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LTX-401 dihydrochloride (1262851-70-6 free base)

产品编号 T13759 CAS T13759

别名: LTX-401 dihydrochloride

LTX-401, targets the Golgi apparatus, and is an oncolytic amino acid derivative.

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LTX-401 dihydrochloride (1262851-70-6 free base) Chemical Structure

LTX-401 dihydrochloride (1262851-70-6 free base), CAS T13759

规格	价格/CNY		货期	数量
100 mg	待询		待询
500 mg	待询		待询

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其他形式的 LTX-401 dihydrochloride (1262851-70-6 free base):

LTX-401 HCl
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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	LTX-401, targets the Golgi apparatus, and is an oncolytic amino acid derivative.
体外活性	LTX-401 displays the highest cytotoxic activity against the human malignant melanoma cell line MDA-MB-435S (13.5 μM), and is least active against the human hepatocellular carcinoma cell line HEPG2 (35.4 μM). For the remaining cell lines, LTX-401 exhibits similar IC50 values, varying slightly within the range of 19-32 μM. No in vitro hemolytic activity against RBCs is observed using the same concentrations required for the induction of cell death in cancer cell lines. A 50% hemolysis is observed using higher concentrations of LTX-401 (400 μg/mL=1087 μM)[1].LTX-401, an oncolytic amino acid derivative, targets the Golgi apparatus[2].?LTX-401 effectively reduces the viability of several tumor cell lines in vitro, with a similar degree of cytotoxicity against non-malignant cell lines such as HUV-EC-C endothelial cells, HaCat keratinocytes and MRC-5 fibroblasts.
体内活性	The majority ?of the animals demonstrate a complete and lasting tumor regression after intratumoral treatment with LTX-401.?Samples are collected from selected animals in the treatment group and control group on days 2 and 7 post-treatment with a single i.t injection.?The immunolabelling of tumor tissue with anti-CD3 antibody reveals that a majority of the infiltrating cells are CD3+ T cells, whereas tumors injected with vehicle only exhibit tumors with a viable tumor tissue, with minimal necrosis and few lymphocytes[1].

别名	LTX-401 dihydrochloride
分子量	440.45
分子式	C23H35Cl2N3O
CAS No.	T13759

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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参考文献

1. Liv-Marie Eike, et al. The Cytolytic Amphipathic β(2,2)-Amino Acid LTX-401 Induces DAMP Release in Melanoma Cells and Causes Complete Regression of B16 Melanoma. PLoS One. 2016; 11(2): e0148980. 2. Heng Zhou, et al. The oncolytic compound LTX-401 targets the Golgi apparatus. Cell Death Differ. 2018 Jan; 25(1): 227–228.

剂量换算

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体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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