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62

抑制剂 & 化合物

39

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T40863	Bisdionin C	Antibacterial	Microbiology/Virology
	Bisdionin C 是一种有效的 GH18 chitinase 抑制剂，对 A. fumigatus ChiB1 的 IC50 为 0.2 μM。 Bisdionin C 抑制人巨噬细胞壳三糖苷酶 (HCHT, IC50 = 8.3 μM) 和酸性哺乳动物几丁质酶 (AMCase, IC50 = 3.4 μM)。
T20237	Fenhexamid Elevate,Teldor,环酰菌胺	Antifungal	Microbiology/Virology
	Fenhexamid (Elevate) 是一种甾醇生物合成抑制剂，对植物病原真菌具有抗真菌活性。 Fenhexamid 用于农业，并在水果和蔬菜中以可测量的量存在。
T9508	MONOCAPRYLIN Sefsol 318,Glyceryl monocaprylate,辛酸甘油酯	Antibacterial	Microbiology/Virology
	Monocaprylin (Sefsol 318) 是一种辛酸甘油单辛酸酯，有出色的抗菌活性，可抑制多种食源性致病和腐败微生物，有用于替代食品防腐剂的研究潜力。
T7897	PK150	Others; Antibacterial	Microbiology/Virology; Others
	PK150 是一种 Sorafenib 类似物，具有抗菌活性。它抑制甲氧西林敏感金黄色葡萄球菌，耐甲氧西林金黄色葡萄球菌，万古霉素中介金黄色葡萄球菌的 MIC 分别为 0.3，0.3-1，0.3 µM。
T9208	1,3,6,8-Tetrahydroxynaphthalene T4HN,1,3,6,8-THN,naphthalene-1,3,6,8-tetrol	Others	Others
	1,3,6,8-Tetrahydroxynaphthalene (T4HN) 是一种独特的对称聚酮起源化合物，是 DHN 黑色素不可缺少的前体。
T9231	Mbx2329	Antiviral	Immunology/Inflammation
	MBX2329 是一种流感病毒抑制剂，能特异性地抑制血凝素介导的病毒进入，HIV/HA(H5) 的 IC90值为8.6 μM。它能够有效地抑制多种甲型流感病毒。
TP1309	Gastric mucin	Antibacterial; Antibiotic	Microbiology/Virology
	Gastric mucin 是一种能保护胃肠道免受酸、蛋白酶、致病微生物和机械创伤影响的糖蛋白。
T37069	Pyribencarb 吡菌苯威,ZINC43065336	Antifungal	Microbiology/Virology
	Pyribencarb ()，一种苯甲酰胺类杀菌剂，针对多种植物病原真菌展现出广谱活性。作为细胞色素b的强效Qo抑制剂，Pyribencarb 对灰霉病菌（Botrytis cinerea）和菌核病菌（Sclerotinia sclerotiorum）特别有效。
T27617	Inz-1	P450	Metabolism
	Inz-1 是一种有效的真菌特异性线粒体细胞色素 bc1 抑制剂，对酵母和人类的 IC50 分别为 8.092 和 45.320 μM。 Inz-1 可逆转氟康唑或其他三唑类抗真菌药对致病性真菌白色念珠菌的耐药性。
T63059	CRK12-IN-1	Antibiotic	Microbiology/Virology
	CRK12-IN-1 是一种有效的CRK12抑制剂。CRK12-IN-1具有杀虫活性，对布氏锥虫 (T.b. brucei) 和刚果锥虫 (T. congolense) 具有抑制作用EC50分别为1.3和18 nM。CRK12-IN-1能迅速杀死病原细胞。
T39057	Rozanolixizumab UCB7665	Others	Others
	Rozanolixizumab（RYSTIGGO）是一种针对人类新生儿 Fc 受体（FcRn）的高亲和力人源化免疫球蛋白 G4 单克隆抗体，用于研究自身免疫和同种免疫疾病中致病性 IgG 。
T74756	SDH-IN-2	Antifungal	Microbiology/Virology
	SDH-IN-2 是一种有效的琥珀酸脱氢酶 (SDH) 抑制剂，IC50 为 0.55 μg/mL。SDH-IN-2 具有抗真菌活性，抑制植物病原真菌的平均 EC50 值为 3.82-9.81 μg/mL
T27300	Olorofim Olorofim,F901318,F-901318
	Olorofim 是一种新型的选择性抗真菌化合物，对烟曲霉DHODH 具有抑制作用（IC50：44 nM），对人类DHODH 几乎没有抑制作用（>100 uM）。Olorofim 对青霉菌属、皮炎杆菌属、镰刀菌属等各种致病性丝状和二形真菌有很好的疗效。
TP1120L	IRBP acetate(211426-18-5 free base) Interphotoreceptor Retinoid Binding Protein Fragment IRBP	Others	Others
	IRBP acetate(211426-18-5 free base) (Interphotoreceptor Retinoid Binding Protein Fragment IRBP) 是一种含有 20 个残基的肽，是一种主要的致病表位。它存在于间质视觉色素结合蛋白肽（IRBP 161-180）的第一个同源重复序列中，可诱导葡萄膜炎后（EAU）。
T75129	Luxdegalutamide ARV-766	Androgen Receptor; PROTACs	Endocrinology/Hormones; PROTAC
	Luxdegalutamide (ARV-766) 是一种可口服且有效的蛋白水解靶向嵌合体 (PROTAC) 的蛋白质降解剂。Luxdegalutamide降解野生型雄激素受体 AR，也降解包括最普遍的致病性 AR L702H、H875Y 和 T878A 突变相关的 AR LBD 突变体。
T66518	BODIPY-FL BDP FL acid
	BODIPY-FL (BDP FL acid) 是一种广谱且有效的荧光染料，可用于标记探针或引物，是一种基于荧光猝灭的定量检测特定 DNA/RNA 的化合物。BODIPY-FL 标记的单萜可用于检测革兰氏阳性和革兰氏阴性细菌的特征和致病真菌。
T63321	20S Proteasome activator 1	Proteasome	Proteases/Proteasome; Ubiquitination
	20S Proteasome activator 1 是一种 20S 蛋白酶激活剂，对胰蛋白酶样位点、胰凝乳蛋白酶样位点和半胱天冬酶位点的 IC50 分别为 0.3 μM、0.7 μM 和 1.8 μM。20S Proteasome activator 1 通过在细胞系统中翻译来防止致病性 α-synuclein A53T 突变体积累从而减少疾病发生的概率。20S Proteasome activator 1 可用于研究神经退行性疾病。
T34350	Ro 15-0216 Ro-15-0216,Ro15-0216
	RO 15-0216, a nitroimidazole compound, is active against human and animal pathogenic trypanosoma africanum in vitro.
T29175	YKAs3003 YKAs-3003
	YKAs3003, a potent inhibitor of pathogenic KAS III, displays minimal inhibitory concentration (MIC) values in the range 128-256 microg/mL against various bacteria.
T24371	L458-BPyne L458 BPyne,L458BPyne
	L458-BPyne is a γ-secretase modulator photoaffinity probe that acts by identifying distinct allosteric binding sites on presenilin. It also can be exploited to reduce levels of pathogenic Aβ species.
T24683	Pterophyllin 2 Pterophyllin-2,Pterophyllin2
	Pterophyllin 2 is an agent of natural antifungal. It also against postharvest fruit pathogenic fungi.
T20748	Furametpyr Limber
	Furametpyr is a kind of low toxicity pesticides used to control plant diseases caused by various pathogenic microorganisms.
T71647	Rustmicin
	Rustmicin is a 14-membered macrolide identified as an inhibitor of plant pathogenic fungi.
T37868	9-OxoOTrE
	9-OxoOTrE is produced by the oxidation of 9-HpOTrE. 9-OxoOTrE exhibits antimicrobial activity against plant pathogenic microorganisms including bacteria and fungi.
T71856	FA-613
	FA-613 is a pyrimidine synthesis inhibitor which exhibits low micromolar antiviral activity against various influenza A and B virus strains, including the highly pathogenic influenza A strains H5N1 and H7N9, enterovirus A71, respiratory syncytial virus, human rhinovirus A, SARS- and MERS-coronavirus.
T71446	Kalafungin
	Kalafungin antimicrobial agent that is inhibitory in vitro against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria, and, to a lesser extent, gram-negative bacteria.
T11743	Kanosamine hydrochloride	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Kanosamine hydrochloride is an antibiotic which inhibits the growth of plant-pathogenic oomycetes, certain fungi and a few bacterial species. Kanosamine inhibits Phytophthora medicaginis M2913 and Aphanomyces euteiches WI-98 with MICs of 25 and 60 μg/mL, respectively.
T24720	RO-57-Bpyne RO57Bpyne
	RO-57-Bpyne is a γ-secretase modulator photoaffinity probe. It also can be exploited to reduce levels of pathogenic Aβ species. It acts by identifying distinct allosteric binding sites on presenilin.
T6105	Phosphorylcholine chloride phosphorylcholine,磷酸胆碱,Phosphocholine chloride	Others	Others
	Phosphorylcholine chloride 是一种构成细胞膜外层结构卵磷脂的组分，血液相容性较好。
T78883	DprE1-IN-9
	DprE1-IN-9（compound B18）是一款高效的可逆DprE1抑制剂，能够结合至DprE1的受体腔。该化合物对分枝杆菌表现出显著的抗菌活性，作用于非致病性菌株H37Ra（MIC=0.18 µg/mL）及致病性H37Rv菌株，并对多重耐药（MDR）和极度耐药（XDR）的临床分离株同样有效。
T36431	7,10-dihydroxy-8(E)-Octadecenoic Acid
	7,10-dihydroxy-8(E)-Octadecenoic acid is a hydroxy fatty acid and metabolite of oleic acid that is produced byP. aeruginosafrom vegetable oils.1It is active against the food-borne pathogenic bacteriaS. aureus,S. typhimurium,L. monocytogenes,B. subtilis, andE. coli(MIC50s = 31.3, 125, 125, 62.5, and 250 μg/ml, respectively), as well as the plant pathogenic bacteriaErwinia,R. solanacearum,C. glutamicum, andP. syringae(MIC90s = 125, 125, 250, and 500 μg/ml, respectively).2,1 1.Sohn, H.-R., Bae, J.-...
TP1120	Interphotoreceptor Retinoid Binding Protein Fragment (IRBP) IRBP,Interphotoreceptor Retinoid Binding Protein Fragment IRBP
	Interphotoreceptor Retinoid Binding Protein Fragment (IRBP) is a 20-residue peptide, which is a major pathogenic epitope. It exists in the first homologous repeat of interstitial visual pigment Binding Protein peptide (IRBP 161-180) and can induce post-uv
T75288	Tebipenem pivoxil hydrochloride
	Tebipenem pivoxil (L084) hydrochloride 是具口服活性、对多种致病菌有效的抗生素。通过结合青霉素结合蛋白 (PBP) 抑制细胞壁合成。
T74392	Antimicrobial photosensitizer-1
	Antimicrobial photosensitizer-1 为抗病原微生物感染的潜在光敏剂，其在金黄色葡萄球菌感染小鼠伤口模型中显示出显著的抗菌活性。
T74537	Antifungal agent 26
	Antifungal agent 26, a derivative of gramicidin A, exhibits antifungal, antiviral, and antiparasitic activities through binding with polysaccharides containing D-mannose (Man) in pathogens.
T76623	(Gln22)-Amyloid β-Protein (1-42)
	'(Gln22)-Amyloid β-Protein (1-42)'，为β-Amyloid (1-42) 的Dutch突变（E22Q）形式，显示出提升的纤维原性及致病性。
T68907	Flutolanil
	Flutolanil is a benzanilide fungicide. It is active against a panel of 241 field isolates of the plant pathogenic fungus R. solani when grown in flutolanil-enriched growth media. Flutolanil inhibits R. solani hyphal growth and infection cushion formation on rice plant leaf sheaths. It is toxic to zebrafish embryos, larvae, and adults. Formulations containing flutolanil have been used to control fungal infections on rice crops.
T76107	Urease
	Urease 由多种类型细菌产生，是一些致病菌的有效毒力因子。Urease 还是幽门螺杆菌代谢和毒力的中心，帮助其在胃粘膜中定植。
T72002	Carbazomycin C
	Carbazomycin C is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities. It is active against S. aureus, B. anthracis, B. subtilis, and M. flavus, the fungi T. asteroides and T. mentagrophytes, and P. falciparum. It is also active against a panel of five plant pathogenic fungi. Carbazomycin C is cytotoxic to MCF-7, KB, and NCI H187 cells. It also inhibits 5-lipoxygenase (5-LO) activity in RBL-1 cell extracts.
T36048	Linearmycin A
	Linearmycin A is a polyene antibiotic that has been found inStreptomyces.1It is active against the bacteriaS. aureusandE. coli(MICs = 3.1 and 1.6 μg/disc, respectively), the fungiS. cerevisiaeandC. albicans(MICs = 0.1 and 1.6 μg/disc, respectively), and the plant pathogenic fungusA. nigerin disc assays (MIC = 0.2 μg/disc). Linearmycin A induces lysis and degradation ofB. subtilisas a component ofStreptomycesMg1 extract.2 1.Sakuda, S., Guce-Bigol, U., Itoh, M., et al.Novel linear polyene antibiot...
T27038	CL385319 HCl CL-385319,CL385319 hydrochloride,CL 385319,CL385319
	CL385319 is a potent inhibitor of H5N1 avian influenza A virus infection by blocking viral entry. CL-385319 is effective in inhibiting infection of highly pathogenic H5N1 influenza A virus in Madin-Darby Canine Kidney (MDCK) cells with an IC50 of 27.03±2.
T80321	The K4 peptide
	K4 peptide 是一种抗菌肽，对革兰氏阳性细菌和革兰氏阴性细菌均显示出显著活性，能够有效作用于包括金黄色葡萄球菌和弧菌属海洋细菌在内的多种人类致病菌。
T37536	Carbazomycin A
	Carbazomycin A is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1,2It is active againstS. aureus,T. asteroides, andT. mentagrophytes(MIC = 12.5 μg/ml for all), as well as the plant pathogenic fungusP. oryzae(MIC = 25 μg/ml). Carbazomycin A is cytotoxic to MCF-7, KB, NCI H187, and Vero cells (IC50s = 26.2, 30.1, 18.4, and 32.6 μg/ml, respectively).2 1.Sakano, K.-I., Ishimaru, K., and Nakamura, S.New antibiotics, carbazomycins A and B. I. Fermenta...
T60756	NLRP3 antagonist 1
	NLRP3 antagonist 1 具有癌症疾病的研究潜力，是NLRP3的有效拮抗剂。NLRP3 参与机体对应激损伤和病原体感染的内在免疫，主要表达在巨噬细胞和中性粒细胞。
T75642	Corydalmine hydrochloride
	Corydalmine hydrochloride 抑制某些植物病原体的孢子萌发以及腐生真菌。Corydalmine hydrochloride 具有口服活性，可用于缓解疼痛的研究。Corydalmine hydrochloride 通过抑制 NF-κB 依赖性的 CXCL1/CXCR2信号传导途径，可缓解 Vincristine 引起的神经性疼痛。
T37750	Benanomicin B (formate)
	Benanomicin B is a microbial metabolite that has been found inActinomycetesand has antifungal, fungicidal, and antiviral activities.1,2It is active against a variety of mammalian and plant pathogenic fungi, includingC. albicans,T. mentagrophytes,C. neoformans, andP. oryzae(MICs = 1.56-50 μg/ml).1Benanomicin B inhibits HIV-1 viral infection in MT-4 cells in a concentration-dependent manner.2 1.Takeuchi, T., Hara, T., Naganawa, H., et al.New antifungal antibiotics, benanomicins A and B from an act...
T37749	Benanomicin A
	Benanomicin A is a microbial metabolite that has been found inActinomycetesand has antifungal, fungicidal, and antiviral activities.1,2It is active against a variety of mammalian and plant pathogenic fungi, includingC. albicans,T. mentagrophytes,C. neoformans,P. oryzae, andA. niger(MICs = 3.13-50 μg/ml).1Benanomicin A inhibits HIV-1 viral infection in MT-4 cells in a concentration-dependent manner.2 1.Takeuchi, T., Hara, T., Naganawa, H., et al.New antifungal antibiotics, benanomicins A and B fr...
T79467	Antifungal agent 60
	Antifungalagent 60（compound 16）是一种抑制麦角甾醇生物合成的广谱抗真菌剂。它能够有效抑制包括7种人类致病真菌、2种耐氟康唑的白色念珠菌分离株以及2种多重耐药的耳念珠菌分离株。
T62098	Antifungal agent 28
	Antifungal agent 28 (化合物 18) 是一种选择性的、有效的抗真菌剂。Antifungal agent 28 可以破坏成熟念珠菌生物膜，能够抑制白念珠菌和非白念珠菌的致病性菌株，包括耐氟康唑菌株。Antifungal agent 28 对隐球菌和曲霉菌株也具有抑制作用。
T79413	Antifungal agent 73
	Antifungalagent 73 (compound A32)是一款用于治疗唑类耐药Candida感染的抗真菌药物。该化合物通过破坏真菌的细胞壁和细胞膜来发挥作用，并且针对病原真菌和氟康唑(Fluconazole)耐药菌株显示出有效的体内抗真菌活性。

化合物

Cat.No: T40863

Target: Antibacterial

Cat.No: T20237

Synonym: Elevate,Teldor,环酰菌胺

Target: Antifungal

Cat.No: T9508

Synonym: Sefsol 318,Glyceryl monocaprylate,辛酸甘油酯

Target: Antibacterial

Cat.No: T7897

Target: Others, Antibacterial

1,3,6,8-Tetrahydroxynaphthalene

Cat.No: T9208

Synonym: T4HN,1,3,6,8-THN,naphthalene-1,3,6,8-tetrol

Target: Others

Cat.No: T9231

Target: Antiviral

Cat.No: TP1309

Target: Antibacterial, Antibiotic

Cat.No: T37069

Synonym: 吡菌苯威,ZINC43065336

Target: Antifungal

Cat.No: T27617

Target: P450

Cat.No: T63059

Target: Antibiotic

Rozanolixizumab

Cat.No: T39057

Synonym: UCB7665

Target: Others

Cat.No: T74756

Target: Antifungal

Cat.No: T27300

Synonym: Olorofim,F901318,F-901318

IRBP acetate(211426-18-5 free base)

Cat.No: TP1120L

Synonym: Interphotoreceptor Retinoid Binding Protein Fragment IRBP

Target: Others

Luxdegalutamide

Cat.No: T75129

Synonym: ARV-766

Target: Androgen Receptor, PROTACs

Cat.No: T66518

Synonym: BDP FL acid

20S Proteasome activator 1

Cat.No: T63321

Target: Proteasome

Cat.No: T34350

Synonym: Ro-15-0216,Ro15-0216

Cat.No: T29175

Synonym: YKAs-3003

Cat.No: T24371

Synonym: L458 BPyne,L458BPyne

Cat.No: T24683

Synonym: Pterophyllin-2,Pterophyllin2

Cat.No: T20748

Synonym: Limber

Cat.No: T71647

Cat.No: T37868

Cat.No: T71856

Cat.No: T71446

Kanosamine hydrochloride

Cat.No: T11743

Target: Akt

Cat.No: T24720

Synonym: RO57Bpyne

Phosphorylcholine chloride

Cat.No: T6105

Synonym: phosphorylcholine,磷酸胆碱,Phosphocholine chloride

Target: Others

Cat.No: T78883

7,10-dihydroxy-8(E)-Octadecenoic Acid

Cat.No: T36431

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP)

Cat.No: TP1120

Synonym: IRBP,Interphotoreceptor Retinoid Binding Protein Fragment IRBP

Tebipenem pivoxil hydrochloride

Cat.No: T75288

Antimicrobial photosensitizer-1

Cat.No: T74392

Antifungal agent 26

Cat.No: T74537

(Gln22)-Amyloid β-Protein (1-42)

Cat.No: T76623

Cat.No: T68907

Cat.No: T76107

Cat.No: T72002

Cat.No: T36048

Cat.No: T27038

Synonym: CL-385319,CL385319 hydrochloride,CL 385319,CL385319

Cat.No: T80321

Cat.No: T37536

NLRP3 antagonist 1

Cat.No: T60756

Corydalmine hydrochloride

Cat.No: T75642

Benanomicin B (formate)

Cat.No: T37750

Cat.No: T37749

Antifungal agent 60

Cat.No: T79467

Antifungal agent 28

Cat.No: T62098

Antifungal agent 73

Cat.No: T79413

Cat. No.	Product Name	Target	Signaling Pathways
TN2279	Totarol (+)-Totarol,桃柁酚	Antibacterial; Antifection	Microbiology/Virology
	Totarol ((+)-Totarol) 对几种致病性革兰氏阳性细菌、结核分枝杆菌具有抗菌作用。
T15001	Corypalmine	Others; Antifungal	Microbiology/Virology; Others
	Corypalmine 是一种来自黄连、紫瑾的生物碱，对植物病原孢子萌发和腐生真菌具有抑制作用。
T5S0993	Kurarinone 苦参酮,苦参黄素	BCL; Others; IκB/IKK; TNF; NF-κB; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; Others; Stem Cells
	Kurarinone 是从灌木苦参中提取的黄酮类化合物，具有抗肿瘤、雌激素和抗炎活性，对免疫反应也有很强的抑制作用。
T10065L	2',3'-cGAMP sodium 2'-3'-cyclic GMP-AMP sodium	STING; cGAS	Immunology/Inflammation
	2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) 是一种cGAMP 合成酶(cGAS)影响细胞质DNA 产生的第二信使，是一种跨膜衔接蛋白，是细胞对致病性细胞质DNA 的先天免疫反应的关键组成部分。
T3S0057	Dihydrochelerythrine 12,13-Dihydrochelerythrine,二氢白屈菜红碱	Antifungal	Microbiology/Virology
	Dihydrochelerythrine (12,13-Dihydrochelerythrine) 是一种从榕树叶片分离出的天然化合物，具有抗真菌活性，有潜力治疗多丝蚴引起的严重感染。
TN6993	Benzylideneacetone Benzalacetone	Phospholipase; Endogenous Metabolite	Metabolism
	Benzylideneacetone 是由昆虫致病细菌 Xenorhabdus nematophila 产生的单萜类化合物，是磷脂酶A2（PLA2）抑制剂，对类花生酸生物合成具有抑制作用，可增强小菜蛾木霉菌的杆状病毒致病性。
TQ0216	Ercalcitriol 1α,25-Dihydroxy Vitamin D2	Others	Others
	Ercalcitriol (1α,25-Dihydroxy Vitamin D2) 是维生素 D2 的活性代谢物。 Ercalcitriol 作为维生素 D 的生理活化形式，通过调节正常细胞和转化细胞中的导管素抗菌肽 (CAMP) 和防御素 β-4 (DEFB4) 基因来增强免疫力，从而对抗病原体感染。
TN2772	2-Methoxyanofinic acid	Antifection	Microbiology/Virology
	2-Methoxyanofinic acid is active against the plant pathogenic fungus Cladosporium cucumerinum.
T39261	Nyssoside
	Nyssoside, an ellagic acid derivative, exhibits notable antioxidant and antibacterial properties against a variety of pathogenic bacteria.
TN1344	8-Hydroxy-3,5,6,7,3',4'-hexamethoxyflavone	Antifection	Microbiology/Virology
	8-Hydroxy-3,5,6,7,3',4'-hexamethoxyflavone may have antifungal activity against phytopathogenic and human pathogenic fungi.
TN5680	Eriobofuran
	Eriobofuran, a phytoalexin, has antimicrobialactivity, it can inhibit strongly the spore germination and germ tube growth of Pestalotia funerea, a host-pathogenic fungus of loquat tree.
TN4328	Isosativenediol	Others	Others
	Isosativenediol is a natural product from the culture filtrates of a Bipolaris species pathogenic to Johnson grass.
TN5629	Averantin
	Averantin exhibits antifungal activity against Fusariumsolani, pathogenic fungus of P. notoginseng, with minimum inhibitory concentrations (MICs) of 16-32 ug/mL, and shows antibacterial activity against Bacillussubtilis with MICs of 16-32 ug/mL.
TN5061	Stephanine	Adrenergic Receptor; Antifection	GPCR/G Protein; Microbiology/Virology; Neuroscience
	l-Stephanine is a potent and highly selective alpha 1 adrenoceptor blocker, inhibits anococcygeus muscle contraction induced by phenylephrine with pA2 values of 6.76. Stephanine shows significant antiplasmodial activities with IC(50) ranged from 1.2 uM to 52.3 uM. Stephanine and crebanine have high inhibitory activity against gram-positive animal pathogenic bacteria, with MIC values of 0.078-0.312g/l, but low inhibitory activity against gram-negative animal pathogenic bacteria, they also inhibit...
T28379	PF-1163B PF1163B,(-)-PF1163B,PF 1163B
	PF-1163B is an antifungal agent form Penicillium sp. II. PF-1163B inhibits ergosterol (ERG) synthesis with IC50 value of 34 ng/ml. PF-1163B showed potent growth inhibitory activity against pathogenic fungal strain Candida albicans but did not show cytotox
TN1931	Methyllinderone	Antifection	Microbiology/Virology
	Methyllinderone is a human chymase inhibitor, it has antioxidant property, it also shows moderate to weak antifungal activities against various pathogenic fungi.
TN6010	Picrasidine S
	Picrasidine S shows the potent cytotoxicity against human HeLa cervical, gastric MKN-28, and mouse melanoma B-16 cancer cells, it also shows the potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus
TN4834	Protoplumericin A	Antifection	Microbiology/Virology
	Protoplumericin A displays distinct activity against some pathogenic bacteria and fungi.
TN1063	Calycanthine 蜡梅碱,腊梅碱	Antifection	Microbiology/Virology
	D-calycanthine has antifungal activity, it shows significant inhibitory activities against five plant pathogenic fungi Exserohilum turcicum, Bipolaris maydis, Alternaria solani, Sclerotinia sderotiorum, and Fusarium oxysportium.
T40600	Iturin A
	Iturin A is a chemical compound with potent antifungal properties against pathogenic yeast and fungi. It interacts with the cytoplasmic membrane of the target cell, leading to the formation of ion conducting pores.
T75456	Dendryphiellin D
	Dendryphiellin D，一种从Septoria rudbeckiae分离的化合物，后者为盐生植物Karelinia caspia中提取的植物病原真菌。该化合物显著抑制一氧化氮(NO)的生成。
T75457	Septeremophilane E
	Septeremophilane E, 从真菌 Septoria rudbeckiae 分离得到，该真菌是盐生植物 Karelinia caspia 的植物病原体。该化合物显著抑制一氧化氮(NO)的产生。
T11009	Destruxin B	Others	Others
	Destruxin B is a cyclic peptide with insecticidal and anticancer activity isolated from the insect pathogenic fungus Metarhizium isopliae. Destruxin B induces apoptosis of human non-small cell lung cancer cells through the Bcl-2 family-dependent mitochond
TN3461	Asebotin	Influenza Virus	Microbiology/Virology
	Asebotin shows anti-influenza A virus activity, it also possesses potent antiviral activity (100% inhibition at the concentration of 1 ug /mL) against highly pathogenic avian influenza strain H5N1. Asebotin can inhibit the proliferation of murine B cells.
T69058	OM173-αA
	OM173-αA is a quinone bacterial metabolite that inhibits the growth of the bacteria M. gallisepticum, M. pneumoniae, and S. aureus. OM173-αA also inhibits the growth of the plant pathogenic fungus P. oryzae and several species of Trichophyton.
T79942	Terpenomycin
	Terpenomycin是从Nocardia分离物中提取的一种多烯化合物，具有细胞毒性和抗真菌活性。
T35741	Gliovirin
	Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decrease...
TN1842	Kushenol I	GABA Receptor; Antifection	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Kushenol I is a GABAA receptor modulator, it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).Kushenol I is shown to be active against the plant pathogenic fungus Cladosporium cucumerinum.
T82433	Eugenitol 7-Noreugenitin
	Eugenitol (Compound 3) 为从Diaporthe eucalyptorum分离出的抗真菌代谢产物，可抑制四种植物病原真菌（Alternaria solani, Botrytis cinerea, Fusarium solani及Gibberella saubinettii）。
T35911	Piliformic Acid
	Piliformic acid is a fungal metabolite that has been found inN. pseudotrichiaand has diverse biological activities.1,2It is cytotoxic to BC-1 human breast cancer cells (IC50= 5 μg/ml).2Piloformic acid is active againstL. braziliensisamastigotes (IC50= 78.5 μM). It is also active against the plant pathogenic fungiC. gloeosporioides(MIC = 292 μM).1 1.Elias, L.M., Fortkamp, D., Sartori, S.B., et al.The potential of compounds isolated from Xylaria spp. as antifungal agents against anthracnoseBraz. J...
T38394	PSMα3
	PSMα3 is a peptide compound that can be utilized to induce tolerance in dendritic cells (DCs) for DC vaccination strategies. It effectively penetrates and modulates human monocyte-derived DCs by modifying the maturation process induced by TLR2 or TLR4. Additionally, PSMα3 inhibits the production of both pro- and anti-inflammatory cytokines and decreases antigen uptake. Notably, PSMα3 is a significant virulence factor released by the most pathogenic strains of methicillin-resistant Staphylococcus...
T75677	Protoneogracillin
	Protoneogracillin 是一种呋甾醇糖苷，具有抑制植物病原真菌 P.oryzae 的活性 (MMDC=94.0 μM)，对 K562 癌细胞的细胞毒活性 (IC50=6.6 μM)。
T79989	Funiculosin	Antibiotic	Microbiology/Virology
	Funiculosin为一种中性亲脂性抗生素，能够抑制DNA及RNA病毒，并具备抗真菌活性。在初级鸡胚成纤维细胞中，Funiculosin可有效抑制致病真菌引发的感染。
T75475	Chaetosemin J
	Chaetosemin J，一种对植物病原真菌（如灰霉病菌、番茄交链孢菌、稻瘟病菌和赤霉素）具有抑制活性的抗真菌代谢产物，MIC值在12.5-25 μM范围内。
T38268	Validamycin A
	Validamycin A is an antifungal agent used to protect rice plants against sheath blight caused by the pathogenic fungus, R. solani, due to its ability to inhibit trehalase, a trehalose-hydrolizing enzyme (Ki = 1.9 nM; IC50 = 0.7 μM). It is also effective against the growth and sporulation of R. cerealis, F. culmorum, and other fungi. This compound has also been used to study trehalase activity and trehalose biosynthesis.
T36348	Cerebroside C
	Cerebroside C is a fungal metabolite and glycosphingolipid that has been found in the rice pathogenic fungusM. grisea.1It induces production of the phytoalexin momilactone A when applied to wounded rice leaves, indicating that cerebroside C is an elicitor of the hypersensitive response in rice. Cerebroside C increases germination rate and reduces germination time in wheat seeds in a concentration-dependent manner at 4°C.2It also increases root length, fresh weight, and dry weight of wheat seedli...
T75600	Coronatine
	Coronatine 是丁香假单胞菌产生的一种植物生长调节剂。Coronatine 模拟生物活性茉莉酸 (jasmonic acid) 缀合物或高等植物的 octadecanoid 信号分子使植物出现致病症状。Coronatine 通过激活抑制水杨酸 (Salicylic acid) 积累的信号级联，促进植物中丁香假单胞菌的毒力。
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...
TN4168	Grifolin	Others	Others
	Grifolin has anti-cancer effects, it induces apoptosis and promotes cell cycle arrest in the A2780 human ovarian cancer cell line via inactivation of the ERK1/2 and Akt pathways; it enhances the differentiation and proliferation of oligodendrocyte precurs

天然产物

Cat.No: TN2279

Synonym: (+)-Totarol,桃柁酚

Target: Antibacterial, Antifection

Cat.No: T15001

Target: Others, Antifungal

Cat.No: T5S0993

Synonym: 苦参酮,苦参黄素

Target: BCL, Others, IκB/IKK, TNF, NF-κB, JAK, STAT

2',3'-cGAMP sodium

Cat.No: T10065L

Synonym: 2'-3'-cyclic GMP-AMP sodium

Target: STING, cGAS

Dihydrochelerythrine

Cat.No: T3S0057

Synonym: 12,13-Dihydrochelerythrine,二氢白屈菜红碱

Target: Antifungal

Benzylideneacetone

Cat.No: TN6993

Synonym: Benzalacetone

Target: Phospholipase, Endogenous Metabolite

Cat.No: TQ0216

Synonym: 1α,25-Dihydroxy Vitamin D2

Target: Others

2-Methoxyanofinic acid

Cat.No: TN2772

Target: Antifection

Cat.No: T39261

8-Hydroxy-3,5,6,7,3',4'-hexamethoxyflavone

Cat.No: TN1344

Target: Antifection

Cat.No: TN5680

Isosativenediol

Cat.No: TN4328

Target: Others

Cat.No: TN5629

Cat.No: TN5061

Target: Adrenergic Receptor, Antifection

Cat.No: T28379

Synonym: PF1163B,(-)-PF1163B,PF 1163B

Methyllinderone

Cat.No: TN1931

Target: Antifection

Cat.No: TN6010

Protoplumericin A

Cat.No: TN4834

Target: Antifection

Cat.No: TN1063

Synonym: 蜡梅碱,腊梅碱

Target: Antifection

Cat.No: T40600

Dendryphiellin D

Cat.No: T75456

Septeremophilane E

Cat.No: T75457

Cat.No: T11009

Target: Others

Cat.No: TN3461

Target: Influenza Virus

Cat.No: T69058

Cat.No: T79942

Cat.No: T35741

Cat.No: TN1842

Target: GABA Receptor, Antifection

Cat.No: T82433

Synonym: 7-Noreugenitin

Piliformic Acid

Cat.No: T35911

Cat.No: T38394

Protoneogracillin

Cat.No: T75677

Cat.No: T79989

Target: Antibiotic

Cat.No: T75475

Cat.No: T38268

Cat.No: T36348

Cat.No: T75600

Cat.No: T35779

Cat.No: TN4168

Target: Others

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