101
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T80069 |
PACAP (6-27) (human, ovine, rat)
Pituitary adenylate cyclase-activating peptide (6-27) |
||
PACAP (6-27) (human, ovine, rat) 是一种对PACAP受体具有拮抗作用的化合物,可以抑制犬肾上腺对外源性VIP的反应。此化合物在心血管疾病和神经系统疾病研究中展现出应用潜力。 | |||
TP1054 |
PACAP (1-38), human, ovine, rat TFA
Pituitary Adenylate Cyclase Activating Polypeptide 38 (TFA) |
||
PACAP (1-38), a novel neuropeptide isolated from the bovine hypothalamus is more active than vasoactive intestinal peptide (VIP) in stimulating adenylate cyclase (EC50=7 nM). PACAP 1-38 (10-9 M) increased substance P (SP), gastrin releasing peptide (GRP), | |||
TP1878 |
PACAP (1-38), human, ovine, rat
Pituitary Adenylate Cyclase Activating Polypeptide 38,腺苷酸环化酶激活肽-38(抗原),PACAP 1-38 |
PACAP | GPCR/G Protein |
PACAP (1-38), human, ovine, rat (Pituitary Adenylate Cyclase Activating Polypeptide 38) 是含有 38 个氨基酸残基的神经肽。它能够结合 PACAP I 型受体(IC50:4 nM)、PACAP II 型受体 VIP1(IC50:2 nM)、PACAP II 型受体 VIP2(IC50:1 nM)。 | |||
T8359 |
Lanreotide acetate
Lanreotide acetate (108736-35-2 free base),BIM 23014 (acetate),BIM 23014 acetate |
Others | Others |
Lanreotide acetate (BIM 23014 acetate) 是生长抑素类似物,具有抗肿瘤活性,可用于类癌综合症。 | |||
T2568L |
Felypressin acetate
2-(L-Phenylalanine)-8-L-lysinevasopressin,醋酸苯赖加压素,PLV2. H-Cys-Phe-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bond),PLV 2,PLV-2 |
Vasopressin Receptor | GPCR/G Protein |
Felypressin acetate (PLV-2) 是加压素 1 的激动剂,作用于所有精氨酸加压素受体 1AS。 Felypressin acetate 可用于牙科手术。 | |||
T2568 |
Felypressin
Octapressin,Felypressin Acetate,PLV-2,H-[Cys-Phe-Phe-Gln-Asn-Cys]-Pro-Lys-Gly-NH2,苯赖加压素 |
Vasopressin Receptor | GPCR/G Protein |
Felypressin (Octapressin) 是一种加压素 1 激动剂,也是血管收缩剂,可用于牙科手术中。 | |||
T20332L |
Bam 12P acetate
Bam 12P acetate(75513-71-2 Free base) |
Endogenous Metabolite | Metabolism |
Bam 12P acetate 是牛肾上腺、垂体和下丘脑中推定的脑啡肽前体。 | |||
TP1144L |
Corticotropin-releasing factor (human) acetate
Corticotropin-releasing factor (human) acetate (86784-80-7 Free base) |
CRFR | GPCR/G Protein |
Corticotropin-releasing factor (human) acetate 刺激垂体前叶合成和分泌促肾上腺皮质激素。 | |||
T9380L |
Antide acetate
安替肽,Antide acetate (112568-12-4 Free base) |
LHRH | Endocrinology/Hormones |
Antide acetate 是一种 LHRH 拮抗剂,可抑制垂体释放 LH 和 FSH。 | |||
TP1022 |
Protirelin Acetate
TSH-RF Acetate,TRH Acetate,TRF Acetate,醋酸普罗瑞林 |
Thyroid hormone receptor(THR); Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Protirelin Acetate (TRH Acetate) 是高度保守的神经肽,具有促甲状腺激素水平的激素控制作用,及神经调节的能力。 | |||
T0293 |
Metyrapone
美替拉酮,甲吡酮,NSC-25265,Su-4885 |
Others; P450; Dehydrogenase; Autophagy | Autophagy; Metabolism; Others |
Metyrapone (NSC-25265) 是 STEROID 11-BETA-MONOOXYGENASE 酶抑制剂。 它被用作库欣综合征诊断中下丘脑-垂体反馈机制的测试。 | |||
TP1648L |
[Gln8]-C517 (LH-RH), chicken acetate
[Gln8]-C517 (LH-RH), chicken acetate(47922-48-5 free base) |
Others | Others |
[Gln8]-C517 (LH-RH), chicken acetate(47922-48-5 free base) 是一种鸟类下丘脑肽,可刺激垂体前叶释放促性腺激素,从而调节生殖功能。 | |||
T21511L |
alpha-Endorphin acetate
α-内啡肽,alpha-Endorphin acetate (59004-96-5 Free base) |
Others | Others |
alpha-Endorphin acetate 是具有特征生物活性的原阿片黑皮质素家族的相关肽,从单个人类垂体中纯化至同质。 | |||
TP1238L |
ACTH 1-14 acetate(25696-21-3 free base)
Adrenocorticotropic Hormone Fragment 1-14 acetate |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
ACTH 1-14 acetate(25696-21-3 free base) (Adrenocorticotropic Hormone Fragment 1-14 acetate) 是促肾上腺皮质激素的片段,可调节皮质醇和雄激素的产生。促肾上腺皮质激素 (ACTH),也称为促肾上腺皮质激素,由垂体前叶产生和分泌。作为对生物应激的反应,ACTH 是下丘脑-垂体-肾上腺轴的重要组成部分。 | |||
TP1240 |
Adrenocorticotropic Hormone (ACTH) (18-39), human TFA
CLIP (human) (TFA) |
Others | Others |
Adrenocorticotropic Hormone (ACTH) (18-39), human TFA (CLIP human TFA) 是一种似皮质促素中叶肽,由垂体中叶的促黑素细胞产生。 | |||
T21410 |
Triptorelin acetate(57773-63-4 free base)
醋酸曲普瑞林,Wy 42422,Triptorelin Acetate,CL 118532,AY 25650,CL 118,532,Wy 42462,BIM 21003 |
GNRH Receptor | GPCR/G Protein |
Triptorelin acetate(57773-63-4 free base) (CL 118,532) 用作 GnRH 激动剂。它通过引起垂体的持续刺激来减少垂体促性腺激素促黄体激素 (LH) 和促卵泡激素 (FSH) 的分泌。曲普瑞林可用于治疗激素反应性癌症,如乳腺癌或前列腺癌、性早熟、雌激素依赖性疾病和辅助生殖。 | |||
T5520L |
Cetrorelix diacetate
NS-75A,醋酸西曲瑞克,SB-075 acetate,SB-075 diacetate,Cetrorelix acetate,NS-75A diacetate |
GNRH Receptor | GPCR/G Protein |
Cetrorelix diacetate (NS-75A) 是GnRH 受体的强效拮抗剂(IC50:1.21 nM)。 | |||
TP1155L |
Human growth hormone-releasing factor acetate
|
GHSR | GPCR/G Protein |
Human growth hormone-releasing factor acetate 是一种下丘脑多肽,通过与垂体前叶细胞上的 GHRH 受体 (GHRHR) 结合来刺激 GH 的产生和释放。 | |||
TP1448L |
Astressin acetate
Astressin acetate (170809-51-5 Free base) |
CRFR | GPCR/G Protein |
Astressin acetate 是促肾上腺皮质激素释放因子 (CRF) 的拮抗剂,对 CRF 结合蛋白具有低亲和力,对克隆垂体受体具有高亲和力 (Ki = 2 nM)。 | |||
TP1112L |
LH-RH, salmon acetate(86073-88-3 free base)
Luteinizing Hormone Releasing Hormone (LH-RH), salmon acetate |
Others | Others |
LH-RH, salmon acetate(86073-88-3 free base) (Luteinizing Hormone Releasing Hormone (LH-RH), salmon acetate) 是一种在下丘脑中合成的垂体激素,在控制生殖功能中起着至关重要的作用。 | |||
T9857 |
Vasopressin
antidiuretic hormone (ADH),argipressin,arginine vasopressin (AVP) |
Endogenous Metabolite | Metabolism |
Vasopressin (argipressin) 是一种由下丘脑神经元合成的环状九肽,是肽原激素合成中的一种激素。Vasopressin 参与下丘脑-垂体-肾上腺轴调节过程,增加无溶质水从肾小管的滤液中重新吸收回循环中的量,收缩小动脉提高压强,增强促肾上腺皮质激素释放因子的刺激作用调节垂体促肾上腺皮质激素分泌。Vasopressin 在神经传导过程中可作为神经递质,与特定的 G 蛋白偶联受体结合发挥作用。 | |||
T78105 |
PAC1R antagonist 1
|
PACAP | GPCR/G Protein |
PAC1R antagonist 1为一种具有口服活性的 PAC1 受体拮抗剂,可抑制由垂体腺苷酸环化酶激活多肽(PACAP)及神经损伤所诱导的异常性疼痛,可用于研究肿瘤和与免疫相关的疾病。 | |||
TP1878L |
PACAP 1-38 acetate
|
PACAP | GPCR/G Protein |
PACAP 1-38 acetate 是一种垂体腺苷酸环化酶激活多肽 (PACAP) 类似物。它与 PACAP I 型受体 (IC50 = 4 nM) 和 PACAP II 型 VIP2 受体 (IC50 = 1 nM) 结合,但不与 PACAP II 型 VIP1 受体结合。 | |||
T1167 |
Cyproterone acetate
Androcur,醋酸环丙氯地孕酮,Cyproterone 17-O-acetate,醋酸环丙孕酮 |
Androgen Receptor | Endocrinology/Hormones |
Cyproterone acetate (Cyproterone 17-O-acetate) 是能够抗雄激素(IC50=7.1 nM) 和孕激素合成的类固醇。它与 progesteron 和糖皮质激素受体有亲和力。 | |||
T21309 |
Nafarelin acetate(76932-56-4 free base)
RS-94991-298,醋酸萘法瑞林,Nafarelin acetate,Nafarelin acetate hydrate,Synarel |
GNRH Receptor | GPCR/G Protein |
Nafarelin acetate(76932-56-4 free base) (RS-94991-298) 是一种 GnRH 激动剂,可作为 GnRH 的类似物。 Nafarelin acetate(76932-56-4 free base) 导致促性腺激素促黄体激素 (LH) 和促卵泡激素 (FSH) 的垂体分泌减少。它可用于治疗雌激素依赖性病症。 | |||
TP1002L |
γ-1-MSH, amide acetate (72629-65-3 free base)
γ-1-MSH, amide acetate |
Others | Others |
γ-1-MSH, amide acetate (72629-65-3 free base) 是 ACTH/β-内啡肽 (β-EP) 前体蛋白 N 末端区域的一种推定激素,RIA 使用抗 γ-3-MSH 抗血清对产生 ACTH 的小鼠进行了研究垂体肿瘤细胞,AtT-20/D16v。 | |||
TP2107L |
Histrelin acetate
Histrelin acetate(76712-82-8 free base),醋酸组氨瑞林 |
GNRH Receptor | GPCR/G Protein |
Histrelin acetate 是促性腺激素释放激素 (GnRH) 的九肽类似物,具有增加的效力。当存在于血流中时,它作用于称为促性腺激素的垂体特定细胞。 Histrelin 刺激这些细胞释放促黄体激素和促卵泡激素。因此,它被认为是促性腺激素释放激素激动剂或 GnRH 激动剂。 | |||
T3630 |
Relugolix
RVT-601,瑞卢戈利,TAK-385 |
GNRH Receptor | GPCR/G Protein |
Relugolix (RVT-601) 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比,它对人和猴子的受体具有高亲和力和强拮抗活性,它们的 IC50值分别为0.33 nM 和0.32 nM。它可用于研究性激素依赖性疾病,如子宫肌瘤、子宫内膜异位症、前列腺癌等。 | |||
T28094 | MR2034 | ||
MR2034 is an agonist of kappa-Opioid receptor. MR2034 stimulates hypothalamic-pituitary-adrenal axis. | |||
T19511 |
PGlu-3-methyl-His-Pro-NH2 TFA
A-42872 TFA |
Others | Others |
PGlu-3-methyl-His-Pro-NH2 TFA, enhances binding to pituitary TRH receptors and increases stimulation of thyroid-stimulating hormone (TSH) release from the pituitary. | |||
T5015L2 |
Gonadorelin HCl
Factrel,AY-24,031,AY24,031,AY 24,031,LH-RH hydrochloride,Gonadorelin hydrochloride |
||
Gonadorelin HCl, as a decapeptide, can stimulate the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE, and FOLLICLE STIMULATING HORMONE. | |||
T71590 | AHR-5645B fumarate | ||
AHR-5645B fumarate is a substituted benzamide that has been shown to inhibit 3H-spiperone binding to bovine anterior pituitary membranes. | |||
T69174 | AHR-5645B free base | ||
AHR-5645B free base is a substituted benzamide which has been shown to inhibit 3H-spiperone binding to bovine anterior pituitary membranes. | |||
T40491 |
Luteinizing hormone (human)
|
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Luteinizing hormone (LH), a heterodimeric glycoprotein hormone synthesized by the pituitary gland, serves vital functions in human reproductive processes. | |||
T37111 |
Corticotropin-releasing factor (human) (acetate)
|
||
Human CRF acetate is a chemical compound that effectively stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary. | |||
T0293L |
Metyrapone Tartrate
SU 4885,Metopirone tartrate,SU-4885,SU4885 |
||
Metyrapone Tartrate is an inhibitor of the STEROID 11-beta-monooxygenase enzyme which is used as a test for feedback hypothalamic-pituitary mechanism in the diagnosis of Cushing SYNDROME. | |||
TP2420 |
Veldoreotide
DG 3173,DG3173,PTR 3173,DG-3173,Somatoprim |
||
Veldoreotide, also known as Somatoprim, is a unique somatostatin receptor subtypes 2-, 4- and 5-selective analogue which effectively reduces GH secretion in human GH-secreting pituitary adenomas, even in Octreotide non-responsive tumours. | |||
T37694 |
N-Acetyloxytocin
|
||
N-Acetyloxytocin, a chemical compound, has been identified and analyzed in the neurointermediate lobe of the rat pituitary (NIL). Furthermore, its presence has also been detected in various brain regions of the rat[1]. | |||
T68551 |
Cabergoline diphosphate
|
||
Cabergoline diphosphate is a dopamine D2 receptor agonist used for prolactinoma treatment. Cabergoline permits rapid and effective hormonal and tumor control by normalizing prolactin-producing pituitary adenomas levels. | |||
TP1247 |
ACTH (1-13)
Adrenocorticotropic Hormone (1-13),ACTH 1-13 |
||
ACTH (1-13) is a 13-aa peptide, with cytoprotective effects in the model of ethanol induced gastric lesions in rats.Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the anterior pituitary gland. ACTH is an impor | |||
T37435 | PACAP-related Peptide (rat) (trifluoroacetate salt) | PACAP | GPCR/G Protein |
PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in rat hypothalamus as well as within the nerves of the median eminence, the anterior pituitary, bed nucleus of the stria terminalis, cerebellum, cerebral cortex, and amygdala. PRP is also expressed in vaginal, uterine cervica... | |||
TP1112 |
Luteinizing Hormone Releasing Hormone (LH-RH), salmon
LH-RH, salmon |
||
Luteinizing Hormone Releasing Hormone (LH-RH) is a pituitary Hormone synthesized in the hypothalamus and plays a crucial role in the control of reproductive function. | |||
T64270 | Lutropin | ||
Lutropin 是一种异二聚体糖蛋白,是一种由垂体前叶促性腺细胞产生的激素,对卵泡的发育具有刺激作用。Lutropin 能够用于研究不孕症。 | |||
TP1648 |
[Gln8]-C517 (LH-RH), chicken
|
||
[Gln8] Luteinizing hormone releasing hormone ([Gln8] LH-RH), Avian hypothalamic peptide that stimulates release of gonadotropins from anterior pituitary, thus regulating reproductive functions. | |||
T78515 |
Follicle-stimulating hormone
|
Others | Others |
卵泡刺激素(Follicle-stimulating hormone, FSH)为一种由垂体前叶分泌的异二聚体糖蛋白,其参与调控动物的生殖能力与繁殖效率。 | |||
T71149 | Triptorelin pamoate | ||
Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, es... | |||
T70309 | Dicetrorelix pamoate | ||
Dicetrorelix pamoate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently lutein... | |||
T41179 |
CL 82198 hydrochloride
|
||
CL 82198 hydrochloride is a selective inhibitor of MMP-13 (89% inhibition at 10μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibitsin vitroinvasion by the human pituitary adenoma cell line HP75. Rescues paclitaxel induced axon degradation and reduces associated neurotoxicity in zebrafish. | |||
T73664 |
Adrenocorticotropic hormone TFA
|
||
Adrenocorticotropic hormone (ACTH) TFA,是由垂体前叶分泌,用于调节皮质醇和雄激素产生的促肾上腺皮质激素。 | |||
TP1144 |
Corticotropin-releasing factor (human)
Human corticotropin-releasing factor,Human CRF,Corticotropin-releasing factor human |
||
Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) is an immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla. Functions b |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0419 |
Testosterone propionate
|
Others; Androgen Receptor; Transferase | Endocrinology/Hormones; Metabolism; Others |
Testosterone Propionate is a short acting oil-based injectable formulation of testosterone. Testosterone inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels. | |||
T2S2108 |
Coixol
薏苡素,6-methoxybenzoxazolone,6-MBOA,6-Methoxy-2-benzoxazolinone,MBOA |
Others; Antibacterial | Microbiology/Virology; Others |
Coixol (MBOA) 是一种从薏苡仁中提取的多酚,有抗菌和抗肿瘤作用。 | |||
T14853 |
Cabergoline
FCE-21336,卡麦角林 |
Dopamine Receptor; 5-HT Receptor; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Cabergoline (FCE-21336) 是一种麦角衍生的多巴胺 D2亚类受体激动剂,高亲和力作用于D2、D3和5-HT2B 受体,Ki 分别为 0.7、1.5 和 1.2。 | |||
T3S0860 |
Gitogenin
|
UGT | Metabolism |
Gitogenin 是一种从Tribulus longipetalus 整株中分离出来的天然类固醇,是一种 UDP-葡萄糖醛酸转移酶 1A4 (UGT1A4) 和 α-葡萄糖苷酶的选择性抑制剂,其IC50分别为 0.69 µM (使用三氟拉嗪为底物) 和 37.2 μM,对人类主要细胞色素 P450 亚型的活性无抑制作用。 | |||
T40458 |
3-Keto petromyzonol
|
||
3-Keto petromyzonol, a key constituent of Sea lamprey male sex pheromones, governs the synthesis and release of gonadotropin releasing hormone (GnRH). This in turn regulates the hypothalamic-pituitary-gonadal (HPG) output in immature sea lamprey. |