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Search Results for " shik "

7

抑制剂 & 化合物

16

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T125535	3-O-Caffeoylshikimic acid
	3-O-Caffeoylshikimic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125535。
T125229	Yashabushiketol
	Yashabushiketol 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125229，CAS号为 24192-00-5。
T125224	Shikokianin
	Shikokianin 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125224。
T123853	3,4-Di-o-galloylshikimicacid
	3,4-Di-o-galloylshikimicacid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T123853，CAS号为 95753-51-8。
T126409	5-0-Galloylshikimicacid
	5-0-Galloylshikimicacid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126409，CAS号为 110082-91-2。
T123852	3,5-Di-O-galloylshikimic acid
	3,5-Di-O-galloylshikimic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T123852，CAS号为 95753-52-9。
T125228	Dihydroyashabushiketol
	Dihydroyashabushiketol 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125228，CAS号为 24192-01-6。

化合物

3-O-Caffeoylshikimic acid

Cat.No: T125535

Yashabushiketol

Cat.No: T125229

Cat.No: T125224

3,4-Di-o-galloylshikimicacid

Cat.No: T123853

5-0-Galloylshikimicacid

Cat.No: T126409

3,5-Di-O-galloylshikimic acid

Cat.No: T123852

Dihydroyashabushiketol

Cat.No: T125228

Cat. No.	Product Name	Target	Signaling Pathways
TN1137	Isobutylshikonin	Others	Others
	Isobutylshikonin 是分离自Lithospermum canescens 毛状根培养的一种紫草素色素。
T2897	(Rac)-Shikonin (±)-Shikonin,Alkanet extract,Anchusin,紫草素,Anchusa acid	Others	Others
	(Rac)-Shikonin (Anchusin) 具有抗肿瘤作用。它能够诱导坏死死亡来绕过癌症耐药性。
T5S2350	Beta-Acetoxyisovalerylshikonin 乙酰氧基异戊酰阿卡宁,Acetoxyisovalerylalkannin,β-乙酰氧基异戊酰阿卡宁	Others	Others
	Acetoxyisovalerylshikonin 是一种萘醌衍生物，提取自Arnebia euchroma 中。
T1125	Shikonin NSC 252844,Isoarnebin 4,(+)-Shikonin,紫草素,Alkanna Red,C.I. 75535,Anchusa acid	TNF; NF-κB; Chloride channel; HIV Protease; PKM	Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Shikonin (Anchusa acid) 属于天然产物，是一种 TMEM16A 氯离子通道抑制剂 (IC50=6.5 μM) 和选择性 PKM2 抑制剂。Shikonin 具有抗肿瘤、抗炎和伤口愈合活性。
T5S2343	Acetylshikonin 乙酰紫草素,Acetyl shikonin	Others; P450; AChE	Metabolism; Neuroscience; Others
	Acetylshikonin 来源于紫草根，具有抗癌、抗炎作用。它是一种 AChE 抑制剂，具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂，对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。
TN2447	Isovalerylshikonin	Antibacterial	Microbiology/Virology
	Isovalerylshikonin 是太子参和紫草的天然产物。
T3S2344	β,β-Dimethylacrylshikonin β,β-二甲基丙烯酰紫草素,Dimethylacrylshikonin,β, β-Dimethylacrylshikonin	ERK; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; MAPK; Metabolism
	β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) 是一种萘醌衍生物，从 Arnebia nobilis 中提取得到。它利用 PI3K 通路诱导 eNOS、VEGF 和 HIF-1α 的表达，促进血管生成，具有抗肿瘤活性。
TN1295	5-O-Caffeoylshikimic acid	IL Receptor; TNF; NO Synthase	Apoptosis; Immunology/Inflammation
	5-O-Caffeoylshikimic acid 具有抗氧化和抗炎作用，可用于非小细胞肺癌的研究。
T5S2347	Deoxyshikonin 去氧紫草素,Arnebin 7	Others; HIF/HIF Prolyl-Hydroxylase; Antibacterial	Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Others
	Deoxyshikonin (Arnebin 7) 是从紫草中分离的天然产物，具有抗肿瘤活性，在体外具有促血管生成作用。它和没食子酸十二烷基酯在体内外均与青霉素有显着的协同抗菌活性。
T2739	Shikimic Acid Shikimate,莽草酸	Others; Endogenous Metabolite	Metabolism; Others
	Shikimic Acid (Shikimate) 是一种三羟基环己烯羧酸，是在微生物和植物中发现的，芳香族氨基酸生物合成途径的关键代谢中间体。
TN1238	3,4-O-Isopropylidene-shikimic acid 3,4-O-异亚丙基莽草酸,3,4-O-Isopropylidene shikimic acid	NOS; NO Synthase	Immunology/Inflammation
	3,4-O-Isopropylidene-shikimic acid (3,4-O-Isopropylidene shikimic acid) 是一种从Hypericum wightianum 中提取得到的天然产物。它具有抗炎症和抗氧化作用。
TN6458	Acetylshikonin
	Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity.
TN1440	Beta-Hydroxyisovalerylshikonin	EGFR; Tyrosine Kinases; Prostaglandin Receptor; Src; AMPK; Fatty Acid Synthase	Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Beta-hydroxyisovalerylshikonin 是分离自Lithospermium radix 的天然产物，具有抑制PTK 的作用，对 EGFR 和 v-Src 受体作用的IC50分别为 0.7 μM 和 1 μM。它对多种肿瘤细胞系均有抑制作用，可以高效诱导 NCI-H522 和 DMS114 细胞的死亡。
TN2207	Shikonofuran A	Others	Others
	Shikonofuran A 是一种分离自 Lithosperraum erythrorhizon Sieb 的根的天然产物。
TN2439	(2-Methylbutyryl)shikonin	Others	Others
	(2-Methylbutyryl)shikonin is a natural product from Lithospermum erythrorhizon Sieb. et Zucc.
TN3052	4-O-Caffeoylshikimic acid	Others	Others
	4-O-Caffeoylshikimic acid is a natural product from Illicium verum.

天然产物

Isobutylshikonin

Cat.No: TN1137

Target: Others

(Rac)-Shikonin

Cat.No: T2897

Synonym: (±)-Shikonin,Alkanet extract,Anchusin,紫草素,Anchusa acid

Target: Others

Beta-Acetoxyisovalerylshikonin

Cat.No: T5S2350

Synonym: 乙酰氧基异戊酰阿卡宁,Acetoxyisovalerylalkannin,β-乙酰氧基异戊酰阿卡宁

Target: Others

Cat.No: T1125

Synonym: NSC 252844,Isoarnebin 4,(+)-Shikonin,紫草素,Alkanna Red,C.I. 75535,Anchusa acid

Target: TNF, NF-κB, Chloride channel, HIV Protease, PKM

Cat.No: T5S2343

Synonym: 乙酰紫草素,Acetyl shikonin

Target: Others, P450, AChE

Isovalerylshikonin

Cat.No: TN2447

Target: Antibacterial

β,β-Dimethylacrylshikonin

Cat.No: T3S2344

Synonym: β,β-二甲基丙烯酰紫草素,Dimethylacrylshikonin,β, β-Dimethylacrylshikonin

Target: ERK, HIF/HIF Prolyl-Hydroxylase

5-O-Caffeoylshikimic acid

Cat.No: TN1295

Target: IL Receptor, TNF, NO Synthase

Cat.No: T5S2347

Synonym: 去氧紫草素,Arnebin 7

Target: Others, HIF/HIF Prolyl-Hydroxylase, Antibacterial

Shikimic Acid

Cat.No: T2739

Synonym: Shikimate,莽草酸

Target: Others, Endogenous Metabolite

3,4-O-Isopropylidene-shikimic acid

Cat.No: TN1238

Synonym: 3,4-O-异亚丙基莽草酸,3,4-O-Isopropylidene shikimic acid

Target: NOS, NO Synthase

Cat.No: TN6458

Beta-Hydroxyisovalerylshikonin

Cat.No: TN1440

Target: EGFR, Tyrosine Kinases, Prostaglandin Receptor, Src, AMPK, Fatty Acid Synthase

Shikonofuran A

Cat.No: TN2207

Target: Others

(2-Methylbutyryl)shikonin

Cat.No: TN2439

Target: Others

4-O-Caffeoylshikimic acid

Cat.No: TN3052

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04466	STK40 Protein, Human, Recombinant (His & GST) SHIK,SgK495,serine/threonine kinase 40	Human	Baculovirus Insect Cells
	STK40 is localized to both the cytoplasm and the nucleus. It is ubiquitously expressed. Mechanistically, Stk40 interacts with Rcn2, which also activates Erk1/2 to induce ExEn specification in mouse ESCs. Stk40 is able to activate the Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse ESCs. Interestingly, cells overexpressing Stk40 exclusively contribute to the ExEn layer of chimeric embryos when injected into host blastocysts. In contrast, deletion of Stk40 in ES...
TMPH-03584	Shikimate dehydrogenase Protein, S. epidermidis, Recombinant (His & Myc)	Staphylococcus epidermidis	E. coli
	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). It can also use NAD to oxidize shikimate. Shikimate dehydrogenase Protein, S. epidermidis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 37.4 kDa and the accession number is Q5HNV1.

重组蛋白

STK40 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04466

Species: Human

Expression System: Baculovirus Insect Cells

Shikimate dehydrogenase Protein, S. epidermidis, Recombinant (His & Myc)

Cat.No: TMPH-03584

Species: Staphylococcus epidermidis

Expression System: E. coli

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