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Search Results for " rna-dependent rna polymerase "

61

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4686	Simeprevir TMC435,西咪匹韦,TMC-435350,Olysio	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Simeprevir (TMC435) 是一种有效的 HCV NS3/4A 蛋白酶抑制剂，抑制 HCV 复制，EC50 为 7.8 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。
T8972	FIT-039	Others; DNA/RNA Synthesis; CDK; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	FIT-039 是一种选择性和 ATP 竞争性的口服活性 CDK9 抑制剂，对CKD9/cyclin T1的IC50为 5.8 μM。它抑制HSV-1(IC50为 0.69 μM)，HSV-2，人腺病毒和人CMV 的复制。它可抑制耐药性HSV 和其他 DNA 病毒，是有前途的抗病毒药物。
T10493	Beclabuvir BMS-791325	Others	Others
	Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the HCV NS5B RNA-dependent RNA polymerase. It inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 (IC50 < 28 nM).
T15282	Filibuvir PF-00868554	HCV Protease; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Filibuvir (PF-00868554) 是 HCV NS5B RNA 依赖性 RNA 聚合酶的选择性非共价抑制剂。 Filibuvir 抑制基因型 1a 和 1b 复制子，EC50 为 59 nM。
T9617	RdRP-IN-2	SARS-CoV	Microbiology/Virology
	RdRP-IN-2 是一种依赖于 RNA 的 RNA 聚合酶 (RdRp) 抑制剂。它显著抑制 SARS-CoV-2 RdRp，IC50 为 41.2 µM。它还抑制猫冠状病毒 (FIPV) 复制。
T6833	Favipiravir T-705,6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide,法匹拉韦,法维拉韦	Others; SARS-CoV; Influenza Virus; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Favipiravir (T-705) 是一种有效且选择性的 RNA 依赖性 RNA 聚合酶抑制剂，用于治疗流感病毒感染。
T27696	JTK-109 JTK109	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	JTK-109 是一种丙型肝炎病毒 NS5B RNA 依赖性 RNA 聚合酶抑制剂，可抑制 G1b 和 G3a 亚基因组复制子和重组酶。
T1501	Rifabutin LM-427,Ansamycin,利福布汀,利福布丁	HSP; DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Rifabutin (LM-427) 是半合成的安莎霉素抗生素，抑制 DNA 依赖性 RNA 聚合酶，有抗分枝杆菌作用。
T3489	Dasabuvir ABT-333,达塞布韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Dasabuvir (ABT-333) 是丙型肝炎病毒非结构蛋白 5B 的非核苷抑制剂，是一种 RNA 依赖性 RNA 聚合酶，具有抗 HCV 的潜在活性。
TQ0090	Nesbuvir HCV-796	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Nesbuvir 是一种选择性丙型肝炎病毒（HCV）非结构蛋白5B（NS5B）RNA 依赖性聚合酶抑制剂。Nesbuvir 对含1b HCV 复制子的肝癌细胞的 IC50为9nM。
T10491	Galidesivir BCX4430,Immucillin-A	Others	Others
	Galidesivir (BCX4430) 是一种广谱抗病毒化合物，是一种腺苷类似物，能抑制病毒 RNA 依赖的 RNA 聚合酶 (RdRp) 活性。Galidesivir 在体外对多种 RNA 病毒病原体有抑制作用，可减少受感染动物的肺部感染。
T63253	AVG-233	DNA/RNA Synthesis; RSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	AVG-233 是一种可口服的RNA 依赖性 RNA 聚合酶 (RdRp) 抑制剂，具有抗病毒活性，可阻断呼吸道合胞病毒和 SARS-CoV-2 复制。AVG-233 可用于研究呼吸道合胞病毒感染。
T1154	Rifaximin	DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Rifaximin 是一种胃肠道选择性抗生素，与细菌 DNA 依赖性 RNA 聚合酶的 β 亚基结合，抑制细菌 RNA 合成。与革兰氏阴性菌（MIC：8-50 毫克/毫升）相比，它对革兰氏阳性菌株（MIC：0.03-5 毫克/毫升）的敏感性更高。
T7766	Remdesivir 瑞德西韦,GS-5734	SARS-CoV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Remdesivir (GS-5734) 是一种核苷类似物，一种广谱的抗病毒化合物，通过抑制病毒的 RNA 依赖性 RNA 聚合酶发挥活性。Remdesivir 对埃博拉病毒、SARS 病毒、MERS病毒等均有活性，对 COVID-19 有潜在治疗价值。
T77520	AOH1996	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	AOH1996 是一种具有口服活性的复制体组分 PCNA (增殖细胞核抗原) 配体，靶向转录-复制冲突 (TRC)。AOH1996 可干扰 PCNA 与其结合蛋白的相互作用，导致 DNA 复制应激，诱导细胞凋亡 (apoptosis)。AOH1996 通过稳定 PCNA 和 RNA 聚合酶 II 的相互作用从而导致蛋白酶体依赖的 rpb1 降解和致命的 DNA 损伤。AOH1996 与 DNA 损伤剂具有协同作用，可抑制肿瘤细胞生长。
T79404	A09-003	Apoptosis; BCL; CDK	Apoptosis; Cell Cycle/Checkpoint
	A09-003 是一种新型细胞周期蛋白依赖性激酶-9 CDK-9 抑制剂。A09-003 能够抑制多种白血病细胞系的增殖，抑制hi髓系细胞白血病序列-1蛋白增加。A09-003还能诱导细胞凋亡，降低 RNA 聚合酶 II 活性，降低 Mcl-1 表达。
T14495	Baloxavir Baloxavir acid,S-033447	Influenza Virus	Microbiology/Virology
	Baloxavir (S-033447) 是衍生自前药 Baloxavir marboxil，是流感病毒聚合酶 PA 亚基的一流帽依赖性核酸内切酶抑制剂。它抑制病毒 RNA 的转录和复制，具有强大的抗病毒活性。
T27260	Emivirine MKC442,MKC-442,MKC 442,DRG-0302,DRG 0302,DRG0302	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Emivirine (MKC-442) 是一种有效和选择性的人类免疫缺陷病毒1型(HIV-1)的非核苷逆转录酶抑制剂。
T40267	RdRP-IN-3
	RdRP-IN-3, a potential anti-influenza drug candidate, functions by inhibiting the activity of RNA-dependent RNA polymerase (RdRp).
T71748	RK-0404678
	RK-0404678 is a novel inhibitor of dengue virus NS5 RNA-dependent RNA polymerase (RdRp), inhibiting the DENV type 2 (DENV2) RdRp activities.
T27485	GSK-625433
	GSK-625433, a homochiral inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase, has the ability to inhibit the polymerase of both HCV genotypes 1a and 1b.
T10491L	Galidesivir hydrochloride BCX 4430 hydrochloride,Immucillin-A hydrochloride	Others	Others
	Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp.
T28538	Rifamycin SV
	Rifamycin SV, a natural antibiotic, blocks RNA-polymerase transcription initiation, modulating ß2m aggregation; inhibits prokaryotic DNA-dependent RNA synthesis and protein synthesis.
T21225	Rifamycin Rifocin,Rifamycin SV
	Rifamycin, a natural antibiotic, inhibits prokaryotic DNA-dependent RNA synthesis and protein synthesis, leading to the block of RNA-polymerase transcription initiation.
T11352	Galidesivir triphosphate BCX4430-triphosphate,Immucillin-A triphosphate,BCX6870	Others	Others
	Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA polymerase activity and protects mice against Ebola. Galidesivir triphosphate (Immucillin-A triphosphate) is converted by the prodrug Galidesivir.
T11062	dmDNA31	Others	Others
	dmDNA31 is a rifamycin antibiotic that can inhibit the DNA-dependent RNA polymerase of bacteria and has strong bactericidal activity against Staphylococcus aureus.
T70855	Favipiravir sodium
	Favipiravir sodium is a selective inhibitor of viral RNA-dependent RNA polymerase with activity against many RNA viruses, influenza viruses, West Nile virus, yellow fever virus, foot-and-mouth disease virus as well as other flaviviruses, arenaviruses, bunyaviruses and alphaviruses.
T16749	Rifalazil 利福拉齐,KRM-1648,ABI-1648	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Rifalazil is a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase. Rifalazil is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis (MIC: 0.00025 to 0.0025 μg/ml).
T62160	AS-136A
	AS-136A 是一种麻疹病毒 RNA 依赖性 RNA 聚合酶(RdRp)的、口服具有活力的非核苷抑制剂，能够作用于麻疹病毒 (IC50: 2 μM)。
T40616	8-Azido-ATP 8-Azidoadenosine 5'-triphosphate,8-N3-ATP,8-Azido-ATP
	8-Azido-ATP is a nucleotide analog that demonstrates photo-reactivity properties. It offers utility in the precise labeling and identification of proteins, particularly those involved in DNA-dependent RNA polymerase activity.
T79233	RdRP-IN-6	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	RdRP-IN-6（化合物27），其针对RNA依赖型RNA聚合酶（RdRP）的抑制IC90值为14.1 μM，适用于抗病毒和抗癌研究领域。
T25106	Aranotin L53185,Lilly 53185,L 53185,L-53185,Antibiotic A 21101-IL
	Aranotin 是一种从金黄色蜘蛛中分离的真菌毒素，具有对抗脊髓灰质炎病毒、柯萨奇病毒、犀牛和副流感病毒等 RNA 病毒的活性。Aranotin 通过阻碍 RNA 依赖性RNA 聚合酶的活性来抑制病毒RNA 的合成。
T63598	DENV-IN-4
	DENV-IN-4 是 DENV 的有效抑制剂 (DENV EC50=4.79 μM, Vero CC50>100 μM, SI>20.9)。DENV-IN-4 能够减少 DENV2 的表达水平，具有浓度依赖性，并可抑制依赖性 RNA 聚合酶 (RNA-dependent RNA polymerase, RdRp) 的活性，表现出抗病毒效果。
T63593	Dasabuvir sodium
	Dasabuvir (ABT-333) sodium 是非核苷丙型肝炎病毒 (HCV) 聚合酶抑制剂。Dasabuvir sodium 对 HCV NS5B 基因编码的 RNA 依赖性 RNA 聚合酶 (RNA polymerase) 表现出抑制作用。Dasabuvir sodium 能够抑制基因型 1a (菌株 H77) 复制子 (EC50: 7.7 nM) 和 1b (菌株 Con1) 复制子 (EC50: 1.8 nM)。
T67814	TMC-649128 PM
	TMC-649128 PM 是HCV NS5B RNA 依赖性RNA 聚合酶的有效核苷抑制剂，EC(50)值为1.2 muM，大鼠体内生物利用度中等(F=14%)。
T73323	RdRP-IN-5	Influenza Virus	Microbiology/Virology
	RdRP-IN-5 (compound 20) 为一种抑制流感病毒RNA依赖性RNA聚合酶(RdRP)的有效药物，适用于该病毒研究。
T72792	trans-RdRP-IN-5
	trans-RdRP-IN-5 是一种有效的流感病毒 RNA 依赖性 RNA 聚合酶 (RdRP) 抑制剂。trans-RdRP-IN-5 可用于流感病毒的研究。
T72896	cis-RdRP-IN-5
	cis-RdRP-IN-5 是一种有效的流感病毒 RNA 依赖性 RNA 聚合酶 (RdRP) 抑制剂。cis-RdRP-IN-5 可用于流感病毒的研究。
T41177	Galidesivir dihydrochloride BCX 4430
	Galidesivir is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide.In vitro, galidesivir displays antiviral activity against a range of RNA viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses, and flaviviruses (EC50values range from 3 μM to >100 μM). Galidesivir protects against Ebola and Marburg viral infection in animal models.
T83251	7-51A	Influenza Virus	Microbiology/Virology
	7-51A为一有效PB2抑制剂，其通过ITC测定的KD值仅为1.64 nM；PB2为流感RNA依赖性RNA聚合酶（RdRP）的关键亚基。
T83296	5-Azacytidine 5′-triphosphate
	5-Azacytidine 5′-triphosphate (5-aza-CMP) 为一种胞苷类似物，可抑制 DNA 依赖性 RNA 聚合酶反响中的 [3H]CTP 并入 RNA，而不影响 [3H]UTP 的并入。
T35533	6-Hydroxypyridin-3-ylboronic Acid
	6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block.1,2It has been used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B).16-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors.2 1.Hendricks, R.T., Spencer, S.R., Blake, J.F., et al.3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymeraseBioorg. Med. Chem. Lett.1...
T83295	5-Azacytidine 5′-triphosphate sodium
	5-Azacytidine 5’-triphosphate sodium 为胞苷类似物，能在DNA依赖性RNA聚合酶反应中抑制[3H]CTP掺入，而不影响[3H]UTP的掺入。
T62287	HIV-1 inhibitor-42
	HIV-1 inhibitor-42 (compound 5b) 是一种 HIV-1 的有效抑制剂 (IC50: 0.06 μM)。HIV-1 inhibitor-42 能够抑制 HIV-1 RT RNA 依赖性 DNA 聚合酶 (IC50: 0.518 μM) 和 DNA 依赖性 DNA 聚合酶 (IC50: 0.072 μM) 。
T10436L	AZD4573 HCl (2057509-72-3 free base) AZD4573 hydrochloride,AZD4573,AZD4573 HCl,AZD-4573,AZD 4573
	AZD-4573 is a selective and short-acting inhibitor of the serine/threonine cyclin-dependent kinase 9, the catalytic subunit of the RNA polymerase II elongation factor positive transcription elongation factor b. It also has a potential antineoplastic activ
TP1641	[pSer2, pSer5, pSer7]-CTD TFA
	[pSer2, pSer5, pSer7]-CTD (TFA) is a substrate for CDK7(cyclin-dependent protein kinase), a phosphorylated polypeptide at ser2, ser5, and ser7 of RNA polymerase II carboxyl terminus (CTD).
T63337	CYP2C19-IN-1
	CYP2C19-IN-1 是强效的，无遗传毒性的、无肝脏毒性的 CYP2C19 抑制剂。 CYP2C19-IN-1 能够抑制 RNA 依赖的 RNA 聚合酶 (RdRP) (Ki: 6.16 μM)，能够用于研究寨卡病毒 (ZIKV) 感染。
T79234	RdRP-IN-7	SARS-CoV	Microbiology/Virology
	RdRP-IN-7是一种抑制剂，针对RNA依赖性RNA聚合酶(RdRP)，对SARS-CoV-2有抑制效果，IC50为8.2μM，IC90为14.1μM，并且CC90为79.1μM。该化合物适用于抗病毒研究。
T18328	MC-Val-Cit-PAB-rifabutin	Others	Others
	MC-Val-Cit-PAB-rifabutin is a drug-linker conjugate designed for antibody-drug conjugates (ADC), featuring the potent antitumor agent rifabutin (a DNA-dependent RNA polymerase inhibitor) connected through the MC-Val-Cit-PAB ADC linker. This configuration endows it with significant antitumor activity.
TP1683	[pSer2, pSer5, pSer7]-CTD
	[pSer2, pSer5, pSer7]-CTD is a substrate for CDK7(cyclin-dependent protein kinase), a phosphorylated polypeptide at ser2, ser5, and ser7 of RNA polymerase II carboxyl terminus (CTD).

化合物

Cat.No: T4686

Synonym: TMC435,西咪匹韦,TMC-435350,Olysio

Target: HCV Protease, SARS-CoV

Cat.No: T8972

Target: Others, DNA/RNA Synthesis, CDK, HSV

Cat.No: T10493

Synonym: BMS-791325

Target: Others

Cat.No: T15282

Synonym: PF-00868554

Target: HCV Protease, DNA/RNA Synthesis

Cat.No: T9617

Target: SARS-CoV

Cat.No: T6833

Synonym: T-705,6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide,法匹拉韦,法维拉韦

Target: Others, SARS-CoV, Influenza Virus, DNA/RNA Synthesis

Cat.No: T27696

Synonym: JTK109

Target: HCV Protease

Cat.No: T1501

Synonym: LM-427,Ansamycin,利福布汀,利福布丁

Target: HSP, DNA/RNA Synthesis, Antibacterial, Antibiotic

Cat.No: T3489

Synonym: ABT-333,达塞布韦

Target: HCV Protease

Cat.No: TQ0090

Synonym: HCV-796

Target: HCV Protease

Cat.No: T10491

Synonym: BCX4430,Immucillin-A

Target: Others

Cat.No: T63253

Target: DNA/RNA Synthesis, RSV

Cat.No: T1154

Target: DNA/RNA Synthesis, Antibacterial, Antibiotic

Cat.No: T7766

Synonym: 瑞德西韦,GS-5734

Target: SARS-CoV, DNA/RNA Synthesis

Cat.No: T77520

Target: Apoptosis, DNA/RNA Synthesis

Cat.No: T79404

Target: Apoptosis, BCL, CDK

Cat.No: T14495

Synonym: Baloxavir acid,S-033447

Target: Influenza Virus

Cat.No: T27260

Synonym: MKC442,MKC-442,MKC 442,DRG-0302,DRG 0302,DRG0302

Target: HIV Protease

Cat.No: T40267

Cat.No: T71748

Cat.No: T27485

Galidesivir hydrochloride

Cat.No: T10491L

Synonym: BCX 4430 hydrochloride,Immucillin-A hydrochloride

Target: Others

Cat.No: T28538

Cat.No: T21225

Synonym: Rifocin,Rifamycin SV

Galidesivir triphosphate

Cat.No: T11352

Synonym: BCX4430-triphosphate,Immucillin-A triphosphate,BCX6870

Target: Others

Cat.No: T11062

Target: Others

Favipiravir sodium

Cat.No: T70855

Cat.No: T16749

Synonym: 利福拉齐,KRM-1648,ABI-1648

Target: DNA/RNA Synthesis

Cat.No: T62160

Cat.No: T40616

Synonym: 8-Azidoadenosine 5'-triphosphate,8-N3-ATP,8-Azido-ATP

Cat.No: T79233

Target: DNA/RNA Synthesis

Cat.No: T25106

Synonym: L53185,Lilly 53185,L 53185,L-53185,Antibiotic A 21101-IL

Cat.No: T63598

Dasabuvir sodium

Cat.No: T63593

Cat.No: T67814

Cat.No: T73323

Target: Influenza Virus

trans-RdRP-IN-5

Cat.No: T72792

Cat.No: T72896

Galidesivir dihydrochloride

Cat.No: T41177

Synonym: BCX 4430

Cat.No: T83251

Target: Influenza Virus

5-Azacytidine 5′-triphosphate

Cat.No: T83296

6-Hydroxypyridin-3-ylboronic Acid

Cat.No: T35533

5-Azacytidine 5′-triphosphate sodium

Cat.No: T83295

HIV-1 inhibitor-42

Cat.No: T62287

AZD4573 HCl (2057509-72-3 free base)

Cat.No: T10436L

Synonym: AZD4573 hydrochloride,AZD4573,AZD4573 HCl,AZD-4573,AZD 4573

[pSer2, pSer5, pSer7]-CTD TFA

Cat.No: TP1641

Cat.No: T63337

Cat.No: T79234

Target: SARS-CoV

MC-Val-Cit-PAB-rifabutin

Cat.No: T18328

Target: Others

[pSer2, pSer5, pSer7]-CTD

Cat.No: TP1683

Cat. No.	Product Name	Target	Signaling Pathways
T5003	Rifamycin sodium Rifamycin sodium salt,利福霉素钠	Antibacterial; Antibiotic	Microbiology/Virology
	Rifamycin sodium (Rifamycin sodium salt) salt 是从地中海曲霉或其突变体的发酵中分离出来的一种安沙霉素抗生素家族。它对革兰氏阳性菌和某些革兰氏阴性菌有抗生素活性。
T8347	Rifamycin S	Reactive Oxygen Species; ROS; Antibacterial; Antibiotic	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Rifamycin S 是一种 DNA 依赖性 RNA 聚合酶抑制剂，是一种醌和一种针对革兰氏阳性细菌的抗生素试剂。它是涉及两个电子的可逆氧化还原系统的氧化形式。它能产生活性氧并抑制微粒体脂质过氧化，可研究肺结核和麻风病。
TN2222	Sotetsuflavone	Others	Others
	Sotetsuflavone is a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase) with an IC50 of 0.16 μM, is the most active compound of this series.

天然产物

Rifamycin sodium

Cat.No: T5003

Synonym: Rifamycin sodium salt,利福霉素钠

Target: Antibacterial, Antibiotic

Cat.No: T8347

Target: Reactive Oxygen Species, ROS, Antibacterial, Antibiotic

Cat.No: TN2222

Target: Others

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