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78

抑制剂 & 化合物

7

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Cat. No. Product Name Target Signaling Pathways
T10640 C-11

Others Others
C-11 is a tubulin inhibitor and acts as an ADC cytotoxin with cytotoxicity for carcinoma cell lines.
T32696 Levetimide C-11

Levetimide C-11 is a radiotracer.
TP1651L Proinsulin C-peptide human acetate

醋酸胰岛素原C-肽(55-89),人,Proinsulin C-peptide human acetate (33017-11-7 Free base)

Others Others
Proinsulin C-peptide human acetate (Proinsulin C-peptide human acetate (33017-11-7 Free base)) 是一种由31个氨基酸残基组成的多肽,它连接胰岛素原的 A 链和 B 链以确保正确折叠,具有生物活性并调节细胞功能。
T32289 jhu-75528c-11

JHU75528 C-11,11c-Omar,JHU 75528 C-11

JHU-75528 C-11 can be used as a Radiotracer for PET Imaging of CB1 Cannabinoid Receptors.
T38161 STING Agonist C11

STING Agonist C11

STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses gro...
T40419 IRES-C11

IRES-C11

c-Myc Cell Cycle/Checkpoint
IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.
T39652 BODIPY 581/591 C11

BODIPY 581/591 C11

C11-BODIPY581/591 is a fluorescent ratio-probe of lipid oxidation . C11-BODIPY581/591 is often used for indexing lipid peroxidation and antioxidant efficacy in model membrane systems and living cells. C11-BODIPY581/591 is applied in the quantitation of ferroptosis.
T37492 11-trans Leukotriene C4

11-trans Leukotriene C4

11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in human neutrophils or RBL-1 cells. It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum. In a radioligand binding assay using guinea pig ileum ...
T13773 Mito-apocynin (C11)

Others Others
Mito-apocynin (C11)是一种线粒体靶向抗氧化剂,通过靶向和中和细胞呼吸过程中产生的活性氧(ROS)发挥作用。三苯基溴化鏻已被发现能有效预防线粒体功能障碍,线粒体功能障碍是衰老过程和各种疾病的主要原因。它具有抗炎、抗凋亡和抗氧化活性。
T17919 Thalidomide-O-amido-C6-NH2 TFA

E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate,Cereblon Ligand-Linker Conjugates 11 TFA,E3 Ligase Ligand-Linker Conjugates 25 TFA

Others; Ligand for E3 Ligase Others; PROTAC
Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物。可用于 PROTAC 的合成分子。
T17694 Br-C10-methyl ester

11-溴代十一烷酸甲酯

Others; PROTAC Linker Others; PROTAC
Br-C10-methyl ester 是一种属于 alkyl/ether 类的 PROTAC linker,可用于一系列 PROTAC 分子的合成。PROTAC 分子含有两个通过 linker 连接的不同配体,一种是 VHL 配体部分,另一种是靶蛋白配体。
T124542 11-Methoxyuncarine C

11-Methoxyuncarine C 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124542。
TF0102 C-HEGA-11

C-HEGA-11 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 TF0102,CAS号为 864434-16-2。
T83914 Glutaminase C Inhibitor 11

Glutaminase C inhibitor 11是一种glutaminase C (GAC)的抑制剂。它能够抑制GAC酶的活性(EC50 = 10.64 nM),降低A549非小细胞肺癌(NSCLC)细胞的活力(IC50 = 4.025 nM)。在A549细胞中,Glutaminase C inhibitor 11(0.1和1 µM)能减少细胞集落形成并降低细胞内谷氨酸水平。在体内,Glutaminase C inhibitor 11(100 mg/kg)能够减缓A549小鼠异位瘤模型中的肿瘤生长。
T79438 c-Myc inhibitor 11

c-Myc Cell Cycle/Checkpoint
c-Myc inhibitor11Compound 67e),一种c-MYC抑制剂(pEC50: 6.4),在大鼠药代动力学评估中表现出高清除率、中等体积分布和短半衰期,适用于癌症研究领域。
T63656 c-Met-IN-11

c-Met-IN-11c-MET (IC50: 41.4 nM) 和 VEGFR-2 (IC50: 71.1 nM) 的有效抑制剂。
T17912 (S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl

VHL Ligand-Linker Conjugates 11,E3 ligase Ligand-Linker Conjugates 11

Others Others
(S,R,S)-AHPC-(C3- PEG) 2- C6- Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-(C3- PEG) 2- C6- Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
T39361 Thalidomide-O-amido-C6-NH2

E3LigaseLigand-LinkerConjugates25,Cereblon Ligand-Linker Conjugates 11,Thalidomide-O-amido-C6-NH2

Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11) is a Thalidomide-based synthetic E3 ligase ligand-linker conjugate, comprising of a cereblon ligand and a linker. This compound is employed in the production of PROTACs (proteolysis-targeting chimeras).
T38733 Ald-Ph-amido-PEG11-C2-NH2

Ald-Ph-amido-PEG11-C2-NH2

Ald-Ph-amido-PEG11-C2-NH2 is an 11-unit polyethylene glycol (PEG) linker that is non-cleavable. It is specifically designed for use in the synthesis of antibody-drug conjugates (ADCs).
T77971 Pomalidomide-C11-NH2 hydrochloride

Pomalidomide-C11-NH2 hydrochloride 是一款以 Pomalidomide 为基础的 E3 泛素连接酶 cereblon (CRBN) 配体,主要应用于募集 cereblon 蛋白。该化合物能够借助 linker 结构与蛋白质配体相连,从而构建 PROTAC 分子。
T77981 Pomalidomide-5-C11-NH2 hydrochloride

Pomalidomide-5-C11-NH2 hydrochloride 是一款基于 Pomalidomide 的 cereblon (CRBN) E3 泛素连接酶配体,能够招募 cereblon 蛋白。通过 linker 结构,该化合物可用于构建 PROTAC,实现其与蛋白质配体的连接。
T77958 Thalidomide-5-O-C11-NH2 hydrochloride

Thalidomide-5-O-C11-NH2 hydrochloride是一款基于Thalidomide的cereblon配体,能够招募CRBN蛋白。该化合物通过linker与靶向蛋白配体结合,用于构建PROTAC分子,如THAL-SNS-032。
T77962 Thalidomide-4-O-C11-NH2 hydrochloride

Thalidomide-4-O-C11-NH2 hydrochloride是Thalidomide衍生的cereblon配体,能够募集CRBN蛋白。该化合物能够利用linker与目标蛋白配体结合,进而形成PROTAC分子,如THAL-SNS-032。
T64611 Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R

Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64611
T9689 M4205

c-Kit Tyrosine Kinase/Adaptors
M4205 是一种 c-Kit 抑制剂,对外显子 11、13、17 中的 c-Kit 突变具有高活性。
T7554 Substance P (7-11)

Substance P 7-11(TFA)

Others; Neurokinin receptor GPCR/G Protein; Neuroscience; Others
Substance P (7-11) (Substance P 7-11(TFA)) 是神经肽物质P 的C-末端片段,可引起细胞内钙浓度的增加。
T62702 Senexin C

CDK Cell Cycle/Checkpoint
Senexin C 是一种新型具有口服活性和特异性的 CDK8/19 抑制剂,具有潜在的抗癌活性。Senexin C 比 Senexin B的代谢更稳定,作用效果更强。Senexin C 抑制 MV4-11 白血病细胞的生长。
T2295 SB-590885

Raf MAPK
SB590885 是一种 B-Raf 抑制剂,Ki 值为 0.16 nM,对其选择性是对 c-Raf 的 11 倍多。
T6078 Saracatinib

AZD0530,塞卡替尼

EGFR; Src; BTK; Autophagy Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Saracatinib (AZD0530) 是一种有效的 Src 抑制剂,抑制 c-Src、Lck、c-YES、Lyn、Fyn、Fgr 和 Blk 的 IC50值在 2.7 到 11 nM 之间,对其他酪氨酸激酶具有选择性。
TP1033L Transdermal Peptide Disulfide Acetate

TD 1 (peptide) acetate,Transdermal Peptide Disulfide Acetate (888486-23-5 free base)

ATPase Membrane transporter/Ion channel
Transdermal Peptide acetate(888486-23-5 free base) (TD 1 (peptide) acetate) 是一种 11 个氨基酸的肽,与 Na+/K+-ATPase β 亚基 (ATP1B1) 结合,主要与 ATP1B1 的 C 端相互作用。透皮肽可以增强许多大分子的透皮传递。透皮肽 TD 1 酰胺是一种新型肽,旨在增强透皮药物传递。
T1661 Crizotinib

PF-02341066,克唑替尼

c-Met/HGFR; ROS; ALK; Autophagy; ROS Kinase Angiogenesis; Autophagy; Immunology/Inflammation; Tyrosine Kinase/Adaptors
Crizotinib (PF-02341066) 是 c-MET 和 ALK 受体的 ATP 竞争性小分子酪氨酸激酶抑制剂,IC50为 8和20 nM。在细胞的实验中,它抑制 NPM-ALK 的酪氨酸磷酸化和 c-Met 的酪氨酸磷酸化。它也是 ROS1抑制剂。它有肿瘤生长抑制作用。
T37494 11-trans Leukotriene E4

11-trans Leukotriene E4

Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.
T76483 [Sar4] Substance P (4-11)

[Sar4] Substance P (4-11)为Substance P (4-11)的类似物,后者是Substance P (Substance P) C端片段并充当Substance P激动剂。
T23925 CYD-2-11

CYD 2 11,CYD211

CYD-2-11 is an effective and selective Bax agonist. It acts by targeting the structural pocket proximal to S184 in the C-terminal region of Bax.
T15808 Merestinib dihydrochloride

LY2801653 dihydrochloride

ROCK Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), RO
T83188 Acetyl-α-MSH (11-13)

Acetyl-α-MSH (11-13)为α-MSH C端三肽的乙酰化形式,展现解热及抗炎特性。
T71186 ORM-13070

ORM-13070 is a selective antagonist radioligand for the α2C adrenoceptor subtype. ORM-13070 C-11 is under investigation in clinical trial.
T26376 11-deoxy-PGF2a

11-deoxyPGF2a,11-deoxy PGF2a

11-deoxy-PGF2a, a selective activator of TREK-2 channels, stimulates DRG c-fiber nociceptor K2P currents and limits calcium influx.
T37493 11-trans Leukotriene D4

11-trans Leukotriene D4

11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.
T73371 BAY-3153

BAY-3153 是一种选择性的 CCR1(C-C motifchemokine receptor1) 拮抗剂 (humanIC50=3 nM ; ratIC50=11 nM ; miceIC50=81 nM)。
T76454 Substance P (5-11)

Substance P (5-11) 是 Substance P (Substance P ) 的 C 端七肽 ,是一种神经肽,可以与NK-1速激肽受体结合。
T76455 Substance P (4-11)

Substance P (4-11) 是 Substance P (Substance P ) 的 C 末端片段,是一种 Substance P 激动剂,对NK1受体具有高度选择性。
T37922 7(Z),11(Z)-Pentacosadiene

Unsaturated, long-chain hydrocarbons are found on the cuticles of insects and can act as pheromones. In mature Drosophila melanogaster, certain cuticular hydrocarbons are sexually dimorphic: males synthesize 23- and 25-C monoenes and females produce 27- and 29-C dienes. Each of these lipids plays specific roles in regulating male sexual behavior, with dienes stimulating courtship. 7(Z),11(Z)-Pentacosadiene is a 25-C hydrocarbon that is found in low abundance on cuticles of mature Drosophila fema...
T75836 JIP-1(153-163) TFA

JIP-1(153-163) TFA (TI-JIP TFA) 是 c-JNK 的肽类抑制剂,该序列是基于 JIP-1 的153-163肽段修饰的 (Modifications: Phe-11 = C-terminal amide)。
T79898 Cbl-b-IN-11

E1/E2/E3 Enzyme Ubiquitination
Cbl-b-IN-11 (Compound 466)作为casitas B系淋巴瘤 (Cbl-b) 及c-Cbl的抑制剂,显示出对Cbl-b和c-Cbl的高度选择性,其IC50值分别为6.4 nM 和6.1 nM。
T126357 Ikarisoside C

Ikarisoside C 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T126357,CAS号为 113558-11-5。
T76453 Substance P (6-11)

Substance P (6-11),Substance P 的C末端六肽酰胺,可与NK-1速激肽受体结合,展现出对运动神经元的去极化作用以及降压效应。
T78892 Glutaminase C-IN-2

Glutaminase Proteases/Proteasome
GlutaminaseC-IN-2(compound 11)为GAC变构抑制剂,IC50值为10.64 nM。该化合物通过干扰谷氨酰胺代谢,调控细胞代谢产物,进而提高ROS水平,并展现出抗癌活性。
T37651 5(S),6(R)-11-trans DiHETE

5(S),6(R)-11-trans DiHETE is a C-11 double bond isomer of 5(S),6(R)-DiHETE that is formed by the enzymatic isomerization of 5(S),6(R)-DiHETE by a membrane bound factor. 5(S),6(R)-11-trans DiHETE has been found in rat kidney homogenates and is potentially formed by the epoxide hydrolase pathway in this tissue. The isomerase activity responsible for the conversion of leukotriene B4 (LTB4) to 6-trans LTB4 in rat kidney homogenates has also been implicated in its formation. 5(S),6(R)-11-trans DiHETE...
T37767 Transdermal Peptide Disulfide TFA

Transdermal Peptide Disulfide TFA (TD 1 Disulfide(peptide) TFA), an 11-amino acid peptide, specifically binds to the Na+/K+-ATPase beta-subunit (ATP1B1), predominantly interacting with its C-terminus. This compound is capable of enhancing the transdermal delivery of various macromolecules[1].

化合物

C-11
Cat.No: T10640
Synonym:
Target: Others
Levetimide C-11
Cat.No: T32696
Synonym:
Target:
Proinsulin C-peptide human acetate
Cat.No: TP1651L
Synonym: 醋酸胰岛素原C-肽(55-89),人,Proinsulin C-peptide human acetate (33017-11-7 Free base)
Target: Others
jhu-75528c-11
Cat.No: T32289
Synonym: JHU75528 C-11,11c-Omar,JHU 75528 C-11
Target:
STING Agonist C11
Cat.No: T38161
Synonym: STING Agonist C11
Target:
IRES-C11
Cat.No: T40419
Synonym: IRES-C11
Target: c-Myc
BODIPY 581/591 C11
Cat.No: T39652
Synonym: BODIPY 581/591 C11
Target:
11-trans Leukotriene C4
Cat.No: T37492
Synonym: 11-trans Leukotriene C4
Target:
Mito-apocynin (C11)
Cat.No: T13773
Synonym:
Target: Others
Thalidomide-O-amido-C6-NH2 TFA
Cat.No: T17919
Synonym: E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate,Cereblon Ligand-Linker Conjugates 11 TFA,E3 Ligase Ligand-Linker Conjugates 25 TFA
Target: Others, Ligand for E3 Ligase
Br-C10-methyl ester
Cat.No: T17694
Synonym: 11-溴代十一烷酸甲酯
Target: Others, PROTAC Linker
11-Methoxyuncarine C
Cat.No: T124542
Synonym:
Target:
C-HEGA-11
Cat.No: TF0102
Synonym:
Target:
Glutaminase C Inhibitor 11
Cat.No: T83914
Synonym:
Target:
c-Myc inhibitor 11
Cat.No: T79438
Synonym:
Target: c-Myc
c-Met-IN-11
Cat.No: T63656
Synonym:
Target:
(S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl
Cat.No: T17912
Synonym: VHL Ligand-Linker Conjugates 11,E3 ligase Ligand-Linker Conjugates 11
Target: Others
Thalidomide-O-amido-C6-NH2
Cat.No: T39361
Synonym: E3LigaseLigand-LinkerConjugates25,Cereblon Ligand-Linker Conjugates 11,Thalidomide-O-amido-C6-NH2
Target:
Ald-Ph-amido-PEG11-C2-NH2
Cat.No: T38733
Synonym: Ald-Ph-amido-PEG11-C2-NH2
Target:
Pomalidomide-C11-NH2 hydrochloride
Cat.No: T77971
Synonym:
Target:
Pomalidomide-5-C11-NH2 hydrochloride
Cat.No: T77981
Synonym:
Target:
Thalidomide-5-O-C11-NH2 hydrochloride
Cat.No: T77958
Synonym:
Target:
Thalidomide-4-O-C11-NH2 hydrochloride
Cat.No: T77962
Synonym:
Target:
Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb #9649R
Cat.No: T64611
Synonym:
Target:
M4205
Cat.No: T9689
Synonym:
Target: c-Kit
Substance P (7-11)
Cat.No: T7554
Synonym: Substance P 7-11(TFA)
Target: Others, Neurokinin receptor
Senexin C
Cat.No: T62702
Synonym:
Target: CDK
SB-590885
Cat.No: T2295
Synonym:
Target: Raf
Saracatinib
Cat.No: T6078
Synonym: AZD0530,塞卡替尼
Target: EGFR, Src, BTK, Autophagy
Transdermal Peptide Disulfide Acetate
Cat.No: TP1033L
Synonym: TD 1 (peptide) acetate,Transdermal Peptide Disulfide Acetate (888486-23-5 free base)
Target: ATPase
Crizotinib
Cat.No: T1661
Synonym: PF-02341066,克唑替尼
Target: c-Met/HGFR, ROS, ALK, Autophagy, ROS Kinase
11-trans Leukotriene E4
Cat.No: T37494
Synonym: 11-trans Leukotriene E4
Target:
[Sar4] Substance P (4-11)
Cat.No: T76483
Synonym:
Target:
CYD-2-11
Cat.No: T23925
Synonym: CYD 2 11,CYD211
Target:
Merestinib dihydrochloride
Cat.No: T15808
Synonym: LY2801653 dihydrochloride
Target: ROCK
Acetyl-α-MSH (11-13)
Cat.No: T83188
Synonym:
Target:
ORM-13070
Cat.No: T71186
Synonym:
Target:
11-deoxy-PGF2a
Cat.No: T26376
Synonym: 11-deoxyPGF2a,11-deoxy PGF2a
Target:
11-trans Leukotriene D4
Cat.No: T37493
Synonym: 11-trans Leukotriene D4
Target:
BAY-3153
Cat.No: T73371
Synonym:
Target:
Substance P (5-11)
Cat.No: T76454
Synonym:
Target:
Substance P (4-11)
Cat.No: T76455
Synonym:
Target:
7(Z),11(Z)-Pentacosadiene
Cat.No: T37922
Synonym:
Target:
JIP-1(153-163) TFA
Cat.No: T75836
Synonym:
Target:
Cbl-b-IN-11
Cat.No: T79898
Synonym:
Target: E1/E2/E3 Enzyme
Ikarisoside C
Cat.No: T126357
Synonym:
Target:
Substance P (6-11)
Cat.No: T76453
Synonym:
Target:
Glutaminase C-IN-2
Cat.No: T78892
Synonym:
Target: Glutaminase
5(S),6(R)-11-trans DiHETE
Cat.No: T37651
Synonym:
Target:
Transdermal Peptide Disulfide TFA
Cat.No: T37767
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
TN5143 threo-1-C-Syringylglycerol

Others Others
threo-1-C-Syringylglycerol 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5143,CAS号为 121748-11-6。
TN2550 1''-Methoxyerythrinin C

Others Others
1''-Methoxyerythrinin C 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN2550,CAS号为 221002-11-5。
TN3725 Cucurbitadienol

Cucurbitadienol has significant anti-inflammatory, anti-tumor effect, is also CucurbitacinBE compounds biosynthesis the key intermediate. Cucurbitadienol synthase, the first committed enzyme for cucurbitacin biosynthesis, is a distinct enzyme from cycloar
T36000 3-Hydroxyterphenyllin

3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi...
T38069 Aquastatin A

Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 μM) andS. aureusfatty acid synthesis (IC50= 3.5 μM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 μM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K....
T36179 Aspulvinone O

Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 11.6 μM).1 Aspulvinone O inhibits aspartate transaminase 1 (GOT1; Kd = 3.32 μM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 μM).2 It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5 mg/kg) redu...
T35624 Ajoene

Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

threo-1-C-Syringylglycerol
Cat.No: TN5143
Synonym:
Target: Others
1''-Methoxyerythrinin C
Cat.No: TN2550
Synonym:
Target: Others
Cucurbitadienol
Cat.No: TN3725
Synonym:
Target:
3-Hydroxyterphenyllin
Cat.No: T36000
Synonym:
Target:
Aquastatin A
Cat.No: T38069
Synonym:
Target:
Aspulvinone O
Cat.No: T36179
Synonym:
Target:
Ajoene
Cat.No: T35624
Synonym:
Target:
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