首页工具

登录

搜索结果

Search Results for " mcl "

Targets Recommended: Melanocortin Receptor

88

抑制剂 & 化合物

6

天然产物

3

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
TP1889	MCL0020 MCL 0020	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	MCL0020 是一种有效的选择性黑素皮质素MC4受体拮抗剂，IC50为 11.63 nM。它剂量依赖性减轻束缚应激诱发的厌食症，在体内表现出抗焦虑样活性。
T12041	MIM1 Inhibitor of Mcl-1	BCL	Apoptosis
	MIM1 (Inhibitor of Mcl-1) 是一种骨髓细胞因子 1 抑制剂。
T40230	Mcl-1 inhibitor 6
	Mcl-1 inhibitor 6 is a potent, orally active chemical compound that selectively inhibits the myeloid cell leukemia 1 (Mcl-1) protein, with a high affinity (K d = 0.23 nM) and binding activity (K i = 0.02 μM). This compound exhibits exceptional selectivity over other members of the Bcl-2 family, including Bcl-2, Bcl2A1, Bcl-xL, and Bcl-w (K d >10 μM). Notably, Mcl-1 inhibitor 6 demonstrates strong antitumor activity.
T11967	Mcl-1 antagonist 1	Others	Others
	Mcl-1 antagonist 1 is a Mcl-1 protein antagonist.
T11972	Mcl-1 inhibitor 3	BCL	Apoptosis
	Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activate macrocyclic Mcl-1 inhibitor (Ki= 0.061 nM; IC50=19 nM in an OPM-2 cell viability assay).
T27986	MCL0129 MCL-0129,MCL 0129
	MCL0129, a selective and non-peptidergic melanocortin 4 (MC4) receptor antagonist, is a potential treatment for cachexia.
T11971	MCL-1/BCL-2-IN-4	Others	Others
	MCL-1/BCL-2-IN-4 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor.
T11969	MCL-1/BCL-2-IN-2	Others	Others
	MCL-1/BCL-2-IN-2 is a potent and selective Bcl-2 and Mcl-1 dual inhibitor.
T11970	MCL-1/BCL-2-IN-3	Others	Others
	MCL-1/BCL-2-IN-3 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor with IC50s of 5.95 and 4.78 μM, respectiely.
T11968	MCL-1/BCL-2-IN-1	BCL	Apoptosis
	MCL-1/BCL-2-IN-2 (Compound Nap-1) 是一种有效的选择性 Mcl-1和 Bcl-2双重抑制剂，IC50分别为 4.45 和 3.18 μM。
T27996	MDK-3298 Mcl-1 Inhibitor-5,Mcl-1 Inhibitor 5,MDK3298,Mcl-1 Inhibitor5
	MDK-3298 is a reversible covalent inhibitor of Mcl-1, a target of protein-protein interaction (PPI).
T27997	MDK-3345 MDK 3345,Mcl-1 Inhibitor11,Mcl-1 Inhibitor 11,Mcl-1 Inhibitor-11
	MDK-3345 is a reversible covalent inhibitor for Mcl-1.
T79242	Mcl-1 inhibitor 16
	Mcl-1 inhibitor16 (Compound 9)为基于铂的线粒体靶向性Mcl-1抑制剂。该化合物通过诱导Bax/Bak依赖的细胞凋亡(apoptosis)，展现出对癌细胞的作用，可以单独使用或与ABT-199联合应用，表现出抗肿瘤活性。
T79036	Mcl-1 inhibitor 13
	Mcl-1 inhibitor13 (Example 9)，一种MCL-1抑制剂（Ki: 8.2 nM），主要用于癌症相关研究。
T79215	Mcl-1 inhibitor 14
	Mcl-1 inhibitor14 (Compound (Ra)-10)作为一种优异的髓系细胞白血病-1 (MCL-1) 抑制剂，其Ki值为0.018 nM，主要应用于抗癌研究领域。
T79216	Mcl-1 inhibitor 15
	Mcl-1 inhibitor15 (Compound (Ra)-15)，作为一种高效的Mcl-1抑制剂（Ki: 0.02 nM），主要应用于癌症的研究领域。
T75143	Mcl-1 inhibitor 12
	Mcl-1 inhibitor12 (Example 10) 作为一种高效的MCL-1抑制剂 (Ki: 0.22 nM)，主要应用于癌症研究领域。
T72610	Mcl-1 inhibitor 9
	Mcl-1 inhibitor9 (example 2) 是一种 myeloid cell leukemia 1(Mcl-1) 抑制剂，IC50值为 0.21889 nM，其具有抗肿瘤活性。
T62249	Bcl-2/Mcl-1-IN-1
	Bcl-2/Mcl-1-IN-1 是一种 Bcl-2 (Ki: 4.53 μM) 和 Mcl-1 (Ki: 1.19 μM) 抑制剂。Bcl-2/Mcl-1-IN-1 能够用于研究癌症。
T62443	Bcl-2/Mcl-1-IN-2
	Bcl-2/Mcl-1-IN-2 是一种 Bcl-2 (Ki: 4.70 μM) 和 Mcl-1 (Ki: 0.88 μM) 抑制剂。Bcl-2/Mcl-1-IN-2 能够用于研究癌症。
T62941	Bcl-2/Mcl-1-IN-3
	Bcl-2/Mcl-1-IN-3 是一种 Bcl-2/Mcl-1 抑制剂，作用于 Mcl-1 (Ki: 0.14 μM) 和 Bcl-2 (Ki: 0.23 μM)，能够用于研究癌症。
T10096L	Voruciclib	CDK	Cell Cycle/Checkpoint
	Voruciclib 是一种具有口服活性和选择性 CDK 抑制剂，Ki 为 0.626 nM-9.1 nM。它在多种弥漫性大 B 细胞淋巴瘤模型中抑制 MCL-1 的表达。它有效阻断 MCL-1 的转录调节子 CDK9。
T18487	NH2-C6-NH-Boc	Others; PROTAC Linker	Others; PROTAC
	NH2-C6-NH-Boc 是一种属于 alkyl/ether 类的 PROTAC linker ，是基于 PROTAC 技术的 Mcl-1 抑制剂。
T16156	MT 63-78	Apoptosis; AMPK; mTOR	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	MT 63-78 是一种有效的直接AMPK 激活剂，EC50为 25 μM。它诱导细胞有丝分裂阻滞和细胞凋亡，通过抑制脂肪生成和mTORC1途径来阻止前列腺癌的生长，具有抗肿瘤作用。
T16027	Mcl1-IN-1	Others	Others
	Mcl1-IN-1 is a myeloid cell factor 1 inhibitor (IC50=2.4 µM).
T68398	MI-223
	MI-223 is an inhibitor of Mcl-1-stimulated homologous recombination (HR) DNA repair, which leads to sensitization of cancer cells to hydroxyurea- or olaparib-induced DNA replication stress.
T11973	Mcl1-IN-11	BCL	Apoptosis
	Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively.
T11977	Mcl1-IN-9	BCL	Apoptosis
	Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM.
T11974	Mcl1-IN-12	BCL	Apoptosis
	Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.
T16029	Mcl1-IN-3	Others	Others
	Mcl1-IN-3 is an Mcl1 inhibitor. It has an IC50 and Ki of 0.67 and 0.13 μM, respectively.
T16028	IMB-XH1 Mcl1-IN-2,7-[(2-吡啶基氨基)-2-噻吩基甲基]-8-喹啉醇	BCL; Antibacterial	Apoptosis; Microbiology/Virology
	IMB-XH1 (Mcl1-IN-2) 是一种骨髓细胞因子 1 抑制剂。它也是非竞争性的 Delhi metallo-β-lactamase(NDM-1) 抑制剂。它对金属 β-内酰胺酶 NDM-1，IMP-4，ImiS 和 L1 的 IC50值分别为 0.4637 μM，3.980 μM，0.2287 μM 和 1.158 μM。
T16030	Mcl1-IN-8	Others	Others
	Mcl1-IN-8 is an Mcl-1-PUMA interface inhibitor (Ki: 0.3 μM). In cancer cells, Mcl1-IN-8 shows dual activity on reducing PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis.
T11976	Mcl1-IN-4	Others	Others
	Mcl1-IN-4 is an inhibitor of Mcl1 ( IC50:0.2 μM).
T24436	Mcl1-IN-26
	Mcl1-IN-26 is an effective and selective myeloid cell leukemia 1 inhibitor.
T2558	Cladribine 2-chlorodeoxyadenosine,克拉屈滨,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA	Apoptosis; Adenosine deaminase	Apoptosis; Metabolism
	Cladribine (2CdA) 是一种嘌呤核苷类似物，是具有口服活性的腺苷脱氨酶抑制剂。它能作为 DNA 合成的抑制剂，可阻断受损 DNA 的修复。它可抑制 DNA 甲基化，具有抗淋巴瘤活性，可研究血液恶性肿瘤和多发性硬化。
T11975	PROTAC Mcl1 degrader-1	BCL; PROTACs	Apoptosis; PROTAC
	PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 degrader-1, a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM.
T19024	MCLA hydrochloride	Others	Others
	MCLA hydrochloride, a chemiluminescent compound, can be used to quantify aqueous concentrations of superoxide.
T13657	dMCL1-2	Others	Others
	dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, which binds to MCL1 with a KD of 30 nM. dmcl-2 activates the apoptosis mechanism by degrading MCL1.
T24812	SOMCL-863
	SOMCL-863 is a selective and orally bioavailable c-Met inhibitor. It shows antitumor activity both in vitro and in vivo.
T2632	A-1210477	Apoptosis; BCL	Apoptosis
	A-1210477 是一种选择性的MCL-1有效抑制剂，Ki 值为 0.45 nM。它特异性结合 MCL-1，并以 MCL-1 依赖性方式促进癌细胞凋亡。
T6281	TW-37 TW 37	BCL	Apoptosis
	TW-37 是重组 Bcl-2、Bcl-xL 和 Mcl-1 的非肽抑制剂，Ki 值分别为 0.26、0.29和1.11μM
T17247	VU0661013 VU661013	BCL	Apoptosis
	VU0661013 是一种有效的选择性 MCL-1 抑制剂。
T5108	ML311	BCL	Apoptosis
	ML311 是 Mcl-1/Bim 相互作用的一种选择性抑制剂。
T6034	UMI-77 UMI77,UMI 77	BCL	Apoptosis
	UMI-77是一种选择性的Mcl-1抑制剂，结合到Mcl-1的 BH3 结合沟，Ki 值为 490 nM，对 Bcl-2 家族的其他成员具有选择性。
T5346	S63845	BCL	Apoptosis
	S63845 是一种选择性骨髓细胞白血病 1 抑制剂，结合人 MCL1的 Kd 值为 0.19 nM。
T13639	Deferasirox (Fe3+ chelate)	Apoptosis	Apoptosis
	Deferasirox (Fe3+ chelate) 是一种可口服的铁螯合剂，具有潜在的抗癌活性，抑制 MCL-1 的抗凋亡活性，可用于研究铁超负荷。
T6650	Sabutoclax BI-97C1	BCL	Apoptosis
	Sabutoclax (BI-97C1) 是一种泛 Bcl-2 抑制剂，包括 Bcl-xL、Bcl-2、Mcl-1 和 Bfl-1，IC50 分别为 0.31 μM、0.32 μM、0.20 μM 和 0.62 μM。
T11944	Maritoclax Marinopyrrole A	BCL	Apoptosis
	Maritoclax (Marinopyrrole A) 是一种新型特异性 Mcl-1 抑制剂，IC50值为 10.1 μM，对 BCL-xl 的 IC50值 > 80 μM。
T6396	(R)-(-)-Gossypol acetic acid (-)-Gossypol acetic acid,AT-101 (acetic acid),(R)-Gossypol acetic acid,AT101醋酸,AT101,AT101 acetate	BCL; Autophagy	Apoptosis; Autophagy
	(R)-(-)-Gossypol acetic acid (AT101 acetate) 是天然产物 Gossypol 的左旋异构体，与 Bcl-2、Bcl-xL 和 Mcl-1 结合，Ki 为 0.32 μM、0.48 μM 和 0.18 μM。
T14665L	Motixafortide TFA(664334-36-5,Free) TF 14016 TFA,BKT140 TFA,BL-8040 TFA,T140 TFA	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Motixafortide TFA(664334-36-5,Free) (BKT140 TFA) 是 CXCR4 的拮抗剂，IC50 为～1 nM。它通过改变 miR-15a/16-1 表达下调 ERK、BCL-2、MCL-1 和 cyclin-D1 来诱导 AML 原始细胞凋亡。

化合物

Cat.No: TP1889

Synonym: MCL 0020

Target: Melanocortin Receptor

Cat.No: T12041

Synonym: Inhibitor of Mcl-1

Target: BCL

Mcl-1 inhibitor 6

Cat.No: T40230

Mcl-1 antagonist 1

Cat.No: T11967

Target: Others

Mcl-1 inhibitor 3

Cat.No: T11972

Target: BCL

Cat.No: T27986

Synonym: MCL-0129,MCL 0129

MCL-1/BCL-2-IN-4

Cat.No: T11971

Target: Others

MCL-1/BCL-2-IN-2

Cat.No: T11969

Target: Others

MCL-1/BCL-2-IN-3

Cat.No: T11970

Target: Others

MCL-1/BCL-2-IN-1

Cat.No: T11968

Target: BCL

Cat.No: T27996

Synonym: Mcl-1 Inhibitor-5,Mcl-1 Inhibitor 5,MDK3298,Mcl-1 Inhibitor5

Cat.No: T27997

Synonym: MDK 3345,Mcl-1 Inhibitor11,Mcl-1 Inhibitor 11,Mcl-1 Inhibitor-11

Mcl-1 inhibitor 16

Cat.No: T79242

Mcl-1 inhibitor 13

Cat.No: T79036

Mcl-1 inhibitor 14

Cat.No: T79215

Mcl-1 inhibitor 15

Cat.No: T79216

Mcl-1 inhibitor 12

Cat.No: T75143

Mcl-1 inhibitor 9

Cat.No: T72610

Bcl-2/Mcl-1-IN-1

Cat.No: T62249

Bcl-2/Mcl-1-IN-2

Cat.No: T62443

Bcl-2/Mcl-1-IN-3

Cat.No: T62941

Cat.No: T10096L

Target: CDK

Cat.No: T18487

Target: Others, PROTAC Linker

Cat.No: T16156

Target: Apoptosis, AMPK, mTOR

Cat.No: T16027

Target: Others

Cat.No: T68398

Cat.No: T11973

Target: BCL

Cat.No: T11977

Target: BCL

Cat.No: T11974

Target: BCL

Cat.No: T16029

Target: Others

Cat.No: T16028

Synonym: Mcl1-IN-2,7-[(2-吡啶基氨基)-2-噻吩基甲基]-8-喹啉醇

Target: BCL, Antibacterial

Cat.No: T16030

Target: Others

Cat.No: T11976

Target: Others

Cat.No: T24436

Cat.No: T2558

Synonym: 2-chlorodeoxyadenosine,克拉屈滨,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA

Target: Apoptosis, Adenosine deaminase

PROTAC Mcl1 degrader-1

Cat.No: T11975

Target: BCL, PROTACs

MCLA hydrochloride

Cat.No: T19024

Target: Others

Cat.No: T13657

Target: Others

Cat.No: T24812

Cat.No: T2632

Target: Apoptosis, BCL

Cat.No: T6281

Synonym: TW 37

Target: BCL

Cat.No: T17247

Synonym: VU661013

Target: BCL

Cat.No: T5108

Target: BCL

Cat.No: T6034

Synonym: UMI77,UMI 77

Target: BCL

Cat.No: T5346

Target: BCL

Deferasirox (Fe3+ chelate)

Cat.No: T13639

Target: Apoptosis

Cat.No: T6650

Synonym: BI-97C1

Target: BCL

Cat.No: T11944

Synonym: Marinopyrrole A

Target: BCL

(R)-(-)-Gossypol acetic acid

Cat.No: T6396

Synonym: (-)-Gossypol acetic acid,AT-101 (acetic acid),(R)-Gossypol acetic acid,AT101醋酸,AT101,AT101 acetate

Target: BCL, Autophagy

Motixafortide TFA(664334-36-5,Free)

Cat.No: T14665L

Synonym: TF 14016 TFA,BKT140 TFA,BL-8040 TFA,T140 TFA

Target: CXCR

Cat. No.	Product Name	Target	Signaling Pathways
T6185	Gambogic Acid 藤黄酸,Beta-Guttiferrin,藤黄酸 A,Guttatic Acid,Guttic Acid	BCL; Autophagy	Apoptosis; Autophagy
	Gambogic Acid (Guttic Acid) 是来自藤黄树的一种藤黄树脂，抑制 Bcl-XL、Bcl-2、Bcl-W、Bcl-B、Bfl-1和 Mcl-1，IC50分别为 1.47 μM、1.21 μM、2.02 μM、0.66 μM、1.06 μM 和 0.79 μM。
T5688	Micheliolide	NOS; NF-κB; COX	Immunology/Inflammation; Neuroscience; NF-κB
	Micheliolide 是一种倍半萜内酯，能够抑制各种炎症反应。它能减弱高糖刺激的NF-κB 活化，IκBα的降解，和MCP-1，TGF-β1，FN 在鼠系膜细胞的表达。
T5668	Triacetylresveratrol 乙酰化白藜芦醇,三乙酰基白藜芦醇,Acetyl-trans-resveratrol	BCL; NF-κB; STAT	Apoptosis; JAK/STAT signaling; NF-κB; Stem Cells
	Triacetylresveratrol (Acetyl-trans-resveratrol) 是 Resveratrol 的乙酰化类似物，可降低 STAT3和 NF-κB 磷酸化，具有抗癌作用。
T2730	Gossypol (acetic acid) (±)-Gossypol-acetic acid,Pogosin,AT101,醋酸棉酚,乙酸棉子酚,Gossypol acetic acid	BCL	Apoptosis
	Gossypol acetic acid (AT101) 是一种从棉籽中分离出来的多酚天然产物，分别与 Bcl-xL 蛋白和 Bcl-2蛋白结合，Ki 值分别为 0.5-0.6 μM 和 0.2-0.3 mM。
T30969	Clitocine	Apoptosis; BCL	Apoptosis
	Clitocine 是一种来从蘑菇中提取的一种腺苷类似物，是一种有效的转录通读剂，是一种无义突变的抑制剂，具有抗癌活性，可诱导携带 p53 无义突变等位基因的细胞产生 p53 蛋白。Clitocine 通过促进 Mcl-1 降解来增强 TRAIL 介导的人结肠癌细胞凋亡。
T3824	Jaceosidin	Apoptosis; BCL; COX; UGT	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
	Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物，可激活Bax，下调 Mcl-1 和 c-FLIP 的表达，诱导癌细胞凋亡。它能够降低炎性因子水平，激活 NF-κB，抑制COX-2的表达，具有抗癌和抗炎作用。

天然产物

Cat.No: T6185

Synonym: 藤黄酸,Beta-Guttiferrin,藤黄酸 A,Guttatic Acid,Guttic Acid

Target: BCL, Autophagy

Cat.No: T5688

Target: NOS, NF-κB, COX

Triacetylresveratrol

Cat.No: T5668

Synonym: 乙酰化白藜芦醇,三乙酰基白藜芦醇,Acetyl-trans-resveratrol

Target: BCL, NF-κB, STAT

Gossypol (acetic acid)

Cat.No: T2730

Synonym: (±)-Gossypol-acetic acid,Pogosin,AT101,醋酸棉酚,乙酸棉子酚,Gossypol acetic acid

Target: BCL

Cat.No: T30969

Target: Apoptosis, BCL

Cat.No: T3824

Target: Apoptosis, BCL, COX, UGT

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02003	FH/Fumarate Hydratase Protein, Human, Recombinant (His) fumarate hydratase,MCL,LRCC,MCUL1,FMRD,HLRCC	Human	E. coli
	Fumarate Hydratase (FH) is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. Fumarate Hydratase is similar to some thermostable class II fumarases and func...
TMPY-01643	CLEC4D Protein, Human, Recombinant (His) CD368,MPCL,Dectin-3,CLEC-6,CLECSF8,C-type lectin domain fami...	Human	HEK293 Cells
	CLEC4D Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.2 kDa and the accession number is Q8WXI8.
TMPY-02293	CD23 Protein, Human, Recombinant (His) MGC40078,CLEC6,MCL,BLAST-2,CD23A,IGEBF,FCE2,MPCL,CL...	Human	HEK293 Cells
	CD23 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.2 kDa and the accession number is P06734-1.

重组蛋白

FH/Fumarate Hydratase Protein, Human, Recombinant (His)

Cat.No: TMPY-02003

Species: Human

Expression System: E. coli

CLEC4D Protein, Human, Recombinant (His)

Cat.No: TMPY-01643

Species: Human

Expression System: HEK293 Cells

CD23 Protein, Human, Recombinant (His)

Cat.No: TMPY-02293

Species: Human

Expression System: HEK293 Cells

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼