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Search Results for " dpph radical "

14

抑制剂 & 化合物

60

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11093	DPPH 2,2-联苯基-1-苦基肼基,2,2-Diphenyl-1-picrylhydrazyl	Others	Others
	DPPH (2,2-Diphenyl-1-picrylhydrazyl) 是一种稳定的自由基，可用于测量抗氧化剂的自由基清除活性。DPPH 中氮原子的奇数电子通过从抗氧化剂吸收氢原子而还原为相应的肼。通过 DPPH 方法可用于水性和非极性有机溶剂中，检查亲水性和亲脂性抗氧化剂。
T82372	Free radical scavenger 1
	Free radical scavenger 1 (compound 8) 显示出对DPPH自由基的清除能力，其半数抑制浓度（IC50）为43.39 μg/ml。
T72511	Antioxidant agent-7
	Antioxidant agent-7 (SD-7), 一种苯二氮卓类衍生物，具备抗氧化作用，其对DPPH(2,2-二苯基-1-三硝基肼基) 自由基的清除能力IC50值为 470 nM。
T81827	MDYYFEER TFA
	MDYYFEER TFA为从C-藻蓝蛋白胰酶水解产物中提取的抗氧化活性肽，展现了显著的DPPH与ABTS自由基清除效果，并能保护斑马鱼幼虫免遭H2O2诱导的氧化伤害。
T81800	MHLWAAK
	MHLWAAK，抗氧化活性肽，源自C-藻蓝蛋白胰酶水解产物。该肽展现出显著DPPH及ABTS自由基清除效能，并能保护斑马鱼幼虫不受H2O2诱导的氧化损害。
T81828	MDYYFEER
	MDYYFEER 是源自 C-藻蓝蛋白胰酶水解产物的抗氧化活性肽，能有效清除 DPPH 及 ABTS 自由基，并能保护斑马鱼幼虫免受 H2O2 诱导的氧化损害。
T81863	MAQAAEYYR TFA
	MAQAAEYYR TFA 是从 C-藻蓝蛋白胰酶水解产物中分离得到的一种具有高抗氧化活性的肽。它展现了显著的 DPPH 及 ABTS 自由基清除作用，并能有效保护斑马鱼幼虫不受 H2O2 诱导的氧化损伤。
T82408	Ferroptosis-IN-3	Ferroptosis	Apoptosis
	Ferroptosis-IN-3（Compound 25）是一款抑制RSL3引起的铁死亡（HT-1080细胞中EC50为8.6nM）的铁死亡抑制剂。此外，Ferroptosis-IN-3能有效清除DPPH和ABTS自由基（EC50分别为3.94μM与6.3μM），并且能降低脂质过氧化水平。
T81799	MHLWAAK TFA
	MHLWAAK TFA是从C-藻蓝蛋白胰酶水解产物中分离的抗氧化活性肽。它展现出了较强的DPPH和ABTS自由基清除效应，并且能保护斑马鱼幼虫免遭H2O2引发的氧化伤害。
T60421	Antitumor agent-68
	Antitumor agent-68 是一种有效的微管蛋白抑制剂，具有良好的抗肿瘤活性，对宫颈癌细胞系 HeLa 和乳腺癌细胞系 MCF-7 细胞的IC50值分别为 3.6 和 3.8 μM。Antitumor agent-68 以剂量依赖的方式表现出良好的 ROS 和DPPH 自由基的清除活性。
T78739	PD07
	PD07是一种口服AChE抑制剂，对hAChE的IC50为0.29 μM。体外实验表明PD07也能抑制ChE、BACE1（IC50：13.42 μM）和Aβ1-42的聚集。作为抗氧化剂，PD07显示出DPPH抑制活性（IC50：26.46 μM），能改善因Scopolamine诱导而失忆的大鼠的记忆和认知功能。该化合物适用于阿尔茨海默病的研究。
T78781	TrxR1-IN-1
	TrxR1-IN-1 (Compound 5j) 是一种具有针对性的TrxR1抑制剂，显示出IC50值为8.8 μM的抑制效能。该化合物在治疗癌症方面表现出潜在效果，其对多种癌细胞系的IC50值分别为：MCF-7细胞系1.5 μM、HeLa细胞系1.7 μM、BGC-823细胞系2.4 μM、SW-480细胞系2.8 μM和 A549细胞系2.1 μM。此外，TrxR1-IN-1还表现出了抗氧化特性，能有效清除DPPH自由基。
T60447	α-Amylase-IN-3
	α-Amylase-IN-3 (Compound 4) 是α-Amylase 的非竞争性型抑制剂，IC50值为 18.04 μM。α-Amylase-IN-3具有自由基清除活性，对DPPH 和ABTS 的IC50值分别为 16.04 μM 和 16.99 μM。α-Amylase-IN-3 显示出良好的 α-淀粉酶蛋白质-配体相互作用，可能具有抗氧化、抗炎等药理活性，有助于研究糖尿病和氧化应激相关疾病。
T36616	DTUN
	DTUN is a lipophilic hyponitrite radical initiator.1It initiates co-autoxidation of STY-BODIPY-embedded egg phosphatidylcholine liposomes when used at a concentration of 0.2 mM. DTUN has been used in fluorescence-enabled inhibited autoxidation (FENIX) assays for the development of ferroptosis inhibitors and the study of antioxidants in lipid membranes.1,2 1.Shah, R., Farmer, L.A., Zilka, O., et al.Beyond DPPH: Use of fluorescence-enabled inhibited autoxidation to predict oxidative cell death res...

化合物

Cat.No: T11093

Synonym: 2,2-联苯基-1-苦基肼基,2,2-Diphenyl-1-picrylhydrazyl

Target: Others

Free radical scavenger 1

Cat.No: T82372

Antioxidant agent-7

Cat.No: T72511

Cat.No: T81827

Cat.No: T81800

Cat.No: T81828

Cat.No: T81863

Ferroptosis-IN-3

Cat.No: T82408

Target: Ferroptosis

Cat.No: T81799

Antitumor agent-68

Cat.No: T60421

Cat.No: T78739

Cat.No: T78781

α-Amylase-IN-3

Cat.No: T60447

Cat.No: T36616

Cat. No.	Product Name	Target	Signaling Pathways
T9135	Epirosmanol	Others	Others
	Epirosmanol 是含有内酯部分的二萜类化合物。 Epirosmanol 是一种极弱碱性（基本中性）的化合物（基于其 pKa）。
T37710	5-Hydroxyoxindole	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	5-Hydroxyoxindole 是尿酸的一种结构类似物，具有脂质过氧化抑制活性和自由基 DPPH 清除活性，可用于氧化应激介导的疾病的研究。
T2936	Antiarol 3,4,5-trimethoxyphenol,3,4,5-三甲氧基苯酚	Others	Others
	Antiarol (3,4,5-trimethoxyphenol) 是一种提取自 Salmaliamalabaricum 中的天然化合物。
T2S1086	Nepitrin 假荆芥属苷,Nepetin-7-glucoside	Antioxidant	oxidation-reduction
	Nepitrin (Nepetin-7-glucoside) 分离自Scrophularia striata 中，具有强大的抗炎、抗关节炎作用。
TN2008	Okanin	NF-κB; TLR	Immunology/Inflammation; NF-κB
	Okanin 是鬼针草中的一种有效成分，可通过抑制TLR4/NF-κB 信号通路减弱 LPS 诱导的小胶质细胞活化。
TN1137	Isobutylshikonin	Others	Others
	Isobutylshikonin 是分离自Lithospermum canescens 毛状根培养的一种紫草素色素。
T5S0281	Tubuloside A	NOS	Immunology/Inflammation
	Tubuloside A 是一种苯乙醇苷，具有抗氧化活性和保肝活性。
TN6489	Regaloside A	Others	Others
	Regaloside A 是一种从百合中提取出的苯丙烷，在 160 ppm 时显示出 DPPH 自由基清除活性。Regaloside A 具有抗炎活性和抗抑郁活性。
T39887	(S)-3-(4-Hydroxyphenyl)lactic acid (S)-3-(4-羟苯基)乳酸,(S)-3-(4-Hydroxyphenyl)lactic acid,(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid	Others	Others
	(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid ((S)-3-(4-Hydroxyphenyl)lactic acid) 是分离自间肠隐球菌培养基的代谢物，具有高的 DPPH 清除自由基活性和抗氧化活性。
TN1788	Isookanin	Amylase	Metabolism
	Isookanin 在多种疾病领域有研究价值，包括肿瘤，皮疹，蛇和昆虫叮咬，糖尿病，腹泻。它可作为抗病毒剂对抗 HSV 和水痘带状疱疹病毒。它也具有抗氧化特性。
TN2211	Silybin B Silibinin B	Apoptosis; Beta Amyloid; Bcr-Abl	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Neuroscience; Tyrosine Kinase/Adaptors
	Silybin B (Silibinin B) 是雷洛昔芬4′-和6-葡萄糖醛酸化的有效抑制剂，是水飞蓟素有效的抗纤维原性和抗低聚物成分，具有清除1,1-二苯基-2-吡啶酰肼(DPPH)自由基的活性，可通过减轻 DNA 损伤和细胞凋亡对顺铂诱导的神经毒性具有保护作用。Silybin B 对人慢性髓系白血病 K562细胞的生长抑制和诱导凋亡有较强的作用。
TN3972	Epimedokoreanin B	Apoptosis; Others; Antibacterial	Apoptosis; Microbiology/Virology; Others
	Epimedokoreanin B （EKB）是一种从韩国淫羊藿中分离出的异戊烯化类黄酮，在人非小细胞肺癌（NSCLC）A549和NCI-H292细胞中展现出抗癌活性。Epimedokoreanin B 还具有抗炎和抗菌活性，可有清除 DPPH 自由基的活性，能以剂量依赖的方式抑制 MCF-7 和 HepG2 的增殖。Epimedokoreanin B 能显著抑制 N (δ) -（羧甲基）赖氨酸（CML）和 N (Ï) -（羧甲基）精氨酸（CMA）的形成，可通过抑制高级糖化终产物（AGEs）预防糖尿病的临床并发症。
TN1896	Luteolin 5-O-glucoside 藤黄菌素,Luteollin 5-glucoside,木犀草素-5-O-葡萄糖苷	Others	Others
	Luteolin 5-O-α2-glucopyranoside has antioxidant activity, it can inhibit lipid peroxidation, and has DPPH radical-scavenging activity.
TN4865	Putraflavone	Beta Amyloid; BACE	Neuroscience
	Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
TN6414	Plantanone B
	Plantanone C exhibited moderate antioxidant activity against DPPH radical scavenging activity,with an IC50 value of 240. 2 μmol·L~(-1).
T13598	Caulophylline B	Others	Others
	Caulophylline B, an alkaloid extracted from the roots of Caulophyllum robustum Maxim, affords a low scavenging effect against DPPH radical.
TN1876	Lobetyolinin 党参炔苷宁	Others	Others
	Lobetyolinin exhibits DPPH radical scavenging activity.
TN4754	Persicoside	Others	Others
	Persicoside exhibits radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical.
TN2545	1-Hydroxypinoresinol 1-O-glucoside	ROS	Immunology/Inflammation
	(+)-1-Hydroxypinoresinol 1-O-beta-D-glucoside exhibits peroxynitrite, total ROS and DPPH radical scavenging activities with IC50 values of 3.23 +/- 0.04, 2.26 +/- 0.07 and 32.3 +/- 0.13 microM, respectively.
TN1503	Cistanoside F 肉苁蓉苷F,肉苁蓉苷 F	NADPH-oxidase	Immunology/Inflammation
	Cistanoside F shows vasorelaxant, and antioxidative effects, it shows a strong free radical scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and xanthine/xanthine oxidase (XOD) generated superoxide anion radical (O2-.).
TN1802	Isoscoparin-2′′O-glucoside 异金雀花素-2”-O-吡喃葡萄糖苷,Isoscoparin-2''-Beta-D-glucopyranoside	Others	Others
	Isoscoparin-2''-Beta-D-glucopyranoside shows prominent free radical scavenging activity in DPPH assay.
TN2129	Quercetin-3-o-rutinose	Others	Others
	Quercetin-3-o-rutinose has antioxidative activity, it exerts strong DPPH radical-scavenging activity.
TN4000	Erythristemine	Others	Others
	(+)-Erythristemine shows moderate toxicity to brine shrimp (LC50 23 ppm) and moderate (IC50=86microg/ml) radical scavenging properties against stable 2,2-diphenyl-1-picrylhy--drazyl (DPPH) radical.
TN4445	Lobetyol	Others	Others
	Lobetyol shows significant antioxidant activity, it exhibits DPPH radical scavenging activity.
TN5052	Ssioriside	Others	Others
	Ssioriside shows moderate antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical.
TN4711	Onitin	Others	Others
	Onitin shows super-oxide and DPPH free radical scavenging effects.It also exhibits hepatoprotective activity on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.
T79946	Isorabaichromone	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Isorabaichromone 为强效抗氧化剂，能有效清除 DPPH 自由基及超氧阴离子。
TN4617	N-trans-Feruloyl-3-methoxytyramine	Others	Others
	N-trans-Feruloyl-3-methoxytyramine shows significantly DPPH radical scavenging activities.
TN4708	Olivil	Others	Others
	(-)-Olivil displays a higher antioxidative effect against the free radical DPPH.
TN4336	Isothymusin	Antifection	Microbiology/Virology
	Isothymusin( MIC= 200 microg/mL) exhibits inhibition activity against Mycobacterium tuberculosis. It ( IC50=7.7 microg/mL ) exhibits antioxidant activity against the radical scavenging ability of DPPH.
TN4080	Fraxamoside	Xanthine Oxidase	Metabolism
	Fraxamoside is a xanthine oxidase inhibitor (XOI) comparable in potency in vitro to the standard antigout drug allopurinol. It shows significant free radical scavenging effect against DPPH(EC50=62.6 uM).
TN3193	6-O-Vanilloylajugol	Others	Others
	6-O-Vanilloylajugol demonstrates scavenging properties toward the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical.
TN1734	Heveaflavone 橡胶树双黄酮	Antioxidant; Topoisomerase	DNA Damage/DNA Repair; oxidation-reduction
	Heveaflavone 抑制拓扑异构酶 I 并清除 DPPH 自由基，具有抗增殖和抗氧化作用。
TN1207	2,4,7-Trihydroxy-9,10-dihydrophenanthrene	Others	Others
	2,4,7-Trihydroxy-9,10-dihydrophenanthrene showS the DPPH free radical scavenging activity with EC(50) from 8.8 to 55.9 microM.
TN3699	Corchoionoside C	Antifection; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Corchoionoside C has antioxidant activity, shows strong scavenging activities on DPPH radical, it also shows weak antifungal activity. Corchoionosides A, B, and C inhibit the histamine release from rat peritoneal exudate cells induced by antigen-antibody reaction.
TN1242	3,3'-Di-O-methylellagic acid 3,8-Di-O-methylellagic acid,3,3'-O-二甲基鞣花酸	Others; TNF; Antifection	Apoptosis; Microbiology/Virology; Others
	3,3'-Di-O-methylellagic acid reveals moderate antibacterial activity, it also shows strong DPPH radical scavenging activities with SC50 of 123.3 ug/mL. It has a lower capacity of stimulating murine peritoneal macrophages to release nitric oxide and tumoural-alpha necrose factor
TN3292	8-Prenyldaidzein	Others	Others
	8-Prenyldaidzein has cytotoxic properties against P-388 cells, its IC 50 values 5.82 ug/mL, it also exhibits very high antioxidant activity against DPPH radical scavenging.
TN3056	4-O-Galloylbergenin	Others	Others
	4-O-Galloylbergenin shows significant 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity with EC50 7.8 uM, it shows more antioxidant activity than the positive control vitamin C (EC50 = 28.3 uM).
T83467	10-O-Trans-p-methoxycinnamoylcatalpol
	10-O-Trans-p-methoxycinnamoylcatalpol 表现出抗氧化特性，DPPH 自由基清除实验中显示其 IC50 为 0.37 μM/mL。
T82724	Chrysophanol 8-O-β-D-(6′-O-galloyl)glucopyranoside
	Chrysophanol 8-O-β-D-(6’-O-galloyl)glucopyranoside为一种从Rheum undulatum L. 分离得到的蒽醌类葡萄糖苷，具备显著的DPPH自由基与?O2-清除作用。
T82640	Cyclobisdemethoxycurcumin
	Cyclobisdemethoxycurcumin，作为一种抗氧化剂，在DPPH自由基清除试验中示出约250 μM的IC50，在2-DR氧化试验中显示为15-20 μM的IC50。
TN2798	20-Deoxocarnosol	ROS; Antifection	Immunology/Inflammation; Microbiology/Virology
	20-Deoxocarnosol has antioxidant activity of measuring the decay of the radical cation diphenyl-picrylhydrazyl (DPPH).It also exhibits non-specific antiprotozoal activity due to high cytotoxicity.
TN3061	4'-O-Methyllicoflavanone	Antioxidant	oxidation-reduction
	4'-O-Methyllicoflavanone 是从 Erythrina orientalis 的茎皮中分离得到的，对 DPPH 自由基具有抗氧化活性，IC50 值为 648.1 μM。
T75547	Maritimetin
	Maritimein，一种可从雪菊提取的橙酮，具有显著的对diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) 自由基清除能力，IC50值仅为4.12 μM。该化合物因此被广泛应用于心血管疾病的研究领域。
TN1011	Rhodionin	P450; AChE	Metabolism; Neuroscience
	Rhodionin 是从红景天的根中分离的特异性非竞争性细胞色素 P450 2D6 抑制剂，IC50=0.761 μM，Ki=0.769 μM。它有 DPPH 自由基清除活性，IC50为 19.49 μM。它抑制乙酰胆碱酯酶，IC50范围为 57.50 至 2.43 μg/mL。
TN1646	Flemiphilippinin A	Others	Others
	Flemiphilippin A has antioxidant activity, it shows DPPH radical scavenging activity with effective half maximal concentration (EC50) of 18.36 ug/mL. Flemiphilippinin A (5 ug/mL) exhibits some level of antitumor activity against human hepatocellular carci
T82699	Cochliodinol
	Cochliodinol（化合物1）是Apis mellifera ligustica代谢产物，表现出强效的2,2-二苯基-1-苦基肼（DPPH）自由基清除能力（IC50=3.06 μg/mL）。
TN4866	Pyracrenic acid	Others	Others
	Pyracrenic acid is a potent elastase inhibitor with an IC50 value of 1.5 mg/mL. Pyracrenic acid shows DPPH radical scavenging activity. It also shows significant cytotoxic activities against human cancer cells COLO 205 and AGS.
TN3444	Aristolactam BII	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Aristolactam BII exhibits antimicrobial and antiinflammatory activity, it shows significant activity towards DPPH radical scavenging and potent inhibitory effects against tyrosinase mushroom. Aristolactam BII also exerts its significant neuroprotective ef
T3852	Rhodiosin	Antioxidant; AChE	Neuroscience; oxidation-reduction
	Rhodiosin 是从红景天的根中分离的特异性非竞争性细胞色素 P450 2D6 抑制剂，IC50=0.761 μM，Ki=0.769 μM。它有 DPPH 自由基清除活性，IC50=27.7 μM。它抑制乙酰胆碱酯酶，IC50范围为 57.50 至 2.43 μg/mL。
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天然产物

Cat.No: T9135

Target: Others

5-Hydroxyoxindole

Cat.No: T37710

Target: Reactive Oxygen Species

Cat.No: T2936

Synonym: 3,4,5-trimethoxyphenol,3,4,5-三甲氧基苯酚

Target: Others

Cat.No: T2S1086

Synonym: 假荆芥属苷,Nepetin-7-glucoside

Target: Antioxidant

Cat.No: TN2008

Target: NF-κB, TLR

Isobutylshikonin

Cat.No: TN1137

Target: Others

Cat.No: T5S0281

Target: NOS

Cat.No: TN6489

Target: Others

(S)-3-(4-Hydroxyphenyl)lactic acid

Cat.No: T39887

Synonym: (S)-3-(4-羟苯基)乳酸,(S)-3-(4-Hydroxyphenyl)lactic acid,(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid

Target: Others

Cat.No: TN1788

Target: Amylase

Cat.No: TN2211

Synonym: Silibinin B

Target: Apoptosis, Beta Amyloid, Bcr-Abl

Epimedokoreanin B

Cat.No: TN3972

Target: Apoptosis, Others, Antibacterial

Luteolin 5-O-glucoside

Cat.No: TN1896

Synonym: 藤黄菌素,Luteollin 5-glucoside,木犀草素-5-O-葡萄糖苷

Target: Others

Cat.No: TN4865

Target: Beta Amyloid, BACE

Cat.No: TN6414

Caulophylline B

Cat.No: T13598

Target: Others

Cat.No: TN1876

Synonym: 党参炔苷宁

Target: Others

Cat.No: TN4754

Target: Others

1-Hydroxypinoresinol 1-O-glucoside

Cat.No: TN2545

Target: ROS

Cat.No: TN1503

Synonym: 肉苁蓉苷F,肉苁蓉苷 F

Target: NADPH-oxidase

Isoscoparin-2′′O-glucoside

Cat.No: TN1802

Synonym: 异金雀花素-2”-O-吡喃葡萄糖苷,Isoscoparin-2''-Beta-D-glucopyranoside

Target: Others

Quercetin-3-o-rutinose

Cat.No: TN2129

Target: Others

Cat.No: TN4000

Target: Others

Cat.No: TN4445

Target: Others

Cat.No: TN5052

Target: Others

Cat.No: TN4711

Target: Others

Isorabaichromone

Cat.No: T79946

Target: Reactive Oxygen Species

N-trans-Feruloyl-3-methoxytyramine

Cat.No: TN4617

Target: Others

Cat.No: TN4708

Target: Others

Cat.No: TN4336

Target: Antifection

Cat.No: TN4080

Target: Xanthine Oxidase

6-O-Vanilloylajugol

Cat.No: TN3193

Target: Others

Cat.No: TN1734

Synonym: 橡胶树双黄酮

Target: Antioxidant, Topoisomerase

2,4,7-Trihydroxy-9,10-dihydrophenanthrene

Cat.No: TN1207

Target: Others

Corchoionoside C

Cat.No: TN3699

Target: Antifection, Histamine Receptor

3,3'-Di-O-methylellagic acid

Cat.No: TN1242

Synonym: 3,8-Di-O-methylellagic acid,3,3'-O-二甲基鞣花酸

Target: Others, TNF, Antifection

8-Prenyldaidzein

Cat.No: TN3292

Target: Others

4-O-Galloylbergenin

Cat.No: TN3056

Target: Others

10-O-Trans-p-methoxycinnamoylcatalpol

Cat.No: T83467

Chrysophanol 8-O-β-D-(6′-O-galloyl)glucopyranoside

Cat.No: T82724

Cyclobisdemethoxycurcumin

Cat.No: T82640

20-Deoxocarnosol

Cat.No: TN2798

Target: ROS, Antifection

4'-O-Methyllicoflavanone

Cat.No: TN3061

Target: Antioxidant

Cat.No: T75547

Cat.No: TN1011

Target: P450, AChE

Flemiphilippinin A

Cat.No: TN1646

Target: Others

Cat.No: T82699

Pyracrenic acid

Cat.No: TN4866

Target: Others

Aristolactam BII

Cat.No: TN3444

Target: HIV Protease

Cat.No: T3852

Target: Antioxidant, AChE

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