Antifungal | Microbiology/Virology |
Caerulomycin A (Caerulomycin) 是抗真菌和抗细菌化合物,能够诱导 T 细胞的产生。它能够抑制 IFN-γ 诱导的 STAT1 通路,从而增强 TGF-β-Smad3 信号通路。它可用于自身免疫病的研究。 | |||
T2814 |
Cryptotanshinone
隐丹参酮,Cryptotanshinon,Tanshinone c,隐丹参醌 |
STAT; Autophagy | Autophagy; JAK/STAT signaling; Stem Cells |
Cryptotanshinone (Cryptotanshinon) 是从丹参的根中提取的一种天然产物,抑制STAT3的IC50为4.6 μM,具有抗肿瘤活性。 | |||
T5681 |
ETHYL CAFFEATE
咖啡酸乙酯,ETHYL 3,4-DIHYDROXYCINNAMATE |
NF-κB; COX; PGE Synthase; NO Synthase | Immunology/Inflammation; Neuroscience; NF-κB |
Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) 是从鬼针草分离的一种酚类天然产物,在体外或在小鼠皮肤中抑制NF-κB 活化及其下游炎症介质的诱导型一氧化氮合酶、环氧合酶 2 和前列腺素 E2。 | |||
T3824 |
Jaceosidin
|
Apoptosis; BCL; COX; UGT | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience |
Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物,可激活Bax,下调 Mcl-1 和 c-FLIP 的表达,诱导癌细胞凋亡。它能够降低炎性因子水平,激活 NF-κB,抑制COX-2的表达,具有抗癌和抗炎作用。 | |||
T6677 |
Sophocarpine
|
ERK; p38 MAPK; NF-κB; TLR; COX; HER; JNK; STAT | Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors |
Sophocarpine 是一种从传统草药苦参中提取的重要生物碱。苦参具有抗病毒、抗肿瘤和抗炎等多种药理作用。它通过多种机制显著抑制癌细胞的生长,具有抗肿瘤活性。 | |||
TN6366 |
Lupinalbin A
鲁冰花 |
||
Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokines and blocking of IFN-β/STAT1 pathw |