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62

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1344	Luciferase	Others	Others
	Luciferase 是一种在生物发光细菌中发现的依赖黄素的单加氧酶。 Luciferase 是识别和表征功能变体的宝贵工具，可用于研究基因表达、细胞内信号传导、转录因子、受体活性和蛋白质折叠。
T38310	Luciferase-IN-1	Reactive Oxygen Species; Antibacterial; Antifungal	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Luciferase-IN-1 是一种荧光素酶抑制剂,可用于研究细菌感染和真菌感染。
T9943	Firefly luciferase-IN-1	Others	Others
	Firefly luciferase-IN-1 是一种 2-亚苄基四氢萘酮衍生物，可在试剂盒中用作萤火虫荧光素酶抑制剂。
TP1774	Luciferase, firefly
	Luciferase, firefly is the light-emitting enzyme responsible for the bioluminescence of fireflies and click beetles. The enzyme catalyses the oxidation of firefly luciferin, requiring oxygen and ATP.
T82398	Firefly Luciferase circRNA
	Firefly Luciferase circRNA 是一种从Photinus pyralis（萤火虫）分离的荧光素酶蛋白，适用于作为环状RNA转染的阳性对照，用于监测和优化转染效率。
T82397	Firefly Luciferase mRNA(N1-Me-Pseudo UTP)
	Firefly luciferase mRNA可编码一种起源于Photinus pyralis（萤火虫）的荧光素酶。作为广泛运用于基因调控和功能研究的生物发光报告系统，Firefly luciferase适合进行基因表达、细胞活性以及活体成像等各类检测分析。
T1971	WAY-262611	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	WAY262611是一种 Wnt/β- 联蛋白激动剂，也是一种Dkk1的抑制剂。它能够增加骨形成速率，在 TCF- 荧光素酶测定实验中的EC50=0.63 μM。
T5537	IDF-11774	HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Chromatin/Epigenetic; Metabolism
	IDF-11774 是新型低氧诱导因子 α (HIFα)-1的抑制剂，其 IC50=3.65 μM。。
T60051	VPC-18005	Others	Others
	VPC-18005 是一种荧光素酶抑制剂。 VPC-18005 抑制 ERG 诱导的转录并直接与 ERG-ETS 结构域相互作用，从而破坏 ERG 与 DNA 的结合。
T15030	CycLuc1	Others	Others
	CycLuc1 是一种荧光素酶底物，具有血脑屏障渗透性。
T22374	N-(beta-Ketocaproyl)-L-hoMoserine lactone N-3-氧-己酰高丝氨酸内酯,N-(β-Ketocaproyl)-L-hoMoserine lactone,N-(Ketocaproyl)-L-homoserine lactone,N-(β-Ketocaproyl)-L-hoMoserine lactone	Others	Others
	N-(beta-Ketocaproyl)-L-hoMoserine lactone (N-(Ketocaproyl)-L-homoserine lactone) 是群体调节感应的成分之一。
T4139	D-Luciferin potassium D-Luciferin K Salt,D-Luciferin Potassium Salt,D-萤光素钾盐,D-荧光素钾盐	Others	Others
	D-Luciferin potassium (D-Luciferin K Salt) 是一种萤光素酶的底物，能够催化生物发光昆虫产生典型的黄绿光。
T36711	FM19G11 FM19G11,HIF-1alpha/2alpha Inhibitor	HIF	Angiogenesis; Chromatin/Epigenetic
	FM19G11 是一种低氧诱导因子 (HIF) α-亚基抑制剂（在低氧诱导的荧光素酶试验中 IC50 为 80 nM）。
T19743	D-Luciferin Sodium D-萤光素钠盐,D-虫荧光素钠	Others	Others
	D-Luciferin sodium 是一种萤光素酶底物，能够催化生物发光昆虫产生典型的黄绿光。
T22062	CCG-100602	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	CCG-100602 是心肌蛋白相关转录因子 A/血清反应因子信号转导的特异性抑制剂。它抑制 PC-3 前列腺癌细胞中 RhoA/C 介导的、SRF 驱动的荧光素酶表达，IC50为 9.8 µM。
T14188	ALLO-2	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	ALLO-2 是一种 Smo 耐药突变体的拮抗剂。在TM3-Gli-Luc 细胞中，它可抑制Smo 激动剂Hh-Ag1.5诱导的荧光素酶表达，其IC50=6 nM。
T8752	BAR 501 impurity	GPCR19	GPCR/G Protein
	BAR 501 impurity 在 BAR501 制剂中发现的一种杂质，可作为 G 蛋白偶联胆汁酸激活受体 (GP-BAR1) 的激动剂。 BAR501 杂质 (10 µM) 在 GP-BAR1 报告基因检测中诱导荧光素酶活性增加 150%。
T78389	Coelenteramine 400a Bisdeoxycoelenterazine,Coelenterazine 400a
	Coelenterazine 400a（Coelenterazine 400a），作为Coelenterazine的一个衍生物，它是海肾荧光素酶（RLuc）的底物。该化合物与RLuc结合后能够在395 nm发射蓝光。Coelenterazine 400a改变了亚甲基桥的硫和氧原子，导致RLuc的生物发光产生色变。它在提供更高的信号分辨率方面具有重要价值，适用于生物发光共振能量转移（BRET）的研究。
TP1616L	Hsp70-derived octapeptide acetate Hsp70-derived octapeptide acetate(736171-62-3 free base)	Others	Others
	Hsp70-derived octapeptide acetate (Hsp70-derived octapeptide acetate)(736171-62-3 free base) 是一组含有四肽重复 (TPR) 的蛋白质，已显示与 70 kDa 热休克同源蛋白 (hsc70) 的 C 末端结构域相互作用。在本研究中，含 TPR 的蛋白质，包括 hsc70 相互作用蛋白 (CHIP)、TPR1 和人富含谷氨酰胺的 TPR 含蛋白 (hSGT) 的 C 端，对 DnaJ 和 hsc70 对荧光素酶重折叠的影响进行了调查。
T4486	iCRT 14	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	iCRT 14 是 β-连环蛋白应答转录抑制剂，能够抑制 Wnt 信号通路(IC50:40.3 nM)。
T31146	CycLuc7 CycLuc 7,CycLuc-7
	CycLuc7 is a cyclic alkylaminoluciferin substrate for firefly luciferase.
T31143	CycLuc12 CycLuc-12,CycLuc 12
	CycLuc12 is a cyclic alkylaminoluciferin substrate for firefly luciferase.
T31145	CycLuc3 Cyc Luc 3,Cyc-Luc-3
	CycLuc3 is a type of mutant firefly luciferase variant with enhanced light emission.
T13364	YAP/TAZ inhibitor-1	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
T68934	VT101 free base
	VT101 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT101 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter.
T71424	VT-102 free base
	VT-102 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT102 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect on the Renilla luciferase reporter.
T29336	2-Bromo-1-decanal Decanal-1-14C, 2-bromo-, (R)-,2-Bromo(1-14C)-1-decanal
	2-Bromo-1-decanal was synthesized as an affinity labeling probe for the aliphatic aldehyde site of Vibrio harveyi luciferase. In the presence of excess amounts of this probe, the inactivation of bacterial luciferase occurred following apparent first order
T9026	MEISi-2 Benzoic acid, 4-hydroxy-, 2-[(Z)-(2-oxo-1(2H)-naphthalenylidene)methyl]hydrazide	Others	Others
	MEISi-2 是 MEIS（造血干细胞自我更新的关键调控因子）选择性抑制剂。它可用于心脏损伤、造血问题、骨髓移植和癌症的研究。
T29796	AkaLumine Aka Lumine
	Akalumine is a luciferin anemone. When the bioluminescence produced in the reaction with natural firefly luciferase is obtained in the near-infrared wavelength range (λ Max =677 nm).
T31144	CycLuc2 CycLuc 2,CycLuc-2
	CycLuc2 is a cyclic alkylaminoluciferin substrate for firefly luciferase. CycLuc2 emits 4.7-fold more light than aminoluciferin, and 2.6-fold more light than D-luciferin.
T28276	OV-potentiator-28 OV potentiator 28
	OV-potentiator-28 is a potentiator of cancer virotherapy. OV-potentiator-28 significantly enhances virus replication-associated luciferase expression, specifically in tumors.
T12916	Silvestrol aglycone	Others	Others
	Silvestrol aglycone is an analogue of Silvestrol, inhibits protein translation initiation in cancer cells(EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively), with nti-cancer activity.
T69241	MEISi-1
	MEISi-1 is a novel MEIS inhibitor (MEISi), significantly inhibiting MEIS-luciferase reporters in vitro and inducing murine (LSKCD34low cells) and human (CD34+, CD133+, and ALDHhi cells) HSC self-renewal ex vivo.
T35891	pyCTZ TFA
	PyCTZ TFA, a pyridyl Coelenterazine (CTZ) analog, is an ATP-independent pyridyl substrate of LumiLuc luciferase. It produces intense blue bioluminescence when luciferases are present, making it suitable for aequorin-based calcium sensing[1].
T39571	pyCTZ Pyridyl CTZ
	PyCTZ (Pyridyl CTZ), a pyridyl Coelenterazine (CTZ) analog, functions as an ATP-independent substrate for LumiLuc luciferase, producing intense blue bioluminescence when combined with luciferases. This compound is also applicable in aequorin-based calcium sensing.
T19167	8pyDTZ	Others	Others
	8pyDTZ is a pyridyl diphenylterazine (DTZ) analog and an ATP-independent pyridyl substrate of LumiLuc luciferase. 8pyDTZ exhibits spectrally shifted emission and improved water solubility. It can be used for in vivo luminescence imaging.
T80539	[Ala28]-β Amyloid(25-35) β(25-35)KA
	"[Ala28]-β Amyloid(25-35) (β(25-35)KA)为Aβ(25-35)的一种电中性变体，能够促进萤火虫荧光素酶聚集。"
T78413	ETZ C3-CA-DTZ
	ETZ (C3-CA-DTZ) 是一种具潜力的荧光素酶前体，能在体内经非特异性酯酶活化，促进荧光素在脑部的传输。
T81381	PROTAC eDHFR Degrader-1	PROTACs	PROTAC
	PROTACeDHFR Degrader-1是一种高效的PROTAC，针对eDHFR-YFP和多种POI（如YFP、荧光素酶）具有显著的降解作用。
T37035	HAPC-Chol
	HAPC-Chol is a cationic cholesterol. HAPC-Chol, as part of a lipoplex with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability. It has also been used to deliver siRNA into mice via intravenous injection, resulting in HAPC-chol accumulation in the lungs.
T79182	PPARγ agonist 8	PPAR	DNA Damage/DNA Repair; Metabolism
	PPARγ agonist8，作为PPARγ的激动剂，能够诱导过氧化物酶体增殖反应元件(PPRE)-萤光素酶活性，其EC50值为0.2 μM。
T37027	MHAPC-Chol
	MHAPC-Chol is a cationic cholesterol. MHAPC-Chol, as part of a lipoplex with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability. It has also been used to deliver siRNA into mice via intravenous injection, resulting in MHAPC-chol accumulation in the liver.
T40100	D-Luciferin 6′-methyl ether 6′-Methoxyluciferin,D-Luciferin 6′-methyl ether
	D-Luciferin 6′-methyl ether (also known as 6′-Methoxyluciferin or compound 19a) is a highly effective inhibitor of luciferase obtained from the North American firefly Photinus pyralis (referred to as PpyLuc). It exhibits an IC50 value of 0.1 μM. This compound, which is an analog of D-luciferin, interacts non-specifically with the ATP and luciferin binding sites within the active site of PpyLuc.
T82697	Coelenteramide
	Coelenteramide为Coelenterazine的氧化产品，与apoAequorin/Ca2+结合形成被称作蓝色荧光蛋白(BFP)的复合物，可在Coelenterazine存在下持续发出微弱荧光，并作为显像剂使用。
T38223	N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
	N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide binds to the cannabinoid 1 (CB1) receptor with a Ki value of 365 nM in a radioligand binding assay using rat brain homogenate. It has an EC50 value of 698 nM for the peroxisome proliferator-activated receptor α (PPARα) in a luciferase reporter assay and, in rats, it decreases food intake. It does not inhibit fatty acid amide hydrolase (FAAH).
T37092	20-HEPE
	20-HEPE is a metabolite of eicosapentaenoic acid that is formed via ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. It activates peroxisome proliferator-activated receptor α (PPARα) in COS-7 cells expressing a luciferase reporter when used at a concentration of 10 μM. 20-HEPE also activates murine transient receptor potential vanilloid receptor 1 (mTRPV1) in vitro but lacks antinociceptive activity in rats.
T78419	lucPpy-IN-1
	LucPpy-IN-1（化合物9）是一种针对ATP依赖性萤火虫荧光素酶（lucPpy）的抑制剂，其IC50为4.0 μM，适用于进行靶点药物敏感性研究。
T81342	pyCTZ hydrochloride Pyridyl CTZ hydrochloride
	pyCTZ hydrochloride（Pyridyl CTZ），作为一种CTZ（腔肠素）类似物，是LumiLuc荧光素酶的ATP非依赖性吡啶基底物。在荧光素酶的作用下，pyCTZ hydrochloride能发出强烈的蓝色生物发光，适用于基于水母发光蛋白的钙感测。
T64182	HP590
	HP590 是一种新型的、强效的、口服具有活力的 STAT3 抑制剂 (STAT3 荧光素酶活性:IC50=27.8 nM; ATP 抑制:IC50=24.7 nM)。HP590 具有抗胃癌细胞增殖的作用，能够诱导细胞凋亡。
T36868	4-oxo Docosahexaenoic Acid
	4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 μM, however it increased proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 μM.

化合物

Cat.No: TP1344

Target: Others

Luciferase-IN-1

Cat.No: T38310

Target: Reactive Oxygen Species, Antibacterial, Antifungal

Firefly luciferase-IN-1

Cat.No: T9943

Target: Others

Luciferase, firefly

Cat.No: TP1774

Firefly Luciferase circRNA

Cat.No: T82398

Firefly Luciferase mRNA(N1-Me-Pseudo UTP)

Cat.No: T82397

Cat.No: T1971

Target: Wnt/beta-catenin

Cat.No: T5537

Target: HIF/HIF Prolyl-Hydroxylase, HIF

Cat.No: T60051

Target: Others

Cat.No: T15030

Target: Others

N-(beta-Ketocaproyl)-L-hoMoserine lactone

Cat.No: T22374

Synonym: N-3-氧-己酰高丝氨酸内酯,N-(β-Ketocaproyl)-L-hoMoserine lactone,N-(Ketocaproyl)-L-homoserine lactone,N-(β-Ketocaproyl)-L-hoMoserine lactone

Target: Others

D-Luciferin potassium

Cat.No: T4139

Synonym: D-Luciferin K Salt,D-Luciferin Potassium Salt,D-萤光素钾盐,D-荧光素钾盐

Target: Others

Cat.No: T36711

Synonym: FM19G11,HIF-1alpha/2alpha Inhibitor

Target: HIF

D-Luciferin Sodium

Cat.No: T19743

Synonym: D-萤光素钠盐,D-虫荧光素钠

Target: Others

Cat.No: T22062

Target: Rho, Ras

Cat.No: T14188

Target: Hedgehog/Smoothened, Smo

BAR 501 impurity

Cat.No: T8752

Target: GPCR19

Coelenteramine 400a

Cat.No: T78389

Synonym: Bisdeoxycoelenterazine,Coelenterazine 400a

Hsp70-derived octapeptide acetate

Cat.No: TP1616L

Synonym: Hsp70-derived octapeptide acetate(736171-62-3 free base)

Target: Others

Cat.No: T4486

Target: Wnt/beta-catenin

Cat.No: T31146

Synonym: CycLuc 7,CycLuc-7

Cat.No: T31143

Synonym: CycLuc-12,CycLuc 12

Cat.No: T31145

Synonym: Cyc Luc 3,Cyc-Luc-3

YAP/TAZ inhibitor-1

Cat.No: T13364

Target: ROCK

VT101 free base

Cat.No: T68934

VT-102 free base

Cat.No: T71424

2-Bromo-1-decanal

Cat.No: T29336

Synonym: Decanal-1-14C, 2-bromo-, (R)-,2-Bromo(1-14C)-1-decanal

Cat.No: T9026

Synonym: Benzoic acid, 4-hydroxy-, 2-[(Z)-(2-oxo-1(2H)-naphthalenylidene)methyl]hydrazide

Target: Others

Cat.No: T29796

Synonym: Aka Lumine

Cat.No: T31144

Synonym: CycLuc 2,CycLuc-2

OV-potentiator-28

Cat.No: T28276

Synonym: OV potentiator 28

Silvestrol aglycone

Cat.No: T12916

Target: Others

Cat.No: T69241

Cat.No: T35891

Cat.No: T39571

Synonym: Pyridyl CTZ

Cat.No: T19167

Target: Others

[Ala28]-β Amyloid(25-35)

Cat.No: T80539

Synonym: β(25-35)KA

Cat.No: T78413

Synonym: C3-CA-DTZ

PROTAC eDHFR Degrader-1

Cat.No: T81381

Target: PROTACs

Cat.No: T37035

PPARγ agonist 8

Cat.No: T79182

Target: PPAR

Cat.No: T37027

D-Luciferin 6′-methyl ether

Cat.No: T40100

Synonym: 6′-Methoxyluciferin,D-Luciferin 6′-methyl ether

Cat.No: T82697

N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide

Cat.No: T38223

Cat.No: T37092

Cat.No: T78419

pyCTZ hydrochloride

Cat.No: T81342

Synonym: Pyridyl CTZ hydrochloride

Cat.No: T64182

4-oxo Docosahexaenoic Acid

Cat.No: T36868

Cat. No.	Product Name	Target	Signaling Pathways
T3313	D-Luciferin Firefly luciferin,D-萤光素,D-荧光素,D-(-)-Luciferin	Others	Others
	D-Luciferin (D-(-)-Luciferin) 是一种萤光素酶的底物，能够催化生物发光昆虫产生典型的黄绿光。
T8086	Decyl aldehyde	Others; Endogenous Metabolite	Metabolism; Others
	Decyl aldehyde 是细菌荧光素酶底物，是十碳醛。
TN7236	Cephalandole B	IL Receptor	Immunology/Inflammation
	cephalandole B 是一种从青黛中分离出两种吲哚生物碱，能明显地抑制了IL-17A 基因的表达，以剂量依赖的方式抑制了Jukat 细胞的IL-17A 荧光素酶报告。
T67867	Mycaminosyltylonolide	Antibacterial	Microbiology/Virology
	Mycaminosyltylonolide 是一种大环内酯类抗生素，它是 tyololide 在位置5上具有β - d -mycaminosyl 残基。Mycaminosyltylonolide 是一种有效的抗生素，具有抗菌活性和抑制荧光素酶的合成。
TN1334	7-Methoxyrosmanol 7ALPHA-甲氧基迷迭香酚,7-O-Methylrosmanol	cAMP	GPCR/G Protein
	7-Methoxyrosmanol (7-O-Methylrosmanol) 是一种酚类二萜，从迷迭香中分离得到，可抑制 PEPCK 和 G6Pase 启动子的 cAMP 反应。
TQ0163	Sagittatoside A Icariin-A,箭藿苷 A	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα.
T79965	11-Oxoisomogroside V		Metabolism
	11-Oxoisomogroside V（compound 3）是从罗汉果粗提物中分离的一种葫芦苷，能够激活PGC-1α的转录活性。荧光素酶实验表明，10 μM 和 20 μM 浓度的11-Oxoisomogroside V分别将荧光素酶活性提高至 133.79% 和 143.81%。
T19122	3-Methylvaleric Acid	Others; Endogenous Metabolite	Metabolism; Others
	3-Methylvaleric Acid 是一种食用级香料，存在于烟草中。3-Methylvaleric Acid 可增强 CHO-K1细胞和HEK293细胞中的细胞内cAMP 积累和CRE-荧光素酶活性。
TN3539	Broussonin A	ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt	Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A c
T6981	1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid 1-甲基-6-氧代-1,6-二氢吡啶-3-羧酸,Nudifloric Acid	Others	Others
	1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (Nudifloric Acid) 是来源于冬虫夏草，能够靶向阻断 AP-1 介导的荧光素酶活性，具有抗炎活性。其中冬虫夏草具有抗氧化，抗癌，抗炎，抗糖尿病，抗肥胖，抗血管生成和抗伤害感受活动。

天然产物

Cat.No: T3313

Synonym: Firefly luciferin,D-萤光素,D-荧光素,D-(-)-Luciferin

Target: Others

Cat.No: T8086

Target: Others, Endogenous Metabolite

Cat.No: TN7236

Target: IL Receptor

Mycaminosyltylonolide

Cat.No: T67867

Target: Antibacterial

7-Methoxyrosmanol

Cat.No: TN1334

Synonym: 7ALPHA-甲氧基迷迭香酚,7-O-Methylrosmanol

Target: cAMP

Sagittatoside A

Cat.No: TQ0163

Synonym: Icariin-A,箭藿苷 A

Target: Estrogen/progestogen Receptor

11-Oxoisomogroside V

Cat.No: T79965

3-Methylvaleric Acid

Cat.No: T19122

Target: Others, Endogenous Metabolite

Cat.No: TN3539

Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt

1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

Cat.No: T6981

Synonym: 1-甲基-6-氧代-1,6-二氢吡啶-3-羧酸,Nudifloric Acid

Target: Others

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