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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8381 |
Amodiaquine
|
Others; Histone Methyltransferase; Parasite | Chromatin/Epigenetic; Microbiology/Virology; Others |
Amodiaquine 是一种合成的4-氨基喹啉类抗疟剂,是一种有口服活性的组胺 N-甲基转移酶抑制剂。它也是一种Nurr1激动剂,有抗炎活性,可特异性结合Nurr1的配体结合域,EC50约为20 μM。 | |||
T8494 |
NS-3-008 hydrochloride
NS-3-008 HCl |
Others | Others |
NS-3-008 hydrochloride (NS-3-008 HCl) 是一种口服具有活性的G0s2转录抑制剂(IC50:2.25 μM)。它可用于慢性肾脏疾病的研究。 | |||
T0381 |
Amodiaquine dihydrochloride dihydrate
Amodiaquine hydrochloride,阿莫地喹盐酸盐,Amodiaquin dihydrochloride dihydrate |
Histone Methyltransferase; Parasite; Histamine Receptor | Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Amodiaquine dihydrochloride dihydrate (Amodiaquine hydrochloride) 是一种具有口服活性的组胺 N-甲基转移酶抑制剂,也是一种Nurr1激动剂,可特异性结合Nurr1的配体结合域,EC50约为20 μM。它是 4-氨基喹啉衍生物,具有抗疟和抗炎特性。 | |||
T2386 |
Pirfenidone
S-7701,AMR-69,S-7701,AMR69,吡非尼酮 |
CCR; TGF-beta/Smad | Immunology/Inflammation; Microbiology/Virology; Stem Cells |
Pirfenidone (AMR69) 是一种抗纤维化剂,可减弱纤维细胞中CCL2和CCL12的产生。它可抑制细胞生长,并能降低人胶质瘤细胞系中的TGF-β2蛋白水平,具有抗炎活性。 | |||
T12485 |
Pirfenidone-d5
AMR69 D5,Pirfenidone D5 |
Others | Others |
Pirfenidone D5 is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. | |||
T76740 |
Carlumab
|
||
Carlumab (CNTO 888) 是一种具有高亲和力的人源化抗 CCL2(趋化因子配体 2) 抗体。Carlumab 可用于癌症,尤其是前列腺癌的研究。 | |||
T19854 |
Evoxine
|
||
Evoxine is a selective inhibitor of CO2-induced immune suppression. It inhibits hypercapnic suppression of interleukin-6 and the chemokine CCL2 expression in human THP-1 macrophages. | |||
T64256 |
Emapticap pegol
|
||
Emapticap pegol 是一种促炎趋化因子 C-C 基序配体 2 (CCL2) 抑制剂。Emapticap pegol 也是一种 40 个核苷酸的寡核苷酸适体,在人 (NOX-E36) 和小鼠 (mNOX-E36) 中表现出不同的 Spiegelmers (L-RNA 适配子) 形式。 | |||
T72970 |
Rosolic Acid
蔷薇色酸 |
||
Rosolic Acid是Nrf2及其下游靶点的激活剂,能够提升血管生成因子的水平,并降低TNF-α和IL-1β等炎症标志物以及CXCL10和CCL2等凋亡标志物的水平。同时,Rosolic Acid能够恢复胰腺细胞功能,并对受到内质网应激影响的内皮细胞(EC)提供保护。 | |||
T62321 | ST247 | ||
ST247 是一种有效的 PPARβ/δ 反向激动剂,对 PPARβ/δ 具有较高的亲和力,能够反向调控激活标记物 CCL2 的表达。ST247 对激动剂诱导的 PPARβ/δ 的转录活性具有抑制作用。ST247 能够有效诱导与辅抑制子的相互作用。 | |||
T83698 |
Cathelicidin-2 (128-153) (chicken) TFA
Fowlicidin-2 (128-153),CATH-2 (128-153),Myeloid Antimicrobial Peptide 27 (128-153) |
||
Cathelicidin-2 (CATH-2) (128-153) 是一种合成抗菌肽,对应于鸡CATH-2的128至153个氨基酸。该化合物对E. coli、S. aureus、S. enteritidis和B. globigii展示出浓度依赖性的活性。CATH-2 (128-153) (40 µM) 可诱导孤立的鸡红细胞溶解,但对孤立的人外周血单个核细胞(PBMCs)无细胞毒性。它能促进化学因子(C-C-基序)配体2 (CCL2)的产生,并抑制LPS诱导的TNF-α、IL-6、IL-8和IL-10在孤立的人PBMCs中的产生。 | |||
T71306 |
Gemfibrozil-d6
|
||
Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated reporter α and PPARγ agonist. In vivo, gemfibrozil reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif l... | |||
T35463 |
(±)14(15)-EET
(±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET |
||
(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) induced by oxidized LDL in primary rat pulmonary artery endothelial cells (RPAECs) when used at a concentration of 1 μM.[3] (±)14(15)-EET induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM).[4] It reduces myocardial infarct size as a percentage o... | |||
T35452 |
β-Defensin-3 (human) (trifluoroacetate salt)
|
||
β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of the periodontopathogenic and cariogenic bacteria F. nucleatum, S. mutans, S. sobrinus, S. salivarius, and L. casei (MICs = 12.5-100 mg/l). It also inhibits the growth of S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. β-Defensin-3 stimulates gene expression and production of IL-6, IL-10, CXC... | |||
T35453 |
β-Defensin-4 (human) (trifluoroacetate salt)
|
||
β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils. β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes. It also stimulates calcium mobilization, migration, and pro... | |||
T37289 |
Resolvin D2 n-3 DPA
Resolvin D2 n-3 DPA |
||
Resolvin D2 n-3 DPA (RvD2 n-3 DPA) is a specialized pro-resolving mediator (SPM).1It is formed from docosapentaenoic acid , an intermediate in the conversion of eicosapentaenoic acid to docosahexaenoic acid , in human leukocytes. RvD2 n-3 DPA (1 nM) reduces TNF-α-induced chemotaxis and adhesion of isolated human neutrophils.In vivo, RvD2 n-3 DPA (100 ng/animal; i.v.) reduces peritoneal neutrophil infiltration and exudate levels of IL-6 and chemokine (C-C motif) ligand 2 (CCL2) in a mouse model o... | |||
T35451 |
β-Defensin-2 (human) (trifluoroacetate salt)
|
||
β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius.2β-Defensin-2 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3It also stimulates calcium mobilization, migration, and proliferation of keratinocytes whe... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6413 |
Bindarit
宾达利,AF2838 |
CCR | Immunology/Inflammation; Microbiology/Virology |
Bindarit (AF2838) 是单核细胞趋化蛋白MCP-1/CCL2,MCP-3/CCL7和MCP-2/CCL8的选择性抑制剂,具有抗炎作用。 | |||
TN3614 |
Cearoin
檀木 |
ERK; BCL; PARP; IκB/IKK; TNF; NF-κB; ROS; Caspase | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; NF-κB; Proteases/Proteasome |
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of TNFα and CCL2. Cearoin induces aut |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00852 |
CCL2 Protein, Rat, Recombinant (His)
C-C motif chemokine 2,Small-inducible cytokine A |
Rat | HEK293 Cells |
Monocyte chemoattractant protein 1 (MCP-1), also called CCL2, is a member of the beta (C-C) subfamily of chemokines that is a chemoattractant for monocytes and basophils but not eosinophils or neutrophils. CCL2 binds the cognate receptor CCR2, and together this signaling pair has been shown to have multiple pro-tumorigenic roles, from mediating tumor growth and angiogenesis to recruiting and usurping host stromal cells to support tumor progression. CCL2 is found in the circulation, where it has ... | |||
TMPJ-00028 |
CCL2 Protein, Mouse, Recombinant
Ccl2,Je,Mcp1,C-C motif chemokine 2 |
Mouse | E. coli |
C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equine, porcine, bovine and canine CCL2, respectively. Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major... | |||
TMPY-00118 |
MCP-1/CCL2 Protein, Human, Recombinant (His)
SCYA2,HC11,MCAF,HSMCR30,MCP-1,MCP1,GDCF-2,... |
Human | P. pastoris (Yeast) |
MCP-1/CCL2 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 10.1 kDa and the accession number is P13500. | |||
TMPJ-00009 |
CCL2 Protein, Human, Recombinant
C-C motif chemokine 2,MCAF,CCL2,M... |
Human | E. coli |
The chemokine (C-C motif) ligand 2 (CCL2), also known as monocyte chemoattractant protein (MCP)-1 and small inducible cytokine A2 (SCYA2)), is a small cytokine that belongs to the CC chemokine family responsible for monocyte attraction. Its cognate receptor, CCR2, play a critical role in regulating nociceptive processes during neuropathic pain. Both CCL2 and CCR2 are implicated in induction of autoimmunity. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation... | |||
TMPK-00010 |
MCP-1/CCL2 Protein, Human, Recombinant (His & Avi)
MCP-1,MCAF,GDCF-2,SMC-CF,C-C motif chemokine 2<... |
Human | HEK293 Cells |
MCP-1/CCL2 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 11.5 kDa and the accession number is P13500. | |||
TMPK-00916 |
MCP-1/CCL2 Protein, Cynomolgus, Recombinant (His)
MCP-1,MCP1,SCYA2,GDCF-2,MCAF,CCL<... |
Cynomolgus | HEK293 Cells |
MCP-1/CCL2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 9.79 kDa and the accession number is P61274. | |||
TMPK-00011 |
MCP-1/CCL2 Protein, Human, Recombinant (His & Avi), Biotinylated
SMC-CF,HC11,MCAF,MCP1,MCP-1,HSMCR30,C-C motif chemokine ... |
Human | HEK293 Cells |
MCP-1/CCL2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 11.5 kDa and the accession number is P13500. | |||
TMPY-00606 |
MCP-1/CCL2 Protein, Mouse, Recombinant (His)
AI323594,HC11,Sigje,MCP-1,MCAF,Scya2,JE,SM... |
Mouse | Baculovirus Insect Cells |
MCP-1/CCL2 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is P10148. | |||
TMPY-05653 |
MCP-1/CCL2 Protein, Mouse, Recombinant (His), Biotinylated
MCP-1,chemokine (C-C motif) ligand 2,HC11,SMC-CF,MC... |
Mouse | Baculovirus Insect Cells |
MCP-1/CCL2 Protein, Mouse, Recombinant (His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is P10148. | |||
TMPY-02828 |
CCL21 Protein, Rhesus, Recombinant
CCL21,chemokine (C-C motif) ligand 2 |
Rhesus | Baculovirus Insect Cells |
CCL21 Protein, Rhesus, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 12 kDa and the accession number is Q8HYP5. | |||
TMPY-05353 |
CCL26 Protein, Human, Recombinant
MIP-4alpha,SCYA26,MIP-4a,chemokine (C-C motif) liga... |
Human | Baculovirus Insect Cells |
The eotaxin subfamily of CC chemokines consists of eotaxin-1/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. All eotaxins induce the trafficking of eosinophils to the sites of inflammation via CC chemokine receptor 3 (CCR3), which is also expressed by several different cell types, including basophils, dendritic cells, smooth muscle cells, epithelial cells and fibroblasts. The sequence similarity between the three eotaxins is limited (<4%), but their functional properties are very similar. Eotaxin-1 ... | |||
TMPJ-01409 |
CCL27 Protein, Human, Recombinant
ILC,Small-Inducible Cytokine A27,IL-11 R-Alpha-Locu... |
Human | E. coli |
Human Chemokine (C-C Motif) Ligand 27 (CCL27) is a small cytokine that is a member of the CC chemokine family; it is expressed in numerous tissues, including gonads, thymus, placenta and skin. CCL27 elicits its chemotactic effects by binding to the chemokine receptor CCR10. Predominantly expressed in the skin, CCL27 is associated with T cell-mediated inflammation of the skin. Human and Mouse CCL27 share 84% sequence identity in the mature form. | |||
TMPY-03728 |
CCL28 Protein, Human, Recombinant (His)
MEC,SCYA28,chemokine (C-C motif) ligand 28... |
Human | E. coli |
CCL28 chemokine is expressed by epithelial cells of various mucosal tissues. This chemokine binds to CCR3 and CCR10 receptors and plays an essential role in the IgA antibody secreting cells (IgA-ASC) homing to mucosal surfaces and lactating mammary gland as well. Besides, CCL28 has been shown to exert a potent antimicrobial activity against both Gram-negative and Gram-positive bacteria and fungi. The potent antimicrobial function of CCL28 combined with its wide distribution in mucosal tissues an... | |||
TMPY-02770 |
CCL20 Protein, Mouse, Recombinant (His)
CKb4,exodus-1,MIP-3[a],ST38,MIP3A,LARC,MIP-3A,chemokine (C-C... |
Mouse | Baculovirus Insect Cells |
CCL20 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 9.3 kDa and the accession number is O89093-1. | |||
TMPY-03935 |
CCL20 Protein, Human, Recombinant (His)
SCYA20,MIP3A,MIP-3-alpha,Exodus,MIP-3a,LARC,ST38,ch... |
Human | E. coli |
CCL20 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 10.2 kDa and the accession number is P78556-1. | |||
TMPY-03779 |
CCL27 Protein, Human, Recombinant (His)
SCYA27,CTAK,ESKINE,ALP,PESKY,ILC,chemokine (C-C mot... |
Human | E. coli |
CCL27, also known as CTACK, is a small cytokine belonging to the CC chemokine family. Members of this family are proteins characterized by two adjacent cysteines. CCL27 is chemotactic for skin-associated memory T lymphocytes. CCL27 may also play a role in mediating homing of lymphocytes to cutaneous sites. CCL27 plays a pivotal role in establishing the inflammatory infiltrate characteristic for common inflammatory skin diseases. Through binding to the chemokine receptor 1 (CCR1), CCL27 mediates ... | |||
TMPY-03886 |
MPIF-1/CCL23 Protein, Human, Recombinant
SCYA23,CKb8,Ckb-8,MPIF-1,MPIF1,chemokine (C-C motif... |
Human | E. coli |
MPIF-1/CCL23 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11.4 kDa and the accession number is P55773-1. | |||
TMPJ-00019 |
CCL28 Protein, Human, Recombinant
Small-Inducible Cytokine A28,Protein CCK1,CCL |
Human | E. coli |
Chemokine (C-C Motif) Ligand 28 (CCL28) is a novel chemokine that shares the most homology with CCL27/CTACK. CCL28 shows chemotactic activity for resting CD4, CD8 T-cells and eosinophils. It Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner. CCR10 (GPR2 orphan receptor) is also the receptor for CCL27/CTACK. CCL28 is preferentially expressed by epithelial cells of diverse tissues, with highest expression level in normal and pathological colon. It is also expresse... | |||
TMPK-01196 |
CCL24 Protein, Mouse, Recombinant (His)
MPIF2,CK-beta-6,member 24,CK-β-6,CCL |
Mouse | HEK293 Cells |
C-C motif chemokine ligand 24 (CCL24) is a chemokine that regulates inflammatory and fibrotic activities through its receptor, C-C motif chemokine receptor (CCR3). CCL24 is a chemokine that regulates inflammation and fibrosis. It was found to be significantly expressed in patients with non-alcoholic steatohepatitis, in whom it regulates profibrotic processes in the liver. CCL24 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight... | |||
TMPY-04889 |
CCL20 Protein, Mouse, Recombinant
LARC,MIP-3A,Scya20,chemokine (C-C motif) ligand |
Mouse | E. coli |
CCL20 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8.1 kDa and the accession number is O89093-1. | |||
TMPY-05089 |
CCL21a Protein, Mouse, Recombinant
ALP,chemokine (C-C motif) ligand 21A (serine),SLC,T... |
Mouse | Baculovirus Insect Cells |
CCL21a Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 12.1 kDa and the accession number is P84444. | |||
TMPY-02244 |
CCL21 Protein, Human, Recombinant
CKb9,MGC34555,TCA4,ECL,6Ckine,SLC,SCYA21,RP11-195F1... |
Human | Baculovirus Insect Cells |
CCL21 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 12.3 kDa and the accession number is O00585. | |||
TMPY-00168 |
MPIF-1/CCL23 Protein, Human, Recombinant (His)
MIP3,MIP-3,Ckb-8-1,CK-BETA-8,Ckb-8,MPIF-1,MPIF1,SCYA2 |
Human | P. pastoris (Yeast) |
MPIF-1/CCL23 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 9.9 kDa and the accession number is P55773.3. | |||
TMPY-05472 |
CCL21a Protein, Mouse, Recombinant (His)
Tca4,6Ckine,SCYA21a,plt,chemokine (C-C motif) ligan... |
Mouse | Baculovirus Insect Cells |
CCL21a Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 13.5 kDa and the accession number is P84444. | |||
TMPJ-01341 |
CCL24 Protein, Mouse, Recombinant
Scya24,Eosinophil chemotactic protein 2,Sm... |
Mouse | E. coli |
Mouse CCL24 is a secreted protein, which is a member of the CC chemokine subfamily. Mouse Ccl24 cDNA encodes a 119 amino acid residue precursor protein, shares approximately 58% amino acid sequence identity with human Ccl24. It is predominantly expressed in the jejunum and spleen and also be induced in the lung by allergen challengeand IL4. Mouse ccl24 has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Ccl24 is chemotactic for resting T-lymphocytes, ... | |||
TMPK-01265 |
CCL24 Protein, Cynomolgus, Recombinant (His)
SCYA24,CK-beta-6,CK-β-6,Ckb-6,MPIF-2,C... |
Cynomolgus | HEK293 Cells |
C-C motif chemokine ligand 24 (CCL24) is a chemokine that regulates inflammatory and fibrotic activities through its receptor, C-C motif chemokine receptor (CCR3). CCL24 is a chemokine that regulates inflammation and fibrosis. It was found to be significantly expressed in patients with non-alcoholic steatohepatitis, in whom it regulates profibrotic processes in the liver. CCL24 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular w... | |||
TMPK-00704 |
CCL24 Protein, Human, Recombinant (hFc)
MPIF2,Ckb-6,SCYA24,CK-beta-6,member 2<... |
Human | HEK293 Cells |
C-C motif chemokine ligand 24 (CCL24) is a chemokine that regulates inflammatory and fibrotic activities through its receptor, C-C motif chemokine receptor (CCR3). CCL24 is a chemokine that regulates inflammation and fibrosis. It was found to be significantly expressed in patients with non-alcoholic steatohepatitis, in whom it regulates profibrotic processes in the liver. CCL24 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight... | |||
TMPK-01195 |
CCL24 Protein, Mouse, Recombinant (hFc)
Ckb-6,CK-β-6,MPIF-2,CK-beta-6,Eotaxin-2,SC... |
Mouse | HEK293 Cells |
C-C motif chemokine ligand 24 (CCL24) is a chemokine that regulates inflammatory and fibrotic activities through its receptor, C-C motif chemokine receptor (CCR3). CCL24 is a chemokine that regulates inflammation and fibrosis. It was found to be significantly expressed in patients with non-alcoholic steatohepatitis, in whom it regulates profibrotic processes in the liver. CCL24 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight... | |||
TMPK-00879 |
CCR2b Protein-VLP, Human, Recombinant
C-C CKR-2,CCR2,MCP-1-R,CCR-2,CMKB... |
Human | HEK293 Cells |
The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammatory diseases. The actin-binding protein filamin A (FLNa) as a protein that associates with the carboxyl-terminal tail of CCR2B. FLNa emerges as an important protein for controlling the internalization and spatial localization of the CCR2B receptor in different dynamic membrane stru... |