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Search Results for " axin "

32

抑制剂 & 化合物

30

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22884	JW 67	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	JW 67 是典型 Wnt 信号通路的抑制剂，IC50为 1.17 μM。它影响由 β- 连环蛋白/GSK-3β/AXIN/APC/CK1 组成的多蛋白复合物，快速降低活性 β- 连环蛋白，随后下调Wnt 靶基因。它也抑制结直肠癌细胞生长。
TP2068L	Cyclotraxin B acetate(1203586-72-4 free base)	Trk receptor	Tyrosine Kinase/Adaptors
	Cyclotraxin B acetate(1203586-72-4 free base) 是 TrkB 受体的拮抗剂；抑制 BDNF 诱导的 TrkB 活性 (IC50 = 0.30 nM)。变构改变 TrkB 受体构象但不改变 BDNF 结合。防止 BDNF 引起的小鼠冷异常性疼痛。还显示在小鼠中表现出推定的抗焦虑特性。
T22453	Venlafaxine Wy 45030,文拉法辛	Serotonin Transporter	Neuroscience
	Venlafaxine (Wy 45030) 是一种口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂，具有抗抑郁活性。
T5380	Ansofaxine hydrochloride Ansofaxine盐酸盐,LPM570065,LY03005	Dopamine Receptor; 5-HT Receptor; Norepinephrine	GPCR/G Protein; Neuroscience
	Ansofaxine hydrochloride (LY03005) 是一种血清素-去甲肾上腺素-多巴胺再摄取抑制剂，IC50值分别为723、491 和 763 nM。
T2064	Semaxinib 司马沙尼,SU5416	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Semaxinib (SU5416) 是一种选择性的 VEGFR(Flk-1/KDR) 抑制剂，其 IC50=1.23 μM。
T0472	Venlafaxine hydrochloride Venlafaxine HCl,盐酸文拉法辛,Wy 45030 hydrochloride	5-HT Receptor; Serotonin Transporter	GPCR/G Protein; Neuroscience
	Venlafaxine hydrochloride (Wy 45030 hydrochloride) 是一种口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂，具有抗抑郁活性。
T2496	(Z)-Semaxinib SU5416	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	(Z)-Semaxinib (SU5416) 是一种有效的选择性 VEGFR(Flk-1/KDR) 抑制剂 (IC50: 1.23 μM)，对 VEGFR 的选择性是 PDGFRβ 的 20 倍，对 FGFR、InsR 和 EGFR 没有抑制作用。 Semaxanib 是一种具有潜在抗肿瘤活性的喹诺酮衍生物。
T10415	Autotaxin-IN-3	PDE	Metabolism
	Autotaxin-IN-3 是 Autotaxin 的抑制剂(IC50 = 2.4 nM)，Autotaxin 负责增加腹水和血浆中的溶血磷脂酸。
T6188	Desvenlafaxine succinate hydrate O-Desmethylvenlafaxine succinate hydrate,WY 45233 Succinate,琥珀酸去甲文拉法辛,Desvenlafaxine Succinate	5-HT Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	Desvenlafaxine succinate hydrate (WY 45233 Succinate) 是 Venlafaxine 主要代谢物的丁二酸盐形式，在人多巴胺转运体上显示弱的结合亲和力。它是具有口服活性的、能透过血脑屏障的5-HT 和去甲肾上腺素再摄取的抑制剂，对 hSERT 和 hNET 的IC50值分别为47.3 nM 和531.3 nM。
T10416	Autotaxin-IN-4	PDE	Metabolism
	Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.
T60508	(S)-Venlafaxine
	(S)-Venlafaxine 是 Venlafaxine 的(S)-构型。Venlafaxine 是一种具有口服活性的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 再摄取双重抑制剂，具有抗抑郁活性。
T10418	Autotaxin modulator 1	PDE	Metabolism
	Autotaxin modulator 1 is a new modulator of Autotaxin.
T10417	Autotaxin-IN-5	PDE	Metabolism
	Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.
T72837	Autotaxin-IN-6
	Autotaxin-IN-6 (compound 23)，一种ATX (自分泌运动分子)抑制剂，具有30 nM的IC50值，能够减少细胞迁移，适用于抗癌研究。
T38134	(S)-O-Desmethyl Venlafaxine N-Oxide
	(S)-O-Desmethyl Venlafaxine N-Oxide, an N-oxide derivative of (S)-O-Desmethyl Venlafaxine, constitutes an active metabolite of the serotonin-norepinephrine reuptake inhibitor (SNRI) class antidepressant, Venlafaxine[1][2].
T73977	(S)-Dehydro Venlafaxine
	(S)-Dehydro Venlafaxine 是 Dehydro Venlafaxine 的非活性 S-对映异构体。Dehydro Venlafaxine 是 Venlafaxine 的杂质。Venlafaxine (Wy 45030) 是有效的 5-羟色胺 (5-HT) / 去甲肾上腺素 (NE) 再摄取双重抑制剂。
TP2068	Cyclotraxin B
	Antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic p
T41060	Ansofaxine Ansofaxine,LPM570065freebase,Toludesvenlafaxine,LY03005freebase
	Ansofaxine, an SNRI compound, is commonly utilized in depression research as a serotonin-norepinephrine reuptake inhibitor.
T1580	Desvenlafaxine 去甲文拉法辛,WY 45233 Succinate,O-Desmethylvenlafaxine	5-HT Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	Desvenlafaxine (O-Desmethylvenlafaxine) 是 Venlafaxine 主要代谢物的丁二酸盐形式，在人多巴胺转运体上显示弱的结合亲和力。它是一种具有口服活性的、能透过血脑屏障的5-HT 和去甲肾上腺素再摄取的抑制剂，对 hSERT 和 hNET 的IC50值分别为 47.3 nM 和 531.3 nM。
T80447	Pardaxin P5
	Pardaxin P5，一种抗菌肽，其对大肠杆菌的最小抑制浓度（MIC）为13 μM。
T81300	Relaxin H3 (human)
	Relaxin H3 (human)为一类松弛素肽，通过与RXFP1受体结合来发挥其抗纤维化的生物学功能。
TP2404	Relaxin C-peptide Relaxin (79-92)
	Relaxin C-peptide, as a synthetic 14-amino acid peptide found in human decidua & placenta, can represent a partial sequence of human relaxin connecting peptide.
T75832	Cyclotraxin B TFA
	Cyclotraxin B TFA 是一种环肽，是一种高效且选择性的 TrkB 抑制剂，且不会改变 BDNF 的结合。Cyclotraxin B TFA 非竞争性地抑制 BDNF 诱导的 TrkB 活性，IC50值为 0.30 nM。Cyclotraxin B TFA 可以穿越血脑屏障，并具有止痛和抗焦虑的行为作用。
T14352	Autotaxin-IN-1	PDE	Metabolism
	Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship and it is used in treatment of osteoarthritis pain[1].
T30237	Axinylsterol
	Axinylsterol is a biochemical.
T27976	Manifaxine BW1555U88,BW-1555U-88,1555U88,1555U-88,GW-320659,GW320659
	Manifaxine, a norepinephrine-dopamine reuptake inhibitor, is used potentially for the treatment of attention deficit.
T11571	HLY78 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) 是 Wnt/β-catenin 信号通路的激活剂，通过靶向通道中 Axin 的 DIX 域，增强 Axin-LRP6 交联，诱导 Wnt 信号转导。
T6989	SKL2001	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	SKL2001 是一种Wnt/β-catenin 信号通路的激动剂，具有抗肿瘤作用。它能够破坏 Axin/β-catenin 相互作用，稳定细胞内 β-catenin。
T2651	IWR-1 IWR-1-endo,endo-IWR 1	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	IWR-1 (IWR-1-endo) 是一种 Wnt 通路抑制剂，可稳定 Axin 破坏复合物 (EC50=0.2 uM)。
T35550	FRATide
	FRATtide 可抑制 Axin 和 β-catenin 的磷酸化，抑制 GSK-3 结合 Axin，是一种源自 GSK-3 结合蛋白的肽。
T27760	KYA1797
	KYA1797 is an inhibitor of the Wnt/ß-catenin pathway. KYA1797 binds directly to the regulators of G-protein signaling domain of axin, initiats ß-catenin and Ras degradation through enhancement of the ß-catenin destruction complex activating GSK3ß, effecti
T69880	YW2065
	YW2065 has excellent anti-colorectal cancer effects in vitro and in vivo. YW2065 achieves its inhibitory activity for Wnt signaling by stabilizing Axin-1, a scaffolding protein that regulates proteasome degradation of β-catenin. Simultaneously, YW2065 also led to the activation of the tumor suppressor AMPK, providing an additional anticancer mechanism. In addition, YW2065 showed favorable pharmacokinetic properties without obvious toxicity.

化合物

Cat.No: T22884

Target: Wnt/beta-catenin

Cyclotraxin B acetate(1203586-72-4 free base)

Cat.No: TP2068L

Target: Trk receptor

Cat.No: T22453

Synonym: Wy 45030,文拉法辛

Target: Serotonin Transporter

Ansofaxine hydrochloride

Cat.No: T5380

Synonym: Ansofaxine盐酸盐,LPM570065,LY03005

Target: Dopamine Receptor, 5-HT Receptor, Norepinephrine

Cat.No: T2064

Synonym: 司马沙尼,SU5416

Target: VEGFR

Venlafaxine hydrochloride

Cat.No: T0472

Synonym: Venlafaxine HCl,盐酸文拉法辛,Wy 45030 hydrochloride

Target: 5-HT Receptor, Serotonin Transporter

Cat.No: T2496

Synonym: SU5416

Target: VEGFR

Cat.No: T10415

Target: PDE

Desvenlafaxine succinate hydrate

Cat.No: T6188

Synonym: O-Desmethylvenlafaxine succinate hydrate,WY 45233 Succinate,琥珀酸去甲文拉法辛,Desvenlafaxine Succinate

Target: 5-HT Receptor, Serotonin Transporter, Norepinephrine

Cat.No: T10416

Target: PDE

(S)-Venlafaxine

Cat.No: T60508

Autotaxin modulator 1

Cat.No: T10418

Target: PDE

Cat.No: T10417

Target: PDE

Cat.No: T72837

(S)-O-Desmethyl Venlafaxine N-Oxide

Cat.No: T38134

(S)-Dehydro Venlafaxine

Cat.No: T73977

Cat.No: TP2068

Cat.No: T41060

Synonym: Ansofaxine,LPM570065freebase,Toludesvenlafaxine,LY03005freebase

Cat.No: T1580

Synonym: 去甲文拉法辛,WY 45233 Succinate,O-Desmethylvenlafaxine

Target: 5-HT Receptor, Serotonin Transporter, Norepinephrine

Cat.No: T80447

Relaxin H3 (human)

Cat.No: T81300

Relaxin C-peptide

Cat.No: TP2404

Synonym: Relaxin (79-92)

Cyclotraxin B TFA

Cat.No: T75832

Cat.No: T14352

Target: PDE

Cat.No: T30237

Cat.No: T27976

Synonym: BW1555U88,BW-1555U-88,1555U88,1555U-88,GW-320659,GW320659

Cat.No: T11571

Synonym: 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine

Target: Wnt/beta-catenin

Cat.No: T6989

Target: Wnt/beta-catenin

Cat.No: T2651

Synonym: IWR-1-endo,endo-IWR 1

Target: Wnt/beta-catenin

Cat.No: T35550

Cat.No: T27760

Cat.No: T69880

Cat. No.	Product Name	Target	Signaling Pathways
T3366	Cephalotaxine ZINC19795976,三尖杉碱,(-)-Cephalotaxine,Cephalotaxlen	Antiviral; Influenza Virus	Immunology/Inflammation; Microbiology/Virology
	Cephalotaxine (ZINC19795976) 是从头孢紫杉中分离得到的一种生物碱，具有抗白血病和抗病毒活性，如抗 Zika 病毒。
T3818	Fraxinol	Others; P450	Metabolism; Others
	Fraxinol 是一种分离自半边莲中的化合物。
T9358	N,N,O-Tridesmethylvenlafaxine Tridesmethylvenlafaxine	Others; Endogenous Metabolite	Metabolism; Others
	N,N,O-Tridesmethylvenlafaxine (Tridesmethylvenlafaxine) 是内源性代谢产物的一种。
T3783	Fraxin Fraxoside,Fraxetin-8-O-glucoside,Paviin,秦皮甙	OAT; transporter; PDE	Membrane transporter/Ion channel; Metabolism
	Fraxin (Fraxoside) 是一种白蜡树内酯的糖苷，可从Acer tegmentosum，F. ornus 和A. hippocastanum 等分离得到，具有抗氧化、抗炎和抗转移活性。它能够抑制环腺苷酸磷酸二酯酶，具有抗氧化作用。
T6S0071	Fraxinellone	HIF/HIF Prolyl-Hydroxylase; STAT; PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Metabolism; Stem Cells
	Fraxinellone 是从白鲜的根皮中分离出来的一种天然产物，是PD-L1抑制剂，可抑制HIF-1α蛋白质合成。它通过靶向 PD-L1，有用于癌症免疫的潜力。
TN3315	9-Deacetyltaxinine E	Others	Others
	9-Deacetyltaxinine E is a natural product from Taxus mairei.
T28834	Spirolaxine
	Spirolaxine, a natural product isolated from Sporotrichum laxum ATCC 15155, has shown a variety of biological activities including promising anti-Helicobacter pylori property.
TN5113	Taxinine B	Others	Others
	Taxinine and taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells. Taxinine B shows stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA).
TN5114	Taxinine	P-gp	Membrane transporter/Ion channel; Neuroscience
	Taxinine and Taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells.
TN6020	4-Hydroxycephalotaxine
	4-Hydroxycephalotaxine is a natural product from Cephalotaxus fortunei.
TN6271	11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester
	11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6271，CAS号为 75911-16-9。
TN5378	Axinysone A (-)-Axinysone A
	Axinysone A 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5378，CAS号为 1114491-57-4。
TN3787	Decinnamoyltaxinine J	Others	Others
	Decinnamoyltaxinine J is a natural product from Taxus brevifolia Nutt.
TN5112	Taxin B	Others	Others
	Taxin B has toxic effects.
TN6236	Taraxinic acid
	Taraxinic acid 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6236，CAS号为 75911-33-0。
TN5116	Taxinine M	Others	Others
	Taxinine M is a natural product from Chinese yew Taxus chinensis.
TN3222	7-Deacetoxytaxinine J	Others	Others
	7-Deacetoxytaxinine J 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3222，CAS号为 18457-45-9。
T75625	Axinelline A
	Axinelline A 是一种有效的 COX 抑制剂，对 COX-2和 COX-1的IC50分别为 2.22 μΜ 和 8.89 μM。Axinelline A 显示抗炎活性。
TN2752	2-Deacetoxytaxinine J	Others	Others
	2-Deacetoxytaxinine J shows significant in vitro activity against breast cancer cell line at a concentration of 20 microM and 10 microM in MCF-7 and MDA-MB-231 respectively.
TN6254	11β,13-Dihydrotaraxinic acid
	11β,13-Dihydrotaraxinic acid 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6254，CAS号为 1274668-83-5。
T81020	Tenaxin I
	Tenaxin I，一种从黄芩提取物中鉴定出的成分，具有神经氨酸酶抑制活性。
TN6269	Taraxinic acid β-D-glucopyranosyl ester
	Taraxinic acid β-D-glucopyranosyl ester 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6269，CAS号为 75911-14-7。
TN2742	2,7-Dideacetoxytaxinine J	Others	Others
	2,7-Dideacetoxytaxinine J 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2742，CAS号为 115810-14-5。
TN5115	Taxinine J	Others	Others
	Taxinine J possesses inhibitory activity on heptoma cell in vitro.
TN4567	Minaxin C	Others	Others
	Minaxin C is a natural product from Caesalpinia minax HANCE.
TN5376	Axinysone B (-)-Axinysone B
	Axinysone B is a natiral product from the metabolites of the mushroom Anthracophyllum sp. BCC18695.
TN2751	2-Deacetoxydecinnamoyltaxinine J	Others	Others
	2-Deacetoxydecinnamoyltaxinine J is a natural product from Taxus cuspidta Sibe et Zucc.
TN3823	Demethylcephalotaxinone	Others	Others
	Demethylcephalotaxinone is a natural product from Cephalotaxus fortunei.
TN3341	Acetylcephalotaxine	Others	Others
	Acetylcephalotaxine是一种天然产物，属于三尖杉科三尖杉属，其产品编号为 TN3341，CAS号为 24274-60-0。Acetylcephalotaxine可用作对照参考。
TN5569	2-Deacetoxytaxinine B
	2-Deacetoxytaxinine B is a strongly inhibitor against U46619-induced aggregation, it shows strong inhibitory effects against arachidonic acid (AA)-induced aggregation.

天然产物

Cat.No: T3366

Synonym: ZINC19795976,三尖杉碱,(-)-Cephalotaxine,Cephalotaxlen

Target: Antiviral, Influenza Virus

Cat.No: T3818

Target: Others, P450

N,N,O-Tridesmethylvenlafaxine

Cat.No: T9358

Synonym: Tridesmethylvenlafaxine

Target: Others, Endogenous Metabolite

Cat.No: T3783

Synonym: Fraxoside,Fraxetin-8-O-glucoside,Paviin,秦皮甙

Target: OAT, transporter, PDE

Cat.No: T6S0071

Target: HIF/HIF Prolyl-Hydroxylase, STAT, PD-1/PD-L1

9-Deacetyltaxinine E

Cat.No: TN3315

Target: Others

Cat.No: T28834

Cat.No: TN5113

Target: Others

Cat.No: TN5114

Target: P-gp

4-Hydroxycephalotaxine

Cat.No: TN6020

11β,13-Dihydrotaraxinic acid β-D-glucopyranosyl ester

Cat.No: TN6271

Cat.No: TN5378

Synonym: (-)-Axinysone A

Decinnamoyltaxinine J

Cat.No: TN3787

Target: Others

Cat.No: TN5112

Target: Others

Cat.No: TN6236

Cat.No: TN5116

Target: Others

7-Deacetoxytaxinine J

Cat.No: TN3222

Target: Others

Cat.No: T75625

2-Deacetoxytaxinine J

Cat.No: TN2752

Target: Others

11β,13-Dihydrotaraxinic acid

Cat.No: TN6254

Cat.No: T81020

Taraxinic acid β-D-glucopyranosyl ester

Cat.No: TN6269

2,7-Dideacetoxytaxinine J

Cat.No: TN2742

Target: Others

Cat.No: TN5115

Target: Others

Cat.No: TN4567

Target: Others

Cat.No: TN5376

Synonym: (-)-Axinysone B

2-Deacetoxydecinnamoyltaxinine J

Cat.No: TN2751

Target: Others

Demethylcephalotaxinone

Cat.No: TN3823

Target: Others

Acetylcephalotaxine

Cat.No: TN3341

Target: Others

2-Deacetoxytaxinine B

Cat.No: TN5569

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