Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9235 |
GW604714X
2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- |
Mitochondrial Metabolism | Metabolism |
GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) 是一种高度特异性的线粒体丙酮酸载体抑制剂,Ki<0.1 nM。它是一种线粒体呼吸抑制剂。它也能抑制质膜单羧酸转运体的 L-乳酸转运,但浓度比 MPC 的大 4 个数量级。 | |||
T21659 |
AZ 11645373
3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE |
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
AZ 11645373 (3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE) 是一种高度选择性和有效的人 P2X7 受体拮抗剂,对小鼠/大鼠 P2X7 受体没有影响。 | |||
T9229 |
Pim-1/2 kinase inhibitor 1
|
Pim | Chromatin/Epigenetic; JAK/STAT signaling |
Pim-1/2 kinase inhibitor 1 是一种具有口服活性的 Pim-1/2 激酶抑制剂。Pim-1/2 kinase inhibitor 1 能阻断 Pim 激酶磷酸化肽的能力,并且抑制4E-BP1和p27Kip1的Pim 蛋白激酶定向磷酸化。Pim-1/2 kinase inhibitor 1 可用于癌症,尤其是前列腺癌的研究。 | |||
T22386 |
NSC 31206
2,4-Thiazolidinedione,5-[(4-hydroxy-3-methoxyphenyl)methylene]- |
Others | Others |
NSC 31206 is a bioactive chemical. | |||
T22708 |
Darglitazone
CP-86325 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Darglitazone (CP-86325) 是一种噻唑烷二酮,是口服有效的PPAR-γ选择性激动剂。Darglitazone 可以有效控制血糖和脂质代谢,在 II 型糖尿病中有研究价值。 | |||
T2607 |
MSDC 0160
CAY10415,Mitoglitazone,MSDC0160,MSDC-0160 |
Others; IGF-1R; Mitochondrial Metabolism | Metabolism; Others; Tyrosine Kinase/Adaptors |
MSDC 0160 (CAY10415) 是一种线粒体丙酮酸载体(MPC) 的调节剂,也是调节噻唑烷二酮的线粒体靶标 (mTOT) 的胰岛素增敏剂。它是一种噻唑烷二酮 (TZD),具有抗糖尿病和神经保护活性作用。它具有用于阿尔茨海默氏病的潜力。 | |||
T22387 |
NSC 55655
5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione |
Others | Others |
NSC 55655 (5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione) 具有抗菌和抗氧化活性,抑制 B. subtilis, S. aureus, K. pneumonia, E. coli, S. typhi ,A. niger 和 C. albicans 的增殖,可用于糖尿病。 | |||
T0214L |
Pioglitazone hydrochloride
U-72107E,AD 4833,U 72107A,Pioglitazone HCl,匹格列酮盐酸盐 |
Ferroptosis; PPAR | Apoptosis; DNA Damage/DNA Repair; Metabolism |
Pioglitazone hydrochloride (AD 4833) 是一种选择性PPARγ激动剂,高亲和力结合到 PPARγ 配体结合域。作用于人和鼠 PPARγ,EC50分别为 0.93 和 0.99 μM。它是一种口服活性噻唑烷二酮的盐酸盐,具有抗糖尿病特性和潜在的抗肿瘤活性。 | |||
T0214 |
Pioglitazone
U 72107,吡格列酮,匹格列酮 |
Ferroptosis; PPAR | Apoptosis; DNA Damage/DNA Repair; Metabolism |
Pioglitazone (U 72107) 是一种胰岛素增敏剂和噻唑烷二酮,适用于治疗 2 型糖尿病。它是一种选择性PPARγ激动剂,高亲和力结合到 PPARγ 配体结合域,作用于人和鼠 PPARγ的EC50分别为 0.93 和 0.99 μM。 | |||
T38715 |
MSDC-0602K
MSDC-0602K,Azemiglitazone potassium |
PPAR | DNA Damage/DNA Repair; Metabolism |
MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (MPC). This compound, MSDC-0602K, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both ... | |||
T10561 |
BM-131246
|
Others | Others |
BM-131246 是一种可口服的且具有抗糖尿病活性的噻唑烷二酮衍生物,可用于研究糖尿病。 | |||
T27841 |
Lobeglitazone Sulfate
CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang |
NOD | Immunology/Inflammation; NF-κB |
Lobeglitazone Sulfate(CKD-501 Sulfate) 是一种新型噻唑烷二酮,具有抗炎活性,抑制LPS诱导的NLRP3炎症小体活化和肝脏炎症,可用于研究 2 型糖尿病 (T2DM)。 | |||
T1622 |
Rosiglitazone maleate
BRL 49653C,BRL 49653,马来酸罗格列酮 |
Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism |
Rosiglitazone maleate (BRL 49653) 是一种选择性PPARγ激活剂,具有抗糖尿病特性和潜在抗肿瘤活性。它也是TRP 通道调节剂,可抑制 TRPM2、TRPM3 的活性,激活 TRPC5。 | |||
T0334 |
Rosiglitazone
BRL49653,罗格列酮 |
Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism |
Rosiglitazone (BRL49653) 是一种 PPARγ 激动剂、TRPC5 激活剂和 TRPM3 抑制剂,具有口服活性。Rosiglitazone 也是一种降糖剂,是噻唑烷二酮类胰岛素增敏剂。 | |||
T0242 |
Sitagliptin
西他列汀,MK0431,西格列汀 |
Proteasome; DPP-4; Autophagy | Autophagy; Proteases/Proteasome; Ubiquitination |
Sitagliptin (MK0431) 是一种有效的 DPP4抑制剂,在 Caco-2 细胞中,IC50值为 19 nM。它是一种新型口服降糖药,可单独使用或与二甲双胍或噻唑烷二酮联合用于治疗 2 型糖尿病。 | |||
T8780 |
AMG131
INT-131,AMG-131,CHS 131 |
PPAR | DNA Damage/DNA Repair; Metabolism |
AMG131 (CHS 131) 是一种新型非噻唑烷二酮(TZD) 选择性过氧化物酶体增殖物激活受体 (PPAR) γ 调节剂,可用于治疗 2 型糖尿病。 | |||
T3989 |
SMI-16a
PIM1/2 Kinase Inhibitor VI |
Pim | Chromatin/Epigenetic; JAK/STAT signaling |
SMI-16a (PIM1/2 Kinase Inhibitor VI) 是选择性 Pim 激酶抑制剂,对 Pim1、Pim2 和 PC3 细胞的 IC50值分别为0.15、0.02 和48 μM。 | |||
T30817 | Cgp 19984 | ||
CGP 19984 is a thiazolidinedione derivative that inhibits luteinizing hormone secretion and has anti-tumor effects. | |||
T61875 | Rivoglitazone | ||
Rivoglitazone 是一种噻唑烷二酮衍生物,PPARγ的激动剂,用于治疗2型糖尿病。 | |||
T37827 |
CAY10506
CAY10506 |
||
Anti-diabetic drugs of the thiazolidinedione (TZD) structural class as well as α-lipoic acid activate peroxisome proliferator-activated receptor γ (PPARγ), a nuclear transcription factor that controls glucose metabolism and lipid homeostasis. CAY10506 is a hybrid lipoic acid-TZD derivative that transactivates human PPARγ with an EC50 value of 10 μM. | |||
T69011 | Lobeglitazone | ||
Lobeglitazone, also known as CKD-501, is an antidiabetic drug in the thiazolidinedione class of drugs. As an agonist for both PPARα and PPARγ, it works as an insulin sensitizer by binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. | |||
T62576 |
Darglitazone Sodium
|
||
Darglitazone Sodium 是一种噻唑烷二酮,是一种选择性的、口服具有活力的 PPAR-γ (过氧化物酶体增殖物激活受体)激动剂。Darglitazone Sodium 可以有效控制血糖和脂质代谢,能够用于研究 II 型糖尿病。 | |||
T36180 |
Azelaoyl PAF
|
||
Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ. One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PAF. Azelaoyl PAF is a potent PPARγ agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF is more potent than 15-deoxy-δ12,14-prostaglandin J2, and equipotent with rosiglitazone as a ligand for this receptor. | |||
T79621 |
TZ4M
|
||
TZ4M 是一种含 2,4-噻唑烷二酮 (TZD) 的抗阿尔茨海默病试剂,可提供神经保护。在人类血浆中,TZ4M 可抑制 AChE。此外,TZ4M 能在东莨菪碱诱导的阿尔茨海默病动物模型中改善成年大鼠的记忆与认知功能。 |