keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation. 在相同实验条件下,摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性,但盐形式 Glucagon (1-29), bovine, human, porcine hydrochloride 的水溶性和稳定性通常比游离态更好。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 2,897 | 5日内发货 |
Glucagon (1-29), bovine, human, porcine 的其他形式现货产品:
产品描述 | Glucagon is a peptide hormone, produced by pancreatic α-cells. Glucagon reduces the activity of HNF-4. Glucagon stimulates gluconeogenesis. Glucagon enhances HNF4α phosphorylation. |
体外活性 | Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia, after binding to its receptor Gcgr. Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis [1]. Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes and that also increases phosphorylation of HNF4α [3]. |
体内活性 | Compared with PBS control, High-dose (1 mg/kg) Glucagon lowers glycemia and stimulates insulin secretion in ambient-fed mice. Low-dose (20 μg/kg) Glucagon enhances glycemia and does not stimulate insulin secretion in ambient-fed mice [4]. |
别名 | 胰高血糖素, Porcine glucagon, Glucagon |
分子量 | 3482.75 |
分子式 | C153H225N43O49S |
CAS No. | 16941-32-5 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (14.36 mM), Sonication is recommended.
H2O: 20 mg/mL (5.74 mM), when pH is adjusted to 2 with HCl. Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 0.2871 mL | 1.4356 mL | 2.8713 mL | 7.1782 mL |
5 mM | 0.0574 mL | 0.2871 mL | 0.5743 mL | 1.4356 mL | |
DMSO | 10 mM | 0.0287 mL | 0.1436 mL | 0.2871 mL | 0.7178 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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