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60

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1883	Des(benzylpyridyl) Atazanavi	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Des(benzylpyridyl) Atazanavi 是 Atazanavir 的 N-脱烷基代谢物 (M1)，一种 HIV 蛋白酶抑制剂。
T15210	Elsulfavirine Elpida,VM-1500	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Elsulfavirine (VM-1500) 是一种 HIV-1 感染的逆转录酶抑制剂，也是抗 HIV 的新药。
T3523	Fostemsavir BMS-663068,磷坦姆沙韦	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Fostemsavir (BMS-663068) 是 BMS-626529 的原药，可抑制 HIV-1 与细胞 CD4 受体的结合，能结合gp120。
T28255	Opaviraline GW420867X,GW-867,HBY-1293,GW867,GW-420867X	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Opaviraline (GW-420867X) 是一种有效逆转录酶抑制剂，对Human immunodeficiency virus 1具有抑制作用，具有治疗HIV 感染的潜力。
T10570	Fostemsavir Tris BMS-663068 Tris	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Fostemsavir Tris (BMS-663068 Tris) 是一种 HIV-1附着抑制剂。
T67804	KM-023	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	KM-023是一种新的第二代非核苷类逆转录酶抑制剂，可用于研究人类免疫缺陷病毒（HIV）1型感染。
T27625	IQP-0528 SJ-3991,SJ3991,IQP0528	Antiviral; HIV Protease; Reverse Transcriptase	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	IQP-0528是一种高效的非核苷类逆转录酶抑制剂（NNRTI），通过阻断病毒进入，有可能用于治疗HIV 感染，并且作为杀微生物凝胶显示出抗病毒活性。IQP-0528对HIV-1和HIV-2都显示出抑制作用，对HIV-1的EC50为0.2 nM，对HIV-2的EC50为100 nM。
T15371	Gardiquimod	TLR; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Gardiquimod 可抑制巨噬细胞和活化的外周血单个核细胞的HIV-1感染。它是一种咪唑喹啉类似物，是一种 TLR7/8 激动剂。
T11074	Dolutegravir intermediate-1 1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid,1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Dolutegravir intermediate-1 (1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid) 是 Dolutegravir 的一种新合成中间体。它是一种整合酶抑制剂，有潜力研究人类免疫缺陷病毒 (HIV)-1 感染。
T16500	PF-3450074 PF-74	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	PF-3450074 (PF-74)是 HIV-1 衣壳蛋白的特异性抑制剂，可广谱抑制 HIV 分离株。它在 HIV-1 感染的早期阶段起作用，通过与 CPSF6 和 NUP153 的结合直接竞争来抑制病毒复制，并阻断病毒生命周期的脱膜，组装和逆转录步骤。
T27154	Dexelvucitabine D-D-4FC,DPC-817,RVT,beta-D-D-4FC,DFC	Reverse Transcriptase	Microbiology/Virology
	Dexelvucitabine (RVT) 是一种胞苷类似物，一种口服有活性的核苷逆转录酶抑制剂。它是一种 2'-脱氧胞苷抗逆转录病毒剂。它是一种有效的抗 HIV-1病毒剂，这些病毒聚合酶中含有胸苷类似物和/或 M184V 突变。
T26240	Surfen dihydrochloride Aminokinuride dihydrochloride,Aminoquinuride dihydrochloride,NSC-12155,Aminokinuride 2HCl,Aminoquinuride 2HCl	FGFR; Antiviral; Antibiotic	Angiogenesis; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Surfen dihydrochloride (Aminoquinuride dihydrochloride) 是一种有效的硫酸肝素小分子拮抗剂，具有抗菌和抗病毒活性，抑制炭疽致死因子、凝血因子 X 和致死因子。Surfen dihydrochloride 可抑制普通肝素和低分子量肝素的抗凝活性，抑制肝素的硫酸化和肝素裂解酶的降解。Surfen dihydrochloridn 抑制阻断硫酸乙酰肝素介导的 FGF2 结合和信号转导。Surfen 抑制 SEVI 和精液介导的 HIV 1 型感染增强。
T11564	HIV-1 inhibitor-3	Others	Others
	HIV-1 inhibitor-3 is an HIV infection inhibitor.
T15483	LEDGIN6 HIV-1 integrase inhibitor 2	Others	Others
	HIV-1 integrase inhibitor 2 is used for the treatment of human immunodeficiency virus (HIV) infection.
T76537	GP120, HIV-1 MN
	GP120，HIV-1MN 是一种肽。GP120,HIV-1MN 可用于 HIV 感染的研究。
T28492	R-18893 R18893
	R-18893, a RNA-directed DNA polymerase inhibitor, is used potentially for the treatment of HIV-1 infection.
T71056	SJP-L-5
	SJP-L-5 is a inhibitor of HIV-1 infection by blocking viral DNA nuclear entry.
T28171	Nifeviroc TD-0232,TD 0232,尼非韦罗,TD0232
	Nifeviroc, a CCR5 antagonist, is used potentially for treatment of inflammatory responses to HIV type-1 infection.
T27742	KRH-3955 Salt KRH-3955,KRH3955,KRH 3955,KRH3955 Salt
	KRH-3955, a CXCR4 antagonist, is an orally bioavailable and extremely potent inhibitor of HIV-1 infection.
T10741	CDK9-IN-1	CDK	Cell Cycle/Checkpoint
	CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection (IC50: 39 nM for CDK9/CycT1).
T71517	Nevirapine quinone methide
	Nevirapine quinone methide is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.
T70627	U 89674
	U 89674 is a non-nucleoside reverse transcriptase inhibitor used for the prevention of the spread of HIV-1 infection.
T14488	Azt-pmap	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	AZT-PMPA, an aryl phosphate derivative of AZT and a nucleoside analogue, demonstrates anti-HIV activity[1]. As a nucleoside reverse transcriptase inhibitor (NRTI), AZT-PMPA targets HIV infection effectively[2].
T74282	HIV-IN-2
	HIV-IN-2 (Compound 100) 是一种有效的HIV 抑制剂。HIV-IN-2 具有研究HIV 感染的潜力。
T69796	Nevirapine hemihydrate
	Nevirapine hemihydrate is a non-nucleoside reverse transcriptase inhibitor (NNRTI) studied for potential treatment of HIV-1 infection and AIDS.
T78551	Glycolithocholic acid 3-sulfate disodium Glycolithocholate sulfate disodium,SLCG disodium,Sulfolithocholylglycine disodium
	Glycolithocholic acid 3-sulfate (disodium) 是抑制HIV-1复制的化合物，同时它也被用于HIV感染和胆囊疾病的研究。
T76982	Teropavimab
	Teropavimab (3BNC117-LS) 是一种抗体。Teropavimab 可用于HIV 感染的研究。
T68836	ADS-J1
	ADS-J1 is an HIV-1 entry inhibitor that potently inhibits seminal amyloid fibrillization and block fibril-mediated enhancement of viral infection. Semen-derived amyloid fibrils, comprising SEVI (semen-derived enhancer of viral infection) fibrils and SEM1 fibrils, may remarkably enhance HIV-1 sexual transmission and are potential targets for the development of an effective microbicide.
T63661	HF51116
	HF51116 是 XCR4 的有效拮抗剂。HF51116 能够显著拮抗 SDF-1α 诱导的细胞迁移、钙动员和 CXCR4 内化，并利用 CXCR4 抑制 HIV-1 感染。HF51116 对HIV-1感染、造血干细胞动员和癌症转移表现出研究潜力。
T27604	INCB-9471 HCl INCB 9471,INCB-9471,INCB9471,INCB-009471,INCB 009471,INCB009471
	INCB-9471 HCl, an allosteric noncompetitive small-molecule antagonist of C-C chemokine receptor 5, has potent inhibitory activity against monocyte migration and HIV-1 infection.
T74106	Hydroxy ritonavir
	Hydroxy ritonavir 是 Ritonavir 的代谢物。Ritonavir 是用于研究HIV 感染和 AIDS 的HIV 蛋白酶的抑制剂。
TP1332	Enfuvirtide
	Enfuvirtide (INN) is an HIV fusion inhibitor, the first of a class of antiretroviral drugs used in combination therapy for the treatment of HIV-1 infection.
T69009	Gnidimacrin
	Gnidimacrin activated HIV-1 replication and killed persistently-infected cells at picomolar concentrations. In addition to its potential to purge HIV-1 from latently infected cells, gnidimacrin potently inhibited a panel of HIV-1 R5 virus infection of peripheral blood mononuclear cells (PBMCs) at an average concentration lower than 10 pM. These results suggest that gnidimacrin could activate latent HIV-1, specifically kill HIV-1 persistently infected cells, and inhibit R5 viruses at picomolar c...
T76903	Alvircept sudotox
	Alvircept sudotox 是一种重组CD4，来源于Pneumonas aeruginosaexotoxin A。Alvircept sudotox 可用于HIV 感染的研究。
T76991	Suvizumab
	Suvizumab (KD-247) 是一种抗HIV-1的中和抗体。Suvizumab 有效中和了HIV-1MN、HIV-1SF2和HIV-189.6，IC50值分别为 0.1 µg/mL、1.0 µg/mL 和 0.2 µg/mL。Suvizumab 减少了HIV 的病毒载量。Suvizumab 具有良好的耐受性，可用于预防HIV 感染。
T63308	Ulonivirine
	Ulonivirine 是口服具有活力的非核苷逆转录酶（reverse transcriptase）抑制剂，表现出较高的抗病毒作用，能够用于研究 HIV-1 感染。
T75330	Lysozyme chloride
	Lysozyme chloride 是一种杀菌酶，它能裂解革兰氏阳性细菌 (bacteria)。Lysozyme chloride 还可用于HIV 感染和肺气肿的研究。
T76292	Tifuvirtide
	Tifuvirtide (T-1249) 是一种肽类人类免疫缺陷病毒 1 型(HIV-1)融合抑制剂。Tifuvirtide 是一种合成设计的杂合逆转录病毒包膜多肽。Tifuvirtide 具有抗逆转录病毒活性。Tifuvirtide 可用于HIV 感染的研究。
T4555	Fosamprenavir GW 433908,福沙那韦,Amprenavir phosphate
	Fosamprenavir (Amprenavir phosphate; GW 433908) 是抗逆转录病毒蛋白酶抑制剂 Amprenavir 的磷酸酯前药，与母体分子相比具有更高的溶解度。具有抗HIV 感染作用。
T27768	L-696229 L696,229,L-696,229,L 696229,L696229,L 696,229
	L-696229 is a specific inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT). L-696229 inhibited RT activity in a mutually exclusive manner with respect to either phosphonoformate or azidothymidine triphosphate and was a weak
T77141	Pegaldesleukin
	Pegaldesleukin 是一种聚乙二醇与白细胞介素-2 的偶联物 (PEG-IL2)。Pegaldesleukin 具有抗病毒活性，在 HIV 中有潜在应用，可能通过保留免疫组库来延缓 HIV 感染的进展。
T80621	Semzuvolimab UB421
	Semzuvolimab是靶向T细胞表面抗原T4/Leu-3，即p55 (CD4)的鼠IgG1κ类抗体。该CD4抗体具备中和HIV感染的能力，潜在用于抑制HAART稳定型HIV感染。
T60811	CXCR4 antagonist 7
	CXCR4 antagonist 7 (Compound PARA-B) 是可用于研究HIV 感染、炎症性疾病、癌症和 WHIM 综合症的CXCR4拮抗剂 (IC50 = 9.3 nM)。
T83707	F9170 TFA
	F9170是一种抗病毒肽，对应HIV-1包膜糖蛋白的789-803氨基酸。它与HIV-1包膜蛋白胞浆尾部的LLP1域结合，并抑制HIV-1 IIIB对MT-2细胞的感染(EC50 = 0.19 µM)。在恒河猴模型的类人猿免疫缺陷病毒(SHIV)感染中，F9170 (3 mg/kg)能降低血浆病毒负荷。
T73904	Ditiocarb
	Ditiocarb (Diethyldithiocarbamic acid) 是一种铜试剂，与 Cu2+溶液反应，生成络合物，提高了铜置换沉淀速率。Sodium diethyldithiocarbamate 可降低HIV 感染，并应用于高危乳腺癌的辅助免疫研究。
T5499	gardiquimod TFA salt
	Gardiquimod diTFA，咪唑啉类似物TLR7/8激动剂，可特异性抑制巨噬细胞和活化外周血单个核细胞(PBMCs)的HIV-1感染。在浓度低于10 μM时，该化合物特异性激活TLR7。
T69081	KRH-1636
	KRH-1636 is an orally active, selective and extremely potent CXC chemokine receptor 4 antagonist. KRH-1636 exhibits a potent and selective anti-HIV-1 activity. KRH-1636 efficiently blocked replication of various T cell line-tropic (X4) HIV type 1 (HIV-1) in MT-4 cells and peripheral blood mononuclear cells through the inhibition of viral entry and membrane fusion via the CXC chemokine receptor (CXCR)4 coreceptor but not via CC chemokine receptor 5. KRH-1636 also inhibits binding of the CXC chem...
T78925	HIV-1 inhibitor-58
	HIV-1inhibitor-58（Compound 10c）是一款抗逆转录病毒活性的广谱非核苷逆转录酶抑制剂，有效抑制MT-4细胞中的HIV-1 WT株IIIB以及NNRTI耐药菌株，如K103N和E138K（EC50 < 50 nM）。此外，HIV-1inhibitor-58对CYP2C9与CYP2C19也表现出抑制作用（IC50分别为2.06 μM与1.91 μM），适用于HIV感染研究。
T81295	Retrocyclin-1
	Retrocyclin-1是一种θ防御素，具有识别并结合含碳水化合物表面分子的能力，能够保护细胞抵御HIV-1感染。该化合物对胎球蛋白、gp120（Kd=35.4 nM）、CD4（Kd=31 nM）以及半乳糖神经酰胺（Kd=24.1 nM）展现出高度亲和性。
T80415	Palicourein
	Palicourein为含37个氨基酸的环状多肽，可体外抑制HIV-1RF对CEM-SS细胞的感染及其所引起的细胞病变，其半抑制浓度(EC50)为0.1 μM，而抑制浓度50%(IC50)为1.5 μM。

化合物

Des(benzylpyridyl) Atazanavi

Cat.No: T1883

Target: HIV Protease

Cat.No: T15210

Synonym: Elpida,VM-1500

Target: HIV Protease

Cat.No: T3523

Synonym: BMS-663068,磷坦姆沙韦

Target: HIV Protease

Cat.No: T28255

Synonym: GW420867X,GW-867,HBY-1293,GW867,GW-420867X

Target: HIV Protease

Fostemsavir Tris

Cat.No: T10570

Synonym: BMS-663068 Tris

Target: HIV Protease

Cat.No: T67804

Target: HIV Protease

Cat.No: T27625

Synonym: SJ-3991,SJ3991,IQP0528

Target: Antiviral, HIV Protease, Reverse Transcriptase

Cat.No: T15371

Target: TLR, HIV Protease

Dolutegravir intermediate-1

Cat.No: T11074

Synonym: 1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid,1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

Target: HIV Protease

Cat.No: T16500

Synonym: PF-74

Target: HIV Protease

Dexelvucitabine

Cat.No: T27154

Synonym: D-D-4FC,DPC-817,RVT,beta-D-D-4FC,DFC

Target: Reverse Transcriptase

Surfen dihydrochloride

Cat.No: T26240

Synonym: Aminokinuride dihydrochloride,Aminoquinuride dihydrochloride,NSC-12155,Aminokinuride 2HCl,Aminoquinuride 2HCl

Target: FGFR, Antiviral, Antibiotic

HIV-1 inhibitor-3

Cat.No: T11564

Target: Others

Cat.No: T15483

Synonym: HIV-1 integrase inhibitor 2

Target: Others

GP120, HIV-1 MN

Cat.No: T76537

Cat.No: T28492

Synonym: R18893

Cat.No: T71056

Cat.No: T28171

Synonym: TD-0232,TD 0232,尼非韦罗,TD0232

Cat.No: T27742

Synonym: KRH-3955,KRH3955,KRH 3955,KRH3955 Salt

Cat.No: T10741

Target: CDK

Nevirapine quinone methide

Cat.No: T71517

Cat.No: T70627

Cat.No: T14488

Target: HIV Protease

Cat.No: T74282

Nevirapine hemihydrate

Cat.No: T69796

Glycolithocholic acid 3-sulfate disodium

Cat.No: T78551

Synonym: Glycolithocholate sulfate disodium,SLCG disodium,Sulfolithocholylglycine disodium

Cat.No: T76982

Cat.No: T68836

Cat.No: T63661

Cat.No: T27604

Synonym: INCB 9471,INCB-9471,INCB9471,INCB-009471,INCB 009471,INCB009471

Hydroxy ritonavir

Cat.No: T74106

Cat.No: TP1332

Cat.No: T69009

Alvircept sudotox

Cat.No: T76903

Cat.No: T76991

Cat.No: T63308

Lysozyme chloride

Cat.No: T75330

Cat.No: T76292

Cat.No: T4555

Synonym: GW 433908,福沙那韦,Amprenavir phosphate

Cat.No: T27768

Synonym: L696,229,L-696,229,L 696229,L696229,L 696,229

Cat.No: T77141

Cat.No: T80621

Synonym: UB421

CXCR4 antagonist 7

Cat.No: T60811

Cat.No: T83707

Cat.No: T73904

gardiquimod TFA salt

Cat.No: T5499

Cat.No: T69081

HIV-1 inhibitor-58

Cat.No: T78925

Cat.No: T81295

Cat.No: T80415

Cat. No.	Product Name	Target	Signaling Pathways
TN5263	1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one Xanthohumol,黄腐酚	Apoptosis; BCL; PARP; HCV Protease; IAP; Caspase; HIV Protease; NMDAR; p53	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one (Xanthohumol) 是一种从蛇麻草中提纯的具有多种生物功能的天然产物。黄腐酚对 HIV-1 有效，可能是一种有趣的先导化合物。它可能代表一种用于 HIV-1 感染的新型化疗药物。
T79934	Clavirolide L
	Clavirolide L (Compound 3)为多拉贝烷二萜类化合物，源自Clavularia viridis。该化合物对HIV-1具有显著抑制效果，同时不针对RT酶，适用于HIV感染的研究。
T73758	Glycolithocholic acid 3-sulfate
	Glycolithocholic acid 3-sulfate (SLCG) 为一种胆汁酸衍生物及甘胆酸的代谢产物，具有抑制HIV-1复制的作用。该化合物在HIV感染和胆囊疾病的研究中有潜在应用价值。

天然产物

1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

Cat.No: TN5263

Synonym: Xanthohumol,黄腐酚

Target: Apoptosis, BCL, PARP, HCV Protease, IAP, Caspase, HIV Protease, NMDAR, p53

Cat.No: T79934

Glycolithocholic acid 3-sulfate

Cat.No: T73758

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