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Cat. No. | Product Name | Target | Signaling Pathways |
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T63919 | IKKβ-IN-1 | ||
IKKβ-IN-1 是一种有效的、口服具有活力的 IkappaB(IKK-β) 抑制剂 (IC50: 0.20 μM)。IKKβ-IN-1 能够减少抑制小鼠巨噬细胞中 PGE2和 TNF-α的产生。IKKβ-IN-1 对小鼠具有保护作用,使其免受感染性休克诱导的死亡。 | |||
T6176 |
IKK 16
IKK Inhibitor VII,IKK-16,IKK16 |
IκB/IKK; LRRK2 | Autophagy; NF-κB |
IKK 16 (IKK Inhibitor VII) 是一种选择性的 IκB 激酶 (IKK) 抑制剂,作用于 IKK2、IKK complex 和 IKK1,IC50分别为 40 nM、70 nM 和 200 nM。它还抑制富亮氨酸重复激酶 2,IC50为 50 nM。 | |||
T36524 |
IKK2-IN-4
5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide,IKK2 Inhibitor IV |
IκB/IKK; TNF | Apoptosis; NF-κB |
IKK2-IN-4 (IKK2 Inhibitor IV)是一种高效的 IKK-2 抑制剂,IC50 值为 25 nM。IKK2-IN-4 对 LPS 诱导的 PBMC 中 TNFα 的产生有抑制作用。 | |||
TP1615L |
IKKγ NBD Inhibitory Peptide acetate
IKKγ NBD Inhibitory Peptide acetate(372146-18-4 free base) |
NF-κB | NF-κB |
IKKγ NBD Inhibitory Peptide acetate 是一种 NEMO 结合结构域肽(NBD 肽)乙酸盐,对应于 NEMO 氨基末端 α-螺旋区域。它显示可阻断 TNF-α 诱导的 NF-kB 活化。 | |||
T15559 |
TBK1/IKKε-IN-2
|
IκB/IKK | NF-κB |
TBK1/IKKε-IN-2 是双重TBK1和IKKε抑制剂。 | |||
T7951 |
TBK1/IKKε-IN-5
|
IκB/IKK | NF-κB |
TBK1/IKKε-IN-5 是一种 TBK1 (IC50:1 nM) 和 IKKε (IC50:5.6 nM) 的双抑制剂。 | |||
T6150 |
TAK-715
|
p38 MAPK; Casein Kinase; JNK | MAPK; Metabolism; Stem Cells |
TAK-715 是一种具有口服活性的p38 MAPK 抑制剂,对 p38α 和 p38β 的IC50分别为 7.1 nM 和200 nM。它抑制酪蛋白激酶 I (CK1δ/ε),调节 Wnt/β-catenin 信号传导的激活,有抗炎活性。 | |||
T40700 | IKK-IN-3 | ||
IKK-IN-3 is a highly potent and selective inhibitor of IkappaB kinase 2 (IKK2 or IKKβ). It exhibits impressive inhibitory activity against IKK2 (IC50 = 19 nM), while also demonstrating significant efficacy against IKK1 (or IKKα) with an IC50 value of 400 nM. | |||
T61059 |
IKK-IN-4
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IKK-IN-4 是IkappaB 激酶2的选择性抑制剂,其对 IKKβ 和 IKKα 的IC50值分别为 45 nM 和 650 nM。 | |||
T39841 |
TBK1/IKKε-IN-6
TBK1/IKKε-IN-6 |
||
TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes. | |||
T38263 |
TBK1/IKKε-IN-4
TBK1/IKKε-IN-4 |
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TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine derivative and a potent, selective TBK1 and IKKε inhibitor with IC50 values of 13 nM and 59 nM, respectively. TBK1/IKKε-IN-4 shows 100- to 1000-fold less activity against other protein kinases including PDK1, PI3K family members and mTOR[1]. TBK1/IKKε-IN-4 (Compound II; 96 hours; A549 andHCC44 cells) treatmentdisplays selective toxicity in TBK1-dependent cancer cell lines (IC50 of ~ 4.2 μM for H441 cells and IC50 of ~0.4 μM for A549 cells)[1].TBK1/IK... | |||
T71747 |
IKKß-IN-124
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IKKß-IN-124 is an allosteric inhibitor of IκBα phosphorylation and NF-κB transcriptional activity through selective capture of the inactive conformation and hence blockade of IKKβ S177/S181 phosphorylation. | |||
T76024 |
IKKγ NBD Inhibitory Peptide TFA
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IKKγ NBD 抑制肽 TFA 是一种高度特异性的NF-κB 抑制剂。IKKγ NBD 抑制肽 TFA 通过阻断 IKKγ/NEMO 结合域 (NBD) 与 IKKα 和 IKKβ 之间的相互作用,而阻断 TNF-α 诱导的NF-κB 激活。IKKγ NBD 抑制肽 TFA 可显著降低炎症、改善脑缺血所致的神经功能缺损。 | |||
TQ0306 |
MLN120B
|
IκB/IKK | NF-κB |
MLN120B 是一种ATP 竞争性的、有效的、具有口服活性的IKKβ抑制剂,IC50=60 nM。它在体内外抑制多发性骨髓瘤细胞生长,也可用于研究类风湿关节炎。 | |||
T5209 |
INH14
|
IκB/IKK | NF-κB |
INH14 是 IKKα (IC50:8.97 μM) / IKKβ (IC50:3.59 μM) 的抑制剂。它能够抑制 IKKα/β 依赖性 TLR 炎症反应,抑制 TAK1/TAB1 的下游和 NF-kB 信号通路。它具有抗炎和抗癌作用。 | |||
T8910 |
2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC
|
IκB/IKK | NF-κB |
2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC 是 IKKβ 的抑制剂。 | |||
T6141 |
IMD-0354
IKK2 Inhibitor V,IMD 0354 |
IκB/IKK | NF-κB |
IMD-0354 (IKK2 Inhibitor V) 是一种选择性IKKβ抑制剂,能够抑制 NF-κB 活性。它能够抑制 TNF-α 诱导的 NF-κB 转录活性,IC50=1.2 μM。 | |||
T125120 |
Cyclo(L-Pro-L-Val)
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IκB/IKK; NOS; NF-κB; COX; Antibacterial | Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB |
Cyclo(L-Pro-L-Val) 是从辣椒溶杆菌AZ2和白斑分枝杆菌果实中提取出的 2,5-二酮哌嗪,具有抗炎活性,对植物病原微生物 (如 R. fascians LMG 3605) 具有毒性活性,能抑制革兰氏阳性植物病原菌。Cyclo(L-Pro-L-Val) 以浓度依赖性方式显著抑制了IKKα、IKKβ、IκBα和NF-κB 的磷酸化以及iNOS 和COX-2的活化,是治疗炎症相关疾病的潜在治疗剂。 | |||
T14567 | BI605906 | IκB/IKK | NF-κB |
BI605906 is an inhibitor of IKKβ. When assayed at 0.1 mM ATP, the IC50 value is 380 nM. | |||
T23137 |
PF 184
|
Others | Others |
IKKβ inhibitor | |||
T14669 |
BMS-066
|
IκB/IKK; Tyrosine Kinases | NF-κB; Tyrosine Kinase/Adaptors |
BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively. | |||
T10237 |
ACHP Hydrochloride
IKK-2 Inhibitor VIII |
IκB/IKK | NF-κB |
ACHP Hydrochloride (IKK-2 Inhibitor VIII) 是选择性的IKK-β抑制剂 (IC50=5.8 nM)。 | |||
T14508 |
Bay 65-1942 hydrochloride
|
IκB/IKK | NF-κB |
Bay 65-1942 hydrochloride is an inhibitor of ATP-competitive and selective IKKβ. | |||
T10472L |
Bay 65-1942 free base
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IκB/IKK | NF-κB |
Bay 65-1942 free base is an inhibitor of ATP-competitive and selective IKKβ. | |||
T10472 |
Bay 65-1942 (R form)
Bay 65-1942 R form |
Others | Others |
Bay 65-1942 R form is the less active R-form of Bay 65-1942. Bay 65-1942 is a selective and ATP-competitive IKKβ inhibitor. | |||
T37449 |
SR 12460
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SR 12460 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1It inhibits TNF-α-induced NF-κB activation in a reporter assay when used at concentrations ranging from 25 to 150 μM. It reduces LPS-induced production of IL-6 in RAW 264.7 cells. SR 12460 (30 mg/kg) improves grip strength in themdxmouse model of Duchenne muscular dystrophy. 1.Zhao, J., Zhang... | |||
T39199 |
ML 120B dihydrochloride
ML120B dihydrochloride |
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MLN120B dihydrochloride (ML120B dihydrochloride) is a highly potent, orally active inhibitor of IKKβ. It competitively binds to ATP and exhibits an impressive IC50 value of 60 nM. This compound effectively suppresses the growth of multiple myeloma cells both in vitro and in vivo. Furthermore, MLN120B dihydrochloride is valuable in the field of rheumatoid arthritis research. | |||
T78371 |
Ac2-26 ammonium
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Ac2-26 ammonium是一种具抗炎作用的annexin 1 N末端肽。该化合物能够通过伴侣介导的自噬(CMA)机制降低溶酶体中的IKKβ蛋白含量,从而改善肺缺血再灌注损伤,并在哮喘大鼠模型中抑制气道炎症以及高反应性的表现。 | |||
T36192 |
CAY10682
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(±)-Nutlin-3 blocks the interaction of p53 with its negative regulator Mdm2 (IC50 = 90 nM), inducing the expression of p53-regulated genes and blocking the growth of tumor xenografts in vivo. CAY10682 is a pyrrolo[3,4c]pyrazole derivative that inhibits the p53-Mdm2 interaction as potently as (±)-nutlin-3 (Ki = 83 nM) and also dose-dependently reduces activation of the NF-κB pathway. It specifically prevents phosphorylation of IκBα by the kinases IKKα, IKKβ, and IKK (IC50s = 80.5, 78.2, and 57.1... | |||
T38158 |
StA-IFN-1
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StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKKβ component of the IFN induction pathway. It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib , which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective f... | |||
T83670 |
F1 TFA
Tat-IKIP (46-60),Tat-Inhibitor of NF-κB Kinase-interacting Peptide |
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F1是一种抗炎肽,由HIV-1 Tat蛋白质转导域与对应于抑制因子NF-κB激酶-相互作用肽(IKIP)46-60残基的15氨基酸肽链接而成。在5 µM浓度下,F1抑制了小鼠腹腔巨噬细胞中LPS诱导的IκB激酶α(IKKα)和IKKβ的磷酸化以及NF-κB(p65)的核内转移。在体内,F1(5 mg/kg)降低了LPS诱导的脓毒症小鼠模型中IL-6、TNF-α和IL-1β的血清水平,并增加了生存率。 | |||
T36408 |
Rhein-13C4
Rhein-13C4 |
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Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically i... | |||
T11573 | HPN-01 | Others | Others |
HPN-01 is a selective IKK inhibitor (pIC50s: 6.4, 7.0, and <4.8 for IKK-α, IKK-β, and IKK-ε). HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, ErbB2, EGFR, GSK3β, Src, PLK1, and VEGFR-2. | |||
T15243 |
Ertiprotafib
PTP 112 |
Phosphatase; PPAR | DNA Damage/DNA Repair; Metabolism |
Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ). | |||
T36779 |
NG 25 (hydrochloride hydrate)
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NG 25 is a type II kinase inhibitor that inhibits MAP4K2 and TAK1 (IC50s = 21.7 and 149 nM, respectively).1It also inhibits the Src family kinases Src and LYN (IC50s = 113 and 12.9 nM, respectively) and Abl family kinases (IC50s = 75.2 nM), as well as CSK, FER, and p38α (IC50s = 56.4, 82.3, and 102 nM, respectively). NG 25 (100 nM) prevents TNF-α-induced IKKα/β phosphorylation and IκB-α degradation in L929 cells. It inhibits secretion of IFN-α and IFN-β induced by CpG type B and CL097, respectiv... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T2765 |
Rosmarinic acid
Labiatenic acid,迷迭香酸,Rosemary acid |
Apoptosis; IκB/IKK; MAO; Endogenous Metabolite; Transferase; Monoamine Oxidase | Apoptosis; Metabolism; Neuroscience; NF-κB |
Rosmarinic acid (Labiatenic acid) 广泛存在植物中,具有抗氧化、抗炎和抗菌活性。它抑制 MAO-A,MAO-B 和 COMT,IC50分别为 50.1,184.6 和 26.7 μM。 | |||
T72208 |
1-Dehydro-[10]-gingerdione
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1-Dehydro-[10]-gingerdione 通过靶向IKKβ的激活环直接抑制 IKKβ 活性,从而破坏用激动剂刺激的巨噬细胞中 IKKβ 催化的 IκBα 磷酸化。1-Dehydro-[10]-gingerdione 抑制 LPS 诱导的NF-κB 转录活性。1-Dehydro-[10]-gingerdione 具有用于NF-κB 相关炎症和自身免疫性疾病研究的潜力。 |