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26

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9110	Ceapin-A7	Others	Others
	Ceapin-A7 是内质网应激 ATF6α信号的选择性阻断剂(IC50:0.59 μM)，可用于探讨 ATF6α 促细胞活化的机制及其在病理环境中的作用。
T9266	Fatostatin	Lipid; Fatty Acid Synthase	Metabolism
	Fatostatin A 是一种SREBP 活化的特异性抑制剂，能够抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合，抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤活性，能抑制ob/ob 小鼠的高血糖。它抑制细胞中成脂基因的转录。
T1855	ZCL278 ZCL 278	CDK; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	ZCL278 是一种选择性 Cdc42 GTPase 抑制剂，与Cdc42结合，Kd 为 11.4 μM。
T10760	Ceramides Mixture 神经酰胺混合物,神经酰胺	Telomerase	DNA Damage/DNA Repair
	Ceramides Mixture 是表皮渗透屏障的主要脂质成分，参与生长抑制，细胞周期停滞和端粒酶活性的调节。它是一种内源性神经酰胺，由含羟基和非羟基脂肪酸的神经酰胺组成。
T8903	Retro-2 Retro 2,2-{[(5-methyl-2-thienyl)methylene]amino}	Others; Virus Protease; Parasite; Autophagy	Autophagy; Microbiology/Virology; Others
	Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) 是一种植物毒素蓖麻毒素抑制剂，它保护 HeLa 细胞免受蓖麻毒素、Stx1 和 Stx2 的侵害，选择性地阻断早期内体蛋白质-高尔基体界面处的逆行毒素运输。
T6832	Fatostatin hydrobromide Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin	NPC1L1; Fatty Acid Synthase	Membrane transporter/Ion channel; Metabolism
	Fatostatin hydrobromide (Fatostatin A HBr) 是一种 SREBP 活化的特异性抑制剂，可抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合，抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤作用，能抑制 ob/ob 小鼠的高血糖。它抑制了细胞中成脂基因的转录。
T6516	Golgicide A	Others; Virus Protease	Microbiology/Virology; Others
	Golgicide A 可抑制柯萨奇病毒 B3 和其他人类肠道病毒的复制。它是一种高度特异性可逆的顺式高尔基体 ADP-核糖基化因子鸟嘌呤核苷酸交换因子抑制剂。
T38399	(Rac)-Golgicide A (Rac)-GCA	Virus Protease	Microbiology/Virology
	(Rac)-Golgicide A ((Rac)-GCA) 是 Golgicide A 的一种消旋体。
T38818	Golgicide A-2 Golgicide A-2,GCA-2
	Golgicide A-2 (GCA-2), a derivative of Golgicide A (GCA), is the highly active enantiomer of GCA. It exhibits exceptional selectivity and efficiency in eradicating An. stephensi larvae, thus making it a valuable tool for researching dengue virus-related diseases.
T38817	Golgicide A-1 GCA-1,Golgicide A-1
	Golgicide A-1 (GCA-1) is a moderately potent cis-diastereomer variant of Golgicide A (GCA) specifically designed to inhibit mosquito reproduction.
T10851	CMP-Sialic acid sodium salt CMP-Neu5Ac sodium salt	Others	Others
	CMP-Sialic acid sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. It provides a substrate for Golgi sialyltransferases. UDP-GlcNAc 2-epimerase initiates sialic acid synthesis.
T22665	PD 128042 CI 976	Acyltransferase	Metabolism
	PD 128042 (CI 976) 是口服有效的ACAT (酰基辅酶 A: 胆固醇酰基转移酶)选择性抑制剂。它也是LPAT(溶血磷脂酰基转移酶) 抑制剂。它抑制高尔基体相关 LPAT 活性 (IC50=15 μM)。它抑制多种膜运输步骤，包括在内吞和分泌途径中发现的步骤。
T23709	alphaSYN-IN-NAB2 alphaSYN inhibitor NAB2,alphaSYNINNAB2,alphaSYN-IN-NAB2,NAB2,alphaSYN inhibitor-NAB2
	alphaSYN-IN-NAB2 是一种神经元保护剂，是一种由 NAB2基因编码的蛋白质。NAB2 高效且具有选择性地保护多种细胞免受 α-syn 毒性。NAB2 对依赖于 E3 泛素连接酶 Rsp5/Nedd4 的内体转运具有促进作用。NAB2 确定 α-syn 生物学中的一个可活性分子节点，该节点可以纠正其潜在病理学的多个方面，包括功能失调的内体和内质网到高尔基体囊泡的运输。NAB2参与细胞分化、凋亡和应激反应等细胞过程，可用来研究癌症、神经发育和神经元活动。
T61265	Exo2
	Exo2 is a secretion inhibitor that hinders the trafficking of Shiga toxin from endosomes to the trans-Golgi network. It inhibits the exit of secretory cargo from the endoplasmic reticulum (ER) and disrupts the Golgi apparatus. Notably, Exo2 does not impact the morphology of the trans-Golgi network (TGN). Additionally, Exo2 has the ability to induce calcium-dependent exocytosis in permeabilized adrenal chromaffin cells [1] [2].
T71797	NC03
	NC03 is a PI4K2A inhibitor which decreases the PI4P pools in Golgi and endosomes.
T24077	G202-0362
	G202-0362 is an antiviral agent against Rift Valley fever virus. It acts by blocking virus budding from the trans Golgi.
T13759	LTX-401 dihydrochloride (1262851-70-6 free base) LTX-401 dihydrochloride	Others	Others
	LTX-401, targets the Golgi apparatus, and is an oncolytic amino acid derivative.
T68528	M-COPA
	M-COPA is a golgi disruptor which inhibits cell surface expression of MET protein and the ADP-ribosylation factor 1 (Arf1) activation. M-COPA also inhibits angiogenesis through suppression of both VEGFR1/2 and nuclear factor-kappaB (NF-kappaB) signaling pathways.
T23933	D011-2120 D0112120,D011 2120
	D011-2120 is an agent of antiviral that acts by blocking microtubule polymerization, disrupting the Golgi complex and inhibiting viral trafficking to the plasma membrane during virus egress.
T78461	C6 NBD Ceramide Nbd-ceramide
	C6 NBD Ceramide 是一种细胞膜渗透性高尔基体荧光探针（Ex=466 nm, Em=536 nm），是一种带有绿色荧光标记的神经酰胺，可识别活体及固定细胞的高尔基体，观测活细胞中高尔基体形态变化。C6 NBD Ceramide 在细胞内可代谢生成荧光鞘磷脂和葡糖基甘油酰胺，从而应用于鞘脂转运和代谢机制研究。
T73747	CMP-Sialic acid
	CMP-Sialic acid (CMP-Neu5Ac) 是 UDP-GlcNAc 2-epimerase 的变构抑制剂。CMP-Sialic acid 可为高尔基体唾液酸转移酶提供底物。CMP-Sialic acid 是唾液酸及其结合物的生物合成中的重要糖类核苷酸。
T79758	BQZ-485	Apoptosis	Apoptosis
	BQZ-485是一种有效的GDI2抑制剂，它通过与Tyr245相互作用以破坏GDI2-Rab1A之间的内在相互作用，阻断了从内质网(ER)至高尔基体的囊泡转运，并触发了随后的凋亡事件。
T82272	Gol-NTR
	Gol-NTR是一种针对高尔基体的选择性和灵敏度极高的探针，由硝基还原酶(NTR)激活，用于可视化急性肺损伤(ALI)及其修复。该探针的检测限低至54.8 ng/mL，适用于监测和评估脓毒症引发的ALI反应。
T36188	Ceramide Phosphoethanolamines (bovine)
	Ceramide phosphoethanolamine (CPE) is an analog of sphingomyelin that contains ethanolamine rather than choline as the head group. It is the principal membrane phospholipid in invertebrates such as Drosophila, which lacks sphingomyelin. It is only produced in small amounts in mammalian cells, accounting for approximately 0.02 mol% of total phospholipids in mouse testis and brain. In Drosophila, CPE is biosynthesized by CPE synthase from ceramide and cytidine diphosphate-ethanolamine in the Golgi...
T35639	Sulfatides (bovine) (sodium salt)
	Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system. They are produced from the combination of ceramide and UDP-galactose in the endoplasmic reticulum followed by sulfation in the Golgi apparatus. The ceramide portion contains variable fatty acid chain lengths, which are tissue- and pathology-dependent. Sulfatides are primarily found in the myelin sheath of oligodendrocytes and Schwann cells, wit...
T65252	Pepsin
	Pepsin is an endopeptidase that breaks down proteins into smaller peptides and amino acids that can be easily absorbed in the small intestine[1]. Pepsin is stable at pH ranges as high as pH 6. Above this pH, pepsin is rapidly irreversibly inactivated and elevation of pH of the reaction mixture to pH 8 results in complete inactivation of pepsin[2]. Pepsin has been posited to be a reliable biological marker of EER. An immunologic pepsin assay of combined sputum and saliva was determined to be 100%...

化合物

Cat.No: T9110

Target: Others

Cat.No: T9266

Target: Lipid, Fatty Acid Synthase

Cat.No: T1855

Synonym: ZCL 278

Target: CDK, Ras

Ceramides Mixture

Cat.No: T10760

Synonym: 神经酰胺混合物,神经酰胺

Target: Telomerase

Cat.No: T8903

Synonym: Retro 2,2-{[(5-methyl-2-thienyl)methylene]amino}

Target: Others, Virus Protease, Parasite, Autophagy

Fatostatin hydrobromide

Cat.No: T6832

Synonym: Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin

Target: NPC1L1, Fatty Acid Synthase

Cat.No: T6516

Target: Others, Virus Protease

(Rac)-Golgicide A

Cat.No: T38399

Synonym: (Rac)-GCA

Target: Virus Protease

Golgicide A-2

Cat.No: T38818

Synonym: Golgicide A-2,GCA-2

Golgicide A-1

Cat.No: T38817

Synonym: GCA-1,Golgicide A-1

CMP-Sialic acid sodium salt

Cat.No: T10851

Synonym: CMP-Neu5Ac sodium salt

Target: Others

Cat.No: T22665

Synonym: CI 976

Target: Acyltransferase

alphaSYN-IN-NAB2

Cat.No: T23709

Synonym: alphaSYN inhibitor NAB2,alphaSYNINNAB2,alphaSYN-IN-NAB2,NAB2,alphaSYN inhibitor-NAB2

Cat.No: T61265

Cat.No: T71797

Cat.No: T24077

LTX-401 dihydrochloride (1262851-70-6 free base)

Cat.No: T13759

Synonym: LTX-401 dihydrochloride

Target: Others

Cat.No: T68528

Cat.No: T23933

Synonym: D0112120,D011 2120

C6 NBD Ceramide

Cat.No: T78461

Synonym: Nbd-ceramide

CMP-Sialic acid

Cat.No: T73747

Cat.No: T79758

Target: Apoptosis

Cat.No: T82272

Ceramide Phosphoethanolamines (bovine)

Cat.No: T36188

Sulfatides (bovine) (sodium salt)

Cat.No: T35639

Cat.No: T65252

Cat. No.	Product Name	Target	Signaling Pathways
T3092	Nigericin sodium salt 尼日利亚菌素,尼日利亚菌素钠盐	Potassium Channel; NOD-like Receptor (NLR); Antibacterial; Antibiotic; NOD	Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; NF-κB
	Nigericin sodium salt 属于抗生素，是一种 NLRP3 激活剂，也是一种阳离子离子载体。Nigericin sodium 可以触发 NALP3 炎性体的激活，可抑制高尔基体功能并抑制革兰氏阳性菌的生长。
T5004	Hyaluronic acid sodium 透明质酸钠,Sodium Hyaluronate	Others	Others
	Hyaluronic acid sodium (Sodium Hyaluronate) 是一种生物聚合物，由二糖的重复单元组成，应用领域广泛。
TN2344	Swainsonine Tridolgosir	Apoptosis; Others; Antibiotic	Apoptosis; Microbiology/Virology; Others
	Swainsonine (Tridolgosir) 是一种从黄芪中分离出来的一种生物碱，是一种强效和可逆的α-甘露糖苷酶抑制剂。Swainsonine 具有抗肿瘤活性，可诱导细胞凋亡和细胞周期停滞在 G2/M 期。

天然产物

Nigericin sodium salt

Cat.No: T3092

Synonym: 尼日利亚菌素,尼日利亚菌素钠盐

Target: Potassium Channel, NOD-like Receptor (NLR), Antibacterial, Antibiotic, NOD

Hyaluronic acid sodium

Cat.No: T5004

Synonym: 透明质酸钠,Sodium Hyaluronate

Target: Others

Cat.No: TN2344

Synonym: Tridolgosir

Target: Apoptosis, Others, Antibiotic

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