159
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP2026L |
GRP (porcine) acetate
GRP (porcine) acetate(74815-57-9 Free base) |
Others | Others |
GRP (porcine) acetate 是从猪胰腺中提取的胃泌素释放肽。 GRP (porcine) acetate 可能在猪胰腺内分泌和外分泌的副交感神经调节中起作用。 | |||
TP1179L |
Porcine dynorphin A(1-13) acetate
Dynorphin A Porcine Fragment 1-13 acetate,Porcine dynorphin A(1-13) acetate(72957-38-1 free base) |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Porcine dynorphin A(1-13) acetate (Dynorphin A Porcine Fragment 1-13 acetate)(72957-38-1 free base) 是一种有效的内源性 κ opioid 受体激动剂,在生理浓度下具有镇痛作用。暴露于强啡肽 A (1-13) 会导致单个神经元中 [Ca2+]i 的急剧增加,类似于急性 NMDA 治疗所见的增加。 | |||
TP1880L1 |
PAMP-12 (human, porcine) acetate
PAMP-12 (human, porcine) acetate(196305-05-2 free base) |
Others | Others |
PAMP-12 (human, porcine) acetate (PAMP-12 (human, porcine) acetate (196305-05-2 free base)) 是 ir-PAMP 的主要成分,由 AM 前体加工而成,PAMP-20 也是如此,并且可能参与心血管控制。 | |||
T21743L |
Beta-Lipotropin (1-10), porcine Acetate
Beta-Lipotropin (1-10), porcine Acetate(77875-68-4 Free base) |
Others | Others |
Beta-Lipotropin (1-10), porcine Acetate (Beta-Lipotropin ) 被发现在其 C 末端序列中包含这些肽的一级结构。 | |||
T15389L |
Glucagon (1-29), bovine, human, porcine hydrochloride
盐酸胰高血糖素,Porcine glucagon hydrochloride,Glucagon hydrochloride |
Glucocorticoid Receptor; Glucagon Receptor | Endocrinology/Hormones; GPCR/G Protein |
Glucagon (1-29), bovine, human, porcine hydrochloride 是一种由胰腺 α 细胞产生的多肽激素。它可激活 HNF4α 并促进 HNF4α 磷酸化,促进糖异生。 | |||
T21582L |
Acetyl Angiotensinogen (1-14), porcine Acetate
Acetyl Angiotensinogen (1-14), porcine Acetate(66641-26-7 Free base) |
Others | Others |
Acetyl Angiotensinogen (1-14), porcine Acetate 是一种肽,序列为 AC-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER-OH。由血管紧张素原基因编码的蛋白质被称为前血管紧张素原或血管紧张素原前体。 | |||
T38648L |
Cecropin P1, porcine acetate
|
Endogenous Metabolite | Metabolism |
Cecropin P1, porcine acetate 是一种在 Hyalophora cecropia 和猪肠道中发现的抗菌肽。 | |||
T76341L |
[DPro10] Dynorphin A (1-11)acetate,porcine
[DPro10] Dynorphin A (1-11)acetate,porcine(94596-26-6 Free base) |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
[DPro10] Dynorphin A (1-11)acetate,porcine 是一种高效的 κ-阿片受体激动剂,其 Ki 值为 0.13 nM。[DPro10] Dynorphin A (1-11), porcine 是一种 N-烷基化衍生物,具有镇痛活性。 | |||
TP1380 |
Galanin (1-16), mouse, porcine, rat
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Galanin (1-16), mouse, porcine, rat 是一种有效的甘丙肽受体激动剂,Kd 为 3 nM。 | |||
T37588L |
GIP (1-30) amide, porcine acetate
|
IGF-1R | Tyrosine Kinase/Adaptors |
GIP (1-30) amide, porcine acetate 是完全葡萄糖依赖性促胰岛素多肽 (GIP) 受体的激动剂。它可弱抑制胃酸分泌,强烈刺激胰岛素。 | |||
T40495 |
Elastase from porcine pancreas
弹性蛋白酶,EC 3.2.1.35 |
Others | Others |
Elastase from porcine pancreas 由 240 个氨基酸残基组成,是一种丝氨酸蛋白酶,可以水解蛋白质和多肽。它可诱发仓鼠气肿。 | |||
TP1425 |
Motilin (26-47), human, porcine
胃动素 (人类,猪) |
Motilin Receptor | GPCR/G Protein |
Motilin (26-47), human, porcine 是内源性 motilin 受体的激动剂,在中国仓鼠卵巢细胞中,Ki 值和EC50值分别为 2.3 和 0.3 nM。 | |||
TP2206 |
[Leu31,Pro34]-Neuropeptide Y (porcine)
LEU 31, PRO34]-神经肽Y(猪) |
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
[Leu31,Pro34]- Neuropeptide Y (porcine) 是神经肽 Y (NPY) 的一种类似物,是对NPY Y1受体有选择性的激动作用。它表现出抗焦虑作用。 | |||
TP1283L |
VIP(6-28)(human, rat, porcine, bovine) acetate
|
Others | Others |
VIP(6-28)(human, rat, porcine, bovine) acetate 是外源性血管活性肠肽 (VIP) 受体对颈上神经节 (SCG) 中 cAMP 作用的拮抗剂。 | |||
TP1048 |
Secretin, porcine
Porcine secretin acetate |
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Secretin, porcine (Porcine secretin acetate) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid. Secretin porcine stimulates pancreatic and gastric secretions to a | |||
T80503 |
Proadrenomedullin (N-20) (bovine, porcine)
ProADM N20(bovine, porcine),PAMP-20(bovine, porcine) |
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Proadrenomedullin (N-20) (bovine, porcine) 是一种来源于嗜铬细胞的、具有降压及抑制 catecholamine release 的非竞争性肽类。该化合物能显著抑制 PC12 嗜铬细胞瘤细胞的 catecholamine 分泌,显示出 350 nM 的 IC50 值。此外,Proadrenomedullin (N-20) (bovine, porcine) 作为 EC50 约为 270 nM 的阻断剂,能够有效抵抗烟碱能激动剂引起的 catecholamine release 脱敏现象和烟碱相关的信号通道 (22Na+摄取)。 | |||
TP1880 |
PAMP-12(human, porcine)
PAMP-12 (human, porcine) |
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Potent endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 57.2 nM). Corresponds to amino acids 9 to 20 of proadrenomedullin. | |||
T80030 |
Oxyntomodulin (bovine, porcine) (TFA)
Glucagon-37 (bovine, porcine) (TFA) |
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Oxyntomodulin (bovine, porcine) TFA为含37个氨基酸的肽类激素,作为胰高血糖素样肽1 (GLP-1) 受体的激动剂。 | |||
TP1219 |
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate
ANP (1-28), human, porcineANP(1-28) |
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Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate 是颗粒鸟苷酸环化酶的刺激剂,已被发现通过增加环鸟苷单磷酸的合成来保护分离的心肌细胞免受复氧诱导的高收缩。Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate 也有助于在反复运动期间刺激脂解,并在运动期间控制脂解。 | |||
T83677 |
Neuropeptide Y (porcine, bovine) TFA
NPY (porcine, bovine) |
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神经肽Y(Neuropeptide Y, NPY)是一种参与调节食欲、血管收缩、心脏收缩力和肠道分泌的神经肽,同时也是NPY受体Y1、Y2和Y5的激动剂。它在全身范围内表达。NPY能够在表达大鼠Y1或Y2以及表达大鼠Y5的HEK293细胞中选择性抑制由forskolin诱导的cAMP积累,而对表达大鼠Y4受体的L-M(TK-)细胞的影响较小(EC50分别为0.15、2.7、0.66和>1,000 nM)。在分离的豚鼠心脏模型中,NPY能够增加灌注压(EC30 = 1.3 nM)。神经内注射NPY(300 pmol/动物)能够在大鼠中增加食物摄取量。 | |||
T36186 |
Globotriaosylceramides (porcine)
|
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Globotriaosycleramides are glycosphingolipids found in mammalian cell membranes that are synthesized from lactosylceramides . They act as receptors for Shiga and Shiga-like toxins in vitro and in vivo. Globotriaosylceramides accumulate in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. G... | |||
T38048 |
Globotetraosylceramides (porcine RBC)
|
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Globotetraosylceramides are bioactive neutral glycosphingolipids. They are the major glycolipids in human erythrocytes. They act as receptors for the Shiga toxins Stx1, Stx2, and Stx2e, the cytotoxic protein pierisin-1, and parvovirus B19. Globotetraosylceramides increase the expression of proteins responsible for enamel deposition, including ameloblastin, amelogenin, and enamelin, in dental epithelial cells and activate the ERK and p38 MAPK signaling pathways. Levels of globotetraosylceramides ... | |||
TP1179 |
Porcine dynorphin A(1-13)
Dynorphin A Porcine Fragment 1-13 |
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Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations. Exposure to dynorphin A (1-13) causes acute increases in [Ca2+]i in individual neurons similar to increases seen with acut | |||
TP1047 |
Secretin, porcine TFA (17034-34-3 free base)
Porcine secretin TFA,Secretin, porcine TFA |
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Secretin, porcine TFA (Porcine secretin TFA) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid.Secretin porcine stimulates pancreatic and gastric secretions to ai | |||
T36185 | Globotriaosylceramides (hydroxy) (porcine) | ||
Globotriaosycleramides are glycosphingolipids found in mammalian cell membranes that are synthesized from lactosylceramides . They act as receptors for Shiga and Shiga-like toxins in vitro and in vivo. Globotriaosylceramides accumulate in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. G... | |||
T15389 |
Glucagon (1-29), bovine, human, porcine
胰高血糖素,Porcine glucagon,Glucagon |
Others | Others |
Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation. | |||
T41065 |
Atrial natriuretic factor (1-28) (human, porcine)
Atrial natriuretic factor (1-28) (human, porcine),Atrial natriuretic peptide (1-28) |
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Atrial natriuretic factor (1-28) from both human and porcine sources is a powerful suppressor of pro-opiomelanocortin (POMC) mRNA, while it only has a modest inhibition effect on βEP-LI release. | |||
T36925 |
Neuromedin C (porcine)
|
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Neuromedin C (porcine) 是一种铃蟾肽样神经肽,可从猪脊髓中获得。Neuromedin C (porcine) 对大鼠子宫具有收缩活性。Neuromedin C (porcine) 有研究神经系统相关疾病的潜力。 | |||
T38648 |
Cecropin P1, porcine
|
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Cecropin P1, porcine is an antibacterial peptide originally identified in moths (Hyalophora cecropia) and later in pig intestine. | |||
TP1085L |
Neuromedin N acetate(92169-45-4 free base)
Neuromedin N (rat, mouse, porcine, canine) acetate |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Neuromedin N acetate(92169-45-4 free base) 是一种神经肽,其衍生自与神经降压素相同的前体多肽,具有相似但略有不同的表达和作用。Neuromedin N 是多巴胺 D2 受体激动剂与大鼠新纹状体膜结合的有效调节剂。 | |||
TP2026 |
GRP (porcine)
|
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Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice | |||
T36447 |
Neuropeptide Y 13-36 (porcine)
|
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Neuropeptide Y 13-36 (porcine) 是选择性的神经肽 Y2 受体激动剂。 | |||
T36480 |
Big Endothelin-1 (1-39), porcine
|
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The big endothelins comprise residues 53-90 (human big ET-1) and 53-91 (porcine big ET-1) of the endothelin precursor (preproendothelin). Compared to the mature endothelin-1 (ET-1), both peptides show less vasoconstrictor activity in vitro, but similar pressor effects in vivo. Former CAS-number 121014-54-8. | |||
TP1961L |
PR 39 (porcine) acetate
|
Proteasome; Antibacterial | Microbiology/Virology; Proteases/Proteasome; Ubiquitination |
PR 39 (porcine) acetate 是一种非竞争性、可逆的变构蛋白酶体抑制剂。 它可逆地与蛋白酶体的 α7 亚基结合,并通过泛素-蛋白酶体途径阻断 NF-κB 抑制剂 IκBα 的降解。 | |||
T37588 |
GIP (1-30) amide, porcine
|
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This GIP fragment has potent insulinotropic activity in the isolated, perfused rat pancreas but greatly reduced somatostatinotropic activity in the isolated perfused rat stomach. The site responsible for insulinotropic activity apparently lies between residues 19 and 30 of GIP. | |||
T37601 |
GIP (1-30) amide, porcine TFA
|
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GIP (1-30) amide, porcine TFA is a high-affinity full agonist of the glucose-dependent insulinotropic polypeptide (GIP) receptor, having a similar potency as the native GIP(1-42) [1]. Furthermore, GIP (1-30) amide, porcine displays weak inhibitory effects on gastric acid secretion while exhibiting potent insulin-stimulating properties. | |||
T40364 |
Proinsulin C-Peptide (31-63), porcine
|
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Proinsulin C-Peptide (31-63), porcine, is a peptide derived from the cleavage of porcine proinsulin, specifically spanning the 31st to 63rd amino acid residues. | |||
TP2243 |
Dynorphin (2-17), amide, porcine
|
Others | Others |
Dynorphins are a class of opioid peptides that arise from the precursor protein prodynorphin. When prodynorphin is cleaved during processing by proprotein convertase 2 (PC2), multiple active peptides are released: dynorphin A, dynorphin B, and α/β-neo-end | |||
TP2250 |
Galanin (1-15) (porcine, rat)
|
Others | Others |
N-terminal galanin fragment used to mediate central cardiovascular effects | |||
TP1317 |
Galanin (1-16), mouse, porcine, rat TFA
|
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Galanin (1-16), mouse, porcine, rat is an agonist of the hippocampal galanin receptor, with a Kd of 3 nM. Galanin (1-16), mouse, porcine, rat shows high biological activity on locus coeruleus neurons. | |||
T39244 |
Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled
|
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Atrial Natriuretic Peptide (1-28), human, porcine, Biotin-labeled, is one of three mammalian natriuretic peptides (NPs) that exerts endocrine effects on fluid homeostasis and blood pressure. Atrial Natriuretic Peptide holds promise for cardiovascular diseases research. | |||
TP1220L |
Carperitide acetate
醋酸卡培立肽,Carperitide acetate (89213-87-6 Free base),Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate |
Endothelin Receptor | GPCR/G Protein |
Carperitide acetate (Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate) 是一种由 28 个氨基酸组成的激素,由心脏产生并分泌,以响应心脏损伤和机械拉伸。Carperitide acetate 抑制内皮素-1 (endothelin-1) 分泌。 | |||
TP1961 |
PR-39
PR 39 (porcine) |
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Antibacterial peptide. Stimulates angiogenesis and inhibits inflammatory responses by selectively blocking proteasome degradation of IκBα. | |||
TP1283 |
VIP(6-28)(human, rat, porcine, bovine)
|
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VIP(6-28)(human, rat, porcine, bovine) is a potent antagonist that effectively counteracts the effects of exogenous vasoactive intestinal peptide (VIP) on cyclic adenosine monophosphate (cAMP) signaling. | |||
T65428 | Secretin,porcine | ||
Secretin,porcine 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T65428。 | |||
T36427 |
PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)
|
PACAP | GPCR/G Protein |
Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells. It binds to PACAP receptors on SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC50s = 24.5, 106, and 105 nM, respectively) and inhibits cAMP accumulation induced by PACAP (1-38) (Kis = 457, 102, and 283 nM, respectively, in SH-SY5Y, ... | |||
T83164 |
Adrenomedullin (porcine)
|
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Adrenomedullin(porcine)是一種多肽,具有调节血管舒张的功能。它在内皮依赖性条件下能诱导大鼠主动脉舒张,IC50为2.4 nM;在内皮非依赖性条件下则能诱导猪冠状动脉舒张,IC50为27.6 nM。 | |||
T76318 |
GHRF, porcine
|
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GHRF, porcine 是一种生长激素释放激素 (GHRH) 多肽 (porcine)。GHRF, porcine 与 GHRHR 受体结合并促进生长激素的释放。 | |||
T80881 |
Valosin (porcine)
|
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Valosin (porcine)是一种含有25个氨基酸的生物活性肽,最近从猪肠中分离得到,主要用于消化系统研究。 | |||
T38109 |
Galanin (2-11) amide (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
|
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Galanin (2-11) amide is a synthetic peptide fragment of the neuropeptide galanin and an agonist of the galanin-2 (GAL2) receptor (EC50= 9.32 nM in a fluorescence imaging plate reader assay).1It selectively binds to the GAL2receptor (IC50= 1.76 nM for the rat receptor) over the GAL1receptor (IC50= 879 nM for the human receptor) but does also bind to the GAL3receptor (Ki= 271 nM for the rat receptor).1,2Intracerebroventricular administration of galanin (2-11) amide (1 nmol/animal) decreases immobi... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T13661 |
Docosatrienoic Acid
cis-13,16,19-docosatrienoic acid,(13Z,16Z,19Z)-13,16,19-Docosatrienoic acid |
Others | Others |
Docosatrienoic acid is a rare omega-3 fatty acid; Ki value is 5×M, which inhibits the binding of LTB4 to porcine neutrophil membrane. | |||
T80259 |
PMAP-23
|
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PMAP-23为具有生物活性的抗菌肽(AMP),源自猪骨髓。 | |||
T38179 |
C16 3'-sulfo Galactosylceramide (d18:1/16:0)
C16 3'-sulfo Galactosylceramide (d18:1/16:0) |
Others | Others |
C16 3'-sulfo Galactosylceramide (d18:1/16:0)是硫酸盐类糖脂的一种。C16 3'-sulfo Galactosylceramide (d18:1/16:0)是在猪脑和血浆中发现的一种比较丰富的硫化物,在小鼠的整个发育过程中会有所减少。C16 3'-sulfo Galactosylceramide (d18:1/16:0)在体外可抑制视网膜神经节细胞生长。C16 3'-sulfo Galactosylceramide (d18:1/16:0)已被用作量化大鼠小脑和多发性硬化症患者分离的白质中的硫化物的参照物。 | |||
T16791 |
Rottlerin
Mallotoxin,NSC 56346,粗糠柴苦素,NSC 94525 |
CaMK; Apoptosis; Others; HIV Protease; PKA; PKC; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Neuroscience; Others; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Rottlerin (NSC-56346) 是一种从Mallotus Philippinensis 中得到的天然产物, 是 PKC 的特异性抑制剂,抑制HIV-1整合和狂犬病病毒感染。它通过活化 caspase 3 诱导细胞凋亡. | |||
T35624 | Ajoene | ||
Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 µg/ml) and Gram-negative bacteria (MICs = 136-200 µg/ml), as well as yeasts (MICs = 10-20 µg/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 µM), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 µM).2It reduces... |