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Search Results for " huntington's "

36

抑制剂 & 化合物

1

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Cat. No.	Product Name	Target	Signaling Pathways
T9998	MIND4-19	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	MIND4-19 是一种具有抗肿瘤活性的 SIRT2 抑制剂。
T8452	Dantrolene	Others	Others
	Dantrolene 是一种肌肉松弛剂，是人红细胞谷胱甘肽还原酶的非竞争性抑制剂，其Ki 和IC50值分别为 111.6 μM 和 52.3 μM。它是兰尼碱受体拮抗剂及Ca2+信号稳定剂。它可用于研究恶性高热、亨廷顿病、肌肉痉挛和其他神经阻滞剂恶性综合征。
T6111	Selisistat EX-527,司来司他,SEN0014196	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Selisistat (EX-527) 是一种去乙酰化酶 SIRT1 的抑制剂 (IC50=38 nM)，具有有效性和特异性。Selisistat 可以用于神经系统疾病如亨廷顿舞蹈病的研究。
T0412	Idebenone 艾地苯醌,CV-2619	Apoptosis; Antioxidant; Mitochondrial Metabolism	Apoptosis; Metabolism; oxidation-reduction
	Idebenone (CV-2619) 是一种线粒体保护剂，具有神经保护功效，可用于研究阿尔茨海默病、亨廷顿舞蹈病，可透过血脑屏障，诱导细胞凋亡。
T3206	NKL 22 Histone Deacetylase Inhibitor IV,PAOA	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	NKL 22 (Histone Deacetylase Inhibitor IV) 是一种有效的选择性组蛋白脱乙酰基酶(HDAC) 抑制剂，对 HDAC2/4/5/7/8 具有选择性，抑制HDAC1和HDAC3的IC50值分别为 199 和 69 nM。它可改善亨廷顿氏病转基因小鼠的疾病表型和转录异常。
T38605	NCT-504	Others	Others
	NCT-504, a selective allosteric inhibitor of PIP4Kγ, exhibits an IC50 value of 15.8 μM. It holds promise for the investigation of Huntington's disease.
T22595	B2 Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline,奥司他韦杂质B(2-叠氮杂合物)	Others; Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	B2 (Linazolamide intermediate B impurity 2) 促进亨廷顿病和帕金森病细胞模型中的包涵体形成。
T23331	SC 51089 SC 51089 free base	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	SC 51089 是一种选择性的前列腺素受体 PGE2 拮抗剂，对前列腺素受体亚型具有选择性，具有抗伤害活性，可改善亨廷顿病 R6/1 小鼠模型中的运动缺陷并挽救记忆力下降。
TP2417	Tidembersat	Others	Others
	Tidembersat 是一种小分子化合物，可用于治疗和/或预防退行性疾病，如亨廷顿舞蹈病、精神分裂症、神经。
T62839	Dalzanemdor SAGE-718	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Dalzanemdor (SAGE-718) 是 NMDA 受体阳性变构调节剂，可用于研究亨廷顿舞蹈病、阿尔茨海默病和认知功能障碍。
T9159	PBT-1033 PB 1033,PBT1033,PBT-2,PBT 2,PBT2	Others	Others
	PBT-1033 (PBT-2) 是一种潜在的神经保护剂，用于治疗阿尔茨海默病和亨廷顿病。
T15035	Cystamine 2,2'-Disulfanediyldiethanamine	Caspase	Apoptosis; Proteases/Proteasome
	Cystamine (2,2'-Disulfanediyldiethanamine) 是一种转谷氨酰胺酶抑制剂，可抑制 caspase-3，IC50 值为 23.6 μM。 Cystamine 可用于亨廷顿氏病的研究。
T61859	MK-28	Antiviral; PERK	Apoptosis; Immunology/Inflammation
	MK-28 是一种具有选择性的 PERK 激动剂，可降低亨廷顿病模型的毒性并延长生存期。MK-28 对MK28胃癌细胞有显著的杀伤作用。
T2075	Pyrazolo[1,5-a]pyrimidine 4h	Others	Others
	Pyrazolo[1,5-a]pyrimidine 4h 是一种吗啉衍生物，是腺苷 A2A 受体的选择性拮抗剂。在帕金森病和亨廷顿舞蹈症的动物模型中，它已被证明具有神经保护作用。
T13133	Tetrabenazine Metabolite (-)-β-Dihydrotetrabenazine,(-)-β-HTBZ	Monoamine Transporter	Membrane transporter/Ion channel
	Tetrabenazine Metabolite ((-)-β-HTBZ) 是一种囊泡单胺转运蛋白 2 (VMAT2) 抑制剂，是 Tetrabenazine 的一种活性代谢物。Tetrabenazine Metabolite 对 VMAT2 具有高亲和力，其Ki 为13.4 nM。Tetrabenazine Metabolite 常常被用于研究与亨廷顿氏病和其他多动障碍相关的舞蹈病。
T9340	1-phenyl-3,4-dihydroisochinoline 3,4-Dihydro-1-phenylisoquinoline,1-苯基-3,4-二氢异喹啉	Others	Others
	1-phenyl-3,4-dihydroisochinoline (3,4-Dihydro-1-phenylisoquinoline) 是神经递质多巴胺的结构类似物，与中枢神经系统中的多巴胺受体相互作用。它已被研究为治疗帕金森病、阿尔茨海默病和亨廷顿舞蹈症等神经疾病的潜在治疗剂。
T40652	Meclizine Meclozine	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Meclizine (Meclozine) (Meclozine)具有抗组胺作用，可可逆地抑制组胺与H1受体的相互作用。Meclizine 是哌嗪类H1拮抗剂的一个成员。Meclizine 是一种有效的抗运动病剂。Meclizine 可通过血脑屏障。Meclizine 是小鼠组成型雄烷受体(CAR)的激动剂配体，也是人CAR 的反向激动剂。Meclizine 可用于polyQ 毒性疾病的研究，如亨廷顿病。
T39480	Lexanersen WVE-120102,Lexanersen
	Lexanersen (WVE-120102), an antisense oligonucleotide, is utilized in Huntington's disease research.
T40843	1-(Anilinocarbonyl)proline
	1-(Anilinocarbonyl)proline is a compound utilized for identifying dual-action probes within a cell model of Huntington's disease.
T28363	PF-02545920
	PF-02545920, a PDE10 inhibitor, is used potentially for the treatment of Huntington's Disease.
T69441	NSC66098
	NSC66098 is a novel potent inhibitor of Huntington's disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein.
T33895	PBT-1033 hydrochloride PBT 1033,PBT2,PBT 2,PBT-2,PBT1033,PBT-1033
	PBT-1033 hydrochloride is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease.
T34662	SMER10 SMER-10,SMER 10
	SMER10 is an enhancer of the clearance of mutant aggregate-prone proteins by autophagy in mammalian cell models of Huntington's and Parkinson's disease, independent of rapamycin.
T79865	Votoplam	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Votoplam作为一种基因剪接调节剂，其应用主要在于抑制亨廷顿病。
T71969	Remacemide
	Remacemide is a low-affinity NMDA antagonist with sodium channel blocking properties. It has been studied for the treatment of acute ischemic stroke, epilepsy, Huntington's disease, and Parkinson's disease.
T38279	C2-8 C2-8
	C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC50s = 25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2...
T38146	Chloroguanabenz (acetate)
	Chloroguanabenz is an antiprion agent and a derivative of the α2-adrenergic receptor agonist guanabenz . It inhibits prion formation in yeast and mammalian cell-based assays. Chloroguanabenz reduces the levels of both soluble and aggregated forms of the truncated Huntingtin derivative Htt48 in an HEK293T cellular model of Huntington's disease.
T7352L	Pridopidine hydrochloride ASP2314 HCl,Pridopidine HCl,FR310826,ASP-2314 hydrochloride
	Pridopidine Hydrochloride is a dopaminergic stabilizer that has been shown to improve a variety of neurological and psychiatric disorders, including Huntington's disease. Pridopidine Hydrochloride stabilizes psychomotor activity in a state-dependent way t
T61497	Rho-Kinase-IN-2
	Rho-Kinase-IN-2 (Compound 23) is an orally active and selective inhibitor of Rho Kinase (ROCK), which can penetrate the central nervous system (CNS). It exhibits a high affinity for ROCK2 with an inhibition constant (IC50) of 3 nM. This compound is of potential interest for further investigations in the field of Huntington's disease research [1].
T26683	AUTEN-67 Autophagy enhancer 67,MTMR14 inhibitor,AUTEN67
	AUTEN-67 is a specific inhibitor of MTMR14 and autophagy enhancer with potent antiaging and neuroprotective effects. AUTEN-67 also delays the onset and decreases the severity of Huntington's disease.
T80813	WAY-354574	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	WAY-354574为针对Sirtuin（脱乙酰酶）的活性化合物，适用于亨廷顿病（HD）研究。
T79038	Tau protein aggregation-IN-1
	Tau protein aggregation-IN-1（化合物 0c）是一种针对Tau protein聚集的抑制剂。该化合物主要应用于研究蛋白质折叠障碍类疾病，包括阿尔茨海默病、痴呆、帕金森病、亨廷顿舞蹈病及基于朊病毒引起的海绵状脑病。
T61991	HTT-D3
	HTT-D3 是有效的，具有口服活性的亨廷顿蛋白 (HTT) 剪接调节剂。 HTT-D3 促进 HTT mRNA 降解和 HTT 水平降低。HTT-D3 减少 p-糖蛋白 (P-gp) 流出，在亨廷顿病中具有研究价值。
T73289	mHTT-IN-1
	mHTT-IN-1 (Example 1) 为针对突变亨廷顿蛋白 (mHTT) 的高效抑制剂，该蛋白具毒性，主导遗传性常染色体显性神经退行性疾病—亨廷顿氏病 (HD) 的发生。mHTT-IN-1 能有效降低 mHTT 水平，其 EC50 值为 0.46 nM。
T83947	HDAC4 CHDI Degrader 11
	HDAC4 CHDI Degrader 11是一种高效且选择性的HDAC4降解剂（PROTAC），其在Jurkat E6-1细胞和Jurkat细胞中的DC50值分别为4 nM和6 nM。该化合物由类IIa HDAC抑制剂三氟甲基噁二唑通过连接体与Von Hippel-Lindau (VHL) 蛋白的配体连接而成。在亨廷顿病小鼠细胞模型中，HDAC4 CHDI Degrader 11能强效地降解HDAC4（DC50= 1nM）。在神经母细胞瘤细胞系中，可与P-糖蛋白抑制剂Elacridar联用以实现更有效的降解。
T74247	TPE-MI
	TPE-MI（Tetraphenylethene maleimide）在与马来酰亚胺与硫醇反应前不具荧光性。在与游离的半胱氨酸硫醇标记时，其荧光被激活，后者多在球形蛋白质的核心，仅在展开时显露。TPE-MI适用于测量细胞中未折叠蛋白质的负荷，并能在亨廷顿病诱导的多能干细胞模型中监测蛋白质平衡失衡，以及在形成可见聚合体之前，监测转染突变亨廷顿外显子1的细胞的状况。此外，TPE-MI用于检测双氢青蒿素处理后疟疾寄生虫的蛋白质损伤。应暗处储存。

化合物

Cat.No: T9998

Target: Sirtuin

Cat.No: T8452

Target: Others

Cat.No: T6111

Synonym: EX-527,司来司他,SEN0014196

Target: Sirtuin

Cat.No: T0412

Synonym: 艾地苯醌,CV-2619

Target: Apoptosis, Antioxidant, Mitochondrial Metabolism

Cat.No: T3206

Synonym: Histone Deacetylase Inhibitor IV,PAOA

Target: HDAC

Cat.No: T38605

Target: Others

Cat.No: T22595

Synonym: Linazolamide intermediate B impurity 2,CPNQ,5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline,奥司他韦杂质B(2-叠氮杂合物)

Target: Others, Sirtuin

Cat.No: T23331

Synonym: SC 51089 free base

Target: Prostaglandin Receptor

Cat.No: TP2417

Target: Others

Cat.No: T62839

Synonym: SAGE-718

Target: NMDAR, iGluR

Cat.No: T9159

Synonym: PB 1033,PBT1033,PBT-2,PBT 2,PBT2

Target: Others

Cat.No: T15035

Synonym: 2,2'-Disulfanediyldiethanamine

Target: Caspase

Cat.No: T61859

Target: Antiviral, PERK

Pyrazolo[1,5-a]pyrimidine 4h

Cat.No: T2075

Target: Others

Tetrabenazine Metabolite

Cat.No: T13133

Synonym: (-)-β-Dihydrotetrabenazine,(-)-β-HTBZ

Target: Monoamine Transporter

1-phenyl-3,4-dihydroisochinoline

Cat.No: T9340

Synonym: 3,4-Dihydro-1-phenylisoquinoline,1-苯基-3,4-二氢异喹啉

Target: Others

Cat.No: T40652

Synonym: Meclozine

Target: Histamine Receptor

Cat.No: T39480

Synonym: WVE-120102,Lexanersen

1-(Anilinocarbonyl)proline

Cat.No: T40843

Cat.No: T28363

Cat.No: T69441

PBT-1033 hydrochloride

Cat.No: T33895

Synonym: PBT 1033,PBT2,PBT 2,PBT-2,PBT1033,PBT-1033

Cat.No: T34662

Synonym: SMER-10,SMER 10

Cat.No: T79865

Target: DNA/RNA Synthesis

Cat.No: T71969

Cat.No: T38279

Synonym: C2-8

Chloroguanabenz (acetate)

Cat.No: T38146

Pridopidine hydrochloride

Cat.No: T7352L

Synonym: ASP2314 HCl,Pridopidine HCl,FR310826,ASP-2314 hydrochloride

Rho-Kinase-IN-2

Cat.No: T61497

Cat.No: T26683

Synonym: Autophagy enhancer 67,MTMR14 inhibitor,AUTEN67

Cat.No: T80813

Target: Sirtuin

Tau protein aggregation-IN-1

Cat.No: T79038

Cat.No: T61991

Cat.No: T73289

HDAC4 CHDI Degrader 11

Cat.No: T83947

Cat.No: T74247

Cat. No.	Product Name	Target	Signaling Pathways
T75319	Taurodeoxycholic acid Taurodeoxychloic acid	Apoptosis; Calcium Channel; Caspase	Apoptosis; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome
	Taurodeoxycholic acid (Taurodeoxychloic acid) 是脱氧胆酸的胆汁酸牛磺酸共轭物，是一种人体代谢物，可稳定线粒体膜，减少自由基形成。Taurodeoxycholic acid 通过阻断钙介导的凋亡通路以及 Caspase-12 激活来抑制凋亡 (apoptosis)。Taurodeoxycholic acid具有神经保护活性，可用于研究 3-硝基丙酸诱导或稳定遗传的亨廷顿舞蹈病 (HD) 。

天然产物

Taurodeoxycholic acid

Cat.No: T75319

Synonym: Taurodeoxychloic acid

Target: Apoptosis, Calcium Channel, Caspase

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