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Search Results for " third-generation "

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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T9865	Almonertinib mesylate	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Almonertinib mesylate 是一种不可逆的 EGFR 酪氨酸激酶抑制剂，对 EGFR 敏感突变和 T790M 耐药突变具有高选择性。它可用于非小细胞肺癌研究。
T60076	Oritinib SH-1028	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Oritinib (SH-1028) 是一种 EGFR 抑制剂，对 EGFR (wt)、EGFR (L858R)、EGFR (L861Q)、EGFR (L858R/T790M)、EGFR (d746-750) 的 IC50 分别为 18、0.7、4、0.1、1.4 和 0.89 nM , EGFR (d746-750/T790M), 分别。奥瑞替尼可用于治疗非小细胞肺癌的研究。
T1223	Ceftriaxone sodium hydrate Ceftriaxone Sodium Trihydrate,头孢曲松钠,Ceftriaxone disodium hemiheptahydrate,头孢曲松钠水合物,Ceftriaxone sodium	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Ceftriaxone sodium hydrate 是一种头孢菌素类抗生素，对革兰氏阳性和革兰氏阴性菌均有活性。它具有抗炎和抗氧化作用。
T3061	Lorlatinib 劳拉替尼,PF-6463922,PF-06463922,Loratinib	Apoptosis; Tyrosine Kinases; ROS; ALK; ROS Kinase	Angiogenesis; Apoptosis; Immunology/Inflammation; Tyrosine Kinase/Adaptors
	Lorlatinib (PF-6463922) 是一种具有口服活性，选择性，脑渗透性和 ATP 竞争性的ROS1/ALK 抑制剂，具有抗癌活性。它对 ROS1、野生型 ALK 和 ALKL1196M 的Ki 值分别为 <0.025 nM、<0.07 nM 和 0.7 nM。
T30787	Cefetamet sodium Ro 15-8074/001,Ro15-8074/001,Ro-15-8074/001
	Cefetamet sodium is a third-generation cephalosporin.
T1599	Ibandronic acid Bonviva,Bondronat,Boniva,伊班膦酸	Others; HBV	Microbiology/Virology; Others
	Ibandronic acid (Bonviva) 是一种高效含氮双磷酸盐，可作用于骨质疏松，具有抗吸收和抗高钙血症作用。
T0138	Cefpiramide acid Cefpiramidum,头孢匹胺,Cefpiramido	Antibacterial	Microbiology/Virology
	Cefpiramide acid (Cefpiramidum) 是第三代头孢菌素类抗生素。
T0198	Ceftiofur sodium Naxcel,头孢噻呋钠,Sodium ceftiofur	Antibacterial; Antibiotic	Microbiology/Virology
	Ceftiofur sodium (Naxcel) 是一种兽用头孢菌素类抗生素。
T0127	Glimepiride Glimperide,HOE-490,格列美脲	Potassium Channel	Membrane transporter/Ion channel
	Glimepiride (HOE-490) 是一种中长效的磺酰脲类抗糖尿病化合物，其 ED50=182 μg/k。
T7120	Cefetamet pivoxil hydrochloride 盐酸头孢他美酯,Ro 15-8075	Antibacterial; Antibiotic	Microbiology/Virology
	Cefetamet pivoxil hydrochloride (Ro 15-8075) 是一种可口服的头孢类抗生素。
T7839	Lasofoxifene Tartrate CP-336156,酒石酸拉索昔芬	Estrogen Receptor/ERR	Endocrinology/Hormones
	Lasofoxifene Tartrate (CP-336156) 是一种非甾体类的雌激素受体选择性调节剂 (SERM)。
T0911	Cefotaxime sodium Cefotaxim sodium salt,头孢噻肟钠,Cefotaxime sodium salt,Cefotaxim (sodium salt),HR-756 (sodium salt)	Antibacterial; Antibiotic	Microbiology/Virology
	Cefotaxime sodium (Cefotaxim sodium salt) 是头孢类抗生素和耐内酰胺酶的头孢菌素，有抗革兰氏阳性菌和革兰氏阴性菌作用。
T6268	Ceftiofur hydrochloride 头孢噻呋盐酸盐,Ceftiofur HCl,U-67279A,Excenel hydrochloride	Antibacterial; Antibiotic	Microbiology/Virology
	Ceftiofur hydrochloride (U-67279A) 是头孢噻呋的盐酸盐形式，是一种β-内酰胺酶稳定的半合成广谱头孢菌素，具有抗菌活性。
T9073	SRS16-86	Ferroptosis	Apoptosis
	SRS16-86 是一种铁死亡抑制剂，可研究肾缺血再灌注损伤和脊髓损伤。它在体内比 Ferrostatin-1 对代谢和血浆更稳定。
T1405	Cefditoren pivoxil 头孢妥仑匹酯,ME 1207,Cefditoren pivaloyloxymethyl ester,Cefditoren pivoxyl	Antibacterial; Antibiotic	Microbiology/Virology
	Cefditoren pivoxil (ME 1207) 是一种半合成、广谱、β-内酰胺酶耐药的第三代头孢菌素抗生素，具有杀菌活性。
T5024	Cefotiam Hexetil Hydrochloride 盐酸头孢替安酯,头孢替安海替酯盐酸盐	Antibacterial; Antibiotic	Microbiology/Virology
	Cefotiam hexetil hydrochloride 是一种可口服头孢菌素，是抗生素 cefotiam 的前药，但无抗菌作用。
T4405	Ceftibuten dihydrate 头孢布烯二水合物,Sch-39720 dihydrate	Antibacterial; Antibiotic	Microbiology/Virology
	Ceftibuten dihydrate (Sch-39720 dihydrate) 是一种具有口服活性的头孢菌素，在体外对多种革兰氏阴性和某些革兰氏阳性病原体有抗菌活性。
T0133	Cefdinir FK-482,头孢地尼,CI-983,PD 134393	Glutathione Peroxidase; Antibacterial; Antibiotic	Metabolism; Microbiology/Virology
	Cefdinir (FK-482) 是头孢菌素类中的一种半合成广谱抗生素，对几种革兰氏阴性和革兰氏阳性细菌引起的感染有效。它可研究耳，鼻窦，喉咙和皮肤的常见细菌感染。
T2490	Osimertinib AZD-9291,Mereletinib,奥希替尼	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Osimertinib (AZD-9291) 是一种 EGFR 三代抑制剂，抑制二代 EGFR 抑制剂产生的 T790M 耐药突变，具有不可逆性和口服活性。Osimertinib 具有抗肿瘤活性，用于治疗 EGFR 突变的非小细胞肺癌。
T4990	Cefcapene pivoxil hydrochloride hydrate Cefcapene Pivoxil Hydrochloride,盐酸头孢卡品酯	Antibacterial; Antibiotic	Microbiology/Virology
	Cefcapene pivoxil hydrochloride hydrate 是一种头孢菌素的前药，具有口服活性和广谱抗菌活性。它可研究掌跖脓疱病等感染性疾病。
T0932	Cefixime FK-027,头孢克肟,Cefspan,Cefiximum,Cephoral,FR-17027,CL-284635	Antibacterial; Antibiotic	Microbiology/Virology
	Cefixime (FR-17027) 是一种头孢菌素类抗生素, 可研究一些细菌感染。
T4998L	Cefpodoxime (free acid)	Others	Others
	Cefpodoxime (free acid) 是一种口服的第三代头孢菌素抗生素。除铜绿假单胞菌、肠球菌和脆弱拟杆菌外，它对大多数革兰氏阳性和革兰氏阴性微生物均有效。
T22354	Levocetirizine Dihydrochloride Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria.
T16398	Opicapone BIA 9-1067	Transferase	Metabolism
	Opicapone (BIA 9-1067) 是第三代儿茶酚-O-甲基转移酶 (COMT)抑制剂，能够降低细胞 ATP 含量，IC50=98 μM。它有用于帕金森病和运动波动的研究潜力。
T4998	Cefpodoxime proxetil	Antibacterial; Antibiotic	Microbiology/Virology
	Cefpodoxime Proxetil 是一种口服的广谱型抗生素。它与青霉素结合蛋白结合，抑制肽聚糖的合成，干扰细菌细胞壁的生物合成。
T1451	Levofloxacin hydrate 左氧氟沙星半水合物,Levaquin hydrate,Cravit hydrate,Quixin hydrate,Levofloxacin Hemihydrate,Tavanic hydrate,Iquix hydrate	DNA gyrase; Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Levofloxacin hydrate (Cravit hydrate) 是抗生素化合物，抑制细菌DNA 旋转酶活性。
T15771	Lobaplatin D-19466,络铂	DNA Alkylation	DNA Damage/DNA Repair
	Lobaplatin (D-19466) 是一种铂 (II) 复合物的非对映混合物，是一种有前途的抗肿瘤化疗药物，在多种肿瘤类型的患者中具有活性。
T1616	Cefotiam hydrochloride 盐酸头孢替安,Pansporin,SCE-963 hydrochloride,Pansporine,头孢替安盐酸盐,Cefotiam dihydrochloride,Halospor	Antibacterial; Antibiotic	Microbiology/Virology
	Cefotiam hydrochloride (SCE-963 hydrochloride) 是一种肠外头孢菌素类广谱抗生素，对革兰氏阳性菌和革兰氏阴性菌有活性。
T21395	Finerenone BAY948862,BAY-948862,BAY94-8862,非奈利酮,BAY 94-8862,BAY-94-8862,BAY 948862	Glucocorticoid Receptor	Endocrinology/Hormones
	Finerenone (BAY-948862) 是一种选择性、具有口服活性的、非甾体类盐皮质激素受体拮抗剂 (IC50=18 nM)。与糖皮质激素受体、雄激素受体和孕酮受体相比，它表现出良好的选择性 (>500-fold)。它在心肾疾病研究中具有潜在的应用前景，如 2 型糖尿病和慢性肾脏疾病。
T8747	Levofloxacin hydrochloride	DNA gyrase; Topoisomerase	DNA Damage/DNA Repair
	Levofloxacin hydrochloride 是一种广谱的第三代氟喹诺酮类抗生素，是氧氟沙星的光学活性 L-异构体，具有抗菌活性。左氧氟沙星通过细菌细胞壁扩散并通过抑制 DNA 促旋酶（细菌拓扑异构酶 II）起作用，这是一种 DNA 复制、RNA 转录和细菌 DNA 修复所需的酶。 DNA 促旋酶活性的抑制导致细菌细胞生长受阻。
T34239	R 8605 R-8605,R8605
	R 8605 is a third-generation retinoid.
T34348	Ro 14-1761 Ro-14-1761
	Ro 14-1761 is a new third-generation cephalosporin.
T10753	Ceftibuten Sch 39720,头孢布烯	Others	Others
	Ceftibuten is a third-generation cephalosporin antibiotic.
T34240	R 8923 R-8923,R8923
	R 8923 is a third-generation retinoid.
T23871	Cefuzonam sodium CZON,L-105,Cosmosin,CL 251931 sodium salt,L 105
	Cefuzonam sodium is a second-generation cephalosporin antibiotic. It may be effective against Staphylococcus aureus against which third-generation cephalosporins are largely ineffective.
T26238	Sumarotene Ro14-9706,Ro-14-9706,Ro 14-9706
	Sumarotene, a third-generation retinoid, is used as a topical dermatologic agent for the repair of antikeratinization, photodamage, and antiproliferation.
T31590	E 4441 E-4441,E4441
	E 4441 is a third-generation difluoroquinolone, which has good activity against G(+) aerobic bacteria and anaerobic bacteria in vitro and in vivo.
T21386	Ceftizoxime Sodium Epocelin,Eposerin,Monosodium Salt, Ceftizoxime,Cefizox,头孢唑肟钠,Ceftizoxime sodium salt,Ceftizoxim-natrium
	Ceftizoxime, a third-generation cephalosporin effective against Gram-negative and Gram-positive bacteria, binds penicillin-binding proteins (PBPs) to inhibit the bacterial cell wall synthesis. It rather resembles cefotaxime in its properties but is not su
T81412	Pradofloxacin
	Pradofloxacin是一种第三代的氟喹诺酮类抗菌化合物。
T4998L2	Cefpodoxime sodium R3746,R 3763,R 3746,R-3746,R-3763
	Cefpodoxime sodium is a third generation cephalosporin antibiotic agent. It targets gram-positive and gram-negative bacteria, especially those responsible for otitis media and pharyngitis.
T23810	BMX-001 MnTnBuOE-3-PyP 5+,manganese butoxyethyl pyridyl porphyrin,BMX001,manganese (III) ortho N-butoxyethylpyridylporphyrin
	BMX-001 is a third-generation, cationic, lipophilic, manganese (Mn), and porphyrin-based mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD). It also has antioxidant and potential chemoprotective activities.
T14030	3-Desacetyl Cefotaxime lactone	Others	Others
	3-Desacetyl Cefotaxime lactone, the active metabolite of Cefotaxime, is derived from its sodium salt form, which is recognized as a third-generation cephalosporin antibiotic.
T38643	Cefixime trihydrate CL-284635trihydrate,FR-17027 trihydrate,FK-027trihydrate
	Cefixime trihydrate (FR-17027 trihydrate) is a potent antibiotic belonging to the third generation of cephalosporins. Its efficacy lies in the treatment of various bacterial infections.
T61764	Zoledronic acid disodium tetrahydrate
	Zoledronic Acid (Zoledronate) disodium tetrahydrate is a potent third-generation bisphosphonate (BP), exhibiting strong anti-resorptive activity. It effectively inhibits osteoclast differentiation and apoptosis, while also demonstrating anti-cancer properties [1].
T41106	Cefpodoxime proxetil impurity B
	Cefpodoxime proxetil impurity B is a constituent found in Cefpodoxime proxetil, which is a third-generation cephalosporin. This compound, known as Cefpodoxime Proxetil, is a highly effective oral antibiotic with a broad spectrum of activity.
T68570	TPI-287
	TPI 287 is a synthetic, third generation taxane with potential antineoplastic activity. TPI 287 binds to tubulin and stabilizes microtubules, resulting in inhibition of microtubule assembly/disassembly dynamics, cell cycle arrest at the G2/M phase, and apoptosis.
T38783	DOTA-tri(t-butyl ester)
	DOTA-tri(t-butyl ester) is a versatile compound employed for the synthesis of third-generation (G3) nanoglobular magnetic resonance imaging (MRI) contrast agents. These contrast agents find application in the fields of MR angiography and tumor angiogenesis imaging.
T36644	Rezivertinib
	Rezivertinib (BPI-7711) is an orally active, highly selective and irreversible third-generation EGFR tyrosine kinase inhibitor (TKI) with potent activity against both common activation EGFR and resistance T790M mutations. Additionally, Rezivertinib demonstrates excellent central nervous system (CNS) penetration and exhibits antitumor activity[1][2].
T67809	simotaxel
	Simotaxel 是一种半合成的、口服生物可利用的第三代紫杉烷衍生物和微管稳定剂，具有潜在的抗肿瘤活性。
T38448	(Rac)-Finerenone (Rac)-Finerenone,(Rac)-BAY 94-8862
	Rac-Finerenone, also known as (Rac)-BAY 94-8862, is the racemate derivative of Finerenone, a selective third-generation nonsteroidal mineralocorticoid receptor antagonist (MR) that is taken orally. With an IC50 value of 18 nM, Finerenone exhibits exceptional selectivity against the glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold).

化合物

Almonertinib mesylate

Cat.No: T9865

Target: EGFR

Cat.No: T60076

Synonym: SH-1028

Target: EGFR

Ceftriaxone sodium hydrate

Cat.No: T1223

Synonym: Ceftriaxone Sodium Trihydrate,头孢曲松钠,Ceftriaxone disodium hemiheptahydrate,头孢曲松钠水合物,Ceftriaxone sodium

Target: Others, Antibacterial, Antibiotic

Cat.No: T3061

Synonym: 劳拉替尼,PF-6463922,PF-06463922,Loratinib

Target: Apoptosis, Tyrosine Kinases, ROS, ALK, ROS Kinase

Cefetamet sodium

Cat.No: T30787

Synonym: Ro 15-8074/001,Ro15-8074/001,Ro-15-8074/001

Ibandronic acid

Cat.No: T1599

Synonym: Bonviva,Bondronat,Boniva,伊班膦酸

Target: Others, HBV

Cefpiramide acid

Cat.No: T0138

Synonym: Cefpiramidum,头孢匹胺,Cefpiramido

Target: Antibacterial

Ceftiofur sodium

Cat.No: T0198

Synonym: Naxcel,头孢噻呋钠,Sodium ceftiofur

Target: Antibacterial, Antibiotic

Cat.No: T0127

Synonym: Glimperide,HOE-490,格列美脲

Target: Potassium Channel

Cefetamet pivoxil hydrochloride

Cat.No: T7120

Synonym: 盐酸头孢他美酯,Ro 15-8075

Target: Antibacterial, Antibiotic

Lasofoxifene Tartrate

Cat.No: T7839

Synonym: CP-336156,酒石酸拉索昔芬

Target: Estrogen Receptor/ERR

Cefotaxime sodium

Cat.No: T0911

Synonym: Cefotaxim sodium salt,头孢噻肟钠,Cefotaxime sodium salt,Cefotaxim (sodium salt),HR-756 (sodium salt)

Target: Antibacterial, Antibiotic

Ceftiofur hydrochloride

Cat.No: T6268

Synonym: 头孢噻呋盐酸盐,Ceftiofur HCl,U-67279A,Excenel hydrochloride

Target: Antibacterial, Antibiotic

Cat.No: T9073

Target: Ferroptosis

Cefditoren pivoxil

Cat.No: T1405

Synonym: 头孢妥仑匹酯,ME 1207,Cefditoren pivaloyloxymethyl ester,Cefditoren pivoxyl

Target: Antibacterial, Antibiotic

Cefotiam Hexetil Hydrochloride

Cat.No: T5024

Synonym: 盐酸头孢替安酯,头孢替安海替酯盐酸盐

Target: Antibacterial, Antibiotic

Ceftibuten dihydrate

Cat.No: T4405

Synonym: 头孢布烯二水合物,Sch-39720 dihydrate

Target: Antibacterial, Antibiotic

Cat.No: T0133

Synonym: FK-482,头孢地尼,CI-983,PD 134393

Target: Glutathione Peroxidase, Antibacterial, Antibiotic

Cat.No: T2490

Synonym: AZD-9291,Mereletinib,奥希替尼

Target: EGFR

Cefcapene pivoxil hydrochloride hydrate

Cat.No: T4990

Synonym: Cefcapene Pivoxil Hydrochloride,盐酸头孢卡品酯

Target: Antibacterial, Antibiotic

Cat.No: T0932

Synonym: FK-027,头孢克肟,Cefspan,Cefiximum,Cephoral,FR-17027,CL-284635

Target: Antibacterial, Antibiotic

Cefpodoxime (free acid)

Cat.No: T4998L

Target: Others

Levocetirizine Dihydrochloride

Cat.No: T22354

Synonym: Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride

Target: Histamine Receptor

Cat.No: T16398

Synonym: BIA 9-1067

Target: Transferase

Cefpodoxime proxetil

Cat.No: T4998

Target: Antibacterial, Antibiotic

Levofloxacin hydrate

Cat.No: T1451

Synonym: 左氧氟沙星半水合物,Levaquin hydrate,Cravit hydrate,Quixin hydrate,Levofloxacin Hemihydrate,Tavanic hydrate,Iquix hydrate

Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic

Cat.No: T15771

Synonym: D-19466,络铂

Target: DNA Alkylation

Cefotiam hydrochloride

Cat.No: T1616

Synonym: 盐酸头孢替安,Pansporin,SCE-963 hydrochloride,Pansporine,头孢替安盐酸盐,Cefotiam dihydrochloride,Halospor

Target: Antibacterial, Antibiotic

Cat.No: T21395

Synonym: BAY948862,BAY-948862,BAY94-8862,非奈利酮,BAY 94-8862,BAY-94-8862,BAY 948862

Target: Glucocorticoid Receptor

Levofloxacin hydrochloride

Cat.No: T8747

Target: DNA gyrase, Topoisomerase

Cat.No: T34239

Synonym: R-8605,R8605

Cat.No: T34348

Synonym: Ro-14-1761

Cat.No: T10753

Synonym: Sch 39720,头孢布烯

Target: Others

Cat.No: T34240

Synonym: R-8923,R8923

Cefuzonam sodium

Cat.No: T23871

Synonym: CZON,L-105,Cosmosin,CL 251931 sodium salt,L 105

Cat.No: T26238

Synonym: Ro14-9706,Ro-14-9706,Ro 14-9706

Cat.No: T31590

Synonym: E-4441,E4441

Ceftizoxime Sodium

Cat.No: T21386

Synonym: Epocelin,Eposerin,Monosodium Salt, Ceftizoxime,Cefizox,头孢唑肟钠,Ceftizoxime sodium salt,Ceftizoxim-natrium

Cat.No: T81412

Cefpodoxime sodium

Cat.No: T4998L2

Synonym: R3746,R 3763,R 3746,R-3746,R-3763

Cat.No: T23810

Synonym: MnTnBuOE-3-PyP 5+,manganese butoxyethyl pyridyl porphyrin,BMX001,manganese (III) ortho N-butoxyethylpyridylporphyrin

3-Desacetyl Cefotaxime lactone

Cat.No: T14030

Target: Others

Cefixime trihydrate

Cat.No: T38643

Synonym: CL-284635trihydrate,FR-17027 trihydrate,FK-027trihydrate

Zoledronic acid disodium tetrahydrate

Cat.No: T61764

Cefpodoxime proxetil impurity B

Cat.No: T41106

Cat.No: T68570

DOTA-tri(t-butyl ester)

Cat.No: T38783

Cat.No: T36644

Cat.No: T67809

(Rac)-Finerenone

Cat.No: T38448

Synonym: (Rac)-Finerenone,(Rac)-BAY 94-8862

Cat. No.	Product Name	Target	Signaling Pathways
T8126	Cefodizime Sodium	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Cefodizime sodium 是一种头孢菌素抗生素，具有抗菌活性。它对肾脏没有毒性，具有良好的耐受性和免疫调节活性，可研究呼吸道和泌尿道的严重感染。

天然产物

Cefodizime Sodium

Cat.No: T8126

Target: Others, Antibacterial, Antibiotic

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